Stimuli-responsive single-chain polymeric nanoparticles towards the development of efficient drug delivery systems

2016 ◽  
Vol 7 (40) ◽  
pp. 6164-6169 ◽  
Author(s):  
Chih-Chia Cheng ◽  
Duu-Jong Lee ◽  
Zhi-Sheng Liao ◽  
Jyun-Jie Huang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Transport ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Stimuli Responsive ◽  
Single Chain ◽  
Transport Efficiency ◽  
Triggered Drug Release

Novel dynamic single-chain polymeric nanoparticles not only significantly improve drug transport efficiency in vitro but can also reside stably and facilitate precisely triggered drug-release in tumor-like microenvironments.

Stimuli-responsive Polymeric nanosystems for therapeutic applications

2021 ◽  
Vol 27 ◽  
Author(s):  
Mayank Handa ◽  
Ajit Singh ◽  
S.J.S. Flora ◽  
Rahul Shukla
Keyword(s):  
Drug Delivery ◽  
Metallic Nanoparticles ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Delivery Systems ◽  
Specific Drug ◽  
Stimuli Responsive

Background: Recent past decades have reported emerging of polymeric nanoparticles as a promising technique for controlled and targeted drug delivery. As nanocarriers, they have high drug loading and delivery to the specific site or targeted cells with an advantage of no drug leakage within en route and unloading of a drug in a sustained fashion at the site. These stimuli-responsive systems are functionalized in dendrimers, metallic nanoparticles, polymeric nanoparticles, liposomal nanoparticles, quantum dots. Purpose of Review: The authors reviewed the potential of smart stimuli-responsive carriers for therapeutic application and their behavior in external or internal stimuli like pH, temperature, redox, light, and magnet. These stimuli-responsive drug delivery systems behave differently in In vitro and In vivo drug release patterns. Stimuli-responsive nanosystems include both hydrophilic and hydrophobic systems. This review highlights the recent development of the physical properties and their application in specific drug delivery. Conclusion: The stimuli (smart, intelligent, programmed) drug delivery systems provide site-specific drug delivery with potential therapy for cancer, neurodegenerative, lifestyle disorders. As development and innovation, the stimuli-responsive based nanocarriers are moving at a fast pace and huge demand for biocompatible and biodegradable responsive polymers for effective and safe delivery.

Poly(N-isopropylacrylamide) derived nanogels demonstrated thermosensitive self-assembly and GSH-triggered drug release for efficient tumor Therapy

2019 ◽  
Vol 10 (29) ◽  
pp. 4031-4041 ◽  
Author(s):  
Jiaojiao Chen ◽  
Ming Wu ◽  
Hanitrarimalala Veroniaina ◽  
Subhankar Mukhopadhyay ◽  
Juequan Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Delivery Systems ◽  
Core Shell ◽  
Stimuli Responsive ◽  
Triggered Drug Release

Recently, interest in stimuli-responsive core–shell nanogels as drug delivery systems for tumor therapy has increased.

scholarly journals Development of Tinidazole Loaded Polymeric Nanoparticles Formulation and its Characterization

2021 ◽  
pp. 72-83
Author(s):  
K. Tirumala Devi ◽  
B. S. Venkateswarlu
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Targeted Drug

