Quatsomes for the treatment of Staphylococcus aureus biofilm

2015 ◽  
Vol 3 (14) ◽  
pp. 2770-2777 ◽  
Author(s):  
Nicky Thomas ◽  
Dong Dong ◽  
Katharina Richter ◽  
Mahnaz Ramezanpour ◽  
Sarah Vreugde ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Staphylococcus Aureus ◽  
Quaternary Ammonium ◽  
Drug Delivery Systems ◽  
Cetylpyridinium Chloride ◽  
Delivery Systems ◽  
Quaternary Ammonium Compound ◽  
Ammonium Compound

The anti-biofilm effect of drug delivery systems composed of the antiseptic quaternary ammonium compound cetylpyridinium chloride (CPC) and cholesterol was evaluated inStaphylococcus aureusbiofilm.

scholarly journals Quaternary Ammonium Chitosans: The Importance of the Positive Fixed Charge of the Drug Delivery Systems

2020 ◽  
Vol 21 (18) ◽  
pp. 6617 ◽  
Author(s):  
Angela Fabiano ◽  
Denise Beconcini ◽  
Chiara Migone ◽  
Anna Maria Piras ◽  
Ylenia Zambito
Keyword(s):  
Drug Delivery ◽  
Quaternary Ammonium ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Fixed Charge ◽  
Innovative Drug ◽  
Natural Polysaccharide ◽  
The Impact

As a natural polysaccharide, chitosan has good biocompatibility, biodegradability and biosecurity. The hydroxyl and amino groups present in its structure make it an extremely versatile and chemically modifiable material. In recent years, various synthetic strategies have been used to modify chitosan, mainly to solve the problem of its insolubility in neutral physiological fluids. Thus, derivatives with negative or positive fixed charge were synthesized and used to prepare innovative drug delivery systems. Positively charged conjugates showed improved properties compared to unmodified chitosan. In this review the main quaternary ammonium derivatives of chitosan will be considered, their preparation and their applications will be described to evaluate the impact of the positive fixed charge on the improvement of the properties of the drug delivery systems based on these polymers. Furthermore, the performances of the proposed systems resulting from in vitro and ex vivo experiments will be taken into consideration, with particular attention to cytotoxicity of systems, and their ability to promote drug absorption.

scholarly journals The minimum inhibitory concentration and exposure time of the combination of quaternary ammonium compound with ethylendiamintetraacetic acid (EDTA) against methicillin-resistant Staphylococcus Aureus

2009 ◽  
Vol 21 (1) ◽  
Author(s):  
Swasty Dwirayunita
Keyword(s):  
Staphylococcus Aureus ◽  
Minimum Inhibitory Concentration ◽  
Exposure Time ◽  
Quaternary Ammonium ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Inhibitory Concentration ◽  
Quaternary Ammonium Compound ◽  
Dilution Method ◽  
Ammonium Compound ◽  
Methicillin Resistant

The aim of this study was to determine The Minimum Inhibitory Concentration (MIC) and the exposure time of the combination of quaternary ammonium compound with ethylenediaminetetraacetic acid (EDTA) towards Methicillin-resistant Staphylococcus aureus so that the combination can be applied as a disinfectant against MRSA.The tested bacteria MRSA was isolated from the RSGM of the Faculty of Dentistry Padjadjaran University. This laboratory experimental study was conducted based on a serial dilution method. The combination of quaternary ammonium compound with EDTA was diluted in 1/1000, 1/2000, 1/4000, 1/8000, 1/16000, 1/32000, 1/64000, and 1/128000 concentration.The result showed that the combination of quaternary ammonium compound with EDTA inhibited the MRSA on 1/1000, 1/2000 and 1/4000 concentrations. The effective exposure time to reduce the number of MRSA colonies are 2.5 and 3 minutes with 1/1000 concentration from the combination. In conclusion that the MIC of the combination of quaternary ammonium compound with EDTA is in 1/4000 concentration and the effective exposure time is more than 3 minutes.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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