scholarly journals The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elissavet Nikolaou ◽  
Esther L. German ◽  
Annie Blizard ◽  
Ashleigh Howard ◽  
Lisa Hitchins ◽  
...  
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Streptococcus Pneumoniae ◽  
Oral Cavity ◽  
Healthy Adults ◽  
Nasal Wash ◽  
Multiplex Qpcr ◽  
Post Exposure ◽  
Oropharyngeal Swab

AbstractPrevious studies have suggested that the pneumococcal niche changes from the nasopharynx to the oral cavity with age. We use an Experimental Human Pneumococcal Challenge model to investigate pneumococcal colonisation in different anatomical niches with age. Healthy adults (n = 112) were intranasally inoculated with Streptococcus pneumoniae serotype 6B (Spn6B) and were categorised as young 18–55 years (n = 57) or older > 55 years (n = 55). Colonisation status (frequency and density) was determined by multiplex qPCR targeting the lytA and cpsA-6A/B genes in both raw and culture-enriched nasal wash and oropharyngeal swab samples collected at 2-, 7- and 14-days post-exposure. For older adults, raw and culture-enriched saliva samples were also assessed. 64% of NW samples and 54% of OPS samples were positive for Spn6B in young adults, compared to 35% of NW samples, 24% of OPS samples and 6% of saliva samples in older adults. Many colonisation events were only detected in culture-enriched samples. Experimental colonisation was detected in 72% of young adults by NW and 63% by OPS. In older adults, this was 51% by NW, 36% by OPS and 9% by saliva. The nose, as assessed by nasal wash, is the best niche for detection of experimental pneumococcal colonisation in both young and older adults.

scholarly journals The nose is the best niche for detection of pneumococcal colonisation following experimental challenge in adults of all ages

2021 ◽  
Author(s):  
Elissavet Nikolaou ◽  
Esther Lauryn German ◽  
Annie Blizard ◽  
Ashleigh Howard ◽  
Lisa Hitchins ◽  
...  
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Streptococcus Pneumoniae ◽  
Healthy Adults ◽  
Nasal Wash ◽  
Multiplex Qpcr ◽  
Post Exposure ◽  
Oropharyngeal Swab ◽  
Experimental Challenge

Abstract Background Previous studies have suggested that the pneumococcal niche changes from the nose to the oropharynx with age. We use an Experimental Human Pneumococcal Challenge model to investigate pneumococcal colonisation in each anatomical niche with age. Methods Healthy adults (n = 112) were intranasally inoculated with Streptococcus pneumoniae serotype 6B (Spn6B) and were categorised as young 18-55yrs (n = 57) or older > 55yrs (n = 55). Colonisation status (frequency and density) was determined by multiplex qPCR targeting the lytA and cpsA-6A/B genes in both raw and culture-enriched nasal wash and oropharyngeal swab samples collected at 2-, 7- and 14-days post-exposure. For older adults, raw and culture-enriched saliva samples were also assessed. Results 64% of NW samples and 54% of OPS samples were positive for Spn6B in young adults, compared to 35% of NW samples, 24% of OPS samples and 6% of saliva samples in older adults. Many colonisation events were only detected in culture-enriched samples. Experimental colonisation was detected in 72% of young adults by NW and 63% by OPS. In older adults, this was 51% by NW, 36% by OPS and 9% by saliva. Conclusions The nose is the best niche for detection of experimental pneumococcal colonisation in both young and older adults.

Processing gender stereotypes in dementia patients and older healthy adults: a self-paced reading study

2019 ◽  
Vol 5 (s2) ◽  
Author(s):  
Daniel Müller-Feldmeth ◽  
Katharina Ahnefeld ◽  
Adriana Hanulíková
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Sentence Processing ◽  
Gender Stereotypes ◽  
Time Course ◽  
Healthy Adults ◽  
Control Group ◽  
Healthy Older Adults ◽  
Dementia Patients ◽  
Age Related

