scholarly journals Mesoporous silica–chondroitin sulphate hybrid nanoparticles for targeted and bio-responsive drug delivery

2015 ◽  
Vol 39 (3) ◽  
pp. 1754-1760 ◽  
Author(s):  
Krishna Radhakrishnan ◽  
Jasaswini Tripathy ◽  
Akshay Datey ◽  
Dipshikha Chakravortty ◽  
Ashok M. Raichur
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Chondroitin Sulphate ◽  
Mesoporous Silica Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Intracellular Degradation

A polysaccharide based gatekeeper is attached to seal the nanopores of drug mesoporous silica nanoparticles, which facilitates uptake by cancer cells and undergoes intracellular degradation to initiate drug release.

Monitoring of “on-demand” drug release using dual tumor marker mediated DNA-capped versatile mesoporous silica nanoparticles

2017 ◽  
Vol 53 (62) ◽  
pp. 8755-8758 ◽  
Author(s):  
Song Wang ◽  
Fei Liu ◽  
Xiang-Ling Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Tumor Marker ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
On Demand ◽  
Controllable Release ◽  
Internal Stimulus

We constructed a versatile drug delivery system using dual internal stimulus, achieving controllable release and monitoring simultaneously.

scholarly journals An aptamer-targeting photoresponsive drug delivery system using “off–on” graphene oxide wrapped mesoporous silica nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (14) ◽  
pp. 6304-6310 ◽  
Author(s):  
Yuxia Tang ◽  
Hao Hu ◽  
Molly Gu Zhang ◽  
Jibin Song ◽  
Liming Nie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Targeted Cancer Therapy

A photoresponsive drug delivery system was developed for light-mediated drug release and aptamer-targeted cancer therapy.

Smart mesoporous silica nanoparticles gated by pillararene-modified gold nanoparticles for on-demand cargo release

2016 ◽  
Vol 52 (95) ◽  
pp. 13775-13778 ◽  
Author(s):  
Xin Wang ◽  
Li-Li Tan ◽  
Xi Li ◽  
Nan Song ◽  
Zheng Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
On Demand

A new drug delivery system, based on mesoporous silica nanoparticles gated by carboxylatopillar[5]arene-modified gold nanoparticles, has been fabricated for controlled drug release.

Glutathione-Mediated Degradation of Surface-Capped MnO2for Drug Release from Mesoporous Silica Nanoparticles to Cancer Cells

2014 ◽  
Vol 32 (2) ◽  
pp. 205-212 ◽  
Author(s):  
Xue Yang ◽  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Zhen Zou ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Mesoporous Silica Nanoparticles

scholarly journals Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 916 ◽  
Author(s):  
Miguel Gisbert-Garzarán ◽  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Textural Properties ◽  
Stimuli Responsive ◽  
Biological Barriers ◽  
And Performance ◽  
Localized Drug Delivery

Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal sequestration of the particles upon internalization. In addition, their open porous structure may lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy of the treatment. First, this review will provide a comprehensive and systematic overview of the different approximations that have been implemented into mesoporous silica nanoparticles to overcome each of such biological barriers. Afterward, the potential premature and non-specific drug release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli-responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.

Thermo-Sensitive Nanogated System Based on Polymer-Modified Mesoporous Silica Hybrid Nanoparticles

2013 ◽  
Vol 538 ◽  
pp. 93-96
Author(s):  
Xin De Tang ◽  
Fa Qi Yu ◽  
Ye Chen ◽  
Mei Shan Pei
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Coupling Reaction ◽  
Solid Support ◽  
Hybrid Nanoparticles ◽  
Chemical Coupling ◽  
External Stimuli

Mesoporous silica nanoparticles (MSNs) have been employed as a versatile solid support for constructing a variety of hybrid materials for controlled drug delivery. Controlled release systems that integrate external stimuli with nanocarriers have attracted much attention for sensors and drug delivery applications. Mesoporous silica nanoparticles grafted with thermo-sensitive polymers on the surface were fabricated via “grafting to” approach through chemical coupling reaction. The encapsulation and release of drug based on the thermo-sensitive nanogated system were investigated. The thermo-sensitive nanogated system can be expected as one of the promising candidates for drug delivery and controlled release.

scholarly journals Application of mesoporous silica nanoparticles for drug delivery to cancer cells

2020 ◽  
pp. 5-15
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Efflux Pump ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Multi Drug Resistance

Cancer is one of the main causes of death worldwide. Chemotherapy is the most common method for cancer therapy which represent non-specific side effects on normal cells and tissues and drug resistance in cancer cells. There are two main mechanisms for Multi Drug Resistance (MDR) in cancer cells including: drug efflux pump and activation of anti-apoptotic pathways. Cancer chemotherapy disadvantages can be overcome by using nanoparticulate drug delivery systems like Mesoporous Silica Nanoparticles (MSNs) that have been used as drug delivery system since 2001. The present review included synthesis, targeted (active or passive) drug delivery to cancer cells, co-delivery of anticancer drugs and siRNA by MSNs and its toxicity. This review revealed that MSNs are good candidate for drug delivery to cancer cells due to its unique properties including: controllable pore and particle sizes, thermal and chemical stability, modifications of outer and inner surfaces of nanoparticles for drug and siRNA loading, attachment of ligand for targeted drug delivery, high drug loading capacity and controlled drug release, biocompatibility and biodegradation in aqueous medium.

Targeted Drug Delivery in Cancer Cells with Red-Light Photoactivated Mesoporous Silica Nanoparticles

Nano Letters ◽  
2013 ◽  
Vol 13 (6) ◽  
pp. 2576-2583 ◽  
Author(s):  
Stephan A. Mackowiak ◽  
Alexandra Schmidt ◽  
Veronika Weiss ◽  
Christian Argyo ◽  
Constantin von Schirnding ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Red Light ◽  
Targeted Drug
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