Screening history and FIGO-stages among Danish women with cervical cancer in 2012–2014: a register-based study

AbstractThe objective was to examine whether attendance in the mass cervical screening programme has implications for the prognosis when cervical cancer is diagnosed. We performed a retrospective analysis of all cases of cervical cancer between 1st of January 2012 and 31st of December 2014 in the Region of Southern Denmark. The cases were retrieved from the Danish National Pathology Registry, PatoBank. Odds ratios (OR) with confidence intervals (95% CI) were calculated for attendees versus non-attendees of the screening programme by using χ2-test. 216 patients were included in the study. 61.6% of the study population had not attended the screening programme. Patients who had attended the programme were characterised by disease in low stage (OR = 3.14, 95% CI; 1.66 to 5.92), treatment with surgery alone (OR = 2.63, 95% CI; 1.49 to 4.64) and a lower risk of death (OR = 0.36, 95% CI; 0.15 to 0.87). Adenocarcinomas were more often detected among attendees of the programme compared to squamous cell carcinomas (OR = 4.06, 95% CI; 2.03 to 8.14). Statistically significant results regarding relapse of cancer (OR = 0.62, 95% CI; 0.23 to 1.68, p = 0.47) and lymph node metastases (OR = 0.62, 95% CI; 0.32 to 1.21, p = 0.19) were not found. Cervical cancer detected in women who had attended the mass cervical screening programme prior to the diagnosis, was shown to have a statistically significant lower FIGO stage (p = 0.0004) and was therefore linked to less extensive treatment options. Continued focus on increasing the participation rate of the programme is of importance, as the nonattendance rate continues to be high.

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Impact of the National Cervical Screening Programme in New Zealand by age: analysis of cervical cancer trends 1985–2013 in all women and in Māori women

Cancer Causes & Control ◽

10.1007/s10552-017-0967-y ◽

2017 ◽

Vol 28 (12) ◽

pp. 1393-1404 ◽

Cited By ~ 10

Author(s):

Megan A. Smith ◽

Simon Edwards ◽

Karen Canfell

Keyword(s):

Cervical Cancer ◽

New Zealand ◽

Screening Programme ◽

Cervical Screening ◽

Cancer Trends

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Cervical cancer screening programme

British Journal of Healthcare Assistants ◽

10.12968/bjha.2019.13.11.526 ◽

2019 ◽

Vol 13 (11) ◽

pp. 526-533

Author(s):

Ian Peate

Keyword(s):

Cervical Cancer ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

Screening Programme ◽

Cervical Screening ◽

Signs And Symptoms ◽

Increased Risk ◽

Cancer Screening Programme ◽

Cervical Cancer Screening Programme ◽

The Uk

Screening for cervical cancer saves lives. This article provides an overview of cervical screening programmes offered by the NHS. All four countries in the UK provide a cervical cancer screening programme. Cervical screening identifies apparently healthy women who may be at increased risk of a disease or condition; this then provides an opportunity for earlier treatment or better informed decisions. In some instances, the healthcare assistant and assistant practitioner (HCA and AP) may be needed in order to provide assistance with the screening procedure, offering the woman physical and psychological support. This article offers the reader an overview of the cervix, along with a brief description of signs and symptoms of cervical cancer.

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Molecular profiles and immune checkpoint inhibitor-related biomarkers analysis in advanced cervical cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.e18003 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. e18003-e18003

Author(s):

Qin Xu ◽

Chuanben Chen ◽

Yang Sun ◽

Yibin Lin ◽

Jing Liu ◽

...

Keyword(s):

