scholarly journals Exposure and risk characterizations of ochratoxins A and aflatoxins through maize (Zea mays) consumed in different agro-ecological zones of Ghana

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nii Korley Kortei ◽  
Theophilus Annan ◽  
Vincent Kyei-Baffour ◽  
Edward Ken Essuman ◽  
Harry Okyere ◽  
...  
Keyword(s):  
Food Safety ◽  
Health Risks ◽  
High Performance ◽  
Safety Concern ◽  
Daily Intake ◽  
Cancer Risks ◽  
Fluorescence Detector ◽  
Ecological Zones ◽  
Adverse Health Effects ◽  
Agro Ecological Zones

AbstractMycotoxin contamination of foodstuffs is a serious food safety concern globally as the prolonged ingestion of these toxins has the tendency to worsen the risk of hepatocellular carcinoma. This study aimed at estimating ochratoxin A (OTA) and aflatoxin (AF) levels above international (European Food Safety Authority, EFSA) and local (Ghana Standards Authority, GSA) standards as well as the health risks associated with the consumption of maize (n = 180) sampled from six (6) regions representing the agro-ecological zones of Ghana. OTA and AF were measured with High-Performance Liquid Chromatography with a Fluorescence detector. Out of the 180 samples analyzed for total aflatoxins (AFtotal), 131/180 tested positive and 127 (70.50%) exceeded the limits of EFSA and ranged 4.27–441.02 µg/kg. While for GSA, 116 (64.44%) of samples exceeded this limit and ranged between 10.18 and 441.02 µg/kg. For OTA, 103/180 tested positive and 94 (52.22%) of samples between the range 4.00–97.51 µg/kg exceeded the tolerable limit of EFSA, whereas 89 (49.44%) and were in the range of 3.30–97.51 µg/kg exceeded the limits of GSA. Risk assessment values for total aflatoxins (AFtotal) ranged between 50 and 1150 ng/kg bw/day, 0.4–6.67, 0–0.0323 aflatoxins ng/kg bw/day and 1.62–37.15 cases/100,000 person/year for Estimated Daily Intake (EDI), Margin of Exposure (MOE), Average Potency, and Cancer Risks respectively. Likewise, ochratoxin (OTA) values were in the ranges of 8.6 × 10–3–450 ng/kg bw/day, 0.05–2059.97, 0–0.0323 ochratoxins ng/kg bw/day and 2.78 × 10–4–14.54 cases/100,000 person/year. Consumption of maize posed adverse health effects in all age categories of the locations studied since the calculated MOE values were less than 10,000.

scholarly journals Co-Occurrence of Ochratoxin a and Aflatoxins in Maize (Zea Mays) and Their Associated Health Risk Estimations in Some Selected Regions (Different Agro-ecological Zones) of Ghana

2021 ◽  
Author(s):  
Nii Korley Kortei ◽  
Theophilus Annan ◽  
Vincent Kyei-Baffour ◽  
Edward Ken Essuman ◽  
Harry Okyere ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
High Performance ◽  
General Trend ◽  
Daily Intake ◽  
Expert Committee ◽  
Cancer Risks ◽  
Fluorescence Detector ◽  
Ecological Zones ◽  
Adverse Health Effects ◽  
Agro Ecological Zones

