Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy

AbstractImplantation-caused foreign-body response (FBR) is a commonly encountered issue and can result in failure of implants. The high L-serine content in low immunogenic silk sericin, and the high D-serine content as a neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials in mitigating the FBR. Here we report highly water soluble, biocompatible and easily accessible PSer hydrogels that cause negligible inflammatory response after subcutaneous implantation in mice for 1 week and 2 weeks. No obvious collagen capsulation is found surrounding the PSer hydrogels after 4 weeks, 3 months and 7 months post implantation. Histological analysis on inflammatory cytokines and RNA-seq assay both indicate that PSer hydrogels show low FBR, comparable to the Mock group. The anti-FBR performance of PSer hydrogels at all time points surpass the poly(ethyleneglycol) hydrogels that is widely utilized as bio-inert materials, implying the potent and wide application of PSer materials in implantable biomaterials and biomedical devices.

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Calculation of Surface Properties of Cubic and Hexagonal Crystals through Molecular Statics Simulations

Crystals ◽

10.3390/cryst10040329 ◽

2020 ◽

Vol 10 (4) ◽

pp. 329 ◽

Cited By ~ 1

Author(s):

Zihan Tang ◽

Yue Chen ◽

Wei Ye

Keyword(s):

Surface Properties ◽

Surface Stress ◽

Critical Role ◽

Constitutive Law ◽

Face Centered Cubic ◽

Hexagonal Close Packed ◽

Surface Stiffness ◽

Pure Metals ◽

Face Centered ◽

Hexagonal Crystals

Surface property is an important factor that is widely considered in crystal growth and design. It is also found to play a critical role in changing the constitutive law seen in the classical elasticity theory for nanomaterials. Through molecular static simulations, this work presents the calculation of surface properties (surface energy density, surface stress and surface stiffness) of some typical cubic and hexagonal crystals: face-centered-cubic (FCC) pure metals (Cu, Ni, Pd and Ag), body-centered-cubic (BCC) pure metals (Mo and W), diamond Si, zincblende GaAs and GaN, hexagonal-close-packed (HCP) pure metals (Mg, Zr and Ti), and wurzite GaN. Sound agreements of the bulk and surface properties between this work and the literature are found. New results are first reported for the surface stiffness of BCC pure metals, surface stress and surface stiffness of HCP pure metals, Si, GaAs and GaN. Comparative studies of the surface properties are carried out to uncover trends in their behaviors. The results in this work could be helpful to the investigation of material properties and structure performances of crystals.

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Mesenchymal stem cell-based bioengineered constructs: foreign body response, cross-talk with macrophages and impact of biomaterial design strategies for pelvic floor disorders

Interface Focus ◽

10.1098/rsfs.2018.0089 ◽

2019 ◽

Vol 9 (4) ◽

pp. 20180089 ◽

Cited By ~ 18

Author(s):

Shayanti Mukherjee ◽

Saeedeh Darzi ◽

Kallyanashis Paul ◽

Jerome A. Werkmeister ◽

Caroline E. Gargett

Keyword(s):

Foreign Body ◽

Pelvic Floor ◽

Critical Role ◽

Pelvic Organ ◽

Foreign Body Response ◽

Design Strategies ◽

Macrophage Response ◽

Improved Outcomes ◽

Key Aspects ◽

Body Response

An excessive foreign body response (FBR) has contributed to the adverse events associated with polypropylene mesh usage for augmenting pelvic organ prolapse surgery. Consequently, current biomaterial research considers the critical role of the FBR and now focuses on developing better biocompatible biomaterials rather than using inert implants to improve the clinical outcomes of their use. Tissue engineering approaches using mesenchymal stem cells (MSCs) have improved outcomes over traditional implants in other biological systems through their interaction with macrophages, the main cellular player in the FBR. The unique angiogenic, immunomodulatory and regenerative properties of MSCs have a direct impact on the FBR following biomaterial implantation. In this review, we focus on key aspects of the FBR to tissue-engineered MSC-based implants for supporting pelvic organs and beyond. We also discuss the immunomodulatory effects of the recently discovered endometrial MSCs on the macrophage response to new biomaterials designed for use in pelvic floor reconstructive surgery. We conclude with a focus on considerations in biomaterial design that take into account the FBR and will likely influence the development of the next generation of biomaterials for gynaecological applications.

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Biomaterial surface properties modulate in vitro rat calvaria osteoblasts response: Roughness and or chemistry?

