A detailed analysis of the mechanism of a carbocationic triple shift rearrangement

The role of Nodal signalling in nervous system asymmetry is still poorly understood. Here, we review and discuss how asymmetric Nodal signalling controls the ontogeny of nervous system asymmetry using a comparative developmental perspective. A detailed analysis of asymmetry in ascidians and fishes reveals a critical context-dependency of Nodal function and emphasizes that bilaterally paired and midline-unpaired structures/organs behave as different entities. We propose a conceptual framework to dissect the developmental function of Nodal as asymmetry inducer and laterality modulator in the nervous system, which can be used to study other types of body and visceral organ asymmetries. Using insights from developmental biology, we also present novel evolutionary hypotheses on how Nodal led the evolution of directional asymmetry in the brain, with a particular focus on the epithalamus. We intend this paper to provide a synthesis on how Nodal signalling controls left–right asymmetry of the nervous system. This article is part of the themed issue ‘Provocative questions in left–right asymmetry’.

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Myths of Europe

Journal of Educational Media Memory and Society ◽

10.3167/jemms.2009.010202 ◽

2009 ◽

Vol 1 (2) ◽

pp. 9-33 ◽

Cited By ~ 3

Author(s):

Chiara Bottici

Keyword(s):

Conceptual Framework ◽

Detailed Analysis ◽

Historical Narratives ◽

Political Symbolism ◽

The Relationship

What are the myths of Europe? This article provides the conceptual framework through which this question may be approached. It begins by defining myth in such a way as to distinguish it from other forms of political symbolism and points to the distinction between cultural and political myths. From here, the relationship between mythical and historical narratives is analyzed via a study of how the main narrative cores through which Europeans have perceived themselves have worked in different periods and contexts as both. It concludes with a more detailed analysis of some of the icons that convey the myths of Europe.

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FUNDAMENTALS OF IMPLEMENTATION OF REGIONAL CONTINUOUS EDUCATION IN THE CONDITIONS OF DIGITALIZATION OF THE ECONOMY

Вестник ГГНТУ. Гуманитарные и социально-экономические науки ◽

10.34708/gstou.2019.17.3.017 ◽

2019 ◽

Author(s):

Э.Д. Алисултанова ◽

Н.А. Моисеенко

Keyword(s):

Human Resources ◽

Continuing Education ◽

Conceptual Framework ◽

Detailed Analysis ◽

Russian Federation ◽

Educational Programs ◽

Educational Environment ◽

Lifelong Education ◽

Digital Competencies ◽

The Russian Federation

В данной статье рассматриваются концептуальные основы реализации непрерывного образованияпо обновлению профессиональных навыков и приобретению цифровых компетенций с учетом региональных потребностей. Определены основные педагогические аспекты и инструментарий формирования инфраструктуры и кадрового потенциала в субъектахРоссийской Федерации с целью создания условий реализации непрерывного образования в течение всей жизни на основе дополнительных профессиональных образовательных программ. В публикации приведен тщательный и детальный анализ рассматриваемой проблемы с учетом актуальности подготовки кадров в рамках федеральных проектов по Цифровой экономике . Основной акцент статьи сделан на описание методов реализации интеграции цифровой образовательной среды вузамежду уровнями образования среднего профессионального, высшего и цифрового образовательного пространства непрерывного образования, в том числе для работников отраслей IT, связи, телекоммуникации. This article discusses the conceptual framework for the implementation of continuing education to upgrade professional skills and the acquisition of digital competencies, taking into account regional needs. The main pedagogical aspects and tools for the formation of infrastructure and human resources in the constituent entities of the Russian Federation are identified with the aim of creating conditions for the implementation of lifelong education throughout life based on additional professional educational programs. The publication provides a thorough and detailed analysis of the problem under consideration, taking into account the relevance of training in the framework of federal projects on the Digital Economy. The main focus of the article is on the description of methods for integrating the digital educational environment of a university between levels of education secondary vocational, higher and digital educational space of continuing education, including for workers in the IT, communications, and telecommunications sectors.

