scholarly journals Abrupt hippocampal remapping signals resolution of memory interference

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Guo Wanjia ◽  
Serra E. Favila ◽  
Ghootae Kim ◽  
Robert J. Molitor ◽  
Brice A. Kuhl

AbstractRemapping refers to a decorrelation of hippocampal representations of similar spatial environments. While it has been speculated that remapping may contribute to the resolution of episodic memory interference in humans, direct evidence is surprisingly limited. We tested this idea using high-resolution, pattern-based fMRI analyses. Here we show that activity patterns in human CA3/dentate gyrus exhibit an abrupt, temporally-specific decorrelation of highly similar memory representations that is precisely coupled with behavioral expressions of successful learning. The magnitude of this learning-related decorrelation was predicted by the amount of pattern overlap during initial stages of learning, with greater initial overlap leading to stronger decorrelation. Finally, we show that remapped activity patterns carry relatively more information about learned episodic associations compared to competing associations, further validating the learning-related significance of remapping. Collectively, these findings establish a critical link between hippocampal remapping and episodic memory interference and provide insight into why remapping occurs.

2021 ◽  
Author(s):  
Wanjia Guo ◽  
Serra Favila ◽  
Ghootae Kim ◽  
Robert Molitor ◽  
Brice Kuhl

Abstract Remapping refers to a decorrelation of hippocampal representations of similar spatial environments. While it has been speculated that remapping may contribute to the resolution of episodic memory interference in humans, direct evidence is surprisingly limited. Here, we tested this idea using high-resolution, pattern-based fMRI analyses. We show that activity patterns in human CA3/dentate gyrus exhibit an abrupt, temporally-specific decorrelation of highly similar memory representations that is precisely coupled with behavioral expressions of successful learning. Strikingly, the magnitude of this learning-related decorrelation was predicted by the amount of pattern overlap during initial stages of learning, with greater initial overlap leading to stronger decorrelation. Finally, we show that remapped activity patterns carry relatively more information about learned episodic associations compared to competing associations, further validating the learning-related significance of remapping. Collectively, these findings establish a critical link between hippocampal remapping and episodic memory interference and provide novel insight into why remapping occurs.


2021 ◽  
Author(s):  
Wanjia Guo ◽  
Serra E. Favila ◽  
Ghootae Kim ◽  
Robert J. Molitor ◽  
Brice A. Kuhl

ABSTRACTRemapping refers to a decorrelation of hippocampal representations of similar spatial environments. While it has been speculated that remapping may contribute to the resolution of episodic memory interference in humans, direct evidence is surprisingly limited. Here, we tested this idea using high-resolution, pattern-based fMRI analyses. We show that activity patterns in human CA3/dentate gyrus exhibit an abrupt, temporally-specific decorrelation of highly similar memory representations that is precisely coupled with behavioral expressions of successful learning. Strikingly, the magnitude of this learning-related decorrelation was predicted by the amount of pattern overlap during initial stages of learning, with greater initial overlap leading to stronger decorrelation. Finally, we show that remapped activity patterns carry relatively more information about learned episodic associations compared to competing associations, further validating the learning-related significance of remapping. Collectively, these findings establish a critical link between hippocampal remapping and episodic memory interference and provide novel insight into why remapping occurs.


2016 ◽  
Vol 113 (4) ◽  
pp. E420-E429 ◽  
Author(s):  
Mariam Aly ◽  
Nicholas B. Turk-Browne

Attention influences what is later remembered, but little is known about how this occurs in the brain. We hypothesized that behavioral goals modulate the attentional state of the hippocampus to prioritize goal-relevant aspects of experience for encoding. Participants viewed rooms with paintings, attending to room layouts or painting styles on different trials during high-resolution functional MRI. We identified template activity patterns in each hippocampal subfield that corresponded to the attentional state induced by each task. Participants then incidentally encoded new rooms with art while attending to the layout or painting style, and memory was subsequently tested. We found that when task-relevant information was better remembered, the hippocampus was more likely to have been in the correct attentional state during encoding. This effect was specific to the hippocampus, and not found in medial temporal lobe cortex, category-selective areas of the visual system, or elsewhere in the brain. These findings provide mechanistic insight into how attention transforms percepts into memories.


2019 ◽  
Author(s):  
Halle R. Dimsdale-Zucker ◽  
Maria E. Montchal ◽  
Zachariah M. Reagh ◽  
Shao-Fang Wang ◽  
Laura A. Libby ◽  
...  

