scholarly journals A demographic and clinical panorama of a sixteen-year cohort of soft tissue sarcoma patients in Brazil

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Luiza Ohasi de Figueiredo ◽  
Augusto Afonso Guerra Júnior ◽  
Francisco de Assis Acurcio ◽  
Alessandra Maciel Almeida ◽  
Mariângela Leal Cherchiglia ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Public Health System ◽  
Histological Grade ◽  
Soft Tissue Sarcomas ◽  
Population Based ◽  
Lower Limbs ◽  
Access To Treatment ◽  
Specific Location ◽  
Incidence And Mortality ◽  
Epidemiological Profile

AbstractLittle is known about soft tissue sarcomas (STS) in Brazil, once the federal statistics regarding estimates on incidence and mortality of the most common cancers that affect the Brazilian population currently do not include STS. This study aims to perform a broad evaluation and description of the epidemiological profile, access to treatment and main clinical outcomes of the Brazilian STS patient. A population-based cohort study of 66,825 patients who underwent procedures related to STS treatment registered in the Brazilian public health system (Sistema Único de Saúde, SUS) databases. Median age was 57 years, 30% of them older than 65 years and 50.7% of the cohort was female. The majority, 50,383 patients (75.4%), was diagnosed between 2008 and 2015. Most prevalent anatomic sites were upper and lower limbs (12.6%) and the registry of sarcomas without a specific location comprehended 29.7% of the cohort. The majority of patients resided in the Northeast (40.2% of the patients). Surgery was the first treatment modality in 77.7% of the cases. For survival analysis, only patients with stage and histological grade information were included. The 1-, 5- and 10-year survival rate of the patients was, respectively, 75.4% (95% CI = 74.1–76.7%), 43.4% (95% CI = 41.5–45.5%) and 18.6% (95% CI = 14.8–23.3%).

scholarly journals A Demographic and Clinical Panorama of a Sixteen-Year Cohort of Soft Tissue Sarcoma Patients in Brazil

2021 ◽  
Author(s):  
Luiza Ohasi Figueiredo ◽  
Augusto Afonso Guerra Júnior ◽  
Francisco Assis Acurcio ◽  
Alessandra Maciel Almeida ◽  
Mariângela Leal Cherchiglia ◽  
...  
Keyword(s):  
Public Health ◽  
Soft Tissue ◽  
Public Health System ◽  
Soft Tissue Sarcomas ◽  
Population Based ◽  
Lower Limbs ◽  
Access To Treatment ◽  
Specific Location ◽  
Incidence And Mortality ◽  
Epidemiological Profile

Abstract Introduction: Little is known about soft tissue sarcomas (STS) in Brazil, once the federal statistics regarding estimates on incidence and mortality of the most common cancers that affect the Brazilian population currently do not include STS. This study aims to perform a broad evaluation and description of the epidemiological profile, access to treatment and main clinical outcomes of the Brazilian STS patient.Methods: A population-based cohort study of 66,825 patients who underwent procedures related to STS treatment registered in the Brazilian public health system (Sistema Único de Saúde, SUS) databases. Results: Median age was 57 years, 30% of them older than 65 years and 50.7% of the cohort was female. The majority, 50,383 patients (75.4%), was diagnosed between 2008 and 2015. Most prevalent anatomic sites were head and neck (13.6%) and upper and lower limbs (12.6%). The registry of sarcomas without a specific location comprehended 29.7% of the cohort. The majority of patients resided in the Northeast (40.2% of the patients). Surgery was the first treatment modality in 77.7% of the cases. The 1-, 5- and 10-year survival rate of the patients was, respectively, 82.3% (95% CI = 82%-82,7%), 57.4% (95% CI = 56.9%-58%) and 42% (95% CI = 41.2%-42.9%).

scholarly journals Population-based Aarhus Sarcoma Registry: validity, completeness of registration, and incidence of bone and soft tissue sarcomas in western Denmark

2013 ◽  
pp. 45 ◽  
Author(s):  
Katja Maretty-Nielsen ◽  
Aggerholm-Pedersen ◽  
Keller ◽  
Safwat ◽  
Baerentzen ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Population Based

Incidence of unplanned excisions of soft tissue sarcomas in the Netherlands: A population-based study

2021 ◽  
Author(s):  
Annemarie S. Melis ◽  
Melissa Vos ◽  
Melinda S. Schuurman ◽  
Thijs van Dalen ◽  
Winan J. van Houdt ◽  
...  
Keyword(s):  
Soft Tissue ◽  
The Netherlands ◽  
Soft Tissue Sarcomas ◽  
Population Based ◽  
Population Based Study