Abstract This study aimed at estimating ochratoxin A (OTA) and aflatoxin (AF) levels above international (European Food Safety Authority, EFSA) and local (Ghana Standards Authority, GSA) standards as well as the health risks associated with the consumption of maize (n=180) sampled from six (6) regions (Upper East, Northern, Ashanti, Eastern, Central, and Western) representing the agro-ecological zones of Ghana. Ochratoxins, total aflatoxins (AFTotal), and the integral aflatoxins (AFB1, AFB2, AFG1, and AFG2) were measured with High-Performance Liquid Chromatography (HPLC) with a Fluorescence detector. Risk assessments were also conducted using models prescribed by the Joint FAO/WHO Expert Committee on Additives (JECFA). The general trend of occurrence of the aflatoxins was in decreasing order of AFB1> AFB2> AFG1>AFG2 and were in the ranges of 0-337µg/kg, 0-101.00µg/kg, 0-24.80 µg/kg, and 0-5.51 µg/kg respectively. The aggregated aflatoxins (AFTotal) were in the range of 0-441.02 µg/kg. While ochratoxins (OTA) levels ranged between 0-97.51 µg/kg. There were significant (p<0.05) differences observed in all categories of the tested samples. Out of the 180 samples analyzed for total aflatoxins (AFTotal), 131/180 tested positive and 127 (70.50%) exceeded the limits of EFSA and ranged 4.27-441.02 µg/kg. While for GSA, 116 (64.44%) of samples exceeded this limit and ranged between 10.18-441.02µg/kg. For OTA, 103/180 tested positive and 94(52.22%) of samples between the range 4.00-97.51 µg/kg exceeded the tolerable limit of the EFSA, whereas 89 (49.44%) and were in the range of 3.30-97.51 µg/kg exceeded the limits of GSA. Risk assessment values for total aflatoxins (AFTotal) ranged between 50-1150 ng/Kg.BW/day, 0.4-6.67, 0-0.0323 ng aflatoxins kg−1bwday−1 and 1.62-37.15 for Estimated Daily Intake (EDI), Margin of Exposure (MOE), Average Potency, and Cancer Risks respectively. Likewise, ochratoxin (OTA) values were in the ranges of 8.6x10-3-450 ng/Kg.bw/day, 0.05-2059.97, 0-0.0323 ng ochratoxins kg−1bwday−1 and 2.78x10-4-14.54. It was deduced that the consumption of maize posed adverse health effects on all age categories of people from some of the locations studied because all calculated MOE values were less than 10,000 respectively for aflatoxins and ochratoxins.

scholarly journals The occurrence of aflatoxins and human health risk estimations in randomly obtained maize from some markets in Ghana

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nii Korley Kortei ◽  
Theophilus Annan ◽  
Papa Toah Akonor ◽  
Seidu A. Richard ◽  
Helen Ama Annan ◽  
...  
Keyword(s):  
Food Safety ◽  
High Performance ◽  
Hazard Quotient ◽  
Human Health Risk ◽  
Daily Intake ◽  
Hazard Index ◽  
Estimated Daily Intake ◽  
Ecological Zones ◽  
Adverse Health ◽  
Margin Of Exposure

AbstractMaize and its products are most often prone to fungal contamination especially during cultivation and storage by toxigenic fungi. Aflatoxicosis still persist in Ghana despite the numerous education on several ways of its prevention at the farm as well as its adverse health implications which are food safety concerns. A random assessment and human risk analysis was conducted on 90 maize (72 white and 18 colored) samples from markets across all the regions of Ghana. Total aflatoxins (AFtotal) and the constitutive aflatoxins (AFB1, AFB2, AFG1, and AFG2) were analyzed by High-Performance Liquid Chromatography (HPLC). Out of a total of ninety (90) samples investigated, 72 (80%) tested positive for AFB1 and the contamination levels ranged from 0.78 ± 0.04 to 339.3 ± 8.6 µg kg−1. Similarly, AFG2 was detected in only 14 (15.5%) samples, and their values ranged between 1.09 ± 0.03 and 5.51 ± 0.26 µg kg−1 while AF total ranged between 0.78 ± 0.04 and 445.01 ± 8.9 µg kg−1 constituting approximately 72 (80%). Limits of AFB1 and total aflatoxins (AFtotal) for the Ghana Standards Authority (GSA) (5 and 10 µg kg−1) and the European Food Safety Authority (EFSA) (2 and 4 µg kg−1), were used as checks. A total of 33 (41.25%) samples were above the limits for both. Risk assessments recorded for Estimated Daily Intake (EDI), Hazard Quotient (H.Q), Hazard Index (H.I), Margin of Exposure (MOE), av. Potency, and population risks ranged 0.087–0.38 μg kg−1 bw day−1, 1.5–6.9, 0.0087–0.38, 3.64–12.09, 0–0.0396 ng Aflatoxins kg−1 bw day−1 and, 3.5 × 10–1–0.015 respectively for total aflatoxins. While ranges for aflatoxins B1 (AFB1) recorded were 0.068–0.3 μg Kg bw−1 day−1, 2.43–10.64, 0.0068–0.030, 4.73–20.51, 0–0.0396 ng Aflatoxins kg−1 bw day−1 and, 2.69 × 10–3–0.012 for Estimated Daily Intake (EDI), Hazard Quotient (H.Q), Hazard Index (H.I), Margin of Exposure (MOE), Av. potency, and population risks respectively. It was deduced that although there was some observed contamination of maize across the different ecological zones, the consumption of maize (white and colored) posed no adverse health effects on the population of Ghana since computed H.I was less than 1 (< 1).

