scholarly journals Predicting lapses of attention with sleep-like slow waves

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Thomas Andrillon ◽  
Angus Burns ◽  
Teigane Mackay ◽  
Jennifer Windt ◽  
Naotsugu Tsuchiya
Keyword(s):  
Neural Activity ◽  
Subjective Experience ◽  
Mind Wandering ◽  
Mental States ◽  
Slow Waves ◽  
Neural Mechanisms ◽  
Stream Of Consciousness ◽  
Attentional Lapses ◽  
Healthy Participants ◽  
Local Sleep

AbstractAttentional lapses occur commonly and are associated with mind wandering, where focus is turned to thoughts unrelated to ongoing tasks and environmental demands, or mind blanking, where the stream of consciousness itself comes to a halt. To understand the neural mechanisms underlying attentional lapses, we studied the behaviour, subjective experience and neural activity of healthy participants performing a task. Random interruptions prompted participants to indicate their mental states as task-focused, mind-wandering or mind-blanking. Using high-density electroencephalography, we report here that spatially and temporally localized slow waves, a pattern of neural activity characteristic of the transition toward sleep, accompany behavioural markers of lapses and preceded reports of mind wandering and mind blanking. The location of slow waves could distinguish between sluggish and impulsive behaviours, and between mind wandering and mind blanking. Our results suggest attentional lapses share a common physiological origin: the emergence of local sleep-like activity within the awake brain.

scholarly journals Wandering minds, sleepy brains: lapses of attention and local sleep in wakefulness

2020 ◽  
Author(s):  
Thomas Andrillon ◽  
Angus Burns ◽  
Teigane MacKay ◽  
Jennifer Windt ◽  
Naotsugu Tsuchiya
Keyword(s):  
Neural Activity ◽  
Subjective Experience ◽  
Mind Wandering ◽  
Mental States ◽  
Cognitive Profiles ◽  
Stream Of Consciousness ◽  
Impact Performance ◽  
Attentional Lapses ◽  
The Mind ◽  
Local Sleep

AbstractAttentional lapses are ubiquitous and can negatively impact performance. They correlate with mind wandering, or thoughts that are unrelated to ongoing tasks and environmental demands. In other cases, the stream of consciousness itself comes to a halt and the mind goes blank. What happens in the brain that leads to these mental states? To understand the neural mechanisms underlying attentional lapses, we cross-analyzed the behavior, subjective experience and neural activity of healthy participants performing a task. Random interruptions prompted participants to indicate whether they were task-focused, mind-wandering or mind-blanking. High-density electroencephalography revealed the occurrence of spatially and temporally localized sleep-like patterns of neural activity. This “local sleep” accompanied behavioral markers of lapses and preceded reports of mind wandering and mind blanking. Furthermore, the location of local sleep distinguished sluggish versus impulsive behaviors, mind wandering versus mind blanking. Despite contrasting cognitive profiles, attentional lapses could share a common physiological origin: the appearance of local islets of sleep within the awake brain.

scholarly journals Wandering minds, sleepy brains: lapses of attention and local sleep in wakefulness

2020 ◽  
Author(s):  
Thomas Andrillon ◽  
Angus Burns ◽  
Teigane Mackay ◽  
Jennifer Windt ◽  
Naotsugu Tsuchiya
Keyword(s):  
Neural Activity ◽  
Subjective Experience ◽  
Mind Wandering ◽  
Mental States ◽  
Cognitive Profiles ◽  
Stream Of Consciousness ◽  
Impact Performance ◽  
Attentional Lapses ◽  
The Mind ◽  
Local Sleep

Abstract Attentional lapses are ubiquitous and can negatively impact performance. They correlate with mind wandering, or thoughts that are unrelated to ongoing tasks and environmental demands. In other cases, the stream of consciousness itself comes to a halt and the mind goes blank. What happens in the brain that leads to these mental states? To understand the neural mechanisms underlying attentional lapses, we cross-analyzed the behavior, subjective experience and neural activity of healthy participants performing a task. Random interruptions prompted participants to indicate whether they were task-focused, mind-wandering or mind-blanking. High-density electroencephalography revealed the occurrence of spatially and temporally localized sleep-like patterns of neural activity. This “local sleep” accompanied behavioral markers of lapses and preceded reports of mind wandering and mind blanking. Furthermore, the location of local sleep distinguished sluggish versus impulsive behaviors, mind wandering versus mind blanking. Despite contrasting cognitive profiles, attentional lapses could share a common physiological origin: the appearance of local islets of sleep within the awake brain.

