Design and construction of self-hidden and pH-reversed targeting drug delivery nanovehicles via noncovalent interactions to overcome drug resistance

2017 ◽  
Vol 5 (15) ◽  
pp. 2823-2831 ◽  
Author(s):  
Dan Zhao ◽  
Xiaoqing Yi ◽  
Jiaqi Xu ◽  
Gongdao Yuan ◽  
Renxi Zhuo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Noncovalent Interactions ◽  
Step Method ◽  
Construction Of Self ◽  
One Step ◽  
Design And Construction

A convenient one-step method was used to construct self-hidden and pH-reversed targeting drug delivery nanovehicles using the host–guest interaction between β-CD and Ad, and borate formation between PBA and serinol.

scholarly journals Drug Delivery: One-Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid-Switchable Surface Charge for Overcoming Drug Resistance (Small 9/2017)

Small ◽  
2017 ◽  
Vol 13 (9) ◽  
Author(s):  
Qiang Feng ◽  
Jianping Liu ◽  
Xuanyu Li ◽  
Qinghua Chen ◽  
Jiashu Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Surface Charge ◽  
One Step

A facile one-step method for preparation of Fe3O4/CS/INH nanoparticles as a targeted drug delivery for tuberculosis

2017 ◽  
Vol 77 ◽  
pp. 1182-1188 ◽  
Author(s):  
Chili Zhao ◽  
Xun Liu ◽  
Xia Zhang ◽  
Hong Yan ◽  
Zhilei Qian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Step Method ◽  
One Step ◽  
Targeted Drug

Effect of Dynamic Crosslinking on Mechanical Properties of PP/EPDM Blends

1993 ◽  
Vol 58 (11) ◽  
pp. 2642-2650 ◽  
Author(s):  
Zdeněk Kruliš ◽  
Ivan Fortelný ◽  
Josef Kovář
Keyword(s):  
Mechanical Properties ◽  
Impact Strength ◽  
Shear Modulus ◽  
High Impact ◽  
Necessary Condition ◽  
Step Method ◽  
Melt Mixing ◽  
One Step ◽  
High Impact Strength ◽  
Dynamic Curing

The effect of dynamic curing of PP/EPDM blends with sulfur and thiuram disulfide systems on their mechanical properties was studied. The results were interpreted using the knowledge of the formation of phase structure in the blends during their melt mixing. It was shown, that a sufficiently slow curing reaction is necessary if a high impact strength is to be obtained. Only in such case, a fine and homogeneous dispersion of elastomer can be formed, which is the necessary condition for high impact strength of the blend. Using an inhibitor of curing in the system and a one-step method of dynamic curing leads to an increase in impact strength of blends. From the comparison of shear modulus and impact strength values, it follows that, at the stiffness, the dynamically cured blends have higher impact strength than the uncured ones.

Bismuth particles imbedded degradable nanohydrogel prepared by one-step method for tumor dual-mode imaging and chemo-photothermal combined therapy

2019 ◽  
Vol 375 ◽  
pp. 122000 ◽  
Author(s):  
Yang Xuan ◽  
Xian-Lin Song ◽  
Xiao-Quan Yang ◽  
Ruo-Yun Zhang ◽  
Zi-Yu Song ◽  
...  
Keyword(s):  
Combined Therapy ◽  
Dual Mode ◽  
Step Method ◽  
One Step

scholarly journals Bio-Based Polyurethane Networks Derived from Liquefied Sawdust

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3138
Author(s):  
Kamila Gosz ◽  
Agnieszka Tercjak ◽  
Adam Olszewski ◽  
Józef Haponiuk ◽  
Łukasz Piszczyk
Keyword(s):  
Biomass Conversion ◽  
Structural Features ◽  
Mechanical Analysis ◽  
Process Efficiency ◽  
Hydroxyl Number ◽  
Step Method ◽  
One Step ◽  
Liquefaction Process ◽  
The Fourier Transform ◽  
Liquefaction Temperature

The utilization of forestry waste resources in the production of polyurethane resins is a promising green alternative to the use of unsustainable resources. Liquefaction of wood-based biomass gives polyols with properties depending on the reagents used. In this article, the liquefaction of forestry wastes, including sawdust, in solvents such as glycerol and polyethylene glycol was investigated. The liquefaction process was carried out at temperatures of 120, 150, and 170 °C. The resulting bio-polyols were analyzed for process efficiency, hydroxyl number, water content, viscosity, and structural features using the Fourier transform infrared spectroscopy (FTIR). The optimum liquefaction temperature was 150 °C and the time of 6 h. Comprehensive analysis of polyol properties shows high biomass conversion and hydroxyl number in the range of 238–815 mg KOH/g. This may indicate that bio-polyols may be used as a potential substitute for petrochemical polyols. During polyurethane synthesis, materials with more than 80 wt% of bio-polyol were obtained. The materials were obtained by a one-step method by hot-pressing for 15 min at 100 °C and a pressure of 5 MPa with an NCO:OH ratio of 1:1 and 1.2:1. Dynamical-mechanical analysis (DMA) showed a high modulus of elasticity in the range of 62–839 MPa which depends on the reaction conditions.

Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance

2021 ◽  
Author(s):  
Peng Xie ◽  
Yushu Wang ◽  
Dengshuai Wei ◽  
Lingpu Zhang ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Platinum Drugs ◽  
Effective Strategy ◽  
Platinum Drug ◽  
Cancer Drug Resistance ◽  
Platinum Drug Resistance

The mechanisms of chemoresistance and nanoparticle-based drug delivery systems for platinum drugs were detailed summarized in this review. The current combination therapy provided an effective strategy to overcome the platinum drug resistance.

scholarly journals Analysis and applicability of a new quartic polynomial one-step method for solving COVID-19 model

2021 ◽  
Vol 1734 ◽  
pp. 012019
Author(s):  
S E Fadugba ◽  
V J Shaalini ◽  
A A Ibrahim
Keyword(s):  
Step Method ◽  
Quartic Polynomial ◽  
One Step

Discussion on Repair Method of Concrete Highway Pavement

2013 ◽  
Vol 321-324 ◽  
pp. 209-212
Author(s):  
Chun Yan Xia
Keyword(s):  
Mechanical Properties ◽  
Preparation Program ◽  
Step Method ◽  
Concrete Technology ◽  
Concrete Material ◽  
Repair Method ◽  
Ordinary Concrete ◽  
One Step ◽  
Highway Pavement

nfluences on properties of the concrete highway pavement were analyzed in this paper, and the optimal formulation materials were gotten to use in the repair of used-broken cement blocks in the experiment. Polyurethane concrete material was prepared, combing the ordinary concrete technology with one-step method of the synthesis of polyurethane hard bubble, and then its mechanical properties of the relevant parameters were measured to determine the optimal preparation program. The results show that the polyurethane concrete also has sufficiently good mechanical properties while it has the characteristic of fast patching.

A novel, one-step method for the conversion of primary alcohols into carbamate-protected amines

2002 ◽  
Vol 43 (21) ◽  
pp. 3887-3890 ◽  
Author(s):  
Michael R. Wood ◽  
June Y. Kim ◽  
Kathy M. Books
Keyword(s):  
Primary Alcohols ◽  
Step Method ◽  
One Step
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