scholarly journals The Occurrence of Aflatoxins and Human Health Risk Estimations in Randomly Obtained Maize from Some Markets in Ghana

2021 ◽  
Author(s):  
Nii Korley Kortei ◽  
Theophilus Annan ◽  
Papa Toah Akonor ◽  
Seidu Richard ◽  
Helen Annan ◽  
...  
Keyword(s):  
Food Safety ◽  
High Performance ◽  
Hazard Quotient ◽  
Human Health Risk ◽  
Daily Intake ◽  
Hazard Index ◽  
Estimated Daily Intake ◽  
Ecological Zones ◽  
Adverse Health ◽  
Margin Of Exposure

Abstract Maize and its products are most often prone to fungal contamination especially during cultivation and storage by toxigenic fungi. Aflatoxicosis still persist in Ghana despite the numerous education on several ways of its prevention at the farm as well as its adverse health implications which are food safety concerns. A random assessment and human risk analysis was conducted on 90 maize (72 white and 18 colored) samples from markets across all the regions of Ghana. Total aflatoxins (AFtotal) and the constitutive aflatoxins (AFB1, AFB2, AFG1, and AFG2) were analyzed by High-Performance Liquid Chromatography (HPLC). Out of a total of ninety (90) samples investigated, 72 (80%) tested positive for AFB1 and the contamination levels ranged from 0.78 ± 0.04–339.3 ± 8.6µg/kg. Similarly, AFG2 was detected in only 14 (15.5%) samples, and their values ranged between 1.09 ± 0.03–5.51 ± 0.26 µg/kg while AF total ranged between 0.78 ± 0.04- 445.01 ± 8.9 µg/kg constituting approximately 72 (80%). Limits of AFB1 and total aflatoxins (AFtotal) for the Ghana Standards Authority (GSA) (5 and 10 µg/kg) and the European Food Safety Authority (EFSA) (2 and 4 µg/kg), were used as checks. A total of 33 (41.25%) samples were above the limits for both. Risk assessments recorded for Estimated Daily Intake (EDI), Hazard Quotient (H.Q), Hazard Index (H.I), Margin of Exposure (MOE), av. Potency, and population risks ranged 0.087–0.38 µg/Kg.bw/day, 1.5–6.9, 0.0087-0.38, 3.64–12.09, 0-0.0396 ng Aflatoxins kg− 1bwday− 1 and, 3.5x10− 1 – 0.015 respectively for total aflatoxins. While ranges for aflatoxins B1 (AFB1) recorded were 0.068-0.3 µg/Kg.bw/day, 2.43–10.64, 0.0068-0.030, 4.73–20.51, 0-0.0396 ng Aflatoxins kg− 1bwday− 1 and, 2.69 x10− 3-0.012 for Estimated Daily Intake (EDI), Hazard Quotient (H.Q), Hazard Index (H.I), Margin of Exposure (MOE), Av. potency, and population risks respectively. It was deduced that although there was some observed contamination of maize across the different ecological zones, the consumption of maize (white and colored) posed no adverse health effects on the population of Ghana since computed H.I was less than 1 (< 1).

scholarly journals Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents

2018 ◽  
Vol 15 (11) ◽  
pp. 2336 ◽  
Author(s):  
Maryam Zare Jeddi ◽  
Mohamad Eshaghi Gorji ◽  
Ivonne Rietjens ◽  
Jochem Louisse ◽  
Yuri Bruinen de Bruin ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Children And Adolescents ◽  
Health Risks ◽  
Safety Concern ◽  
Hazard Quotient ◽  
Daily Intake ◽  
Hazard Index ◽  
Internal Exposure ◽  
Combined Exposure ◽  
Iranian Children

This study aimed to estimate the exposure and related health risks of phthalates, and to assess the health risks from combined exposure to three of the phthalates sharing the same mode of action (anti-androgenicity) in children. We determined the internal exposure of 56 Iranian children and adolescents aged 6 to 18 years by analyzing seven urinary metabolites of five phthalates. The estimated daily intake values derived from the biomonitoring data ranged from 0.01 µg/kg bw/day for butyl benzyl phthalate (BBP), to 17.85 µg/kg bw/day for di(2-ethylhexyl) phthalate (DEHP). The risk assessment revealed that not only the exposure to the individual phthalates, but also the combined exposure to the three anti-androgenic phthalates (DEHP, DBP, BBP) did not raise a safety concern (hazard index values averaged 0.2). The range of maximum cumulative ratio values varied from around 1 for most individuals to around 2 in some individuals, indicating that the combined exposures were dominated by one and in some cases by two of the three anti-androgenic phthalates, especially dibutyl phthalate (DBP) and/or DEHP. Based on biomonitoring data, the overall combined exposure of Iranian children to phthalates does not raise a concern, while reduction of exposure is best focused on DEHP and DBP that showed the highest hazard quotient.

