scholarly journals Physical Exercise and Spatial Training: A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Luise Woost ◽  
Pierre-Louis Bazin ◽  
Marco Taubert ◽  
Robert Trampel ◽  
Christine L. Tardif ◽  
...  
Keyword(s):  
Growth Factors ◽  
Longitudinal Study ◽  
Physical Exercise ◽  
Hippocampal Plasticity ◽  
Spatial Training

scholarly journals PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT

2021 ◽  
Vol 27 (8) ◽  
pp. 779-782
Author(s):  
Wei Shen ◽  
Xiaojun Liang
Keyword(s):  
Gene Therapy ◽  
Growth Factors ◽  
Growth Factor ◽  
Physical Exercise ◽  
Fracture Healing ◽  
Bone Morphogenetic Protein ◽  
Bone Growth ◽  
Transforming Growth Factor ◽  
Transforming Growth Factors ◽  
Morphogenetic Protein

ABSTRACT Introduction: In recent years, genetic engineering has made outstanding contributions to sports, and it has played a huge role in promoting the development of sports-related fields. Objective: We analyze the tissue source of bone growth and healing by studying the role of bone morphogenetic protein and transforming growth factors in fracture injuries caused by sports. Methods: We established a human fracture model to express the shape and content of bone morphogenetic protein and transforming growth factor during fracture healing. Results: In the fracture healing stage caused by different sports, the expression levels of the two genes are different. Bone morphogenetic protein has a high content in the osteogenesis stage of the membrane, while transforming growth factor is high in the cartilage ossification stage. Conclusion: Gene therapy for fractures caused by physical exercise has certain advantages. Osteoblasts and chondrocytes are involved in the synthesis of transforming growth factors. Level of evidence II; Therapeutic studies - investigation of treatment results.

scholarly journals Effect of acute physical exercise on motor sequence memory

2020 ◽  
Author(s):  
Blanca Marin Bosch ◽  
Aurélien Bringard ◽  
Maria Grazia Logrieco ◽  
Estelle Lauer ◽  
Nathalie Imobersteg ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Sequence Learning ◽  
High Intensity ◽  
Moderate Intensity ◽  
Motor Sequence Learning ◽  
Motor Sequence ◽  
Memory Functions ◽  
Hippocampal Plasticity ◽  
Sequence Memory ◽  
Acute Physical Exercise

ABSTRACTAcute physical exercise improves memory functions by increasing neural plasticity in the hippocampus. In animals, a single session of physical exercise has been shown to boost anandamide (AEA), an endocannabinoid known to promote hippocampal plasticity. Hippocampal neuronal networks encode episodic memory representations, including the temporal organization of elements, and can thus benefit motor sequence learning. While previous work established that acute physical exercise has positive effects on declarative memory linked to hippocampal plasticity mechanisms, its influence on memory for motor sequences, and especially on neural mechanisms underlying possible effects, has been less investigated.Here we studied the impact of acute physical exercise on motor sequence learning, and its underlying neurophysiological mechanisms in humans, using a cross-over randomized within-subjects design. We measured behavior, fMRI activity, and circulating AEA levels in fifteen healthy participants while they performed a serial reaction time task (SRTT) before and after a short period of exercise (moderate or high intensity) or rest.We show that exercise enhanced motor sequence memory, significantly for high intensity exercise and tending towards significance for moderate intensity exercise. This enhancement correlated with AEA increase, and dovetailed with local increases in caudate nucleus and hippocampus activity.These findings demonstrate that acute physical exercise promotes sequence learning, thus attesting the overarching benefit of exercise to hippocampus-related memory functions.

scholarly journals Longitudinal Study of Cytokine Expression, Lipid Profile and Neuronal Growth Factors in Human Breast Milk from Term and Preterm Deliveries