AbstractWe used self-paced reading to examine whether stereotypical associations of verbs with women or men as prototypical agents (e.g. the craftsman knits a sweater) are activated during sentence processing in dementia patients and healthy older adults. Effects of stereotypical knowledge on language processing have frequently been observed in young adults, but little is known about age-related changes in the activation and integration of stereotypical information. While syntactic processing may remain intact, semantic capacities are often affected in dementia. Since inferences based on gender stereotypes draw on social and world knowledge, access to stereotype information may also be affected in dementia patients. Results from dementia patients (n = 9, average age 86.6) and healthy older adults (n = 14, average age 79.5) showed slower reading times and less accuracy in comprehension scores for dementia patients compared to the control group. While activation of stereotypical associations of verbs was visible in both groups, they differed with respect to the time-course of processing. The effect of stereotypes on comprehension accuracy was visible for healthy adults only. The evidence from reading times suggests that older adults with and without dementia engage stereotypical inferences during reading, which is in line with research on young adults.

scholarly journals Determining the Underlying Relationship Between Swallowing and Maximum Vocal Pitch Elevation: A Preliminary Study of Their Hyoid Biomechanics in Healthy Adults

2020 ◽  
Vol 63 (10) ◽  
pp. 3408-3418
Author(s):  
Anumitha Venkatraman ◽  
Robert Brinton Fujiki ◽  
Bruce A. Craig ◽  
M. Preeti Sivasankar ◽  
Georgia A. Malandraki
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Healthy Adults ◽  
Age Group ◽  
Age Related ◽  
Vocal Pitch ◽  
Preliminary Study ◽  
Muscle Changes ◽  
Underlying Mechanisms ◽  
Moderate Positive Correlation

Purpose Deficiencies in swallowing (aspiration) and in maximum vocal pitch elevation have been shown to correlate in dysphagia. However, the underlying mechanisms that may explain this relationship are not known. In this study, we compare hyoid kinematics between swallowing and maximum vocal pitch elevation in healthy adults. Method Ten young ( M = 21 ± 1.33 years) and eight older ( M = 72.85 ± 5.59 years) healthy adults completed trials of maximum vocal pitch elevation (vowels /a/ and /i/) and swallowing (thin liquid and pudding) under videofluoroscopy. Superior and anterior hyoid excursions were obtained using kinematic analysis. Two-way analyses of variance and Spearman rho correlations were used to examine differences and relationships between swallowing and maximum pitch elevation biomechanics. Results Superior hyoid excursion was significantly greater for liquid swallows compared to pitch elevation tasks (/a/ and /i/; p = .002; Cohen's d = 1.28; p = .0179, Cohen's d = 1.03, respectively) and for pudding swallows compared to pitch tasks ( p = .000, Cohen's d = 1.64; p = .001, Cohen's d = 1.38, respectively). Anterior hyoid excursion was not significantly different between the two functions, but was overall reduced in the older group ( p = .0231, Cohen's d = .90). Furthermore, there was a moderate positive correlation between the degree of superior excursion during liquid swallows and maximum pitch elevation for both vowels ( r s = .601, p = .001; r s = .524, p = .003) in young adults, and between the degree of anterior excursion during liquid swallows and pitch elevation for both vowels ( r s = .688, p = .001; r s = .530, p = .008) in older adults. Conclusions Swallowing and maximum pitch elevation require similar anterior, but not superior, hyoid excursion in healthy adults. Differential correlations between the two tasks for each age group may be associated with age-related muscle changes. We provide evidence of partially shared biomechanics between swallowing and maximum pitch elevation.

Task-Switching Training and Transfer

2018 ◽  
Vol 32 (3) ◽  
pp. 106-130 ◽  
Author(s):  
Zsófia Anna Gaál ◽  
István Czigler
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Cognitive Training ◽  
Task Switching ◽  
Difficulty Level ◽  
Training Procedure ◽  
Far Transfer ◽  
Near Transfer ◽  
Related Potentials ◽  
Transfer Tasks

Abstract. We used task-switching (TS) paradigms to study how cognitive training can compensate age-related cognitive decline. Thirty-nine young (age span: 18–25 years) and 40 older (age span: 60–75 years) women were assigned to training and control groups. The training group received 8 one-hour long cognitive training sessions in which the difficulty level of TS was individually adjusted. The other half of the sample did not receive any intervention. The reference task was an informatively cued TS paradigm with nogo stimuli. Performance was measured on reference, near-transfer, and far-transfer tasks by behavioral indicators and event-related potentials (ERPs) before training, 1 month after pretraining, and in case of older adults, 1 year later. The results showed that young adults had better pretraining performance. The reference task was too difficult for older adults to form appropriate representations as indicated by the behavioral data and the lack of P3b components. But after training older adults reached the level of performance of young participants, and accordingly, P3b emerged after both the cue and the target. Training gain was observed also in near-transfer tasks, and partly in far-transfer tasks; working memory and executive functions did not improve, but we found improvement in alerting and orienting networks, and in the execution of variants of TS paradigms. Behavioral and ERP changes remained preserved even after 1 year. These findings suggest that with an appropriate training procedure older adults can reach the level of performance seen in young adults and these changes persist for a long period. The training also affects the unpracticed tasks, but the transfer depends on the extent of task similarities.

