scholarly journals Microfluidic assembly of multistage porous silicon–lipid vesicles for controlled drug release

Lab on a Chip ◽  
2014 ◽  
Vol 14 (6) ◽  
pp. 1083-1086 ◽  
Author(s):  
Bárbara Herranz-Blanco ◽  
Laura R. Arriaga ◽  
Ermei Mäkilä ◽  
Alexandra Correia ◽  
Neha Shrestha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Silicon ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Double Emulsion ◽  
Lipid Vesicles ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Lipid Vesicle ◽  
Microfluidic Assembly

Thermally hydrocarbonized porous silicon microparticles are encapsulated into the aqueous cores of double emulsion lipid vesicle drops to form advanced multistage drug delivery systems.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

Nanocarriers with multi-locked DNA valves targeting intracellular tumor-related mRNAs for controlled drug release

Nanoscale ◽  
2017 ◽  
Vol 9 (44) ◽  
pp. 17318-17324 ◽  
Author(s):  
Yanhua Li ◽  
Yuanyuan Chen ◽  
Wei Pan ◽  
Zhengze Yu ◽  
Limin Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Cells ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Normal Cells ◽  
Tremendous Challenge

The fabrication of well-behaved drug delivery systems that can transport drugs to specifically treat cancer cells rather than normal cells is still a tremendous challenge.

scholarly journals Near infrared laser-controlled drug release of thermoresponsive microgel encapsulated with Fe3O4 nanoparticles

RSC Advances ◽  
2017 ◽  
Vol 7 (32) ◽  
pp. 19604-19610 ◽  
Author(s):  
Xiaofang Qi ◽  
Lu Xiong ◽  
Jing Peng ◽  
Dongyan Tang
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Drug Release ◽  
Fe3o4 Nanoparticles ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
External Stimuli

One major issue in thermosensitive drug delivery systems is the remote, repeatable control of temperature in vivo through external stimuli such as light, ultrasound, and magnetic field.

scholarly journals Chitosan Nanoparticles-Insight into Properties, Functionalization and Applications in Drug Delivery and Theranostics

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 272
Author(s):  
Jhanvi Jhaveri ◽  
Zarna Raichura ◽  
Tabassum Khan ◽  
Munira Momin ◽  
Abdelwahab Omri
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Chitosan Nanoparticles ◽  
Controlled Drug Release ◽  
Drug Regimen ◽  
Delivery Systems ◽  
Important Place ◽  
Nano Drug Delivery ◽  
Insight Into

Nanotechnology-based development of drug delivery systems is an attractive area of research in formulation driven R&D laboratories that makes administration of new and complex drugs feasible. It plays a significant role in the design of novel dosage forms by attributing target specific drug delivery, controlled drug release, improved, patient friendly drug regimen and lower side effects. Polysaccharides, especially chitosan, occupy an important place and are widely used in nano drug delivery systems owing to their biocompatibility and biodegradability. This review focuses on chitosan nanoparticles and envisages to provide an insight into the chemistry, properties, drug release mechanisms, preparation techniques and the vast evolving landscape of diverse applications across disease categories leading to development of better therapeutics and superior clinical outcomes. It summarizes recent advancement in the development and utility of functionalized chitosan in anticancer therapeutics, cancer immunotherapy, theranostics and multistage delivery systems.

Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon

2020 ◽  
Vol 26 ◽  
Author(s):  
Phuong H.L. Tran ◽  
Thao T.D. Tran
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Basic Principle ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Sustained Drug Release ◽  
Mucosal Tissues

: Mucoadhesive formulations have been demonstrated to result in efficient drug delivery systems with advantages over existing systems such as increased local retention and sustained drug release via adhesiveness to mucosal tissues. The controlled release of colon-targeted, orally administered drugs has recently attracted a number of studies investigating mucoadhesive systems. Consequently, substantial designs, from mucoadhesive cores to shells of particles, have been studied with promising applications. This review will provide an overview of and discuss specific strategies for developing mucoadhesive systems for colon-targeted oral delivery with controlled drug release, including mucoadhesive matrices, cross-linked mucoadhesive microparticles, coatings and mucoadhesive nanoparticles. The understanding of the basic principle of these designs and advanced formulations throughout will lead to the development of products with efficient drug delivery at the colon for therapies for different diseases.

scholarly journals Recent Advances in Lipid-Based Drug Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 926
Author(s):  
Koyo Nishida
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Recent Advances

Here, I report recent advances in lipid-based drug delivery systems, with a focus on their production, controlled drug release, targeting, and co-delivery [...]

A mannose-conjugated multi-layered polymeric nanocarrier system for controlled and targeted release on alveolar macrophages

2018 ◽  
Vol 9 (5) ◽  
pp. 656-667 ◽  
Author(s):  
Rajendran Amarnath Praphakar ◽  
Harshavardhan Shakila ◽  
Vijayan N. Azger Dusthackeer ◽  
Murugan A. Munusamy ◽  
Suresh Kumar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Alveolar Macrophages ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Polymeric Carriers ◽  
Targeted Release ◽  
Polymeric Nanocarrier

To improve the performance of drug delivery systems in macrophages, targeted ligand-conjugated polymeric carriers have been realized to be vital for targeted, sustainable and controlled drug release with remarkable biocompatibility and bioavailability.

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