Background:
Gastric cancer (GC) is one of the most common malignancies worldwide. However, the biomarkers for the
prognosis and diagnosis of Gastric cancer were still need.
Objective:
The present study aimed to evaluate whether CPZ could be a potential biomarker for GC.
Method:
Kaplan-Meier plotter (http://kmplot.com/analysis/) was used to determine the correlation between CPZ expression and overall
survival (OS) and disease-free survival (DFS) time in GC [9]. We analyzed CPZ expression in different types of cancer and the
correlation of CPZ expression with the abundance of immune infiltrates, including B cells, CD4+ T cells, CD8+ T cells,
neutrophils, macrophages, and dendritic cells, via gene modules using TIMER Database.
Results:
The present study identified that CPZ was overexpressed in multiple types of human cancer, including Gastric cancer. We
found that overexpression of CPZ correlates to the poor prognosis of patients with STAD. Furthermore, our analyses show that
immune infiltration levels and diverse immune marker sets are correlated with levels of CPZ expression in STAD.
Bioinformatics analysis revealed that CPZ was involved in regulating multiple pathways, including PI3K-Akt signaling pathway, cGMP-PKG signaling pathway, Rap1 signaling pathway, TGF-beta signaling pathway, regulation of cell adhesion,
extracellular matrix organization, collagen fibril organization, collagen catabolic process.
Conclusion:
This study for the first time provides useful information to understand the potential roles of CPZ in tumor immunology and
validate it to be a potential biomarker for GC.
Species generalization and differences in Hedgehog pathway regulation of fungiform and circumvallate papilla taste function and somatosensation demonstrated with sonidegib