Materials Science and Engineering C ◽

10.1016/j.msec.2007.10.085 ◽

2008 ◽

Vol 28 (5-6) ◽

pp. 990-1001 ◽

Cited By ~ 54

Author(s):

Carine Wirth ◽

Brigitte Grosgogeat ◽

Christelle Lagneau ◽

Nicole Jaffrezic-Renault ◽

Laurence Ponsonnet

Keyword(s):

Surface Properties ◽

Rat Calvaria ◽

Biomaterial Surface

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A Dimensionless Analysis of the Effect of Material and Surface Properties on Adhesion. Applications to Medical Device Design

UK Colloids 2011 ◽

10.1007/978-3-642-28974-3_11 ◽

2012 ◽

pp. 59-65

Author(s):

Polina Prokopovich

Keyword(s):

Medical Device ◽

Surface Properties ◽

Device Design ◽

Medical Device Design ◽

Dimensionless Analysis

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The effects of metal ion post-implantation on the near surface properties of TiN deposited by CVD

Surface and Coatings Technology ◽

10.1016/s0257-8972(00)00942-7 ◽

2000 ◽

Vol 133-134 ◽

pp. 203-207 ◽

Cited By ~ 9

Author(s):

Anthony J Perry ◽

Rafael R Manory ◽

Liam P Ward ◽

Premsagar P Kavuri

Keyword(s):

Surface Properties ◽

Metal Ion ◽

Near Surface ◽

Post Implantation

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Mechanically Matched Silicone Brain Implants Reduce Brain Foreign Body Response

10.1101/2020.12.13.422566 ◽

2020 ◽

Author(s):

Edward Zhang ◽

Alia Alameri ◽

Jean-Pierre Clement ◽

Andy Ng ◽

Timothy E Kennedy ◽

...

Keyword(s):

Foreign Body ◽

Neurological Disorders ◽

Foreign Body Response ◽

Brain Implants ◽

Rat Neocortex ◽

The Brain ◽

Post Implantation ◽

Body Response ◽

Clinical Adoption

Brain implants are increasingly used to treat neurological disorders and diseases. However, the brain foreign body response (FBR) elicited by implants affects neuro-electrical transduction and long-term reliability limiting their clinical adoption. The mismatch in Young's modulus between silicon implants (~180 GPa) and brain tissue (~1-30 kPa) exacerbates the FBR resulting in the development of flexible implants from polymers such as polyimide (~1.5-2.5 GPa). However, a stiffness mismatch of at least two orders of magnitude remains. Here, we introduce (i) the first mechanically matched brain implant (MMBI) made from silicone (~20 kPa), (ii) new microfabrication methods, and (iii) a novel dissolvable sugar shuttle to reliably implant MMBIs. MMBIs were fabricated via vacuum-assisted molding using sacrificial sugar molds and were then encased in sugar shuttles that dissolved within 2 min after insertion into rat brains. Sections of rat neocortex implanted with MMBIs, PDMS implants, and silicon implants were analyzed by immunohistochemistry 3 and 9-weeks post-implantation. MMBIs resulted in significantly higher neuronal density and lower FBR within 50 μm of the tissue-implant interface compared to PDMS and silicon implants suggesting that materials mechanically matched to brain further minimize the FBR and could contribute to better implant functionality and long-term reliability.

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Hydrophilic titanium surfaces reduce neutrophil inflammatory response and NETosis

Biomaterials Science ◽

10.1039/c9bm01474h ◽

2020 ◽

Vol 8 (8) ◽

pp. 2289-2299 ◽

Cited By ~ 3

Author(s):

Jefferson O. Abaricia ◽

Arth H. Shah ◽

Ryan M. Musselman ◽

Rene Olivares-Navarrete

Keyword(s):

Inflammatory Response ◽

Surface Properties ◽

Inflammatory Microenvironment ◽

Biomaterial Surface ◽

Titanium Surfaces ◽

Novel Target

Neutrophils are sensitive to biomaterial surface properties, controlling activation and inflammatory microenvironment, revealing a novel target for enhancing biomaterial integration.

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Engineering Bone with Mesenchymal Stem Cells: Challenges and Obstacles

Stem Cells and Regenerative Medicine - Biomedical and Health Research ◽

10.3233/bhr210011 ◽

2021 ◽

Author(s):

Guotian Luo ◽

Giuliana E. Salazar-Noratto ◽

Esther Potier ◽

Hervé Petite

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Metabolic Regulation ◽

Critical Role ◽

Bone Defects ◽

Massive Cell Death ◽

Scaffold Degradation ◽

Large Bone ◽

Post Implantation ◽

Large Bone Defects

Repair and reconstruction of large bone defects remain a significant challenge. Cell construct, containing mesenchymal stem cells (MSCs) and scaffold, is a promising strategy for addressing and treating major orthopedic clinical conditions. However, the design of an ideal cell construct for engineering bone faces two critical challenges (i) matching the scaffold degradation rate to that of new bone formation and (ii) preventing the massive cell death post-implantation (caused by disruption of oxygen and nutrient supply). We will hereby primarily focus on the challenge of survival of MSCs post-implantation. Increasing evidence indicates that metabolic regulation plays a critical role in cell fate and functions. In cell metabolism, glucose is considered the major metabolic substrate to produce ATP via glycolysis when the availability of oxygen is limited. In this paper, we delineate the essential roles of glucose on MSC survival. We aim to provide a different perspective which highlights the importance of considering glucose in the development of tissue engineering strategies in order to improve the efficiency of MSC-based cell constructs in the repair of large bone defects.

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