Multi-layered, membrane-integrated microfluidics based on replica molding of a thiol–ene epoxy thermoset for organ-on-a-chip applications

Lab on a Chip ◽  
2015 ◽  
Vol 15 (24) ◽  
pp. 4542-4554 ◽  
Author(s):  
Drago Sticker ◽  
Mario Rothbauer ◽  
Sarah Lechner ◽  
Marie-Therese Hehenberger ◽  
Peter Ertl
Keyword(s):  
Replica Molding ◽  
Microinjection Molding ◽  
Integrated Microfluidics ◽  
Organ On A Chip ◽  
Membrane Cell

Versatile microfabrication of biocompatible OSTEMER using replica and microinjection molding enables fabrication of complex multi-layered micropump and 3D multi-membrane cell chips.

Enrichment of vitronectin- and fibronectin-like proteins in NaCI-adapted plant cells and evidence for their involvement in plasma membrane-cell wall adhesion

1993 ◽  
Vol 3 (5) ◽  
pp. 637-646 ◽  
Author(s):  
Jian-Kang Zhu ◽  
Jun Shi ◽  
Utpal Singh ◽  
Sarah E. Wyatt ◽  
Ray A. Bressan ◽  
...  
Keyword(s):  
Cell Wall ◽  
Plasma Membrane ◽  
Plant Cells ◽  
Membrane Cell

Purification of catechins from Camellia sinensis using membrane cell

2019 ◽  
Vol 117 ◽  
pp. 203-212 ◽  
Author(s):  
Vijaykumar L. Dhadge ◽  
Murchana Changmai ◽  
Mihir Kumar Purkait
Keyword(s):  
Camellia Sinensis ◽  
Membrane Cell

A Versatile Wax Assisted Double Replica Molding and its Application in Flexible Electronic Skin

2021 ◽  
pp. 130132
Author(s):  
Huihui Chai ◽  
Feng Chen ◽  
Zhaoxi Song ◽  
Lulu Xiong ◽  
Gang Xiao ◽  
...  
Keyword(s):  
Replica Molding ◽  
Electronic Skin ◽  
Flexible Electronic

scholarly journals Microfluidic integration of regeneratable electrochemical affinity-based biosensors for continual monitoring of organ-on-a-chip devices

2021 ◽  
Author(s):  
Julio Aleman ◽  
Tugba Kilic ◽  
Luis S. Mille ◽  
Su Ryon Shin ◽  
Yu Shrike Zhang
Keyword(s):  
Organ On A Chip

Moldability improvement in microinjection molding via film lamination

2021 ◽  
pp. 096739112098650
Author(s):  
Dah Hee Kim ◽  
Young Seok Song
Keyword(s):  
Heat Transfer ◽  
Light Guide ◽  
Wall Slip ◽  
Skin Layer ◽  
Pattern Transfer ◽  
Plastic Plate ◽  
Resin Infusion ◽  
Microinjection Molding ◽  
Insulation Effect ◽  
Thin Plastic

The purpose of this study is to integrate a polymeric film onto a mold to impede thermal heat transfer during resin infusion. A thin plastic plate was fabricated by using microinjection molding. A polyimide (PI) film was laminated onto a mold in an effort to produce a thin light guide plate (LGP). The film could decelerate the solidification of molten polymer in the cavity of mold and enhance the wall slip of resin on the mold. The insulation effect was modeled numerically. The surface roughness and pattern transfer characteristics of the LGP were evaluated. It was found that the fluidity of the resin increased due to the decreased skin layer during mold filling. The results showed that the strategy proposed in this study could help decrease the thickness of LGP effectively when manufacturing the part via injection molding.

A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature

2021 ◽  
Author(s):  
Benjamin Fook Lun Lai ◽  
Rick Xing Ze Lu ◽  
Locke Davenport Huyer ◽  
Sachiro Kakinoki ◽  
Joshua Yazbeck ◽  
...  
Keyword(s):  
Organ On A Chip

scholarly journals Factors Influencing the Formation of Sodium Hydroxide by an Ion Exchange Membrane Cell

Batteries ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 34
Author(s):  
Jimmy Aurelio Rosales-Huamani ◽  
Juan Taumaturgo Medina-Collana ◽  
Zoila Margarita Diaz-Cordova ◽  
Jorge Alberto Montaño-Pisfil
Keyword(s):  
Ion Exchange ◽  
Sodium Hydroxide ◽  
Linear Trend ◽  
Electrolytic Cell ◽  
Electrolysis Time ◽  
Operational Parameters ◽  
Graphite Electrodes ◽  
Exchange Membrane ◽  
Membrane Cell ◽  
Production Cell

The present study aimed to evaluate the factors that influence the formation of sodium hydroxide (NaOH) by means of an electrolytic cell with ion exchange membranes. To achieve this experiment, the NaOH production cell had to be designed and built inexpensively, using graphite electrodes. The operational parameters in our study were: initial NaOH concentration, applied voltage, and temperature. All experiments were carried out using model NaCl solutions with a concentration of 40 g/L for 150 min. The results of the experiment were that the NaOH concentration, conductivity, and pH presented an increasing linear trend with the electrolysis time. Finally, it was possible to obtain the efficiency level of the electric current in our investigation, which was an average of 80.2%, that indicated good performance of the built cell.

scholarly journals Mechanical Strain-Enabled Reconstitution of Dynamic Environment in Organ-on-a-Chip Platforms: A Review

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 765
Author(s):  
Qianbin Zhao ◽  
Tim Cole ◽  
Yuxin Zhang ◽  
Shi-Yang Tang
Keyword(s):  
Cell Culture ◽  
Shear Stress ◽  
Cultured Cells ◽  
Mechanical Strain ◽  
3D Cell Culture ◽  
Small Scale ◽  
Mechanical Stimuli ◽  
Human Organ ◽  
Organ On A Chip

Organ-on-a-chip (OOC) uses the microfluidic 3D cell culture principle to reproduce organ- or tissue-level functionality at a small scale instead of replicating the entire human organ. This provides an alternative to animal models for drug development and environmental toxicology screening. In addition to the biomimetic 3D microarchitecture and cell–cell interactions, it has been demonstrated that mechanical stimuli such as shear stress and mechanical strain significantly influence cell behavior and their response to pharmaceuticals. Microfluidics is capable of precisely manipulating the fluid of a microenvironment within a 3D cell culture platform. As a result, many OOC prototypes leverage microfluidic technology to reproduce the mechanically dynamic microenvironment on-chip and achieve enhanced in vitro functional organ models. Unlike shear stress that can be readily generated and precisely controlled using commercial pumping systems, dynamic systems for generating proper levels of mechanical strains are more complicated, and often require miniaturization and specialized designs. As such, this review proposes to summarize innovative microfluidic OOC platforms utilizing mechanical actuators that induce deflection of cultured cells/tissues for replicating the dynamic microenvironment of human organs.

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