Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment

2018 ◽  
Vol 47 (17) ◽  
pp. 6454-6472 ◽  
Author(s):  
Lian-Hua Fu ◽  
Chao Qi ◽  
Jing Lin ◽  
Peng Huang
Keyword(s):  
Glucose Oxidase ◽  
Cancer Diagnosis ◽  
State Of The Art ◽  
Diagnosis And Treatment ◽  
Biological Applications ◽  
Future Prospects ◽  
Therapeutic Approaches ◽  
Catalytic Systems ◽  
Current Trends ◽  
Catalytic Chemistry

This tutorial review focuses on the state-of-the-art progress in GOx-based cancer diagnosis and treatment, including the general principles for the design and construction of GOx-based biosensors and cancer therapeutic approaches, and their biological applications in detail. Moreover, the current trends and key problems, as well as the challenges and future prospects of GOx-based catalytic systems in biomedicine are also discussed in the end.

scholarly journals State-of-the-Art Clinical Microbiology in South Korea: Current Trends and Future Prospects

2022 ◽  
Vol 10 (1) ◽  
pp. 174
Author(s):  
Garima Sharma ◽  
Jin-Chul Kim
Keyword(s):  
South Korea ◽  
Human Body ◽  
Clinical Microbiology ◽  
State Of The Art ◽  
Clinical Aspects ◽  
Future Prospects ◽  
Microbial Species ◽  
Current Trends

Researchers and clinicians have repeatedly explored the clinical aspects of microorganisms because the human body is inhabited by several different microbial species and their strains [...]

Current advances in the diagnosis and personalized treatment of breast cancer: lessons from tumor biology

2020 ◽  
Vol 17 (5) ◽  
pp. 399-420 ◽  
Author(s):  
Rodrigo Kern ◽  
Stephany Christiane Correa ◽  
Thalita Basso Scandolara ◽  
Janaína Carla da Silva ◽  
Bruno Ricardo Pires ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Cancer Diagnosis ◽  
Tumor Biology ◽  
Breast Cancer Diagnosis ◽  
Breast Cancer Treatment ◽  
Point Of View ◽  
Diagnosis And Treatment ◽  
Therapeutic Approaches ◽  
Diagnosis And Prognosis

Breast cancer treatment has advanced enormously in the last decade. Most of this is due to advances reached in the knowledge regarding tumor biology, mainly in the field of diagnosis and treatment. This review brings information about how the genomics-based information contributed to advances in breast cancer diagnosis and prognosis perspective, as well as presents how tumor biology discoveries fostered the main therapeutic approaches available to treat such patients, based on a personalized point of view.

Biological Production of (S)-acetoin: A State-of-the-Art Review

2019 ◽  
Vol 19 (25) ◽  
pp. 2348-2356 ◽  
Author(s):  
Neng-Zhong Xie ◽  
Jian-Xiu Li ◽  
Ri-Bo Huang
Keyword(s):  
Side Effects ◽  
Chemical Synthesis ◽  
State Of The Art ◽  
Optically Active ◽  
Considerable Progress ◽  
Future Prospects ◽  
Chiral Compound ◽  
Biological Production ◽  
Acetoin Production ◽  
Made In

Acetoin is an important four-carbon compound that has many applications in foods, chemical synthesis, cosmetics, cigarettes, soaps, and detergents. Its stereoisomer (S)-acetoin, a high-value chiral compound, can also be used to synthesize optically active drugs, which could enhance targeting properties and reduce side effects. Recently, considerable progress has been made in the development of biotechnological routes for (S)-acetoin production. In this review, various strategies for biological (S)- acetoin production are summarized, and their constraints and possible solutions are described. Furthermore, future prospects of biological production of (S)-acetoin are discussed.

Recent Advances of Silver Nanoparticles in Cancer Diagnosis and Treatment

2020 ◽  
Vol 20 (11) ◽  
pp. 1276-1287 ◽  
Author(s):  
Tran Q. Huy ◽  
Pham T.M. Huyen ◽  
Anh-Tuan Le ◽  
Matteo Tonezzer
Keyword(s):  
Silver Nanoparticles ◽  
Cancer Treatment ◽  
Cancer Diagnosis ◽  
Essential Role ◽  
Review Paper ◽  
Diagnosis And Treatment ◽  
Antimicrobial Material ◽  
Pathogenic Agents ◽  
New Generation ◽  
Carrier Systems

Background: Silver nanoparticles (AgNPs) are well-known as a promising antimicrobial material; they have been widely used in many commercial products against pathogenic agents. Despite a growing concern regarding the cytotoxicity, AgNPs still have attracted considerable interest worldwide to develop a new generation of diagnostic tool and effective treatment solution for cancer cells. Objective: This paper aims to review the advances of AgNPs applied for cancer diagnosis and treatment. Methods: The database has been collected, screened and analysed through up-to-date scientific articles published from 2007 to May 2019 in peer-reviewed international journals. Results: The findings of the database have been analysed and divided into three parts of the text that deal with AgNPs in cancer diagnosis, their cytotoxicity, and the role as carrier systems for cancer treatment. Thanks to their optical properties, high conductivity and small size, AgNPs have been demonstrated to play an essential role in enhancing signals and sensitivity in various biosensing platforms. Furthermore, AgNPs also can be used directly or developed as a drug delivery system for cancer treatment. Conclusion: The review paper will help readers understand more clearly and systematically the role and advances of AgNPs in cancer diagnosis and treatment.

CLINICAL AND FORENSIC ASPECTS OF PHARMACOBEZOARS

2020 ◽  
Vol 12 ◽  
Author(s):  
Francisco Basílio ◽  
Ricardo Jorge Dinis-Oliveira
Keyword(s):  
State Of The Art ◽  
Signs And Symptoms ◽  
Immediate Release ◽  
Diagnosis And Treatment ◽  
Blood Concentrations ◽  
Forensic Practice ◽  
Wide Range ◽  
Therapeutic Doses ◽  
Complete History ◽  
Lethal Blood

Background: Pharmacobezoars are specific types of bezoars formed when medicines, such as tablets, suspensions, and/or drug delivery systems, aggregate and may cause death by occluding airways with tenacious material or by eluting drugs resulting in toxic or lethal blood concentrations. Objective: This work aims to fully review the state-of-the-art regarding pathophysiology, diagnosis, treatment and other relevant clinical and forensic features of pharmacobezoars. Results: patients of a wide range of ages and in both sexes present with signs and symptoms of intoxications or more commonly gastrointestinal obstructions. The exact mechanisms of pharmacobezoar formation are unknown but is likely multifactorial. The diagnosis and treatment depend on the gastrointestinal segment affected and should be personalized to the medication and the underlying factor. A good and complete history, physical examination, image tests, upper endoscopy and surgery through laparotomy of the lower tract are useful for diagnosis and treatment. Conclusion: Pharmacobezoars are rarely seen in clinical and forensic practice. They are related to controlled or immediate-release formulations, liquid or non-digestible substances, in normal or altered digestive motility/anatomy tract, and in overdoses or therapeutic doses, and should be suspected in the presence of risk factors or patients taking drugs which may form pharmacobezoars.

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