Introduction: The development of safe drug delivery systems for a therapeutic agent with less side effects and more bioavailability to the targeted site is very vital in drugs formulation. Tinidazole (TZ) is a drug used to treat giardiasis, amebiasis for colon infections and other infections also such as trichomoniasis, bacterial vaginosis. But the oral bioavailability for the current using drugs low. So, the current study was aimed to develop colon targeted drug delivery system for Tinidazole (TZ) with polymeric nanoparticles (NPs). Methodology: The nanoparticles formulations of TZ were prepared with modified ionic gelation method using chitosan and hydroxypropyl methylcellulose phthalate (HPMCP) are in different combinations by magnetic stirring method followed by temperature modulated solidification. The solvent evaporation method applied to coat TZ nanoparticles with Eudragit S100. The prepared TZ nanoparticle were studied to evaluate physiochemical properties, In-vitro drug release, mucopenetration and In-vivo mucoadhesive studies were carried out. Results: The results of study indicate, 1:1 ratio of chitosan and HPMCP formulation of nanoparticles provides better spatial interaction between them and TZ with spherical porous and the particles size was diverging between 202 - 236 nm. In vitro release of TZ followed Higuchi and first order equations better than zero order equation. The drug release results of nanoparticles formulations of TZ indicate that the NPs have potential as a drug delivery system compare to uncoated TZ and coated nanoparticles have comparatively less mucoadhesive detachment force. Conclusion: In conclusion, the study was an evidence to use nanoparticles in colon targeted drug delivery systems for better bioavailability of drugs at targeted site and the biodistribution properties of drugs using nanoparticle will be depend on their composition, particle size and their adhesive abilities.

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

Schiff base-containing dextran nanogel as pH-sensitive drug delivery system of doxorubicin: Synthesis and characterization

2018 ◽  
Vol 33 (2) ◽  
pp. 170-181 ◽  
Author(s):  
Hongying Su ◽  
Wen Zhang ◽  
Yayun Wu ◽  
Xiaodong Han ◽  
Gang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Cell Uptake ◽  
Stimuli Responsive ◽  
Drug Release Profile

Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. Approximately 66, 28, and 9% of drug was released in 72 h at pH 2.0, 5.0, and 7.4, respectively. Cell uptake by the human breast cancer cell (MCF-7) demonstrated that the DOX-loaded dextran nanogel could be internalized through endocytosis and distributed in endocytic compartments inside tumor cells. These results indicated that the Schiff base-containing nanogel can serve as a pH-sensitive drug delivery system. And the presence of multiple aldehyde groups on the nanogel are available for further conjugations of targeting ligands or imaging probes.

scholarly journals Nanoparticles vs. nanofibers: a comparison of two drug delivery systems on assessing drug release performance in vitro

2015 ◽  
Vol 18 (7) ◽  
pp. 678-689 ◽  
Author(s):  
Xiaoqian Shan ◽  
Changsheng Liu ◽  
Fengqian Li ◽  
Chunfa Ouyang ◽  
Qun Gao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals The Effective Combination between 3D Cancer Models and Stimuli-Responsive Nanoscale Drug Delivery Systems

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3295
Author(s):  
Federica Foglietta ◽  
Loredana Serpe ◽  
Roberto Canaparo
Keyword(s):  
Drug Delivery ◽  
Cancer Cell ◽  
Cell Cultures ◽  
Drug Delivery Systems ◽  
In Vitro Models ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Cancer Models

Stimuli-responsive drug-delivery systems (DDSs) have emerged as a potential tool for applications in healthcare, mainly in the treatment of cancer where versatile nanocarriers are co-triggered by endogenous and exogenous stimuli. Two-dimensional (2D) cell cultures are the most important in vitro model used to evaluate the anticancer activity of these stimuli-responsive DDSs due to their easy manipulation and versatility. However, some limitations suggest that these in vitro models poorly predict the outcome of in vivo studies. One of the main drawbacks of 2D cell cultures is their inadequate representation of the 3D environment’s physiological complexity, which sees cells interact with each other and the extracellular matrix (ECM) according to their specific cellular organization. In this regard, 3D cancer models are a promising approach that can overcome the main shortcomings of 2D cancer cell cultures, as these in vitro models possess many peculiarities by which they mimic in vivo tumors, including physiologically relevant cell–cell and cell–ECM interactions. This is, in our opinion, even more relevant when a stimuli-responsive DDS is being investigated. In this review, we therefore report and discuss endogenous and exogenous stimuli-responsive DDSs whose effectiveness has been tested using 3D cancer cell cultures.

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