Radiotherapy of Soft Tissue Sarcomas

1970 ◽  
Vol 56 (5) ◽  
pp. 297-310
Author(s):  
Giovanni Crema ◽  
Bruno Damascelli ◽  
Renato Musumeci ◽  
Carlo Uslenghi
Keyword(s):  
Soft Tissue ◽  
Patient Survival ◽  
Radical Surgery ◽  
Postoperative Radiotherapy ◽  
Soft Tissue Sarcomas ◽  
Lower Limbs ◽  
Histologic Type ◽  
Complementary Treatment ◽  
Histologic Types ◽  
First Time

This review series comprises 245 patients with soft tissue sarcomas of various sites and histologic types observed at this Institute between 1928 and 1966. 132 patients were men (54.2%) and 113 women (45.8%). Fibrosarcomas accounted for the largest number of cases (161 cases - 65.5%), followed by undifferentiated sarcomas (36 cases). Other histologic types accounted for a smaller number of cases. As to the site of the primary tumor, the lower limbs accounted for 32.2% and the abdomen for 26.5% of the cases. 152 of the 245 patients attended for the first time and 93 presented recurrences of the tumor sometime after receiving surgical treatment and/or radiotherapy elsewhere. 159/245 cases were subjected at this Institute to designedly radical surgery followed by postoperative radiotherapy by various techniques. In the remaining 86 cases, in which surgery was either not indicated or not possible because of the patients’ local or general condition, radiotherapy only was given, where possible curative. Radium was used in 97 cases almost always as complementary treatment in superficial tumors that had developed mainly towards the surface and been removed surgically either radically or as radically as conditions allowed. The therapeutic techniques and results are discussed in relation to patient survival by histologic type and to failures and recurrences.

Prognostic factors and proposed grading system for cutaneous and subcutaneous soft tissue sarcomas in cats, based on a retrospective study

2020 ◽  
pp. 1098612X2094239
Author(s):  
Melanie J Dobromylskyj ◽  
Victoria Richards ◽  
Ken C Smith
Keyword(s):  
Soft Tissue ◽  
Survival Time ◽  
Clinical Outcomes ◽  
Histological Grade ◽  
Soft Tissue Sarcomas ◽  
Prognostic Indicators ◽  
Grading System ◽  
Anatomical Location ◽  
Diagnostic Laboratory ◽  
Histological Features

Objectives The objectives of this study included utilising a large database from a diagnostic laboratory to identify any breed, sex or age predilections for cutaneous and subcutaneous soft tissue sarcomas (STSs), and the most common anatomical locations. The second aim was to obtain clinical outcomes and to assess histological features of those tumours to identify any potentially useful prognostic indicators and propose a grading system. Methods Records from the laboratory were searched for feline submissions received from January 2012 to December 2013 diagnosed with STSs; the breed, age, sex and neuter status of the cat and anatomical location of the tumour were recorded. Clinical outcomes were acquired using a questionnaire to submitting practices, and histological features of tumours from patients with known outcomes were assessed. Results No sex, neuter status or breed predispositions were found. Most STSs arise in middle-aged and older cats, and the most common anatomical location was the trunk. Forty-seven cases had a known clinical outcome and archived tissues allowing for histological assessment of the tumour. Significant differences in median survival time (MST), mitotic index and histological score were detected between those cats that died of tumour-related disease and those that did not. A novel grading system applied to these tumours produced significant differences in MST between cats with low (MST = 900.5 days), intermediate (MST = 514 days) and high grade tumours (MST = 283 days). Conclusions and relevance This is the first study applying a histological grading system to these common tumours. Local recurrence is often the cause of a poor outcome, with metastatic disease apparently rare. The proposed grading system incorporates features that can be assessed on routine haematoxylin and eosin-stained sections; in this small study, the histological grade of the tumour appears to be associated with survival time.

Total and cancer-attributable phase-based costs for adolescent cancer care: A population–based study in British Columbia, Canada.