Cervical Cancer ◽

Checkpoint Inhibitors ◽

Treatment Options ◽

Figo Stage ◽

Advanced Cervical Cancer ◽

Single Nucleotide Variants ◽

Paired Samples ◽

Target Capture ◽

Pathological Subtype ◽

Molecular Profiles

e18003 Background: Treatment options for advanced cervical cancer (ACC) are limited and patients experiencing recurrence after first-line chemotherapy and bevacizumab have a poor prognosis. Checkpoint inhibitors targeting the PD-1/PD-L1 are promising treatment option. However, related genomic biomarker study is rare reported in ACC. Methods: We prospectively enrolled 102 pts with ACC. Tumor and plasma samples were obtained to analysis genomic profiles. DNA was sequenced by target-capture deep sequencing with the pan-cancer panel. TMB of tissue (tTMB) and blood (bTMB) analysis interrogated single nucleotide variants, small insertion and deletion. PD-L1 expression was evaluated in tumor specimens by immunohistochemistry (IHC) using a combined-positive-score (CPS) cutoff of ≥1. Results: The median age of enrolled pts was 63 yrs, and most (84.3 %, 86/102 pts) weresquamous carcinoma. A total of 93 tissues and 96 plasma were collected from 102 pts. The most frequently mutated genes were PIK3CA (40.9%, 38/93 pts), KMT2D (35.5%, 33/93 pts), and KMT2C (28.0%, 26/93 pts) in tissues. 80% (77/96 pts) of plasma was detected positive, with PIK3CA (23.4%, 18/77 pts), KMT2D (20.8%, 16/77 pts), KMT2C (20.8%, 17/77 pts) mutant frequently. Among 87 pts with paired samples, at least a tumor-derived mutation was detected in 35 (40.2%)plasma. Median of tTMB was 11.9 mut/Mb, and 45% pts were TMB-H. Significant correlation was found between tTMB and bTMB (Pearson r = 0.39, P = 0.001). Higher tTMB was identified in KMT2D- or KMT2C-mut pts (P = 0.002 or P = 0.01, respectively). tTMB showed no relation with clinic characteristics, including pathological subtype, FIGO stage, and status of distant metastasis. PD-L1 expression (CPS≥1) was identified in 53 pts (93 %, 53/57) and mutually independent with TMB status. Conclusions: Molecular profiles and TMB in plama showed high consistence with that in tissue. Prospective clinical trial is ongoing to determine the genomic biomarkers and the PD-L1 expression as predictive factors for the ICI efficacy in ACC (ChiCTR1900023015).

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Underscreened Women Remain Overrepresented in the Pool of Cervical Cancer Cases in Spain: A Need to Rethink the Screening Interventions

BioMed Research International ◽

10.1155/2015/605375 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 7

Author(s):

Raquel Ibáñez ◽

María Alejo ◽

Neus Combalia ◽

Xavier Tarroch ◽

Josefina Autonell ◽

...

Keyword(s):

Cervical Cancer ◽

Older Women ◽

Cancer Diagnosis ◽

Invasive Cervical Cancer ◽

Previous History ◽

Figo Stage ◽

Normal Cytology ◽

Highly Sensitive ◽

History Of ◽

Screening History

Objective. Audit of women with invasive cervical cancer (CC) is critical for quality control within screening activities. We analysed the screening history in the 10 years preceding the study entry in women with and without CC during 2000–2011.Methods. 323 women with CC from six pathology departments in Catalonia (Spain) and 23,782 women with negative cytology were compared. Age, previous history of cytologies, and histological type and FIGO stage were collected from the pathology registries. Logistic regression analysis was used to estimate odds ratios (OR) and 95% confidence intervals (CI95%).Results. History of cytology was registered in 26.2% of CC cases and in 78% of the control women (P<0.0001) and its frequency decreased with increasing age. Compared to women with squamous cell carcinoma, adenocarcinoma cases were significantly more likely to have a cytology within the 3-year interval preceding cancer diagnosis (OR=2.6CI 95%: 1.2–5.6) and to have normal cytology results in previous screenings (OR=2.4CI 95%: 1.2–4.5). FIGO II–IV cases were more common among older women (older than 60 years).Conclusions. Absence of prior screening history was extremely common among CC cases compared to controls. Organized actions to reduce underscreened women and use of highly sensitive HPV-based tests could be important to reduce CC burden.

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Relation between FIGO stage, primary tumor volume, and presence of lymph node metastases in cervical cancer patients referred for radiotherapy

International Journal of Gynecological Cancer ◽

10.1046/j.1525-1438.2003.13026.x ◽

2003 ◽

Vol 13 (5) ◽

pp. 657-663 ◽

Cited By ~ 40

Author(s):

K. Narayan ◽

A.F. Mckenzie ◽

R.J. Hicks ◽

R. Fisher ◽

D. Bernshaw ◽

...

Keyword(s):

Cervical Cancer ◽

Lymph Node ◽

Cancer Patients ◽

Lymph Node Metastases ◽

Primary Tumor ◽

Tumor Volume ◽

Figo Stage ◽

Primary Tumor Volume ◽

Node Metastases

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Impact of media reporting of cervical cancer in a UK celebrity on a population-based cervical screening programme

Journal of Medical Screening ◽

10.1258/jms.2011.011092 ◽

2011 ◽

Vol 18 (4) ◽

pp. 204-209 ◽

Cited By ~ 28

Author(s):

Georgina J Macarthur ◽

Melissa Wright ◽

Helen Beer ◽

Shantini Paranjothy

Keyword(s):

Cervical Cancer ◽

Screening Programme ◽

Cervical Screening ◽

Population Based ◽

Media Reporting

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Rural community’s perspectives on cervical cancer screening: Report of a consensus-planning workshop

Advances in Modern Oncology Research ◽

10.18282/amor.v3.is1.199 ◽

2017 ◽

Vol 3 (s1) ◽

pp. 73

Author(s):

Smita Asthana ◽

Satyanarayana Labani

Keyword(s):

Cervical Cancer ◽

Rural Community ◽

Rural Women ◽

Elderly Women ◽

Screening Programme ◽

Cervical Screening ◽

Community Setting ◽

The Elderly ◽

Hpv Infection ◽

Using Data

The success of any screening programme depends largely on the acceptability of the community to undergo screening. This study is an attempt to explore the perspectives of rural women on screening through qualitative research, using data generated in a consensus workshop for an unscreened population prior to the start of a screening programme. The study adopted a qualitative method in the form of consensus-planning workshop prior to the start of the careHPV screening project. Knowledge about cervical cancer and human papillomavirus (HPV) infection was found to be very low. Special efforts are needed to educate the elderly women of the family and the peers of the rural community so that the project runs successfully, as their views can influence community participation. The response by rural women in undertaking selfsamplings was good. Cervical screening is acceptable and can be implemented in a rural community setting. The success of screening programme depends on health education of the rural community.

