Genetically engineering of Escherichia coli and immobilization on electrospun fibers for drug delivery purposes

2016 ◽  
Vol 4 (42) ◽  
pp. 6820-6829 ◽  
Author(s):  
Songzhi Xie ◽  
Sihan Tai ◽  
Haixing Song ◽  
Xiaoming Luo ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Drug Delivery ◽  
Covalent Binding ◽  
Fiber Surface ◽  
Coaxial Electrospinning ◽  
Electrospun Fibers ◽  
Affinity Adsorption

Engineered EcN bacteria were entrapped in core-sheath fibersviacoaxial electrospinning or grafted on the fiber surfaceviacovalent binding or affinity adsorption.

scholarly journals Study on the Morphologies and Formational Mechanism of Poly(hydroxybutyrate-co-hydroxyvalerate) Ultrafine Fibers by Dry-Jet-Wet-Electrospinning

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Shuqi Zhu ◽  
Hao Yu ◽  
Yanmo Chen ◽  
Meifang Zhu
Keyword(s):  
Fiber Surface ◽  
Double Diffusion ◽  
Electrospun Fibers ◽  
Surface Porosity ◽  
Morphological Comparison ◽  
Ultrafine Fibers ◽  
Stability And Instability ◽  
Boundary Of Stability

Dry-jet-wet-electrospinning (DJWE) was carried out to study the formational mechanism of poly(hydroxybutyrate-co-hydroxyvalerate) electrospun fibers. Morphological comparison between normal electrospinning (NE) and DJWE was investigated. The results showed that jet could solidify quickly in DJWE to avoid bead collapse or fiber coherence. Jet structures could be maintained at very low collection distance. Beanpod-like beads, which were named as primary beads, could be seen at the boundary of stability and instability section and divided into spindle-like beads with longer collection distance. Bead-free electrospun fibers from DJWE had few bonding points among each other, and fast solidification and double-diffusion led to rough and shriveled fiber surface. DJWE mats were higher hydrophobic than that from NE due to more loose structure and higher surface porosity. Higher bead ratio on the surface and rounder bead structure resulted in higher hydrophobicity.

Coaxial electrospun fibers: applications in drug delivery and tissue engineering

2016 ◽  
Vol 8 (5) ◽  
pp. 654-677 ◽  
Author(s):  
Yang Lu ◽  
Jiangnan Huang ◽  
Guoqiang Yu ◽  
Romel Cardenas ◽  
Suying Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Electrospun Fibers

Electrospun Fibers for Drug Delivery

2011 ◽  
pp. 445-462 ◽  
Author(s):  
W. Cui ◽  
J. Chang ◽  
P.D. Dalton
Keyword(s):  
Drug Delivery ◽  
Electrospun Fibers

Polymer nanofibers for biomedical applications: advances by electrospinning

2021 ◽  
Vol 04 ◽  
Author(s):  
Anna L.M.M. Toledo ◽  
Talita N. da Silva ◽  
Arianne C. dos S. Vaucher ◽  
Arthur H. V. Miranda ◽  
Gabriela C. C. Silva de Miranda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
New Technologies ◽  
Low Cost ◽  
Electrospun Nanofibers ◽  
Delivery Systems ◽  
Electrospun Fibers ◽  
Sustained Delivery ◽  
Biomedical Devices ◽  
Ultrathin Fibers

Background: The demand for novel biomaterials has been exponentially rising in the last years as well as the searching for new technologies able to produce more efficient products in both drug delivery systems and regenerative medicine. Objective: The technique that can pretty well encompass the needs for novel and high-end materials with a relatively low-cost and easy operation is the electrospinning of polymer solutions. Methods: Electrospinning usually produces ultrathin fibers that can be applied in a myriad of biomedical devices including sustained delivery systems for drugs, proteins, biomolecules, hormones, etc that can be applied in a broad spectrum of applications, from transdermal patches to cancer-related drugs. Results: Electrospun fibers can be produced to mimic certain tissues of the human body, being an option to create new scaffolds for implants with several advantages. Conclusions: In this review, we aimed to encompass the use of electrospun fibers in the field of biomedical devices, more specifically in the use of electrospun nanofibers applications toward the production of drug delivery systems and scaffolds for tissue regeneration.

