scholarly journals Insulin-like growth factors and cancer: no role in screening. Evidence from the BUPA study and meta-analysis of prospective epidemiological studies

2006 ◽  
Vol 95 (1) ◽  
pp. 112-117 ◽  
Author(s):  
J K Morris ◽  
L M George ◽  
T Wu ◽  
N J Wald
Keyword(s):  
Growth Factors ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Insulin Like Growth Factors

scholarly journals Diabetes mellitus and cancer: a system of insulin-like growth factors

2021 ◽  
Vol 67 (5) ◽  
pp. 34-42
Author(s):  
E. M. Frantsiyants ◽  
E. I. Surikova ◽  
I. V. Kaplieva ◽  
V. A. Bandovkina ◽  
I. V. Neskubina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factors ◽  
Molecular Mechanisms ◽  
Malignant Tumors ◽  
Tumor Development ◽  
Strong Relationship ◽  
Epidemiological Studies ◽  
Cellular Processes ◽  
Signaling Axis ◽  
Insulin Like Growth Factors

Diabetes mellitus and malignant tumors are among the most common and complex diseases. Epidemiological studies have shown a strong relationship between these pathologies. The causality of this relationship has not yet been unambiguously established, but a number of probable biological mechanisms have been proposed to explain it through the effects of hyperglycemia, hyperinsulinemia on the process of oncogenesis. An important role in this is played by the axis of insulin-like growth factors, their receptors and binding proteins (IGF / IGFR / IGFBP). The review provides data on the structural elements of the insulin / IGF / IGFR / IGFBP signaling axis and their internal relationships in diabetes mellitus and in the development of malignant tumors. Significant changes in the axis that occur during the formation of the diabetic environment prepare the background, which, under certain conditions, can lead to the stimulation or inhibition of tumor development. The considered signaling system, playing a significant role in the physiology of normal cells, often functions as a decisive factor in the survival of tumor cells, providing fine context-dependent regulation of many cellular processes associated with oncogenesis. However, despite many years of in-depth studies of the pathogenesis of diabetes mellitus and malignant tumors, the molecular mechanisms of the relationship between these pathologies are still largely unclear, and the internal heterogeneity of pathologies complicates research and interpretation of the results, leaving many questions.

scholarly journals Inflammatory biomarkers and tumoral growth factors are modulated by exercise in breast cancer survivors

2020 ◽  
Author(s):  
Meneses-Echávez José Francisco ◽  
Ramírez-Vélez Robinson ◽  
González Jiménez Emilio ◽  
Río-Valle Jacqueline Schmidt ◽  
Izquierdo Mikel
Keyword(s):  
Breast Cancer ◽  
Growth Factors ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Meta Analysis ◽  
Cochrane Central Register ◽  
Random Effects Model ◽  
Cancer Cell Proliferation ◽  
Central Register ◽  
Insulin Like Growth Factors

Introduction: Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancer-related outcomes and survival, although its effects on IGF´s are not well understood. This meta-analysis aimed to determine the effects of exercise in modulating IGF´s system in breast cancer survivors. Methods: Databases of PuMed, EMBASE, Cochrane Central Register of Controlled Trials, EMBASE, ClinicalTrials.gov, SPORTdiscus, LILACS and Scopus were systematically searched up to November 2014. Effect estimates were calculated through a random-effects model of meta- analysis according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I 2 test. Risk of bias and methodological quality were evaluated using the PEDro score.

Insulin-like growth factors in vitreous. Studies in control and diabetic subjects with neovascularization

Diabetes ◽  
1986 ◽  
Vol 35 (4) ◽  
pp. 416-420 ◽  
Author(s):  
M. Grant ◽  
B. Russell ◽  
C. Fitzgerald ◽  
T. J. Merimee
Keyword(s):  
Growth Factors ◽  
Insulin Like Growth Factors

Von Willebrand factor (VIII R:Ag), fibronectin, and insulin-like growth factors I and II in diabetic retinopathy and nephropathy

Diabetes ◽  
1984 ◽  
Vol 33 (2) ◽  
pp. 125-129 ◽  
Author(s):  
R. P. Lamberton ◽  
A. D. Goodman ◽  
A. Kassoff ◽  
C. L. Rubin ◽  
D. H. Treble ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Growth Factors ◽  
Factor Viii ◽  
Von Willebrand Factor ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Insulin Like Growth Factors

scholarly journals To which extent are per-and poly-fluorinated substances associated to metabolic syndrome?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Maryam Zare Jeddi ◽  
Rozita Soltanmohammadi ◽  
Giulia Barbieri ◽  
Aline S. C. Fabricio ◽  
Gisella Pitter ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
General Population ◽  
Meta Analysis ◽  
Small Body ◽  
Epidemiological Studies ◽  
Cross Sectional ◽  
Random Effects Models ◽  
Epidemiologic Evidence ◽  
Adults And Children ◽  
Meta Analyses

Abstract Exposure to per- and polyfluoroalkyl substances (PFAS), ubiquitous persistent environmental contaminants, has led to substantial global concern due to their potential environmental and human health effects. Several epidemiological studies have assessed the possible association between PFAS exposure and risk of metabolic syndrome (MetS), however, the results are ambiguous. The aim of this study was to assess the current human epidemiologic evidence on the association between exposure to PFAS and MetS. We performed a systematic search strategy using three electronic databases (PubMed, Scopus, and Web of Science) for relevant studies concerning the associations of PFAS with MetS and its clinical relevance from inception until January 2021. We undertook meta-analyses where there were five or more studies with exposure and outcomes assessments that were reasonably comparable. The pooled odd ratios (ORs) were calculated using random effects models and heterogeneity among studies was assessed by I2 index and Q test. A total of 12 cross-sectional studies (10 studies on the general population and two studies in the occupational settings) investigated the association between PFAS exposure and MetS. We pooled data from seven studies on the general population for perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) and five studies for perfluorohexanesulfonate (PFHxS) and perfluorononanoic acid (PFNA). Predominately, most studies reported no statistically significant association between concentrations of PFAS and MetS. In the meta-analysis, the overall measure of effect was not statistically significant, showing no evidence of an association between concentrations of PFOA, PFOS, PFNA, and PFHxS and the risk of MetS. Based on the results of the meta-analysis, current small body of evidence does not support association between PFAS and MetS. However, due to limited number of studies and substantial heterogeneity, results should be interpreted with caution. Further scrutinizing cohort studies are needed to evaluate the association between various and less well-known PFAS substances and their mixture with MetS and its components in both adults and children in different settings.

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