Fungal metabolites diversity in maize and associated human dietary exposures relate to micro-climatic patterns in Malawi

2015 ◽  
Vol 8 (3) ◽  
pp. 269-282 ◽  
Author(s):  
L. Matumba ◽  
M. Sulyok ◽  
M. Monjerezi ◽  
T. Biswick ◽  
R. Krska
Keyword(s):  
Management Strategies ◽  
Daily Intake ◽  
Dietary Exposure ◽  
Climatic Conditions ◽  
Human Consumption ◽  
Cool Temperature ◽  
Fungal Metabolites ◽  
Ecological Zones ◽  
Daily Intakes ◽  
Agro Ecological Zones

This study investigated the diversity of fungal metabolites in maize across four agro-ecological zones of Malawi. A total of 90 maize samples (for human consumption), collected from farmsteads, were analysed for 235 fungal metabolites using liquid chromatography-tandem mass spectrometry. A total of 65 metabolites were found in the samples. 75% of samples from the hottest agro-ecological zone contained either aflatoxins, fumonisins, deoxynivalenol, zearalenone; or a combination thereof in levels exceeding European Union (EU) maximum levels, whereas the related fraction was only 17% in the cool temperature zone. Aflatoxins, citrinin, 3-nitropropionic acid, monocerin and equisetin were most prevalent and in higher levels in samples from hot agro-ecological zones, whereas deoxynivalenol, nivalenol, zearalenone and aurofusarin were most prevalent in cool agro-ecologies. On the basis of per-capita maize consumption, estimated daily intakes for all samples from hot ecologies were well above the JECFA's provisional maximum tolerable daily intake (PMTDI) of 2.0 μg/kg body weight (bw)/day for fumonisins, whereas the PMTDI of 1.0 μg/kg bw/day for deoxynivalenol was exceeded in relatively more (90%) samples from the cool highlands than the other zones. These results demonstrate the influence of micro-climatic conditions on mycotoxin prevalence patterns and underscores the need for development of agro-ecological specific mycotoxin dietary exposure management strategies.

scholarly journals Levels and health risk assessment of organochlorine pesticide residues in vegetables from Yamaltu area in Gombe, Nigeria

2021 ◽  
Vol 9 (1) ◽  
pp. 19-30
Author(s):  
Mohammad Sulaiman ◽  
Aishatu Maigari ◽  
Janefrances Ihedioha ◽  
Rasheed Lawal ◽  
Abdullahi Gimba ◽  
...  
Keyword(s):  
Health Risks ◽  
High Performance ◽  
Health Effect ◽  
Daily Intake ◽  
Hazard Index ◽  
Acceptable Daily Intake ◽  
Estimated Daily Intake ◽  
Organochlorine Pesticide Residues ◽  
The Mean ◽  
Almost All

The study determined the levels of organochlorine pesticides (OCPs) residues and assesses health risks linked with the consumption of vegetables cultivated in the Yamaltu area in Gombe, Nigeria. OCPs residues were solvent extracted and analyzed with a high performance liquid chromatography equipped with UV/VIS Detector. The mean concentrations of ten detected OCPs residues were almost all above the set limit of EU/WHOMRL. The estimated daily intake of OCPs from samples was below the acceptable daily intake, hazard index estimated were <1, indicated no probable non-carcinogenic health effect, while the carcinogenic health effect showed that children were more vulnerable for the consumption of the contaminated vegetables.

scholarly journals Occurrence and Exposure Assessment of Aflatoxin B1 and Ochra-toxin A in Pearl Millet (Pennisetum glaucum L.) from Tunisia

2020 ◽  
Author(s):  
S. Lasram ◽  
Z. Hamdi ◽  
A. Ghorbel
Keyword(s):  
Pearl Millet ◽  
Aflatoxin B1 ◽  
High Performance ◽  
Pennisetum Glaucum ◽  
Statistical Tests ◽  
Daily Intake ◽  
Dietary Exposure ◽  
Contamination Rate ◽  
The European Union ◽  
Fluorescence Detector