scholarly journals Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 305 ◽  
Author(s):  
Bishweshwar Pant ◽  
Mira Park ◽  
Soo-Jin Park
Keyword(s):  
Drug Delivery ◽  
Electrospun Nanofibers ◽  
Coaxial Electrospinning ◽  
Burst Release ◽  
High Porosity ◽  
Nanofiber Membrane ◽  
Initial Burst ◽  
Initial Burst Release ◽  
Small Pore ◽  
Drug Delivery Applications

Electrospinning has emerged as one of the potential techniques for producing nanofibers. The use of electrospun nanofibers in drug delivery has increased rapidly over recent years due to their valuable properties, which include a large surface area, high porosity, small pore size, superior mechanical properties, and ease of surface modification. A drug loaded nanofiber membrane can be prepared via electrospinning using a model drug and polymer solution; however, the release of the drug from the nanofiber membrane in a safe and controlled way is challenging as a result of the initial burst release. Employing a core-sheath design provides a promising solution for controlling the initial burst release. Numerous studies have reported on the preparation of core-sheath nanofibers by coaxial electrospinning for drug delivery applications. This paper summarizes the physical phenomena, the effects of various parameters in coaxial electrospinning, and the usefulness of core-sheath nanofibers in drug delivery. Furthermore, this report also highlights the future challenges involved in utilizing core-sheath nanofibers for drug delivery applications.

Electrospun fibers for tissue engineering, drug delivery, and wound dressing

2013 ◽  
Vol 48 (8) ◽  
pp. 3027-3054 ◽  
Author(s):  
Yi-Fan Goh ◽  
Imran Shakir ◽  
Rafaqat Hussain
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Dressing ◽  
Electrospun Fibers

Processing-Mechanical Property Relationship of Hollow and Porous Carbon Fibers Fabricated by Coaxial Electrospinning

2018 ◽  
Author(s):  
Yijun Chen ◽  
Jizhe Cai ◽  
James G. Boyd ◽  
Mohammad Naraghi
Keyword(s):  
Mechanical Property ◽  
Carbon Fibers ◽  
Mechanical Performance ◽  
Fiber Surface ◽  
High Strength ◽  
Hollow Fibers ◽  
Coaxial Electrospinning ◽  
Solid Shell ◽  
Porous Shell ◽  
Hollow Carbon

High strength hollow carbon fibers with both porous and solid shell were fabricated by a combination of coaxial electrospinning and emulsion electrospinning. In the coaxial electrospinning, a Polyacrylonitrile (PAN)/ Poly(methyl methacrylate) (PMMA)/Dimethylformamide (DMF) emulsion was used to form the porous shell and a PAN/DMF solution was used to form the solid shell. Fiber surface and cross-section morphology was studied by scanning electron microscope (SEM). Mechanical property of the hollow fibers was characterized by single fiber tensile test using microelectromechanical system devices (MEMS). The effect of pores on mechanical performance of the hollow fibers was studied. Hollow carbon fibers with porous and solid shell both showed a brittle fracture behavior. The modulus and strength of the hollow carbon fibers with solid shell was ∼ 76.1 GPa and 2.04 GPa, respectively. For the hollow carbon fibers with porous shell, the porosity led to ∼ 35 % reduction in strength. The porous fibers with the mediocre strength measured here open new horizons for combining structural functionality with energy storage, in so-called structural batteries.

scholarly journals Ciprofloxacin-loaded polymeric nanoparticles incorporated electrospun fibers for drug delivery in tissue engineering applications

2020 ◽  
Vol 10 (3) ◽  
pp. 706-720 ◽  
Author(s):  
Cemre Günday ◽  
Shivesh Anand ◽  
Hikmet Burcu Gencer ◽  
Sara Munafò ◽  
Lorenzo Moroni ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Polymeric Nanoparticles ◽  
Electrospun Fibers ◽  
Engineering Applications
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