scholarly journals Does the mind wander when the brain takes a break? Local sleep in wakefulness, attentional lapses and mind-wandering

2019 ◽  
Author(s):  
Thomas Andrillon ◽  
Jennifer Windt ◽  
Tim Silk ◽  
Sean Drummond ◽  
Mark Bellgrove ◽  
...  
Keyword(s):  
Subjective Experience ◽  
Neural Mechanism ◽  
Mind Wandering ◽  
Subjective Experiences ◽  
Impaired Performance ◽  
Behavioural Profile ◽  
The Difference ◽  
Attentional Lapses ◽  
The Mind ◽  
Local Sleep

Sleep has been classically described as an all-or-nothing global phenomenon. However, recent research suggests that this view requires tempering. Invasive and non-invasive recordings in animals and humans show that neural activity typically associated with sleep can locally occur during wakefulness. Although local sleep is defined neuronally, it has been associated with impaired performance during cognitive tasks. Comparatively, the phenomenology of local sleep (i.e. what it feels like when your brain is partially asleep) has been less explored. Taking into account the literature on the neuronal and behavioural profile of local sleep intrusions in wakefulness, we propose that occurrences of local sleep could represent the neural mechanism underlying many attentional lapses. In particular, we argue that a unique physiological event such as local sleep could account for a diversity of behavioural outcomes from sluggish to impulsive responses. We further propose that local sleep intrusions could impact individuals’ subjective experience. Specifically, we propose that the timing and anatomical sources of local sleep intrusions could be responsible for both the behavioural consequences and subjective content of attentional lapses and may underlie the difference between subjective experiences such as mind wandering and mind blanking. Our framework aims to build a parallel between spontaneous experiences in sleep and wakefulness by integrating evidence across neuronal, behavioural and experiential levels. We use the example of attention deficit hyperactivity disorder (ADHD) to illustrate how local sleep could explain complex cognitive profiles which include inattention, impulsivity, mind-wandering and mind-blanking.

scholarly journals Exploring the role of expectations and stimulus relevance on stimulus-specific neural representations and conscious report

2019 ◽  
Vol 2019 (1) ◽  
Author(s):  
Erik L Meijs ◽  
Pim Mostert ◽  
Heleen A Slagter ◽  
Floris P de Lange ◽  
Simon van Gaal
Keyword(s):  
Attentional Blink ◽  
Neural Activity ◽  
Subjective Experience ◽  
Activity Patterns ◽  
Neural Mechanisms ◽  
Top Down ◽  
Neural Representations ◽  
Dependent Signal ◽  
Task Irrelevant

Abstract Subjective experience can be influenced by top-down factors, such as expectations and stimulus relevance. Recently, it has been shown that expectations can enhance the likelihood that a stimulus is consciously reported, but the neural mechanisms supporting this enhancement are still unclear. We manipulated stimulus expectations within the attentional blink (AB) paradigm using letters and combined visual psychophysics with magnetoencephalographic (MEG) recordings to investigate whether prior expectations may enhance conscious access by sharpening stimulus-specific neural representations. We further explored how stimulus-specific neural activity patterns are affected by the factors expectation, stimulus relevance and conscious report. First, we show that valid expectations about the identity of an upcoming stimulus increase the likelihood that it is consciously reported. Second, using a series of multivariate decoding analyses, we show that the identity of letters presented in and out of the AB can be reliably decoded from MEG data. Third, we show that early sensory stimulus-specific neural representations are similar for reported and missed target letters in the AB task (active report required) and an oddball task in which the letter was clearly presented but its identity was task-irrelevant. However, later sustained and stable stimulus-specific representations were uniquely observed when target letters were consciously reported (decision-dependent signal). Fourth, we show that global pre-stimulus neural activity biased perceptual decisions for a ‘seen’ response. Fifth and last, no evidence was obtained for the sharpening of sensory representations by top-down expectations. We discuss these findings in light of emerging models of perception and conscious report highlighting the role of expectations and stimulus relevance.