AbstractThe hippocampus plays a critical role in supporting episodic memory. Although we know that temporal context is a defining feature of episodic memory, we understand relatively little about how this information may be represented by the hippocampus. Research in rodents has suggested that the hippocampus represents temporal information on an absolute scale or in terms of relative temporal intervals, but cognitive models of memory have argued that temporal context in episodic memory is a consequence of changes in cognitive states and experiences. Here, we combined high-resolution fMRI imaging with voxel pattern similarity analyses to answer the question of how human hippocampal subfields represent retrieved information about cognitive states and the time at which a past event took place. As participants recollected previously presented items, activity patterns in the CA23DG subregion carried information about prior cognitive states, along with coarse-grained information about when the item was previously encountered. These findings are consistent with the idea that CA23DG supports temporal context in episodic memory by encoding an integrated representation of discrete and gradually-changing cognitive states.


Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.


2006 ◽  
Vol 73 ◽  
pp. 109-119 ◽  
Author(s):  
Chris Stockdale ◽  
Michael Bruno ◽  
Helder Ferreira ◽  
Elisa Garcia-Wilson ◽  
Nicola Wiechens ◽  
...  

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.


2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Olav Sundnes ◽  
William Ottestad ◽  
Camilla Schjalm ◽  
Peter Lundbäck ◽  
Lars la Cour Poulsen ◽  
...  

Abstract Background Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple trauma. In this study we explored high-resolution concentration kinetics of the alarmin interleukin-33 (IL-33) early after human trauma. Methods Plasma samples were serially collected from 136 trauma patients immediately after hospital admission, 2, 4, 6, and 8 h thereafter, and every morning in the ICU. Levels of IL-33 and its decoy receptor sST2 were measured by immunoassays. Results We observed a rapid and transient surge of IL-33 in a subset of critically injured patients. These patients had more widespread tissue injuries and a greater degree of early coagulopathy. IL-33 half-life (t1/2) was 1.4 h (95% CI 1.2–1.6). sST2 displayed a distinctly different pattern with low initial levels but massive increase at later time points. Conclusions We describe for the first time early high-resolution IL-33 concentration kinetics in individual patients after trauma and correlate systemic IL-33 release to clinical data. These findings provide insight into a potentially important axis of danger signaling in humans.


2021 ◽  
Author(s):  
Kevin Michael Torres ◽  
Noura Al Madani ◽  
Rodrigo Rafael Gutierrez

Abstract The study presents the sequence stratigraphy of the carbonate platform focused in lower part of Shuaiba Formation, as well as the organization of the arrangement formed by the cyclical sedimentological evolution at high-resolution scale, through the facies analysis, diagenetical imprints and finally, significance of stable carbonate isotope results in the building up of carbonate platform in southeast Abu Dhabi. Interpreted stratigraphic surfaces from integration of depositional facies reviewed in all available cored data within studied area and stable carbon isotope results allowed that four small-scale regression-transgression depositional cycles can be discriminated which are stacked into a medium-scale sequence, that may record a 600 kyr Milankovitch signal. The small-scale sequences were correlated within the studied area using both conventional well logs and stable isotope records. Transgression hemicycles represent the increasing of accommodation space and can be identified in direct evidence, such as 25-40 ft. thickness of lithocodium/bacinella floatstones and skeletal peloidal packstones facies, association of facies interpreted within upper slope sub-environment. Likewise, in δ13C profiles, the rise/fall turnarounds of small-scale sequences are marked by negative δ13C peaks and associated with characteristics patterns: (1) proportion decrease of shallower sub-environments facies is interpreted as an rising relative sea-level and (2) decreasing δ13C trends interpreted to be related to decreasing nutrient supply. The medium/big pores of floatstones poorly connected in packstone matrix are expressed in the medium/high porosity with low permeabilities. In contrast, regressive hemicycles represent the reduction in accommodation space and can be characterized in direct evidence, such as the growing up of persistent 10-20 ft. thickness with thousands of meters of correlation of stromatoporoids and rudist facies, association of facies interpreted within shelf-margin complex sub-environment. In addition, the fall/rise turnarounds are marked by positive δ13C peaks, associated with the stromatoporoids/rudists mounds with characteristic patterns: (1) proportion increase of shallower sub-environments facies is interpreted as falling relative sea-level and increase in proximity and (2) increasing δ13C values interpreted to reflect increasing nutrient supply. Unusually very high permeability is attributed to the present of fractures and dissolution events that is enhanced where proportion of stromatoporoids facies are more pronounced. The described characterization resulted in the identification of genetic cycles that reproduce the sedimentological evolution, which are presented in small-scale sequences. In addition, the δ13C values enabled to understand the internal organization and the development of the carbonate building up in the Shuaiba shallow platform evolution. This study provides update and understanding on sedimentary facies, depositional pattern, and expands on previous published works, using new approach from semi-regional to local scales. Finally, results help to understand the laterally extensive water break-through thin intervals, which are directly related to the regressive hemicycles described previously.


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