Background: Ochratoxin A (OTA) and Aflatoxin B1 (AFB1) are toxic secondary  metabolites produced by certain mold species. In this primarily survey, we examined the OTA and AFB1 contamination of pearl millet grains distributed in Tunisia. Methods: Twenty-five pearl millet (Pennisetum glaucum L.) samples from different regions of Tunisia were analyzed by High Performance Liquid Chromatography coupled with fluorescence detector in order to evaluate the contamination with of AFB1 and OTA. Statistical tests were performed with XLSTAT 2018. Results: AFB1 and OTA were detected in 32 and 28% millet samples, respectively. Mean amounts of these mycotoxins in the contaminated samples were of 24.54±17.54 µg/kg for OTA and 22.72±23.09 µg/kg for AFB1. Approximately, 28 and 24% of analyzed samples were found above the European Union limits for AFB1 and OTA, respectively. The estimated daily intake of OTA and AFB1 were 3.76 and 3.89 ng/kg b.w. per day, respectively. No significantly (p>0.05) difference in OTA and AFB1 contamination rate was found between samples taken from different regions. Conclusion: Consumption of millet in Tunisia might be an important contributing factor to the risk of dietary exposure to OTA and AFB1

Exposure to Aflatoxins Above Permissible Limits in Maize (Zea Mays) Meant for Consumption and Their Health Risk Estimations in the Volta Region of Ghana

2021 ◽  
Author(s):  
Nii Korley Kortei ◽  
Theophilus Annan ◽  
John Dzikunoo
Keyword(s):  
Zea Mays ◽  
High Performance ◽  
Daily Intake ◽  
Aflatoxin Contamination ◽  
Risk Assessments ◽  
Expert Committee ◽  
Middle Income ◽  
Adverse Health Effects ◽  
Adolescents And Adults ◽  
Volta Region

Abstract Aflatoxin contamination in foods is a vital health challenge for low and middle-income countries in subtropical regions. Maize (Zea mays L.), a staple food most widely grown in Africa including Ghana, and extensively consumed as much as three times per day is a source of aflatoxin contamination owing to its susceptibility to fungal attack. This study aimed at evaluating aflatoxin levels above international (European Food Safety Authority, EFSA) and local (Ghana Standards Authority, GSA) standards and health risks associated with maize sampled from the Volta Region (Hohoe, Ho, Battor Dugame, and Keta) of Ghana. Total aflatoxins (AFTotal) and the constituent aflatoxins (AFB1, AFB2, AFG1, and AFG2) were measured with High-Performance Liquid Chromatography (HPLC). Risk assessments were also conducted using models prescribed by the Joint FAO/WHO Expert Committee on Additives (JECFA). The degree of occurrence of aflatoxins was observed to be in decreasing order of AFG2< AFG1< AFB2<AFB1 and were within the ranges of 0.78±0.04-234.73±3.8 µg/kg, 0.47±0.03-21.6±0.33 µg/kg, 1.01±0.05-13.75±1.2 µg/kg and 0.66±0.06-5.51±0.26 µg/kg respectively. Out of the 100 samples analyzed for total aflatoxins (AFTotal), 68% exceeded the limits of EFSA and were of range 4.98±0.6-444.01±8.9 µg/kg whereas 58% and ranged between 12.12±1.4-444.01±8.9 µg/kg exceeded for GSA limits. Risk assessments of total aflatoxins (AFTotal) for infants, children, and adolescents, and adults ranged between 0.0083-0.3427 μg/Kg.bw/day, 0.116-4.8192, 0-0.0396 ng Aflatoxins kg−1bwday−1 and 3.2868x10-4 -0.0136 for Estimated Daily Intake (EDI), Margin of Exposure (MOE), Average Potency, and Population Risks respectively. It was inferred that the consumption of maize posed adverse health effects on all age categories studied because all calculated MOE values were greater than 0.04 ngkg−1bwday−1.

scholarly journals Tingkat Keamanan Konsumsi Residu Karbamat dalam Buah dan Sayur Menurut Analisis Pascakolom Kromatografi Cair Kinerja Tinggi