Nutrients ◽  
2015 ◽  
Vol 7 (10) ◽  
pp. 8577-8591 ◽  
Author(s):  
Maria Collado ◽  
Marina Santaella ◽  
Laia Mira-Pascual ◽  
Elena Martínez-Arias ◽  
Parisá Khodayar-Pardo ◽  
...  
Keyword(s):  
Growth Factors ◽  
Longitudinal Study ◽  
Breast Milk ◽  
Lipid Profile ◽  
Cytokine Expression ◽  
Human Breast Milk ◽  
Neuronal Growth ◽  
Human Breast

scholarly journals Exercise and brain

2018 ◽  
pp. 104-110
Author(s):  
А.А. Пальцын
Keyword(s):  
Mental Health ◽  
Physical Activity ◽  
Growth Factors ◽  
Physical Exercise ◽  
Neurodegenerative Diseases ◽  
Drug Addiction ◽  
Clinical Data ◽  
Life Experience ◽  
Beneficial Effects ◽  
Stimulation Of

Жизненный опыт, многочисленные экспериментальные и клинические данные свидетельствуют о благотворном действии движения, физических нагрузок на сохранение телесного и душевного здоровья человека. Более того, множество психических, неврологических и нейродегенеративных болезней и состояний, таких как инсульт, травмы мозга, наркомании, для которых нет эффективных фармакологических средств, могут быть предотвращены, существенно облегчены, замедленны в развитии физическими упражнениями. Современная неврология выяснила ряд механизмов, которыми мышечное движение обеспечивает профилактический и лечебный эффект: синтез нейротрансмиттеров, нейротрофинов и других факторов роста, стимуляция нейропластичности, образование новых связей и перекомбинация старых, ангиогенез, митогормезис, нейрогенез. Life experience and numerous experimental and clinical data evidence beneficial effects of mobility and physical activity on maintaining human bodily and mental health. Moreover, many mental, neurological, and neurodegenerative diseases and conditions, such as stroke, brain trauma, and drug addiction, for which there are no effective pharmacological therapies, can be prevented, considerably alleviated or slowed by physical exercise. Modern neurology has identified a number of mechanisms, by which muscular movements provide preventive and curative effects, including synthesis of neurotransmitters, neurotrophins and other growth factors, stimulation of neuroplasticity, formation of new and recombination of old connections, angiogenesis, mitohormesis, and neurogenesis.

Effects of Maternal Physical Exercise on Global DNA Methylation and Hippocampal Plasticity of Rat Male Offspring

Neuroscience ◽  
2019 ◽  
Vol 418 ◽  
pp. 218-230
Author(s):  
Ethiane Segabinazi ◽  
Christiano Spindler ◽  
André Luís Ferreira de Meireles ◽  
Francele Valente Piazza ◽  
Filipe Mega ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Physical Exercise ◽  
Male Offspring ◽  
Global Dna Methylation ◽  
Hippocampal Plasticity

scholarly journals Effect of acute physical exercise on motor sequence memory

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Blanca Marin Bosch ◽  
Aurélien Bringard ◽  
Maria Grazia Logrieco ◽  
Estelle Lauer ◽  
Nathalie Imobersteg ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Sequence Learning ◽  
High Intensity ◽  
Moderate Intensity ◽  
Motor Sequence Learning ◽  
Motor Sequence ◽  
Memory Functions ◽  
Hippocampal Plasticity ◽  
Sequence Memory ◽  
Acute Physical Exercise

Abstract Acute physical exercise improves memory functions by increasing neural plasticity in the hippocampus. In animals, a single session of physical exercise has been shown to boost anandamide (AEA), an endocannabinoid known to promote hippocampal plasticity. Hippocampal neuronal networks encode episodic memory representations, including the temporal organization of elements, and can thus benefit motor sequence learning. While previous work established that acute physical exercise has positive effects on declarative memory linked to hippocampal plasticity mechanisms, its influence on memory for motor sequences, and especially on neural mechanisms underlying possible effects, has been less investigated. Here we studied the impact of acute physical exercise on motor sequence learning, and its underlying neurophysiological mechanisms in humans, using a cross-over randomized within-subjects design. We measured behavior, fMRI activity, and circulating AEA levels in fifteen healthy participants while they performed a serial reaction time task before and after a short period of exercise (moderate or high intensity) or rest. We show that exercise enhanced motor sequence memory, significantly for high intensity exercise and tending towards significance for moderate intensity exercise. This enhancement correlated with AEA increase, and dovetailed with local increases in caudate nucleus and hippocampus activity. These findings demonstrate that acute physical exercise promotes sequence learning, thus attesting the overarching benefit of exercise to hippocampus-related memory functions.

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