Do we need Green Analytical Chemistry?

There is very strong opinion that Green Analytical Chemistry is needed beside so-called common Analytical Chemistry. However, the developments in Analytical Chemistry must lead to environmentally safe, economical and cost-effective methods on the whole.

Eco-Friendly Separation of Antihyperlipidemic Combination Using UHPLC Particle-Packed and Monolithic Columns by Applying Green Analytical Chemistry Principles

Separations ◽

10.3390/separations8120246 ◽

2021 ◽

Vol 8 (12) ◽

pp. 246

Author(s):

Naser F. Al-Tannak ◽

Ahmed Hemdan

Keyword(s):

Analytical Chemistry ◽

Flow Rate ◽

Monolithic Column ◽

Internal Standard ◽

Back Pressure ◽

Pharmacokinetic Studies ◽

Fenofibric Acid ◽

Key Factor ◽

Efficient separation of pharmaceuticals and metabolites with the adequate resolution is a key factor in choosing the most suitable chromatographic method. For quality control, the analysis time is a key factor, especially in pharmacokinetic studies. High back pressure is considered as one of the most important factors in chromatography’s flow control, especially in UHPLC. The separation of the anti-hyperlipidemic mixtures was carried out using two columns: a column silica-based particle packed UHPLC and a monolithic column. The systematic suitability of the two columns was compared for the separation of Fenofibrate, its active metabolite, Fenofibric acid and Pravastatin using Atorvastatin as an internal standard. Separation on both columns was obtained using ethanol: buffer potassium dihydrogen orthophosphate pH = 3 (adjusted with orthophosphoric acid) (75:25 v/v) as mobile phase and flow rate 0.8 mL/min. The analytes’ peak detection was achieved by using a PDA detector at 287 nm, 214 nm, 236 nm, and 250 nm for Fenofibrate, Fenofibric acid, Pravastatin, and Atorvastatin, respectively. Reduction of back-pressure was achieved with the monolithic column, where the analytes could be completely separated in less than 1.5 min at a flow rate of 5 mL/min. The principles of Green Analytical Chemistry (GAC) were followed throughout the developed method using environmentally safe solvents.

Combining Normal/Reversed-Phase HPTLC with Univariate Calibration for the Piperine Quantification with Traditional and Ultrasound-Assisted Extracts of Various Food Spices of Piper nigrum L. under Green Analytical Chemistry Viewpoint

Molecules ◽

10.3390/molecules26030732 ◽

2021 ◽

Vol 26 (3) ◽

pp. 732

Author(s):

Mohammed H. Alqarni ◽

Prawez Alam ◽

Ahmed I. Foudah ◽

Magdy M. Muharram ◽

Faiyaz Shakeel

Keyword(s):

Analytical Chemistry ◽

High Performance ◽

Black Pepper ◽

Reversed Phase ◽

Normal Phase ◽

Piper Nigrum ◽

Pharmaceutical Samples ◽

Analytical Technique ◽

Ultrasound Assisted

Due to unavailability of sustainable analytical techniques for the quantitation of piperine (PPN) in food and pharmaceutical samples, there was a need to develop a rapid and sensitive sustainable analytical technique for the quantitation of PPN. Therefore, the current research presents a fast and highly sensitive normal/reversed-phase high-performance thin-layer chromatography (HPTLC) technique with classical univariate calibration for the quantitation of PPN in various food spices of black pepper with traditional (TE) and ultrasound-assisted extracts (UBE) of various food spices of Piper nigrum L. under green analytical chemistry viewpoint. The amount of PPN in TE of four different spices of black pepper—namely BPMH, BPLU, BPSH, and BPPA—was found to be 309.53, 304.97, 282.82, and 232.73 mg g−1, respectively using a sustainable normal-phase HPTLC technique. However, the amount of PPN in UBE of BPMH, BPLU, BPSH, and BPPA was recorded as 318.52, 314.60, 292.41, and 241.82 mg g−1, respectively using a sustainable normal phase HPTLC technique. The greenness of normal/reversed-phase HPTLC technique was predicted using AGREE metric approach. The eco-scale was found to be 0.90, suggested excellent greenness of normal/reversed-phase technique. UBE of PPN was also found to be superior over TE of PPN. Overall, the results of this research suggested that the proposed normal/reversed-phase densitometry technique could be effectively used for the quantitation of PPN in food and pharmaceutical samples.

Solvent-free microwave extraction of bioactive compounds provides a tool for green analytical chemistry

TrAC Trends in Analytical Chemistry ◽

10.1016/j.trac.2013.02.007 ◽

2013 ◽

Vol 47 ◽

pp. 1-11 ◽

Cited By ~ 115

Author(s):

Ying Li ◽

Anne Sylvie Fabiano-Tixier ◽

Maryline Abert Vian ◽

Farid Chemat

Keyword(s):

Analytical Chemistry ◽

Bioactive Compounds ◽

Solvent Free ◽

Microwave Extraction ◽

Green Analytical Chemistry

Sustainable extraction bioactive compounds procedures in medicinal Plants based on the principles of Green Analytical Chemistry: A review

Microchemical Journal ◽

10.1016/j.microc.2022.107184 ◽

2022 ◽

pp. 107184

Author(s):

Rodrigo F. da Silva ◽

Candice N. Carneiro ◽

Cheila B. do C. de Sousa ◽

Federico J. V. Gomez ◽

Magdalena Espino ◽

...