2013 ◽  
Vol 7 (7) ◽  
pp. 317 ◽  
Author(s):  
Bambang Wispriyono ◽  
Arry Yanuar ◽  
Laila Fitria
Keyword(s):  
High Performance ◽  
Fruits And Vegetables ◽  
Health Effect ◽  
Daily Intake ◽  
Human Consumption ◽  
Acceptable Daily Intake ◽  
Fluorescence Detector ◽  
Traditional Market ◽  
Margin Of Safety ◽  
Wet Weight

Karbamat merupakan salah satu jenis pestisida yang banyak digunakan untuk membasmi hama buah dan sayur. Untuk menentukan bahwa residu karbamat dalam sayuran masih aman dikonsumsi manusia, telah dilakukan analisis beberapa residu karbamat seperti metomil, karbaril, karbofuran, dan propoksur. Sampel-sampel tomat, apel, selada air, kubis, dan sawi hijau dikumpulkan dari tiga supermarket dan satu pasar tradisional di Depok, Jawa Barat. Analisis dilakukan serempak untuk ke empat residu karbamat menggunakan kromatografi cair kinerja tinggi denganpereaksi o-ftalaldehida dan 2-merkaptoetanol dalam reaktor pascakolom dengan detektor fluoresensi. Dari sampel-sampel buah dan sayur yang dianalisis, hanya sawi hijau asal pasar tradisional yang positif mengandung propoksur dengan kadar 1,2 mg/25 gram berat basah (0,048 mg/g berat basah). Dengan Acceptable Daily Intake(ADI) propoksur 0,005 mg/kg berat badan/hari, konsumsi sawi hijau harian seberat 20 g/hari masih cukup aman dari gangguan kesehatan akibat pajanan kronik propoksur dengan margin of safety 298,7 (> 100 sebagai batas aman).Carbamat is a group of pesticides which is commonly used to control fruits and vegetables pests. To determine that carbamat residues in fruits and vegetables are safe for human consumption, carbamate residues such as methomyl, carbaryl, carbofuran, and propoxur in vegetables and fruits have been analyzed. Samples of tomato, apple, water lettuces, cabbage, and mustard greens were collected from three supermarkets and one traditional market in Depok, West Java. The analysis was carried out simultaneously for all four carbamate residues by high performance liquid chromatography using o-phtaladehyde and 2 mercaptoethanol reagents in post-column reactor with a fluorescence detector. Of fruits and vegetable samples analyzed, only mustard greens from traditional market positively containe propoxur at 1.2 mg/ 25 gram wet weight (0,048 mg/gram wet weight). With Acceptable Daily Intake (ADI) of 0.005 mg/kg body weight/day, mustard greens consumption of 20 g/day is safe from adverse health effect from chronic exposure to propoxur with Margin of Safety of 298.7 (> 100 as safe limit).

scholarly journals Human Health Risk Assessment of Heavy Metals Bioaccumulation In Fish and Mussels from Jakarta Bay

2017 ◽  
Vol 12 (2) ◽  
pp. 75
Author(s):  
Ajeng Kurniasari Putri ◽  
Giri Rohmad Barokah ◽  
Nuri Andarwulan
Keyword(s):  
Heavy Metals ◽  
Risk Assessment ◽  
Food Safety ◽  
Human Health ◽  
Safety Concern ◽  
Hazard Quotient ◽  
Ingestion Rate ◽  
Human Health Risk ◽  
Daily Intake ◽  
Target Hazard Quotient

Aquatic environment of Jakarta Bay have already been highlighted due to its heavy metals contamination which may lead into food safety concern of fisheries products derived from this region. This research aimed to investigate bioaccumulation level of heavy metals (Pb, Cd, and As) in fish and mussels from Jakarta Bay, as a human risk assessment of seafood consumption. Samples of mussels and fish were taken from Penjaringan, Tarumanegara, Cilincing, and Tanjung Pasir district. Bioaccumulation of heavy metals was analyzed by Inductively Coupled Plasma -Mass Spectrometry technique. Results of the study revealed that metals bioaccumulation in fisheries products were varied, with As (Arsenic) as the highest metal contaminant (0.68 mg/kg, dry weight). Furthermore, estimated daily intake (EDI), target hazard quotient (THQ), total target hazard quotient (TTHQ), and safety limits prescribed by various agencies, showed that consumption of fisheries products from Jakarta Bay considered as relatively safe for human health in total of food ingestion rate of fish 57.34 g/day. These results are expected to serve as a baseline to construct preventive and palliative policies for food safety of fisheries products from Jakarta Bay.

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