Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model

Supplementation with low doses of a cocoa extract induces metabolic benefits in the prevention of metabolic syndrome in rats, reducing body-weight gain, visceral adiposity and liver steatosis and improving insulin sensitivity and glucose tolerance.

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The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

Frontiers in Pharmacology ◽

10.3389/fphar.2013.00165 ◽

2013 ◽

Vol 4 ◽

Cited By ~ 16

Author(s):

Michel A. Steiner ◽

Carla Sciarretta ◽

Anne Pasquali ◽

Francois Jenck

Keyword(s):

Metabolic Syndrome ◽

Rat Model ◽

Diet Induced Obesity

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Serum biochemical and inflammatory cytokines in a rat model of metabolic syndrome

Asian Journal of Medical Sciences ◽

10.3126/ajms.v11i4.28963 ◽

2020 ◽

Vol 11 (4) ◽

pp. 46-52

Author(s):

Mohammed Haruna Yeldu ◽

Ahmed Mus’ab

Keyword(s):

Metabolic Syndrome ◽

Body Weight ◽

Inflammatory Cytokines ◽

Rat Model ◽

Fasting Blood Glucose ◽

Interleukin 10 ◽

Treated Group ◽

Tnf Α ◽

Serum Biochemical ◽

Factor Α

Background: Metabolic syndrome (MetS) is a combination of cardio-metabolic risk factors including obesity, hyperglycaemia, dyslipidaemia, oxidative stress and hypertension. Aims and Objectives: This study was aimed at determining the serum concentrations of biochemical and inflammatory cytokines and assesses the correlation between the biochemical and inflammatory cytokines in a rat model of metabolic syndrome. Materials and Methods: Twenty rats were divided into 2 groups of 10 each: control (fructose untreated) and the fructose treated group. MetS was induced by oral administration of 10% fructose in water for 32 weeks. At the end of the experiment, rats were fasted for 12 hours and blood samples collected and body weight, body mass index (BMI), fasting blood glucose (FBG), serum lipid profile, interleukin-6 (IL-6), interleukin-10 (IL-10), tumour necrosis factor-α (TNF-α) were measured using standard techniques. Result: Result indicated significantly (P< 0.05) increased FBG, body weight, BMI, serum TC and LDL-C while, HDL-C levels significantly (P< 0.05) decreased in MetS group compared with controls. However, the levels of VLDL-C, TG and AIX were not significantly (P > 0.05) different between the groups. Significantly (P< 0.05) increased serum IL-6, IL-10 and TNF-α were observed in MetS group compared with controls. Serum IL-10 and TNF- α were inversely correlated with BMI. Serum IL-10 negatively correlated with FBG while, IL-6 was not correlated with either of BMI and FBG.Serum AIX and VLDL-C were positively correlated with TG while, HDL-C level was inversely correlated with TG. With the exception of serum LDL-C which positively correlated with TC, significant correlation was not established between serum TC and each of AIX, HDL-C and VLDL-C. Conclusion: The rat model of MetS was established after treatment with 10% fructose in water. This plays an important role in the pathogenesis of components of metabolic syndrome, including dyslipidaemia, hyperglycaemia and obesity; and serum IL-6, IL-10 and TNF- α are raised in metabolic syndrome and this underscores the role of these cytokines in inflammation associated with metabolic syndrome.

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The protective role of amla (Emblica officinalis Gaertn.) against fructose-induced metabolic syndrome in a rat model

British Journal Of Nutrition ◽

10.1017/s0007114509991978 ◽

2009 ◽

Vol 103 (4) ◽

pp. 502-512 ◽

Cited By ~ 51

Author(s):

Hyun Young Kim ◽

Tsutomu Okubo ◽

Lekh Raj Juneja ◽

Takako Yokozawa

Keyword(s):