2017 ◽  
Vol 35 (5_suppl) ◽  
pp. 12-12
Author(s):  
Mary L McBride ◽  
Ross Duncan ◽  
Karen Bremner ◽  
Claire De Oliveira ◽  
Ning Liu ◽  
...  
Keyword(s):  
British Columbia ◽  
Soft Tissue ◽  
End Of Life ◽  
Late Effects ◽  
Healthcare Costs ◽  
Soft Tissue Sarcomas ◽  
Population Based ◽  
Economic Evaluations ◽  
First Year ◽  
Adolescent Cancer

12 Background: Cancer among adolescents presents unique issues regarding diagnosis, treatment, late effects, and survival; but little is known about their healthcare costs, which are useful for economic evaluations and planning care. This study estimates total and cancer-attributable (net) medical costs for a population-based adolescent cancer cohort in British Columbia, Canada, by phase of care. Methods: Patients diagnosed with cancer aged 15 to 19 years from 1995 to 2009 were identified from the British Columbia Cancer Registry, and followed to December 31st2010. Data were linked with clinical and provincial administrative healthcare databases covering all medically-necessary costs. Total resource-specific costs (Canadian $ 2012) by phase of care were estimated for all patients and specific common cancers. Net costs were calculated by subtracting healthcare costs for propensity-score-matched provincial samples of adolescents without cancer from cancer patient costs. Results: Of the 750 cases, approximately 26% had lymphoma, 17% germ cell, 14% bone and soft tissue sarcomas, 12% central nervous system (CNS), and 11% leukemia; 94% survived > = 1 year. Total mean pre-diagnosis costs per patient were $3657, of which $3554 was attributable to the cancer. First-year mean costs were $60,531 ($59,826). Continuing phase mean costs were $8,413 ($7,708). Final year of life mean costs were $224,243 ($221,018). Cancer types with highest costs were CNS (pre-diagnosis), leukemia (first-year); bone and soft tissue (continuing), and leukemia (end-of-life). Virtually all inpatient hospitalizations were cancer-related, representing ~40% of pre-diagnosis, ~62% of first-year, ~56%of continuing, and ~72%of end-of-life costs respectively. Conclusions: Management of adolescent cancer is costly, but is lower than for childhood cancer in all phases of care. Total costs, cancer-attributable costs, and inpatient activity were highest in the end-of-life period. Hospitalizations were the largest driver of costs in all post-diagnosis phases of care. Costs in the continuing phase, including surveillance and care for late effects, were 14% of first-year phase costs.

scholarly journals Brain Metastases in Patients With Soft-Tissue Sarcomas: Management and Survival—A SEER Population-Based Cohort Study

2021 ◽  
Vol 5 (10) ◽  
Author(s):  
Marcos Roberto Gonzalez ◽  
Mayte Bryce-Alberti ◽  
Juan Alonso Leon-Abarca ◽  
Juan Pretell-Mazzini
Keyword(s):  
Cohort Study ◽  
Soft Tissue ◽  
Brain Metastases ◽  
Soft Tissue Sarcomas ◽  
Population Based

scholarly journals Descriptive study of the epidemiological profile of deaths by suicide in the state of Roraima, Brazil, from 2014 to 2017

2020 ◽  
Vol 45 ◽  
pp. e020018
Author(s):  
João Pedro Soares de Macedo ◽  
Thalia Inácia Araújo Cardoso
Keyword(s):  
Preventive Measures ◽  
Public Health System ◽  
Population Based ◽  
The State ◽  
Suicide Method ◽  
The Face ◽  
State Capital ◽  
Epidemiological Profile ◽  
Age Range ◽  
Source Of Information

Introduction: Suicide is one of the top three reasons of death worldwide for the 15- to 44-year age range. The Brazilian state of Roraima has shown indicators that draw attention when compared to national rates of suicide. In this sense, for the proposal of preventive measures appropriate to the state’s reality, it is important to understand the local epidemiological particularities. Objective: to identify the epidemiological profile of deaths by suicide in the state of Roraima, Brazil, between 2014 and 2017. Methods: Descriptive, population-based documentary research. The source of information was the database from the Brazilian public health system (DATASUS). The analysis included deaths by residence caused by suicide from 2014 to 2017. Cut-outs were established according to the variables incidence by municipality, marital status, age, gender, color/race, place of occurrence and method of suicide. Results: 176 deaths were reported in the state of Roraima during the period studied. The average mortality coefficient was 8,6/100.000 inhabitants. Deaths were more frequent among men (73.9%), aged 20 to 29 years (31.2%), resident in the state capital (52.8%), brown (64.2%) or indigenous (25.6%) and single (69.9%). The main suicide method was hanging, strangulation and suffocation (87.5%), with the domicile being the most usual place (72.1%). Conclusion: The results imply the need to act on the problem, which grows in proportion and gains prominence in the national indicators. Suspicion of suicidal behavior in the face of consolidated data may reduce the incidence.

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