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Screening History and Diagnostic Characteristics of Cervical Adenocarcinoma: a Retrospective Study

10.21203/rs.3.rs-43697/v1 ◽

2020 ◽

Author(s):

Jing Li ◽

Minjuan Ye ◽

Huixia Ye ◽

Junxian He ◽

Xiaomao Li ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cervical Screening ◽

Participation Rate ◽

Cervical Squamous Cell Carcinoma ◽

Hpv Infection ◽

Cervical Adenocarcinoma ◽

Diagnostic Characteristics ◽

Screening History

Abstract Background: An increasing trend in incidence of cervical adenocarcinoma has been observed in recent years. This research aims to study the screening history and diagnostic characteristics of cervical adenocarcinoma.Methods: Cervical cancer patients hospitalized in the Gynecology Department of the Third Affiliated Hospital of Sun Yat-sen University between 1st Jan 2017 and 31st Mar 2020 were included. Cervical screening history investigation and analysis were carried out by medical record data inquiry and case investigation.Results: (1)The chief complaint of 72.0% of cervical squamous cell carcinoma was vaginal bleeding. 75.6% of adenocarcinoma came in for abnormal vaginal discharge, p<0.001. (2)The HPV infection rate in adenocarcinoma(74.2%) was lower than that in squamous cell carcinoma(92.9%), p<0.001. (3)The participation rate of cervical screening before diagnosis of adenocarcinoma(21.2%) was higher than that of squamous cell carcinoma(2.8%), p＜0.01. (4) The proportion of early-stage in adenocarcinoma (46.3%) was larger than in SCC (28.3%), p<0.01. Conclusion: Compared to cervical squamous cell carcinoma, HPV infection was found to be less closely associated with adenocarcinoma of uterine cervix. The participation rate and frequency of cervical screening of patients with cervical adenocarcinom were more than squamous cell carcinoma. The screening methods at present may not be sensitive enough for precancerous lesion of adenocarcinoma, but regular and multiple screening are still of great significance for early diagnosis of adenocarcinoma of uterine cervix.

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Clinical Features of Women Diagnosed With Invasive Cervical Cancer in Ghana

Journal of Global Oncology ◽

10.1200/jgo.18.29000 ◽

2018 ◽

Vol 4 (Supplement 2) ◽

pp. 40s-40s

Author(s):

Y. Nartey ◽

P. Hill ◽

K. Amo-Antwi ◽

K. Nyarko ◽

J. Yarney ◽

...

Keyword(s):

Cervical Cancer ◽

Clinical Features ◽

Teaching Hospital ◽

Cervical Screening ◽

Invasive Cervical Cancer ◽

Figo Stage ◽

Middle Income ◽

Increased Risk ◽

Referral Hospitals

Background: The incidence of cervical cancer continues to increase in many low- and middle-income countries. It remains the commonest cancer affecting females in Ghana. However, comprehensive information on the clinical characteristics of women diagnosed with invasive cervical cancer is scarce. Aim: To characterize the clinical features of women with invasive cervical cancer in Ghana. Methods: We conducted a retrospective study in two large referral hospitals in Ghana: the Korle Bu teaching hospital, Accra and Komfo Anokye teaching hospital, Kumasi. Through the review of paper-based, electronic, and pathology medical records, information on women diagnosed with invasive cervical cancer from 1st January 2010 to 31st December 2013 was collected. The information was entered onto a standardized data abstraction sheet and included demographics, comorbid conditions, treatment and follow-up. All analyses were conducted in STATA and described the distribution of key clinical features by the stage at diagnosis. Results: A total of 1,725 women with invasive cervical cancer were included in the analysis. Few had cervical screening before their cervical cancer diagnosis (1.1%). Women who were resident in a metropolitan area ( P = 0.034), or who had any comorbidity ( P < 0.001) were at an increased risk of FIGO stage III-IV disease. The majority of women had at least two diagnostic investigations (75%) with cervical biopsy performed for 95.5% of women. More than half received radiotherapy (55.4%) and only 22.4% receiving chemotherapy. Clinical follow-up after the first consultation was performed for 61%, with 73% of women with clinical follow-up having at least one follow-up investigation. Conclusion: Improvements in access to early diagnosis and optimal treatment of cervical cancer, such as an increased use of chemoradiation would reduce the burden of the disease in Ghana.

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