Metabolic Syndrome ◽

Body Weight ◽

Total Cholesterol ◽

Rat Model ◽

Regulatory Element ◽

Thiobarbituric Acid Reactive Substance ◽

Emblica Officinalis ◽

Etoac Extract ◽

High Fructose Diet ◽

High Fructose

We investigated the effects of amla (Emblica officinalis Gaertn.) on fructose-induced metabolic syndrome using a rat model. Male Wistar rats were fed a high-fructose (65 %) diet or standard chow for 1 week, and treated with an ethyl acetate (EtOAc) extract of amla, a polyphenol-rich fraction, at 10 or 20 mg/kg body weight per d, or vehicle, for 2 weeks. Serum glucose, TAG, total cholesterol and blood pressure levels of the high-fructose diet-fed rats were increased compared with those of the normal rats (P < 0·001). However, the EtOAc extract of amla ameliorated the high fructose-induced metabolic syndrome, including hypertriacylglycerolaemia and hypercholesterolaemia. Also, the elevated levels of hepatic TAG and total cholesterol in rats given the high-fructose diet were significantly reduced by 33·8 and 24·6 %, respectively (P < 0·001), on the administration of the EtOAc extract of amla at the dose of 20 mg/kg with the regulation of sterol regulatory element-binding protein (SREBP)-1 expression. The protein levels of PPARα and SREBP-2 were not affected by the feeding of the high-fructose diet or EtOAc extract of amla. In addition, oral administration of the amla extract at the dose of 20 mg/kg significantly inhibited the increased serum and hepatic mitochondrial thiobarbituric acid-reactive substance levels (21·1 and 43·1 %, respectively; P < 0·001). Furthermore, the amla extract inhibited the increase of cyclo-oxygenase-2 with the regulation of NF-κB and bcl-2 proteins in the liver, while the elevated expression level of bax was significantly decreased by 8·5 and 10·2 % at the doses of 10 and 20 mg/kg body weight per d, respectively. These findings suggest that fructose-induced metabolic syndrome is attenuated by the polyphenol-rich fraction of amla.

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Effect of Exercise Training on Metabolic Homeostasis and Some Hepatic and Cardiovascular Functions in a Rat Model of High Fat Diet Induced Obesity

The Medical Journal of Cairo University ◽

10.21608/mjcu.2018.56930 ◽

2018 ◽

Vol 86 (6) ◽

pp. 1983-1994

Author(s):

NABIL A. SOLIMAN, Ph.D.; ALI KH. ASALAH, M.D. ◽

SUZAN M.M. MOURSI, M.D.; SAMAR M. GAMAL, Ph.D.

Keyword(s):

Exercise Training ◽

Rat Model ◽

High Fat Diet ◽

Metabolic Homeostasis ◽

High Fat ◽

Diet Induced Obesity ◽

Cardiovascular Functions

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Healthy Body Weight may Modify Effect of Abnormal Birth Weight on Metabolic Syndrome in Adolescents

Obesity ◽

10.1002/oby.22391 ◽

2019 ◽

Vol 27 (3) ◽

pp. 462-469

Author(s):

Bin Dong ◽

Yan-Hui Dong ◽

Zhao-Geng Yang ◽

Xi-Jie Wang ◽

Zhi-Yong Zou ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Weight ◽

Birth Weight ◽

Healthy Body Weight ◽

Modify Effect ◽

Healthy Body

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Myocardial Ischemic-reperfusion Injury in a Rat Model of Metabolic Syndrome

Obesity ◽

10.1038/oby.2008.356 ◽

2008 ◽

Vol 16 (10) ◽

pp. 2253-2258 ◽

Cited By ~ 11

Author(s):

Mahmood S. Mozaffari ◽

Stephen W. Schaffer

Keyword(s):

Metabolic Syndrome ◽

Reperfusion Injury ◽

Rat Model ◽

Ischemic Reperfusion Injury ◽

Ischemic Reperfusion

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What Types of Exercise Are More Effective in Reducing Obesity and Blood Pressure for Middle-Aged Women? A Systematic Review With Meta-Analysis

Biological Research For Nursing ◽

10.1177/10998004211015424 ◽

2021 ◽

pp. 109980042110154

Author(s):

Seong-Hi Park ◽

Chul-Gyu Kim

Keyword(s):

Systematic Review ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Body Weight ◽

Waist Circumference ◽

Meta Analysis ◽

Physical Activities ◽

Risk Of Bias ◽

Cochrane Library ◽

Middle Aged

Background: A systematic review was performed to identify the types of physical activities effective as interventions in preventing metabolic syndrome in middle-aged women. Methods: Electronic databases (MEDLINE, EMBASE, the Cochrane Library, and CINAHL) served as the data sources. Cochrane’s Risk of Bias 2 was applied to assess the risk of bias of the randomized controlled trials. Meta-analyses were performed on selected studies using Review Manager 5.3. Thirty-one trials enrolling 2,202 participants were included. Results: Compared to controls, the effects of physical activity were indicated by pooled mean differences, which were −0.57 kg for body weight, −0.43 kg/m2 for body mass index, −1.63 cm for waist circumference, −4.89 mmHg for systolic blood pressure (BP), and −2.71 mmHg for diastolic BP. The effects were greater on the measurements of waist circumference and BP than on body weight and BMI. The types of physical activities were further analyzed according to sub-groups. Only aerobic exercise did not affect body weight and resistance exercise did not significantly change any results. Contrarily, combined exercises significantly reduced measurements of waist circumference and BP. Conclusion: This review can provide valuable information for research and implementation of measures to prevent metabolic syndrome in middle-aged women.

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