APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome

Nutrition is a key environmental factor that is particularly involved in the pathogenesis and progression of several polygenic, diet-related diseases. Nutrigenomics refers to the interaction between nutrition and the human genome. Dietary fatty acids interact with multiple nutrient-sensitive transcription factors. This explains the molecular basis of some of the health effects associated with altered dietary fatty acid composition. The metabolic syndrome is a very common condition, characterized by insulin resistance, abdominal obesity, dyslipidaemia and hypertension. It often precedes Type 2 diabetes mellitus, and is associated with a greater risk of cardiovascular disease. Several lines of evidence suggest that the interaction between nutrient-derived metabolic stressors and pro-inflammatory signals play an important role in the aetiology of insulin resistance and the development of the metabolic syndrome. This paper will address the interaction between several nutrient-sensitive transcription factors, including SREBP (sterol-regulatory-element-binding protein) and NFκB (nuclear factor κB), demonstrating how this interaction may be altered with dietary fatty acid interventions.

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Plasma fatty acid profile and prooxidative-antioxidative parameters in vegetarians

Nahrung/Food ◽

10.1002/food.19950390509 ◽

1995 ◽

Vol 39 (5-6) ◽

pp. 452-457 ◽

Cited By ~ 2

Author(s):

M. Krajčovičová-Kudláčková ◽

R. Šimončič ◽

A. Béderová ◽

J. Klvanová ◽

K. Babinska ◽

...

Keyword(s):

Fatty Acid ◽

Fatty Acid Profile ◽

Plasma Fatty Acid ◽

Plasma Fatty Acid Profile

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Plasma fatty acid profile in dairy cows associated with the inclusion of annatto in their diet

Acta Scientiarum Animal Sciences ◽

10.4025/actascianimsci.v42i1.47651 ◽

2020 ◽

Vol 42 ◽

pp. e47651

Author(s):

Clarissa Sampaio de Oliveira Lima ◽

Albericio Pereira de Andrade ◽

André Luiz Rodrigues Magalhães ◽

Omer Cavalcanti de Almeida ◽

Sebastião Inocêncio Guido ◽

...

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Dairy Cows ◽

Fatty Acid Profile ◽

Plasma Lipid ◽

High Density Lipoproteins ◽

Plasma Fatty Acid ◽

Randomized Design ◽

Completely Randomized Design ◽

Plasma Fatty Acid Profile

The objective of this study was to evaluate the plasma lipid profile and plasma fatty acids of dairy cows receiving diets supplemented with annatto. A total of 32 Holstein cows (550 kg), distributed in a completely randomized design, were allocated to individual stalls and submitted to following treatments: C0 = no annatto; C4 = inclusion of annatto at 4 g kg-1 dry matter (DM) of diet (0.07 g bixin kg-1 diet); C5 = inclusion of annatto at 5 g kg-1 DM of diet (0.09 g bixin kg-1 diet); and C7 = inclusion of annatto at 7 g kg-1 DM of diet (0.12 g bixin kg-1 diet). Blood samples were collected via epigastric vein puncture, centrifuged, and frozen for subsequent analysis. The results indicate that the inclusion (p > 0.05) of annatto does not decrease the total cholesterol or low and high density lipoproteins. However, it impacts the profile of fatty acids, evidenced by the reduction (p < 0.05) in levels of hypercholesterolemic fatty acids viz, myristic acid and palmitic acid. It also causes an increase in the levels of arachidonic acid, rumenic acid, linoleic acid, and total polyunsaturated fatty acids. Therefore, bixin included in the diets of dairy cows induces changes in the plasma fatty acid profile.

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