Discovery of a potent and highly fluorescent sirtuin inhibitor

MedChemComm ◽  
2015 ◽  
Vol 6 (10) ◽  
pp. 1857-1863 ◽  
Author(s):  
Y. K. Yoon ◽  
M. A. Ali ◽  
A. C. Wei ◽  
T. S. Choon ◽  
A. N. Shirazi ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Multiple Cancer ◽  
Growth Inhibitory

Highly fluorescent sirtuin inhibitor was discovered to possess growth inhibitory effect against multiple cancer cell lines.

Growth inhibitory effect of paradicsompaprika in cancer cell lines

2002 ◽  
Author(s):  
T. Mori ◽  
M. Ohnishi ◽  
M. Komiyama ◽  
A. Tsutsui ◽  
H. Yabushita ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Growth Inhibitory

Differential growth inhibitory effect of melatonin on two endometrial cancer cell lines

2000 ◽  
Vol 28 (4) ◽  
pp. 227-233 ◽  
Author(s):  
Yosuke Kanishi ◽  
Yoichi Kobayashi ◽  
Seiko Noda ◽  
Bunpei Ishizuka ◽  
Kaoru Saito
Keyword(s):  
Endometrial Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Differential Growth ◽  
Endometrial Cancer Cell ◽  
Growth Inhibitory

scholarly journals Design, Synthesis and Anticancer Profile of New 4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-amine-Linked Sulfonamide Derivatives with V600EBRAF Inhibitory Effect

2021 ◽  
Vol 22 (19) ◽  
pp. 10491
Author(s):  
Mohammed S. Abdel-Maksoud ◽  
Ahmed A. B. Mohamed ◽  
Rasha M. Hassan ◽  
Mohamed A. Abdelgawad ◽  
Garri Chilingaryan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cell Cycle Progression ◽  
Pyrimidine Ring ◽  
Cancer Cell Lines ◽  
Inhibitory Effect ◽  
Docking Studies ◽  
Binding Modes ◽  
Multiple Cancer

A new series of 4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-amine linked sulfonamide derivatives 12a–n was designed and synthesized according to the structure of well-established V600EBRAF inhibitors. The terminal sulfonamide moiety was linked to the pyrimidine ring via either ethylamine or propylamine bridge. The designed series was tested at fixed concentration (1 µM) against V600EBRAF, finding that 12e, 12i and 12l exhibited the strongest inhibitory activity among all target compounds and 12l had the lowest IC50 of 0.49 µM. They were further screened on NCI 60 cancer cell lines to reveal that 12e showed the most significant growth inhibition against multiple cancer cell lines. Therefore, cell cycle analysis of 12e was conducted to investigate the effect on cell cycle progression. Finally, virtual docking studies was performed to gain insights for the plausible binding modes of vemurafenib, 12i, 12e and 12l.

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