Keyword(s):

Analytical Chemistry ◽

Medicinal Plants ◽

Bioactive Compounds ◽

Sustainable Extraction

Green analytical chemistry metrics: A review

Talanta ◽

10.1016/j.talanta.2021.123046 ◽

2021 ◽

pp. 123046

Author(s):

Muhammad Sajid ◽

Justyna Płotka-Wasylka

Keyword(s):

Analytical Chemistry ◽

Green Analytical Chemistry

NEW, GREEN AND MINIATURIZED ANALYTICAL METHOD FOR DETERMINATION OF CEFADROXIL MONOHYDRATE IN CAPSULES

Drug Analytical Research ◽

10.22456/2527-2616.91086 ◽

2019 ◽

Vol 3 (1) ◽

pp. 23-28 ◽

Cited By ~ 1

Author(s):

Bianca Marco ◽

Ana Kogawa ◽

Hérida Salgado

Keyword(s):

Analytical Chemistry ◽

Standard Sample ◽

Low Cost ◽

Visible Region ◽

Hplc Method ◽

Minimal Amount ◽

Color Reagent ◽

Routine Quality Control

Cefadroxil, an oral antimicrobial, presents few techniques optimized for the reduction of solvents and toxic residues and/or non-use of them. So, a quantitative, new and miniaturized method for determination of cefadroxil monohydrate in capsules has been developed and validated by spectrophotometric method in the visible region according to the international guidelines. The analyzes were performed using microplates containing 96 wells, 1 % of phenolphthalein and sodium hydroxide 0.1 M as reagent at 552 nm. The method was (i) linear in the range of 15-115 µg mL-1, (ii) selective when comparing standard, sample, adjuvants and color reagent, (iii) precise with deviations below 4 %, (iv) accurate when comparing the proposed method with the HPLC method, (v) robusts by making small and deliberate modifications to the method, (vi) besides being fast, low cost, eco-friendly and generates minimal amount of waste. The method can be applied to the routine quality control of cefadroxil monohydrate in capsules and an effective and accessible alternative that contemplates the concepts of current and sustainable green analytical chemistry.

EXPERIENCE IN CONSTRUCTION OF HORIZONTAL WELLS AT THE KOSHILSKOYE OIL FIELD

Oil and Gas Studies ◽

10.31660/0445-0108-2018-4-34-37 ◽

2018 ◽

pp. 34-37

Author(s):

N. A. Aksenova ◽

E. Yu. Lipatov ◽

T. A. Haritonova

Keyword(s):

Horizontal Wells ◽

Cost Effective ◽

Oil Field ◽

Drilling Mud ◽

The article presents the experience of drilling horizontal wells at the Koshilskoye oil field in Jurassic sediments (UV1 formation) with application of environmentally safe emulsion drilling mud system BARADRIL-N XP-07 which has proved cost-effective.

Silver Nanoparticles: Properties, Synthesis, Characterization, Applications and Future Trends

10.5772/intechopen.99173 ◽

2021 ◽

Author(s):

Sunil T. Galatage ◽

Aditya S. Hebalkar ◽

Shradhey V. Dhobale ◽

Omkar R. Mali ◽

Pranav S. Kumbhar ◽

...

Keyword(s):

Silver Nanoparticles ◽

Metallic Nanoparticles ◽

Large Scale ◽

Cost Effective ◽

Nano Particles ◽

Scale Production ◽

Green Technologies ◽

Synthesis Of Nanoparticles ◽

Vital Importance ◽

Nanotechnology is an expanding area of research where we use to deal with the materials in Nano-dimension. The conventional procedures for synthesizing metal nanoparticles need to sophisticated and costly instruments or high-priced chemicals. Moreover, the techniques may not be environmentally safe. Therefore “green” technologies for synthesis of nanoparticles are always preferred which is simple, convenient, eco-friendly and cost effective. Green synthesis of nanoparticle is a novel way to synthesis nanoparticles by using biological sources. It is gaining attention due to its cost effective, ecofriendly and large scale production possibilities. Silver nanoparticles (AgNPs) are one of the most vital and fascinating nanomaterials among several metallic nanoparticles that are involved in biomedical applications. It has vital importance in nanoscience and naomedicines to treat and prevent vital disease in human beings especially in cancer treatment. In current work we discussed different methods for synthesis of AgNPs like biological, chemical and physical along with its characterization. We have also discussed vital importance of AgNPs to cure life threatnign diseases like cancer along with antidiabetic, antifungal, antiviral and antimicrobial alog with its molecular mode of action etc. Finally we conclude by discussing future prospects and possible applications of silver nano particles.