scholarly journals Anti-inflammatory diet consumption reduced fatty liver indices

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mitra Darbandi ◽  
Behrooz Hamzeh ◽  
Azad Ayenepour ◽  
Shahab Rezaeian ◽  
Farid Najafi ◽  
...  

AbstractThe aim of this study was to assess the association between dietary inflammatory index (DII) and non-invasive markers of liver status in adults. This cross-sectional study was performed on 8520 adults, recruited in Ravansar Non-Communicable Diseases (RaNCD) cohort study, western Iran. The DII score was calculated based on participants’ dietary intakes obtained from Food Frequency Questionnaire (FFQ). Fatty Liver Index (FLI) score was calculated by anthropometric measurements and some non-invasive markers of liver status. Linear regression models were applied to estimate the associations and adjust the possible confounding factors. A greater DII score was significantly associated with higher energy intake, body mass index (BMI), body fat mass (BFM), blood pressure, and FLI (P < 0.001). Participants with the highest DII score had a significantly higher consumption saturated fat, trans fat and red meat than those in the lowest quartile (P < 0.001). After adjustments of age and sex, participants in the highest quartile of the DII score had a greater risk of FLI (β: 0.742, 95% CI: 0.254, 0.601). More pro-inflammatory diet in participants was associated with a higher FLI. The DII score was positively associated with non-invasive liver markers. Thus, having an anti-inflammatory diet can help balance liver enzymes, reduce obesity, and decrease fatty liver.

2021 ◽  
Author(s):  
Mitra Darbandi ◽  
Behrooz Hamzeh ◽  
Azad Ayenepour ◽  
Shahab Rezaeian ◽  
Farid Najafi ◽  
...  

Abstract The aim of this study was the assess association between of dietary inflammatory index (DII) and non-invasive markers of liver status in adults. This cross-sectional study was performed on 8,520 adults, recruited in Ravansar Non-Communicable Diseases (RaNCD) cohort study, the west of Iran. DII score was calculated based on participants’ dietary intakes obtained from Food Frequency Questionnaire (FFQ). Fatty Liver Index (FLI) score was calculated by anthropometric measurements and some non-invasive markers of liver status. Linear regression models were used to estimate the associations and adjust for possible confounding factors. A greater DII score was significantly associated with higher energy intake, BMI (body mass index), BFM (body fat mass), blood pressure and FLI (P<0.001). Participants with the highest DII score had a significantly higher consumption saturated fat, trans fat and red meat than those in the lowest quartile (P<0.001). After adjustment for age and sex, participants in the highest quartile of DII score had a greater risk of FLI (β: 0.742, 95% CI: 0.254, 0.601). The more pro-inflammatory diet in participants was associated with higher FLI; DII score was positively associated with non-invasive liver markers. Thus having an anti-inflammatory diet can help balance liver enzymes, reduce obesity and fatty liver.


2020 ◽  
Author(s):  
Mitra Darbandi ◽  
Behrooz Hamzeh ◽  
Azad Ayenepour ◽  
Shahab Rezaeian ◽  
Farid Najafi ◽  
...  

Abstract Background The aim of this study was the assess association between of dietary inflammatory index (DII) and non-invasive markers of liver status in adults. Methods This cross-sectional study was performed on 8,520 individuals aged 35–65 years, recruited in Ravansar Non-Communicable Diseases (RaNCD) cohort study, the west of Iran. DII score was calculated based on participants’ dietary intakes obtained from Food Frequency Questionnaire (FFQ). Fatty Liver Index (FLI) score was calculated by anthropometric measurements and some non-invasive markers of liver status. Linear regression models were used to estimate the associations and adjust for possible confounding factors. Results The mean of age was 47.24 ± 8.31 years and 4275 (%50.18) were male. A greater DII score was significantly associated with higher energy intake, BMI (body mass index), BFM (body fat mass), blood pressure and FLI (P < 0.001). Participants with the highest DII score had a significantly higher consumption saturated fat, trans fat and red meat than those in the lowest quartile (P < 0.001). With one point increment in the physical activity, on average the risk of having FLI decreased by 5 (95% CI, -0.484 to -0.519). After adjustment for age and sex, participants in the highest quartile of DII score had a greater risk of FLI (β: 0.742, 95% CI: 0.254, 0.601). Conclusion The more pro-inflammatory diet in participants was associated with higher FLI; DII score was positively associated with non-invasive liver markers (ALT, AST and GGT). FLI had positive association with BMI, WC, BFM and energy intake. Thus having an anti-inflammatory diet can help balance liver enzymes, reduce obesity and fatty liver.


