Tri- and tetranuclear RuII–GdIII2 and RuII–GdIII3 d–f heterometallic complexes as potential bimodal imaging probes for MRI and optical imaging

2016 ◽  
Vol 40 (5) ◽  
pp. 4606-4616 ◽  
Author(s):  
A. Nithyakumar ◽  
V. Alexander
Keyword(s):  
Hela Cell ◽  
Contrast Agents ◽  
Anticancer Activity ◽  
Fluorescence Imaging ◽  
Cell Lines ◽  
Heterometallic Complexes ◽  
Bimodal Imaging ◽  
Hela Cell Lines ◽  
Imaging Probes

Tri- and tetranuclear RuII–GdII2 and RuII–GdIII3 d–f heterometallic complexes, which function as contrast agents for MRI and as optical probes for fluorescence imaging, are reported. In vitro studies using the HeLa cell lines show that these complexes exhibit anticancer activity.

scholarly journals In-vitro Cytotoxicity and In-silico Insights of the Multi-target Anticancer Candidates from Haplophyllum tuberculatum

2021 ◽  
Vol 4 (3) ◽  
pp. 192-201
Author(s):  
Mosab Yahya Al-Nour ◽  
Ahmed H Arbab ◽  
Mohammad Khalid Parvez ◽  
Arwa Y Mohamed ◽  
Mohammed S Al-Dosari
Keyword(s):  
Hela Cell ◽  
Anticancer Activity ◽  
Cell Lines ◽  
In Vitro Cytotoxicity ◽  
Binding Modes ◽  
Web Servers ◽  
Hela Cell Lines ◽  
Ic50 Values ◽  
Haplophyllum Tuberculatum

This study aimed to investigate the anticancer activity of Haplophyllum tuberculatum(Forsk.) aerial parts ethanol extract and fractions and reveal the potential anticancer targets, binding modes, pharmacokinetics, and toxicity properties of its phytoconstituents. MTT assay was used to investigate the anticancer activity. TargetNet, ChemProt version 2.0, and CLC-Pred web servers were used for virtual screening, and Cresset Flare software was used for molecular docking with the 26 predicted targets. Moreover, pkCSM, swiss ADME, and eMolTox web servers were used to predict pharmacokinetics and safety. Ethanolic extracts of H. tuberculatum on HepG2 and HeLa cell lines showed promising activities with IC50 values 54.12 and 48.1 µg/mL, respectively. Further, ethyl acetate fraction showed the highest cytotoxicity on HepG2 and HeLa cell lines with IC50 values 41.7 and 52.31 µg/mL. Of 70 compounds screened virtually, polygamain, justicidin A, justicidin B, haplotubine, kusunokinin, and flindersine were predicted as safe anticancer drugs candidates. They showed the highest binding scores with targets involved in cell growth, proliferation, survival, migration, tumor suppression, induction of apoptosis, metastasis, and drug resistance. Our findings revealed the potency of H. tuberculatum as a source of anticancer candidates that further studies should support.

Synthesis, relaxivity, and in vitro fluorescence imaging studies of a novel d–f heterometallic trinuclear complex as a potential bimodal imaging probe for MRI and optical imaging

2015 ◽  
Vol 44 (40) ◽  
pp. 17800-17809 ◽  
Author(s):  
A. Nithyakumar ◽  
V. Alexander
Keyword(s):  
Molecular Docking ◽  
Contrast Agent ◽  
Hela Cell ◽  
Fluorescence Imaging ◽  
Optical Probe ◽  
Trinuclear Complex ◽  
Imaging Studies ◽  
Bimodal Imaging ◽  
Hela Cell Lines

A novel heterometallic RuII–GdIII2 complex which functions as a contrast agent for MRI and an optical probe for fluorescence imaging and in vitro fluorescence imaging studies with HeLa cell lines and molecular docking with DNA and HSA are reported.

Effect of black seeds (Nigella sativa) volatile oil on the cervical cancer: In vitro study, on Hela cell lines

2019 ◽  
Vol 7 (4) ◽  
pp. 91-96
Author(s):  
Isra'a Al-sobhi ◽  
◽  
Rawan Al-Ghabban ◽  
Soad Shaker Ali ◽  
Jehan Al-Amri ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Hela Cell ◽  
Cell Lines ◽  
Nigella Sativa ◽  
In Vitro Study ◽  
Volatile Oil ◽  
Vitro Study ◽  
Hela Cell Lines ◽  
Black Seeds

Ag Nanoparticles Synthesized Using β-Caryophyllene Isolated from Murraya koenigii: Antimalarial (Plasmodium falciparum 3D7) and Anticancer Activity (A549 and HeLa Cell Lines)

2017 ◽  
Vol 28 (3) ◽  
pp. 1667-1684 ◽  
Author(s):  
Chinnaperumal Kamaraj ◽  
Govindasamy Balasubramani ◽  
Chinnadurai Siva ◽  
Manickam Raja ◽  
Velramar Balasubramanian ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Hela Cell ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Ag Nanoparticles ◽  
Murraya Koenigii ◽  
Hela Cell Lines

Evaluation of photodynamic therapy and nuclear imaging potential of subphthalocyanine integrated TiO2 nanoparticles in mammary and cervical tumor cells

2019 ◽  
Vol 23 (07n08) ◽  
pp. 908-915 ◽  
Author(s):  
Fatma Yurt ◽  
Kasim Ocakoglu ◽  
Ozge Er ◽  
Hale Melis Soylu ◽  
Mine Ince ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hela Cell ◽  
Cell Line ◽  
Cell Lines ◽  
Nuclear Imaging ◽  
Target Tissue ◽  
Hela Cell Lines ◽  
Wi38 Cell

This study, subphthalocyanines (SubPc) and SubPc integrated TiO2 nanoparticles (SubPc-TiO[Formula: see text] were synthesized as novel photosensitizers. Their PDT effects were evaluated. Furthermore, nuclear imaging potential of [Formula: see text]I-labelled SubPc/SubPc-TiO2 were examined in mouse mammary carcinoma (EMT6) and cervix adenocarcinoma (HeLa) cell lines. The uptake results show that SubPc labelled with [Formula: see text]I radionuclide ([Formula: see text]I-SubPc) in EMT6 and HeLa cell lines was found to be approximately the same as in the WI38 cell line. However, the uptake values of SubPc-TiO2 labelled with [Formula: see text]I ([Formula: see text]I-SubPc-TiO[Formula: see text] in EMT6 and HeLa cell lines were determined to be two times higher than in the WI38 cell line. In other words, the target/non-target tissue ratio was identified as two in the EMT6 and HeLa cell lines. [Formula: see text]I-SubPc-TiO2 is promising for imaging or treatment of breast and cervix tumors. In vitro photodynamic therapy studies have shown that SubPc and SubPc-TiO2 are suitable agents for PDT. In addition, SubPc-TiO2 has higher phototoxicity than SubPc. As a future study, in vivo experiments will be held and performed in tumor-bearing nude mice.

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