scholarly journals Mesoscale cortex-wide neural dynamics predict self-initiated actions in mice several seconds prior to movement

2021 ◽  
Author(s):  
Catalin Mitelut ◽  
Yongxu Zhang ◽  
Yuki Sekino ◽  
Jamie Boyd ◽  
Federico Bolanos ◽  
...  
Keyword(s):  
Neural Activity ◽  
Subjective Experience ◽  
Random Processes ◽  
Neural Mechanisms ◽  
Human Studies ◽  
Voluntary Action ◽  
Neural Dynamics ◽  
Behavior Prediction ◽  
Natural Behavior ◽  
Changes Over Time

Volition - the sense of control or agency over one's voluntary actions - is widely recognized as the basis of both human subjective experience and natural behavior in non-human animals. To date, several human studies have found peaks in neural activity preceding voluntary actions, e.g. the readiness potential (RP), and some have shown upcoming actions could be decoded even before awareness. These findings remain controversial with some suggesting they pose a challenge to traditional accounts of human volition while others proposing that random processes underlie pre-movement neural activity. Here we seek to address part of this controversy by evaluating whether pre-movement neural activity in mice contains structure beyond that expected from random processes. Implementing a self-initiated water-rewarded lever pull paradigm in mice while recording widefield [Ca++] neural activity we find that cortical activity changes in variance seconds prior to movement and that upcoming lever pulls or spontaneous body movements could be predicted between 1 second to more than 10 seconds prior to movement, similar to but even earlier than in human studies. We show that mice, like humans, are biased towards initiation of voluntary actions during specific phases of neural activity oscillations but that the pre-movement neural code in mice changes over time and is widely distributed as behavior prediction improved when using all vs single cortical areas. These findings support the presence of structured multi-second neural dynamics preceding voluntary action beyond that expected from random processes. Our results also suggest that neural mechanisms underlying self-initiated voluntary action could be preserved between mice and humans.

scholarly journals Does the Mind Wander When the Brain Takes a Break? Local Sleep in Wakefulness, Attentional Lapses and Mind-Wandering

2019 ◽  
Vol 13 ◽  
Author(s):  
Thomas Andrillon ◽  
Jennifer Windt ◽  
Tim Silk ◽  
Sean P. A. Drummond ◽  
Mark A. Bellgrove ◽  
...  
Keyword(s):  
Mind Wandering ◽  
Attentional Lapses ◽  
The Mind ◽  
The Brain ◽  
Local Sleep

scholarly journals Mind-wandering Is Accompanied by Both Local Sleep and Enhanced Processes of Spatial Attention Allocation

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Christian Wienke ◽  
Mandy V Bartsch ◽  
Lena Vogelgesang ◽  
Christoph Reichert ◽  
Hermann Hinrichs ◽  
...  
Keyword(s):  
Search Task ◽  
Brain Activity ◽  
Target Selection ◽  
Mind Wandering ◽  
Attentional Selection ◽  
Self Report ◽  
Cortical Processing ◽  
High Frequency Activity ◽  
External Stimuli ◽  
Local Sleep

Abstract Mind-wandering (MW) is a subjective, cognitive phenomenon, in which thoughts move away from the task toward an internal train of thoughts, possibly during phases of neuronal sleep-like activity (local sleep, LS). MW decreases cortical processing of external stimuli and is assumed to decouple attention from the external world. Here, we directly tested how indicators of LS, cortical processing, and attentional selection change in a pop-out visual search task during phases of MW. Participants’ brain activity was recorded using magnetoencephalography, MW was assessed via self-report using randomly interspersed probes. As expected, the performance decreased under MW. Consistent with the occurrence of LS, MW was accompanied by a decrease in high-frequency activity (HFA, 80–150 Hz) and an increase in slow wave activity (SWA, 1–6 Hz). In contrast, visual attentional selection as indexed by the N2pc component was enhanced during MW with the N2pc amplitude being directly linked to participants’ performance. This observation clearly contradicts accounts of attentional decoupling that would predict a decrease in attention-related responses to external stimuli during MW. Together, our results suggest that MW occurs during phases of LS with processes of attentional target selection being upregulated, potentially to compensate for the mental distraction during MW.