2021 ◽  
Vol 10 ◽  
Author(s):  
Fahimeh Haghighatdoost ◽  
Awat Feizi ◽  
Ahmad Esmaillzadeh ◽  
Ammar Hassanzadeh Keshteli ◽  
Hamid Afshar ◽  
...  

Abstract The authors investigate the association of breakfast skipping and its interaction with a dietary inflammatory index (DII) with the severity of psychological disorders. A total of 2876 Iranian general adults were enrolled in this cross-sectional study. Psychological problems profile score was calculated using the regression method in the framework of factor analysis based on depression, anxiety and psychological distress. The higher scores indicate more severity of mental problem. The frequency of breakfast eating in a week was assessed. Dietary intakes were assessed using a food-frequency questionnaire and twenty-seven items were included in the calculation of DII. In the crude model, individuals who ate breakfast seldom had the highest odds for having worse psychological problems profile (OR 3⋅59; 95 % CI 2⋅52, 5⋅11). Adjustment for various confounders did not change the associations (OR 3⋅35; 95 % CI 2⋅11, 5⋅32). In the adjusted multinomial logistic regression model, participants with high DII (>median) who skipped breakfast had highest risk of being in the higher tertiles of psychological problems profile compared with those who had low DII (<median) and ate breakfast (OR 6⋅67; 95 % CI 3⋅45, 12⋅90). Similar results were observed in women and men regarding the impact of breakfast skipping alone and interaction with DII on scores of psychological problems profile. Breakfast skipping is associated with higher risk of psychological problems. Similar findings were obtained in the stratified analysis by sex. Our findings confirmed that the DII and breakfast skipping are associated with mental health, interactionally. Further longitudinal studies are needed to confirm the true link between breakfast skipping and psychological problems.


2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Asma Salari-Moghaddam ◽  
Ammar Hassanzadeh Keshteli ◽  
Ahmad Esmaillzadeh ◽  
Peyman Adibi

Abstract Objective There is no prior study that examined the association between nutrient-based dietary inflammatory index (DII) and odds of Irritable Bowel Syndrome (IBS). We examined the association between DII score and odds of IBS and its severity among Iranian adults. Methods In this cross-sectional study, dietary intakes of 3363 Iranian adults were examined using a validated Dish-based 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ). DII was calculated based on dietary intakes derived from DS-FFQ. IBS was assessed using a modified Persian version of Rome III questionnaire. Results After adjustment for potential confounders, we found that participants in the highest quintile of DII score had greater chance for IBS compared with those in the lowest quintile (OR: 1.36; 95% CI: 1.03–1.80). By gender, we found a significant association between DII score and IBS among women (OR: 1.41; 95% CI: 1.00–2.00). By BMI status, overweight or obese (BMI ≥ 25 kg/m2) individuals in top quintile of DII score had greater odds for IBS than those in the bottom quintile (OR: 1.64; 95% CI: 1.07–2.53). No significant association was observed between a pro-inflammatory diet and severity of IBS symptoms. Conclusions Consumption of a pro-inflammatory diet was associated with increased odds of IBS, in particular among women and those with BMI ≥ 25 kg/m2.


Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1947
Author(s):  
Andrea Y. Arikawa ◽  
Mindy S. Kurzer

The purpose of this cross-sectional study was to examine the relationship between diet and anthropometric measures in postmenopausal women. Data collected from 937 women enrolled in the Minnesota Green Tea Trial (NTC00917735) were used for this analysis. Dietary intake and health-related data were collected via questionnaires. Body weight, height, and waist circumference (WC) were measured by the study staff. The mean age of participants was 59.8 years and mean WC was 83 cm. Approximately 30% of the participants had WC greater than 88 cm. Healthy Eating Index-2015 score was 72.6 and the Dietary Inflammatory Index score was 0. Intakes of whole grains, dairy, protein, sodium, and saturated fat did not meet the dietary guidelines. Only 12.5% consumed the recommended daily amount of calcium (mean intake = 765 mg/day). When calcium supplements were considered, only 35.2% of the participants had adequate intakes, even though 68.9% reported taking a calcium supplement. We found that age and number of medications taken were significantly associated with waist circumference (p = 0.005). Women who reported taking two or more medications had greater WC (85 cm) compared to women who reported not taking any medications (82.2 cm), p = 0.002. Our findings suggest that achieving adequate calcium and vitamin D intake may be challenging to postmenopausal women.


2020 ◽  
Author(s):  
Peng Ju Liu ◽  
Fang Ma ◽  
Yan Ning Zhu ◽  
Hui Ping Lou

Abstract Background: To compare the potential of triglyceride glucose index (TyG) and fatty liver index (FLI) and to explore which index is better for detecting nonalcoholic fatty liver disease (NAFLD).Methods: A cross-sectional study was conducted in 594 Chinese nondiabetic postmenopausal women retrospectively. NAFLD was defined as a hepatic steatosis observed on liver ultrasonography in the absence of a second cause. Binary Logistic regression model analysis was used to determine odds ratio (OR) and corresponding 95% confidence interval (CI) between hepatic steatosis and TyG as well as FLI. Receiver operating characteristic curve (ROC) and area under curve (AUC) were employed to determine the ability of FLI and TyG as well as the combination of TyG with obesity indices to detect hepatic steatosis, and the AUC values were also compared between them. Results: women with the highest value of FLI or TyG had significantly higher odds of hepatic steatosis. The AUC values of FLI was significantly larger than that of TyG in either overall women (difference between area: 0.0743, 95% CI: 0.0396-0.109, P < 0.0001) or women younger (difference between area: 0.0629, 95% CI: 0.0262-0.0996, P=0.0008) and older (difference between area: 0.116, 95% CI: 0.0242-0.207, P=0.0132) than 60 years. Furthermore, when TyG was added to each obesity index, the AUC value of FLI was still significantly larger than that of each combination. Conclusions: Compared with TyG along or combination of TyG and obesity indices, FLI is a better surrogate index for detecting hepatic steatosis among Chinese nondiabtic postmenopausal women.


Author(s):  
Syed Safiullah Ghori ◽  
Hafsa Khalid ◽  
Mohammed Alim ◽  
Mohammed Abdul Quddus

The present study was conducted in Osmania General Hospital,Hyderabad.The study included evaluation of liver fibrosis in patients with diabetes and metabolic syndrome. Liver fibrosis is now being considered as reversible process which is characterized by excessive accumulation of extra cellular matrix. The use of non-invasive methods to assess liver fibrosis in patients with HCV, Non-Alcoholic Fatty Liver Disease (NAFLD) and alcohol abuse has been well validated. However use of these non-invasive methods in patients with diabetes mellitus and metabolic syndrome assessed might develop fibrosis during asymptomatic stages. Hence we tried to use these non-invasive methods in patients with diabetics and metabolic syndrome who are at high risk of developing NAFLD or liver fibrosis in routine clinical practice. This was a single center, prospective study. 50 patients with diabetes and metabolic syndrome attending the endocrinology department of Osmania General Hospital were assessed for fatty liver and enrolled in to the study. NAFLD fibrosis score was used to assess liver fibrosis and BARD score was used for staging of fibrosis as per metavir classificationThe mean age of the patients was 50.8 ± 8.2 with 22 males and 28 females. 90% of the population was found to have some degree of fibrosis. 56% of the patients were at advance fibrosis stage as per the BARD score.Patients with diabetes and metabolic syndrome should be constantly evaluated for liver fibrosis apart from development of diabetes and other complications and to prevent any adverse effects due to waning of liver functions.


PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120443 ◽  
Author(s):  
Bi-Ling Yang ◽  
Wen-Chieh Wu ◽  
Kuan-Chieh Fang ◽  
Yuan-Chen Wang ◽  
Teh-Ia Huo ◽  
...  

2017 ◽  
Vol 118 (6) ◽  
pp. 463-472 ◽  
Author(s):  
Sahoko Takagi ◽  
Mariko Naito ◽  
Sayo Kawai ◽  
Rieko Okada ◽  
Chisato Nagata ◽  
...  

AbstractAlthough higher circulating levels of oestrogen are related to postmenopausal breast cancer risk, limited information is available regarding effects of diet on endogenous oestrogen. Thus, we examined associations between macronutrient intakes and serum oestrogen with consideration of polymorphisms in oestrogen-metabolising genes. In this cross-sectional study, 784 naturally menopaused Japanese women aged 47–69 years were selected from participants of the Japan Multi-Institutional Collaborative Cohort Study. We documented dietary intakes, measured serum concentrations of oestrone (E1) and oestradiol (E2) and genotyped polymorphisms in oestrogen-metabolising CYP19A1 (rs4441215 and rs936306) and HSD17B1 (rs605059) genes. Trends and interactions were examined using linear regression models. In addition, we calculated the ratios of the oestrogen concentrations of the second to the highest quartiles (Q2–Q4) of dietary intake to those of the lowest quartiles (Q1). After adjustment for potential confounders, E2 was significantly associated with intake of carbohydrate and noodles; ratios of Q4 v. Q1 were 1·15 (95 % CI 1·04, 1·28) and 1·15 (95 % CI 1·04, 1·26), respectively. In contrast, E2 levels were inversely associated with intake of total energy, SFA and n-3 highly unsaturated fatty acids (n-3 HUFA); ratios of Q4 v. Q1 were 0·90 (95 % CI 0·82, 0·99), 0·89 (95 % CI 0·81, 0·98) and 0·91 (95 % CI 0·83, 1·00), respectively. In stratified analysis by polymorphisms, the rs605059 genotype of HSD17B1 significantly modified associations of E2 with intake of n-3 HUFA and fish; the associations were limited to those with the CC genotype. Macronutrient intakes were associated with serum E2 level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal women.


Author(s):  
C. Mele ◽  
A. Crinò ◽  
D. Fintini ◽  
S. Mai ◽  
A. Convertino ◽  
...  

Abstract Purpose Angiopoietin-like 8 (ANGPTL8) is a liver- and adipose tissue-produced protein that predicts non-alcoholic fatty liver disease (NAFLD) and altered metabolic homeostasis in the general population as well as in persons with common and genetic obesity, including the Prader–Willi syndrome (PWS). However, its metabolic correlate in paediatric patients with respect to PWS is unknown. Methods This cross-sectional study investigated circulating ANGPTL8 and adipocytokines levels in 28 PWS and 28 age-, sex- and BMI-matched children and adolescents (age, 7.0–17.8y) in relation to NAFLD and metabolic homeostasis assessed by OGTT, paediatric metabolic index (PMI) and fatty liver index (FLI), liver ultrasonography (US), as well as dual-energy X-ray absorptiometry (DEXA) for analysis of fat (FM) and fat-free mass (FFM). Results At the set level of significance, PWS children showed lower values of FFM (p < 0.01) but healthier insulin profiles (p < 0.01) and PMI values (p < 0.05) than matched controls. By US, the prevalence of NAFLD was similar between groups but less severe in PWS than controls. Analysis of ANGPTL8 levels showed no difference between groups, yet only in PWS ANGPTL8 levels were associated with ALT levels, FLI values and NAFLD. In stepwise multivariable regression analysis on merged data, ANGPTL8 levels were independently predicted by BMI SDS, leptin levels and NAFLD. Conclusion ANGPTL8 levels are similar in PWS and controls and, overall, they are directly associated with the presence and severity of NAFLD in patients with PWS.


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