Inefficient Encoding as an Explanation for Age-Related Deficits in Recollection-Based Processing

2014 ◽  
Vol 28 (3) ◽  
pp. 148-161 ◽  
Author(s):  
David Friedman ◽  
Ray Johnson
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Cognitive Processes ◽  
Brain Activity ◽  
Memory Performance ◽  
Brain Regions ◽  
Semantic Retrieval ◽  
Age Related ◽  
The Face ◽  
Episodic Memories

A cardinal feature of aging is a decline in episodic memory (EM). Nevertheless, there is evidence that some older adults may be able to “compensate” for failures in recollection-based processing by recruiting brain regions and cognitive processes not normally recruited by the young. We review the evidence suggesting that age-related declines in EM performance and recollection-related brain activity (left-parietal EM effect; LPEM) are due to altered processing at encoding. We describe results from our laboratory on differences in encoding- and retrieval-related activity between young and older adults. We then show that, relative to the young, in older adults brain activity at encoding is reduced over a brain region believed to be crucial for successful semantic elaboration in a 400–1,400-ms interval (left inferior prefrontal cortex, LIPFC; Johnson, Nessler, & Friedman, 2013 ; Nessler, Friedman, Johnson, & Bersick, 2007 ; Nessler, Johnson, Bersick, & Friedman, 2006 ). This reduced brain activity is associated with diminished subsequent recognition-memory performance and the LPEM at retrieval. We provide evidence for this premise by demonstrating that disrupting encoding-related processes during this 400–1,400-ms interval in young adults affords causal support for the hypothesis that the reduction over LIPFC during encoding produces the hallmarks of an age-related EM deficit: normal semantic retrieval at encoding, reduced subsequent episodic recognition accuracy, free recall, and the LPEM. Finally, we show that the reduced LPEM in young adults is associated with “additional” brain activity over similar brain areas as those activated when older adults show deficient retrieval. Hence, rather than supporting the compensation hypothesis, these data are more consistent with the scaffolding hypothesis, in which the recruitment of additional cognitive processes is an adaptive response across the life span in the face of momentary increases in task demand due to poorly-encoded episodic memories.

Older adults consider others’ intentions less but allocentric outcomes more than young adults during an ultimatum game.

2020 ◽  
Vol 35 (7) ◽  
pp. 974-980
Author(s):  
Isu Cho ◽  
Hyun-joo Song ◽  
Hackjin Kim ◽  
Sunhae Sul
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Ultimatum Game

Low awareness and use of post-exposure prophylaxis among adolescents and young adults in South Africa: implications for the prevention of new HIV infections

2020 ◽  
Vol 19 (3) ◽  
pp. 242-248
Author(s):  
Anthony Idowu Ajayi ◽  
Mohammed Sanusi Yusuf ◽  
Elmon Mudefi ◽  
Oladele Vincent Adeniyi ◽  
Ntombana Rala ◽  
...  
Keyword(s):  
South Africa ◽  
Young Adults ◽  
Hiv Infections ◽  
Adolescents And Young Adults ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Exposure Prophylaxis

Evaluation of the Degree of Dental Anxiety in a Lot of Patients Altered in Young Adults

2019 ◽  
Vol 70 (2) ◽  
pp. 689-692
Author(s):  
Gheorghe Raftu ◽  
Elena-Claudia Sin ◽  
Aureliana Caraiane ◽  
Steliana Gabriela Bustiuc ◽  
Raluca Briceag
Keyword(s):  
Young Adults ◽  
Oral Cavity ◽  
Dental Treatment ◽  
Economic Status ◽  
Dental Anxiety ◽  
Background Level ◽  
Anxiety Scale ◽  
Statistical Relationships ◽  
And Gender ◽  
Age Range

