Neodymium-doped NaHoF4 nanoparticles as near-infrared luminescent/T2-weighted MR dual-modal imaging agents in vivo

2017 ◽  
Vol 5 (3) ◽  
pp. 504-510 ◽  
Author(s):  
Yamin Feng ◽  
Qingbo Xiao ◽  
Yanhui Zhang ◽  
Fujin Li ◽  
Yanfang Li ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Near Infrared ◽  
Imaging Agents ◽  
Nir Luminescence

Efficient NIR luminescence and high r2 value are simultaneously achieved for NaHoF4:Nd3+ nanoplates, which are successfully applied for NIR luminescence and MR imaging in vivo.

Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo

2017 ◽  
Vol 5 (44) ◽  
pp. 8761-8769 ◽  
Author(s):  
Congyang Yan ◽  
Lili Cui ◽  
Qi Yang ◽  
Xiaobao Zhou ◽  
Lixing Pan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Mr Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Dual Modality ◽  
Dual Modality Imaging

Coordination polymer hybridized Au nanocages (AuNC@CPs) were prepared, which were used for near-infrared (NIR)-driven photothermal therapy (PTT) guided by photoacoustic (PA) and magnetic resonance (MR) imaging in vivo.

scholarly journals J-Aggregates of meso- [2.2] Paracyclophanyl-BODIPY Dye for NIR-II Imaging

2020 ◽  
Author(s):  
Zhipeng Liu ◽  
Kang Li ◽  
Xingchen Duan ◽  
Zhiyong Jiang ◽  
Dan Ding ◽  
...  
Keyword(s):  
Near Infrared ◽  
Organic Dyes ◽  
Fluorescent Imaging ◽  
Imaging Agents ◽  
Aggregation State ◽  
Guided Surgery ◽  
Lymph Node Imaging ◽  
Diluted Solution ◽  
J Aggregates

Abstract J-aggregation has been proved to be an efficient strategy for the development of fluorescent imaging agents in the second near-infrared (NIR-II, 1000–1700 nm) window. However, the design of NIR-II fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracyclophanyl-3,5-bis-N,N-dimethylaminostyrl BODIPY (PCP-BDP2) as the first example of BODIPY dye with J-aggregation induced NIR-II fluorescence. PCP-BDP2 shows emission maximum at 795 nm in diluted solution and NIR-II emission at 1010 nm in the J-aggregation state. Mechanism studies reveal that the steric and conjugation effect of the PCP group on the BODIPY core plays key roles in the J-aggregation behavior and NIR-II fluorescence tuning. Notably, NIR-II emissive J-aggregates of PCP-BDP2 can be efficiently stabilized in the assembled nanoparticle. Taking advantage of high quantum yield and good photo-/chemo-stability, J-aggregates of PCP-BDP2 show high-resolution and long-term in vivo NIR-II imaging ability. Furthermore, J-aggregates of PCP-BDP2 can be utilized for lymph node imaging and fluorescence-guided surgery in the nude mouse, which demonstrates their potential clinical application. This study not only demonstrates BODIPY dye as a new J-aggregation platform for developing NIR-II imaging agents but also encourages further exploration on J-aggregation induced NIR-II emission of the other conventional organic dyes.

scholarly journals Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

Nanoscale ◽  
2015 ◽  
Vol 7 (36) ◽  
pp. 14889-14896 ◽  
Author(s):  
Benjamin P. Burke ◽  
Neazar Baghdadi ◽  
Alicja E. Kownacka ◽  
Shubhanchi Nigam ◽  
Gonçalo S. Clemente ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Surface Interactions ◽  
Imaging Agents ◽  
Oxide Nanorods ◽  
Gallium 68

Silica coated iron oxide nanorods can be radiolabelled with gallium-68 without the need for a chelator to give in vivo stable multimodal PET/MR imaging agents.

The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques

2015 ◽  
Vol 51 (58) ◽  
pp. 11665-11668 ◽  
Author(s):  
Kaixiang Zhou ◽  
Hualong Fu ◽  
Liang Feng ◽  
Mengchao Cui ◽  
Jiapei Dai ◽  
...  
Keyword(s):  
Barbituric Acid ◽  
Near Infrared ◽  
Amyloid Plaques ◽  
Imaging Agents ◽  
In Vivo Detection ◽  
Infrared Probes

A new array of near-infrared probes containing barbituric acid acceptors has been developed as Aβ imaging agents.

Compact chelator-free Ni-integrated CuS nanoparticles with tunable near-infrared absorption and enhanced relaxivity for in vivo dual-modal photoacoustic/MR imaging

Nanoscale ◽  
2015 ◽  
Vol 7 (42) ◽  
pp. 17631-17636 ◽  
Author(s):  
Duyang Gao ◽  
Pengfei Zhang ◽  
Chengbo Liu ◽  
Chi Chen ◽  
Guanhui Gao ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Infrared Absorption ◽  
Near Infrared ◽  
Nir Absorption

A novel PA/MRI dual-modal imaging nanoprobe with tunable NIR absorption and enhanced T1 relaxivity was prepared via chelator-free method.