The Clinician’s Subjective Experience during the Interaction with Adolescent Psychiatric Patients: Validity and Reliability of the Assessment of Clinician’s Subjective Experience

2021 ◽  
pp. 1-8
Author(s):  
Angelo Picardi ◽  
Sara Panunzi ◽  
Sofia Misuraca ◽  
Chiara Di Maggio ◽  
Andrea Maugeri ◽  
...  
Keyword(s):  
Clinical Examination ◽  
Subjective Experience ◽  
Rating Scale ◽  
Mood State ◽  
Psychiatric Patients ◽  
Temporal Stability ◽  
Young Patients ◽  
Reliability And Validity ◽  
Mental States ◽  
Validity And Reliability

<b><i>Introduction:</i></b> The last decade has witnessed a resurgence of interest in the clinician’s subjectivity and its role in the diagnostic assessment. Integrating the criteriological, third-person approach to patient evaluation and psychiatric diagnosis with other approaches that take into account the patient’s subjective and intersubjective experience may bear particular importance in the assessment of very young patients. The ACSE (Assessment of Clinician’s Subjective Experience) instrument may provide a practical way to probe the intersubjective field of the clinical examination; however, its reliability and validity in child and adolescent psychiatrists seeing very young patients is still to be determined. <b><i>Methods:</i></b> Thirty-three clinicians and 278 first-contact patients aged 12–17 years participated in this study. The clinicians completed the ACSE instrument and the Brief Psychiatric Rating Scale after seeing the patient, and the Profile of Mood State (POMS) just before seeing the patient and immediately after. The ACSE was completed again for 45 patients over a short (1–4 days) retest interval. <b><i>Results:</i></b> All ACSE scales showed high internal consistency and moderate to high temporal stability. Also, they displayed meaningful correlations with the changes in conceptually related POMS scales during the clinical examination. <b><i>Discussion:</i></b> The findings corroborate and extend previous work on adult patients and suggest that the ACSE provides a valid and reliable measure of the clinician’s subjective experience in adolescent psychiatric practice, too. The instrument may prove to be useful to help identify patients in the early stages of psychosis, in whom subtle alterations of being with others may be the only detectable sign. Future studies are needed to determine the feasibility and usefulness of integrating the ACSE within current approaches to the evaluation of at-risk mental states.

scholarly journals Harmonic Brain Modes: A Unifying Framework for Linking Space and Time in Brain Dynamics

2017 ◽  
Vol 24 (3) ◽  
pp. 277-293 ◽  
Author(s):  
Selen Atasoy ◽  
Gustavo Deco ◽  
Morten L. Kringelbach ◽  
Joel Pearson
Keyword(s):  
Neural Activity ◽  
Brain Activity ◽  
Activity Patterns ◽  
Structural Connectivity ◽  
Building Blocks ◽  
Mental States ◽  
Brain Dynamics ◽  
Space And Time ◽  
Wide Range ◽  
The Brain

A fundamental characteristic of spontaneous brain activity is coherent oscillations covering a wide range of frequencies. Interestingly, these temporal oscillations are highly correlated among spatially distributed cortical areas forming structured correlation patterns known as the resting state networks, although the brain is never truly at “rest.” Here, we introduce the concept of harmonic brain modes—fundamental building blocks of complex spatiotemporal patterns of neural activity. We define these elementary harmonic brain modes as harmonic modes of structural connectivity; that is, connectome harmonics, yielding fully synchronous neural activity patterns with different frequency oscillations emerging on and constrained by the particular structure of the brain. Hence, this particular definition implicitly links the hitherto poorly understood dimensions of space and time in brain dynamics and its underlying anatomy. Further we show how harmonic brain modes can explain the relationship between neurophysiological, temporal, and network-level changes in the brain across different mental states ( wakefulness, sleep, anesthesia, psychedelic). Notably, when decoded as activation of connectome harmonics, spatial and temporal characteristics of neural activity naturally emerge from the interplay between excitation and inhibition and this critical relation fits the spatial, temporal, and neurophysiological changes associated with different mental states. Thus, the introduced framework of harmonic brain modes not only establishes a relation between the spatial structure of correlation patterns and temporal oscillations (linking space and time in brain dynamics), but also enables a new dimension of tools for understanding fundamental principles underlying brain dynamics in different states of consciousness.

Sign in / Sign up

Export Citation Format

Share Document