The study aims at identifying and highlighting dental anxiety in a group of young adults, analyzing patients� concerns about the main dental treatment procedures, and establishing statistical relationships between anxiety and gender, the background, level of education, socio-economic status and knowledge of habits of care and hygiene of oral cavity characteristic of the studied group. The study group consists of 150 female (50%) and male (50%) patients , aged between 20 and 40 years. The inclusion criteria in the batch were those related to the age range of 20 to 40 years.Two respondents (Corah�s Dental Anxiety Scale, Revised (DAS-R)) were given two questionnaires ( Corah�s Dental Anxiety Scale, DAS-R), and the second questionnaire contained 7 questions about the habits dental care). Most patients� concerns about the main procedures of dental treatment / other concerns are: dental extraction, material expenses, possibility of treatments and shame she felt oppressed health of the oral cavity. Regardless of the level of dental anxiety, the oral cavity hygiene habits are not properly performed by patients, with an increased tendency for them to be disregarded by patients with severe dental anxiety.

scholarly journals The Hidden Cost of Age Oppression: Adultism, Ageism, and Interest in Serving Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 594-594
Author(s):  
Katherine King ◽  
Kirsten Graham ◽  
Briana Reid ◽  
Molly Church ◽  
Juan Rosario
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Doctoral Students ◽  
Internal Consistency ◽  
Clinical Psychology ◽  
Career Choices ◽  
Hidden Cost ◽  
Psychology Doctoral Students ◽  
Positive Correlations ◽  
Psychology Doctoral

Abstract Adultism is an underappreciated influence on young adults’ career choices and a hidden contributing factor to the geropsychology workforce shortage. This study reports on the development of an Adultist Concerns scale and its correlations with several factors relevant to careers in aging. Clinical psychology doctoral students (n = 109) completed the new scale along with measures of ageism, training interests, and experience working with older adults. The Adultist Concerns scale had strong internal consistency (α = .952) and factor loadings .853 and .929. Females scored significantly higher than males (p = .003). There were significant positive correlations between Adultist Concerns and both overall ageist behaviors (p = .002) and negative ageist behaviors specifically (p = .002). Adultist concerns were significantly negatively correlated with age (p = .000), interest in working with older adults (p = .003), and experience with this population (p = .043).

scholarly journals Asking Young Adults about Their Attitudes toward and Knowledge of Sex in Later Life

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 870-871
Author(s):  
Iulia Fratila ◽  
Liza Berdychevsky
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Survey Methods ◽  
Leisure Activity ◽  
Later Life ◽  
Health And Wellbeing ◽  
Knowledge And Attitudes ◽  
Intercept Survey ◽  
Knowledge Practice ◽  
Research Questions

Abstract Sexual expression is a lifelong need related to health and wellbeing. However, older adults’ sexuality is often neglected and stigmatized due to societal ageist stereotypes portraying them as asexual. Although baby boomers’ generation resists such portrayals, societal acceptance of sexuality in later life is slow to materialize. The purpose of this study was to explore this acceptance among young adults while focusing on three research questions: (1) How much do young adults know about older adults’ sexuality and how do they feel about it? (2) Do young adults’ knowledge and views of later-life sexuality vary by gender? (3) Do young adults’ views of later-life sexuality vary based on their general attitudes toward sexuality? Data collection included online and intercept survey methods. The sample (N=270) was young (M=21.58 years, SD=4.32) and included 149 women and 113 men. Results revealed that young adults had medium levels of knowledge, yet rather permissive/open-minded attitudes regarding later-life sexuality. Higher levels of knowledge were unrelated to more permissive attitudes. Independent samples t-test revealed no differences by gender in young adults’ knowledge and attitudes. However, multiple regression results indicated that general liberal attitudes toward sexuality (β=.772, t=17.867, p=.000) and viewing sex as leisure activity (β=.147, t=3.338, p=.001) are significant predictors of having more permissive/open-minded attitudes toward older adults’ sexuality (R2=.557, F(3,266)=111.390, p=.000). These findings suggest that socio-psychological (rather than cognitive and demographic) factors drive the acceptance of later-life sexuality among young adults. This study offers valuable insights for knowledge, practice, and advocacy concerning older adults’ sexuality.

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