scholarly journals MiR-92a and miR-486 are potential diagnostic biomarkers for mercury poisoning and jointly sustain NF-κB activity in mercury toxicity

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Enmin Ding ◽  
Jun Guo ◽  
Ying Bai ◽  
Hengdong Zhang ◽  
Xin Liu ◽  
...  
Keyword(s):  
Mercury Toxicity ◽  
Mercury Poisoning ◽  
Diagnostic Biomarkers

scholarly journals Diagnostic Value of Urine Mercury Measurements

1977 ◽  
Vol 14 (1-6) ◽  
pp. 297-300 ◽  
Author(s):  
Andrew Taylor ◽  
Vincent Marks
Keyword(s):  
Heavy Metals ◽  
Case Reports ◽  
Diagnostic Value ◽  
Mercury Toxicity ◽  
Mercury Poisoning ◽  
Urine Mercury

A review of referrals to a regional heavy metals centre for possible mercury poisoning was made. Samples were received either from subjects who were well but were known to have some contact with mercury or from patients with an illness under investigation but undiagnosed. The problems associated with diagnosis of mercury toxicity in the absence of known exposure are illustrated by two case reports.

scholarly journals Mercury Toxicity on Sodium Pump and Organoseleniums Intervention: A Paradox

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Ige Joseph Kade
Keyword(s):  
Sodium Pump ◽  
Living System ◽  
Mercury Toxicity ◽  
Thiol Groups ◽  
Mercury Poisoning ◽  
Concomitant Increase ◽  
Organoselenium Compounds ◽  
Antioxidant Effects

Mercury is an environmental poison, and the damage to living system is generally severe. The severity of mercury poisoning is consequent from the fact that it targets the thiol-containing enzymes, irreversibly oxidizing their critical thiol groups, consequently leading to an inactivation of the enzyme. The Na+/K+-ATPase is a sulfhydryl protein that is sensitive to Hg2+assault. On the other hand, organoseleniums are a class of pharmacologically promising compounds with potent antioxidant effects. While Hg2+oxidizes sulfhydryl groups of Na+/K+-ATPase underin vitroandin vivoconditions, the organoselenium compounds inhibit Na+/K+-ATPasein vitrobut enhance its activities underin vivoconditions with concomitant increase in the level of endogenous thiols. Paradoxically, it appears that these two thiol oxidants can be used to counteract one another underin vivoconditions, and this hypothesis serves as the basis for this paper.

Study of The Role of Mercury Poisoning in Rheumatoid Arthritis Patients and Its Relation with Zinc and Copper Levels

2012 ◽  
Vol 20 (2) ◽  
pp. 49-64
Author(s):  
Afaf Attia ◽  
Sohayla Attalla ◽  
Reham Shaat ◽  
Enas Hmmad ◽  
Mohammed El-Dafrawy
Keyword(s):  
Rheumatoid Arthritis ◽  
Mercury Poisoning

MiRNA-145 and Its Direct Downstream Targets in Digestive System Cancers: A Promising Therapeutic Target

2020 ◽  
Vol 26 ◽  
Author(s):  
Yini Ma ◽  
Xiu Cao ◽  
Guojuan Shi ◽  
Tianlu Shi
Keyword(s):  
Digestive System ◽  
Target Genes ◽  
Malignant Neoplasm ◽  
Vital Role ◽  
Diagnostic Biomarkers ◽  
Cellular Processes ◽  
Promising Therapeutic Target ◽  
Direct Target ◽  
Potential Strategy

: MicroRNAs (miRNAs) play a vital role in the onset and development of many diseases, including cancers. Emerging evidence shows that numerous miRNAs have the potential to be used as diagnostic biomarkers for cancers, and miRNA-based therapy may be a promising therapy for the treatment of malignant neoplasm. MicroRNA-145 (miR-145) has been considered to play certain roles in various cellular processes, such as proliferation, differentiation and apoptosis, via modulating expression of direct target genes. Recent reports show that miR-145 participates in the progression of digestive system cancers, and plays crucial and novel roles for cancer treatment. In this review, we summarize the recent knowledge concerning the function of miR-145 and its direct targets in digestive system cancers. We discuss the potential role of miR-145 as valuable biomarkers for digestive system cancers and how miR-145 regulates these digestive system cancers via different targets to explore the potential strategy of targeting miR-145.

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