Fabrication of multi-walled carbon nanotubes/oxide reinforced hollow fibers by sol-gel technique for rapid determination of metronidazole in milk

2014 ◽  
Vol 6 (5) ◽  
pp. 1404-1411 ◽  
Author(s):  
Jia Li ◽  
Yan-Bin Wang ◽  
Lan Wu ◽  
Ke-Yao Li ◽  
Wei Feng
Keyword(s):  
Carbon Nanotubes ◽  
Self Assembly ◽  
Rapid Determination ◽  
Sol Gel ◽  
Hollow Fibers ◽  
Milk Samples ◽  
Multi Walled Carbon Nanotubes ◽  
Gel Technique ◽  
Walled Carbon Nanotubes

Three types of multi-walled carbon nanotubes (MWCNTs)/oxide reinforced hollow fibers layer were fabricated by self-assembly techniques, then compared and applied to extract metronidazole in milk samples by SPME/GC-MS.

Multi-walled Carbon Nanotubes Reinforced into Hollow Fiber by Chitosan Sol-gel for Solid/Liquid Phase Microextraction of NSAIDs from Urine Prior to HPLC-DAD Analysis

2019 ◽  
Vol 20 (5) ◽  
pp. 390-400 ◽  
Author(s):  
Nabil N. AL-Hashimi ◽  
Amjad H. El-Sheikh ◽  
Rania F. Qawariq ◽  
Majed H. Shtaiwi ◽  
Rowan AlEjielat
Keyword(s):  
Carbon Nanotubes ◽  
Liquid Phase ◽  
Hollow Fiber ◽  
Sol Gel ◽  
Liquid Phase Microextraction ◽  
Extraction Device ◽  
Multi Walled Carbon Nanotubes ◽  
Solid Liquid ◽  
Walled Carbon Nanotubes

Background: The efficient analytical method for the analysis of nonsteroidal antiinflammatory drugs (NSAIDs) in a biological fluid is important for determining the toxicological aspects of such long-term used therapies. Methods: In the present work, multi-walled carbon nanotubes reinforced into a hollow fiber by chitosan sol-gel assisted-solid/ liquid phase microextraction (MWCNTs-HF-CA-SPME) method followed by the high-performance liquid chromatography-diode array detection (HPLC–DAD) was developed for the determination of three NSAIDs, ketoprofen, diclofenac, and ibuprofen in human urine samples. MWCNTs with various dimensions were characterized by various analytical techniques. The extraction device was prepared by immobilizing the MWCNTs in the pores of 2.5 cm microtube via chitosan sol-gel assisted technology while the lumen of the microtube was filled with few microliters of 1-octanol with two ends sealed. The extraction device was operated by direct immersion in the sample solution. Results: The main factors influencing the extraction efficiency of the selected NSAIDs have been examined. The method showed good linearity R2 ≥ 0.997 with RSDs from 1.1 to 12.3%. The limits of detection (LODs) were 2.633, 2.035 and 2.386 µg L-1, for ketoprofen, diclofenac, and ibuprofen, respectively. The developed method demonstrated a satisfactory result for the determination of selected drugs in patient urine samples and comparable results against reference methods. Conclusion: The method is simple, sensitive and can be considered as an alternative for clinical laboratory analysis of selected drugs.

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