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A Tool Perspective on Design of Interactive Computer Support for Skilled Workers

DAIMI Report Series ◽

10.7146/dpb.v14i190.6547 ◽

1986 ◽

Vol 14 (190) ◽

Cited By ~ 7

Author(s):

Pelle Ehn ◽

Morten Kyng

Keyword(s):

Conceptual Framework ◽

Detailed Analysis ◽

Information Flow ◽

Professional Education ◽

Computer Support ◽

Skilled Workers ◽

Systems Perspective ◽

Labour Process ◽

Production Development

This paper presents a conceptual framework, useful when designing computer support for skilled workers. We call this framework a tool perspective. It has emerged as a result of a growing dissatisfaction with the systems perspective, which tends to give an outwardly understanding, making men, machines and materials look alike and reducing work to algorithmic procedures, some of them candidates for inclusion into the edp programs.The tool perspective takes the labour process as its origin rather than data or information flow, emphasising the development of tools to be used with skill by workers in control of the production. Development of professional education is in focus, rather than detailed analysis and description of the work.

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Prosodic Impairment Associated With Traumatic Brain Injury

Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders ◽

10.1044/nnsld19.3.97 ◽

2009 ◽

Vol 19 (3) ◽

pp. 97-102

Author(s):

Billy Irwin

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Detailed Analysis ◽

Acoustic Characteristics ◽

Individual Variations

Abstract Purpose: This article discusses impaired prosody production subsequent to traumatic brain injury (TBI). Prosody may affect naturalness and intelligibility of speech significantly, often for the long term, and TBI may result in a variety of impairments. Method: Intonation, rate, and stress production are discussed in terms of the perceptual, physiological, and acoustic characteristics associated with TBI. Results and Conclusions: All aspects of prosodic production are susceptible to the effects of damage resulting from TBI. There are commonly associated prosodic impairments; however, individual variations in specific aspects of prosody require detailed analysis.

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A conceptual framework for advanced practice: an action research project operationalizing anadvanced practitioner/consultant nurse role

Journal of Clinical Nursing ◽

10.1046/j.1365-2702.1997.00143.x ◽

1997 ◽

Vol 6 (3) ◽

pp. 179-190 ◽

Cited By ~ 20

Author(s):

Kim Manley

Keyword(s):

Action Research ◽

Conceptual Framework ◽

Advanced Practice ◽

Action Research Project ◽

Research Project ◽

Nurse Role

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Evaluating research in developmental disabilities: a conceptual framework for reviewing treatment outcomes

Developmental Medicine & Child Neurology ◽

10.1017/s0012162299000110 ◽

1999 ◽

Vol 41 (1) ◽

pp. 55-59 ◽

Cited By ~ 51

Author(s):

Charlene Butler ◽

Henry Chambers ◽

Murray Goldstein ◽

Susan Harris ◽

Judy Leach ◽

...

Keyword(s):

Developmental Disabilities ◽

Conceptual Framework ◽

Treatment Outcomes

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Understanding Why Older People Develop a Wish to Die

Crisis ◽

10.1027/0227-5910/a000078 ◽

2011 ◽

Vol 32 (4) ◽

pp. 204-216 ◽

Cited By ~ 52

Author(s):

M. L. Rurup ◽

H. R. W. Pasman ◽

J. Goedhart ◽

D. J. H. Deeg ◽

A. J. F. M. Kerkhof ◽

...

Keyword(s):

Older People ◽

Cohort Studies ◽

Conceptual Framework ◽

Life Events ◽

Traumatic Life Events ◽

Quantitative Studies ◽

Wish To Die ◽

Open Coding ◽

Death Wishes ◽

Depth Interviews

Background: Quantitative studies in several European countries showed that 10–20% of older people have or have had a wish to die. Aims: To improve our understanding of why some older people develop a wish to die. Methods: In-depth interviews with people with a wish to die (n = 31) were carried out. Through open coding and inductive analysis, we developed a conceptual framework to describe the development of death wishes. Respondents were selected from two cohort studies. Results: The wish to die had either been triggered suddenly after traumatic life events or had developed gradually after a life full of adversity, as a consequence of aging or illness, or after recurring depression. The respondents were in a situation they considered unacceptable, yet they felt they had no control to change their situation and thus progressively “gave up” trying. Recurring themes included being widowed, feeling lonely, being a victim, being dependent, and wanting to be useful. Developing thoughts about death as a positive thing or a release from problems seemed to them like a way to reclaim control. Conclusions: People who wish to die originally develop thoughts about death as a positive solution to life events or to an adverse situation, and eventually reach a balance of the wish to live and to die.

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