A high-performance imaging probe with NIR luminescence and synergistically enhanced T1–T2 relaxivity for in vivo hepatic tumor targeting and multimodal imaging

2015 ◽  
Vol 51 (69) ◽  
pp. 13369-13372 ◽  
Author(s):  
Jian Liu ◽  
Zhengzheng Li ◽  
Xiangliang Yang ◽  
Weisheng Liu ◽  
Baodui Wang ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Multimodal Imaging ◽  
Tumor Targeting ◽  
High Performance ◽  
Hepatic Tumor ◽  
Imaging Probe ◽  
Nir Luminescence

A high-performance nanoprobe with high tumor-targeting efficacy, NIR luminescence and synergistically enhanced T1-/T2-weighted MR imaging in vivo was synthesized.

scholarly journals Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications

2018 ◽  
Vol 2018 ◽  
pp. 1-19 ◽  
Author(s):  
Bishnu P. Joshi ◽  
Thomas D. Wang
Keyword(s):  
Optical Imaging ◽  
Cancer Detection ◽  
Near Infrared ◽  
Expression Patterns ◽  
Fluorescence Labeling ◽  
Imaging Agents ◽  
Wide Range ◽  
Molecular Specificity ◽  
Molecular Expression

Molecular imaging is an emerging strategy for in vivo visualization of cancer over time based on biological mechanisms of disease activity. Optical imaging methods offer a number of advantages for real-time cancer detection, particularly in the epithelium of hollow organs and ducts, by using a broad spectral range of light that spans from visible to near-infrared. Targeted ligands are being developed for improved molecular specificity. These platforms include small molecule, peptide, affibody, activatable probes, lectin, and antibody. Fluorescence labeling is used to provide high image contrast. This emerging methodology is clinically useful for early cancer detection by identifying and localizing suspicious lesions that may not otherwise be seen and serves as a guide for tissue biopsy and surgical resection. Visualizing molecular expression patterns may also be useful to determine the best choice of therapy and to monitor efficacy. A number of these imaging agents are overcoming key challenges for clinical translation and are being validated in vivo for a wide range of human cancers.

scholarly journals Er3+-Ions-Doped Multiscale Nanoprobes for Fluorescence Imaging in Cellular and Living Mice

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2676
Author(s):  
Cong Cao ◽  
Yu Xie ◽  
Shi-Wen Li ◽  
Chang Hong
Keyword(s):  
Light Scattering ◽  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Cell Imaging ◽  
Diagnostic Techniques ◽  
Single Nanoparticle ◽  
Nir Fluorescence ◽  
Nir Luminescence

With the development of biotechnology, luminescent nanoprobes for biological disease detection are widely used. However, the further application in clinic is limited by the reduced penetration depth in the tissues and light scattering. In this work, we have synthesized NaYF4:Yb,Er,Ce@SiO2-OAlg nanomaterials, which have both upconversion and near-infrared (NIR) luminescence. The optimized probes were determined to achieve cell imaging by its upconversion (UCL) luminescence and in vivo imaging through collection of NIR fluorescence signals simultaneously. The research is conducive to developing accurate diagnostic techniques based on UCL and NIR fluorescence imaging by a single nanoparticle.

Fluorescent proteins for in vivo imaging, where's the biliverdin?

2020 ◽  
Vol 48 (6) ◽  
pp. 2657-2667
Author(s):  
Felipe Montecinos-Franjola ◽  
John Y. Lin ◽  
Erik A. Rodriguez
Keyword(s):  
Hydrogen Peroxide ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Fluorescent Protein ◽  
Fluorescent Proteins ◽  
Fluorescent Imaging ◽  
Infrared Light ◽  
Red Fluorescent Protein ◽  
Color Palette

Noninvasive fluorescent imaging requires far-red and near-infrared fluorescent proteins for deeper imaging. Near-infrared light penetrates biological tissue with blood vessels due to low absorbance, scattering, and reflection of light and has a greater signal-to-noise due to less autofluorescence. Far-red and near-infrared fluorescent proteins absorb light >600 nm to expand the color palette for imaging multiple biosensors and noninvasive in vivo imaging. The ideal fluorescent proteins are bright, photobleach minimally, express well in the desired cells, do not oligomerize, and generate or incorporate exogenous fluorophores efficiently. Coral-derived red fluorescent proteins require oxygen for fluorophore formation and release two hydrogen peroxide molecules. New fluorescent proteins based on phytochrome and phycobiliproteins use biliverdin IXα as fluorophores, do not require oxygen for maturation to image anaerobic organisms and tumor core, and do not generate hydrogen peroxide. The small Ultra-Red Fluorescent Protein (smURFP) was evolved from a cyanobacterial phycobiliprotein to covalently attach biliverdin as an exogenous fluorophore. The small Ultra-Red Fluorescent Protein is biophysically as bright as the enhanced green fluorescent protein, is exceptionally photostable, used for biosensor development, and visible in living mice. Novel applications of smURFP include in vitro protein diagnostics with attomolar (10−18 M) sensitivity, encapsulation in viral particles, and fluorescent protein nanoparticles. However, the availability of biliverdin limits the fluorescence of biliverdin-attaching fluorescent proteins; hence, extra biliverdin is needed to enhance brightness. New methods for improved biliverdin bioavailability are necessary to develop improved bright far-red and near-infrared fluorescent proteins for noninvasive imaging in vivo.

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