A label-free visual platform for self-correcting logic gate construction and sensitive biosensing based on enzyme-mimetic coordination polymer nanoparticles

2017 ◽  
Vol 5 (24) ◽  
pp. 4607-4613 ◽  
Author(s):  
Ting Hou ◽  
Tongxing Zhao ◽  
Wei Li ◽  
Feng Li ◽  
Panpan Gai
Keyword(s):  
Coordination Polymer ◽  
Logic Gate ◽  
Polymer Nanoparticles ◽  
Label Free ◽  
Enzyme Mimetic ◽  
Molecular Logic Gate ◽  
Molecular Logic

We proposed a label-free visual platform based on Cu–GMP CPNs for both self-correcting molecular logic gate construction and sensitive biosensing.

Graphene quantum dots as nanosensor for rapid and label-free dual detection of Cu2+ and tiopronin by means of fluorescence “on–off–on” switching: mechanism and molecular logic gate

2021 ◽  
Author(s):  
Jun Yao ◽  
Li Wang
Keyword(s):  
Quantum Dots ◽  
Logic Gate ◽  
Graphene Quantum Dots ◽  
Truth Table ◽  
Schematic Diagram ◽  
Label Free ◽  
Emission Signal ◽  
Molecular Logic Gate ◽  
Molecular Logic ◽  
Dual Detection

(A) Schematic diagram of the interaction and dual detection of Cu2+ and MPG by means of fluorescence “on–off–on” switching. (B) Molecular logic gate and truth table constructed based on Cu2+ and MPG as inputs and emission signal as output.

A Molecular Logic Gate Enables Super-Resolved Imaging of Intracellular Lipid Droplets

2019 ◽  
Author(s):  
Adam Eördögh ◽  
Carolina Paganini ◽  
Dorothea Pinotsi ◽  
Paolo Arosio ◽  
Pablo Rivera-Fuentes
Keyword(s):  
Single Molecule ◽  
Lipid Droplets ◽  
Neutral Lipids ◽  
Logic Gate ◽  
Living Cells ◽  
Three Dimensions ◽  
Single Molecule Imaging ◽  
Molecular Logic Gate ◽  
Molecular Logic ◽  
Cellular Compartments

<div>Photoactivatable dyes enable single-molecule imaging in biology. Despite progress in the development of new fluorophores and labeling strategies, many cellular compartments remain difficult to image beyond the limit of diffraction in living cells. For example, lipid droplets, which are organelles that contain mostly neutral lipids, have eluded single-molecule imaging. To visualize these challenging subcellular targets, it is necessary to develop new fluorescent molecular devices beyond simple on/off switches. Here, we report a fluorogenic molecular logic gate that can be used to image single molecules associated with lipid droplets with excellent specificity. This probe requires the subsequent action of light, a lipophilic environment and a competent nucleophile to produce a fluorescent product. The combination of these requirements results in a probe that can be used to image the boundary of lipid droplets in three dimensions with resolutions beyond the limit of diffraction. Moreover, this probe enables single-molecule tracking of lipids within and between droplets in living cells.</div>

Boolean operations mediated by an ion-pair receptor of a multi-readout molecular logic gate

2013 ◽  
Vol 49 (94) ◽  
pp. 11056 ◽  
Author(s):  
Raúl Gotor ◽  
Ana M. Costero ◽  
Salvador Gil ◽  
Margarita Parra ◽  
Pablo Gaviña ◽  
...  
Keyword(s):  
Logic Gate ◽  
Ion Pair ◽  
Boolean Operations ◽  
Molecular Logic Gate ◽  
Molecular Logic

Recent advances in molecular logic gate chemosensors based on luminescent metal organic frameworks

2021 ◽  
Author(s):  
Bei Li ◽  
Dongsheng Zhao ◽  
Feng Wang ◽  
Xiaoxian Zhang ◽  
Wenqian Li ◽  
...  
Keyword(s):  
Logic Gate ◽  
Metal Organic Frameworks ◽  
Logic Gates ◽  
Design Strategies ◽  
Molecular Logic Gate ◽  
Future Developments ◽  
Molecular Logic ◽  
Molecular Logic Gates ◽  
Recent Advances ◽  
Metal Organic

This review covers the latest advancements of molecular logic gates based on LMOF. The classification, design strategies, related sensing mechanisms, future developments, and challenges of LMOFs-based logic gates are discussed.

A fluorescent colorimetric azo dye based chemosensor for detection of S2− in perfect aqueous solution and its application in real sample analysis and building a molecular logic gate

2018 ◽  
Vol 10 (20) ◽  
pp. 2317-2326 ◽  
Author(s):  
Amit Kumar Manna ◽  
Jahangir Mondal ◽  
Rukmani Chandra ◽  
Kalyani Rout ◽  
Goutam Kumar Patra
Keyword(s):  
Aqueous Solution ◽  
Schiff Base ◽  
Azo Dye ◽  
Color Change ◽  
Logic Gate ◽  
Real Sample ◽  
Sample Analysis ◽  
Real Sample Analysis ◽  
Molecular Logic Gate ◽  
Molecular Logic

A fluorescent-colorimetric azo dye based bis-Schiff base chemosensor, L, has been developed. L can selectively detect S2− through a color change from yellow to orange in perfect aqueous solution by deprotonation mechanism.

A Label-Free Fluorescent AND Logic Gate Aptasensor for Carbohydrate Antigen 15-3 Detection Based on Graphene Oxide

2021 ◽  
Vol 24 ◽  
Author(s):  
Wenxiao Hu ◽  
Yafei Dong ◽  
Luhui Wang ◽  
Yue Wang ◽  
Mengyao Qian ◽  
...  
Keyword(s):  
Fluorescent Dyes ◽  
Logic Gate ◽  
High Sensitivity ◽  
Carbohydrate Antigen ◽  
Fluorescence Signal ◽  
Label Free ◽  
Molecular Logic ◽  
Long Stem ◽  
Middle Ring ◽  
Fluorescent Aptasensor

Background: Molecular logic gate always used fluorescent dyes to realize fluorescence signal. The labeling of the fluorophore is relatively expensive, low yield and singly labeled impuritiesaffects the affinity between the target and the aptamer. Label-free fluorescent aptamer biosensor strategy has attracted widespread interest due to lower cost and simple. Objective: Herein, we have designed a AND logic gate fluorescent aptasensor for detecting carbohydrate antigen 15-3(CA15-3) based on label-free fluorescence signal output. Materials and Methods: A hairpin DNA probe consists of CA15-3 aptamer and partly anti-CA15-3 aptamer sequences as a long stem and G-rich sequences of the middle ring as a quadruplex-forming oligomer. G-rich sequences can fold into a quadruplex by K+, and then G-quadruplex interacts specifically with N-methylmesoporphyrin IX(NMM), leading to a dramatic increase in fluorescence of NMM. With CA15-3 and NMM as the two inputs, the fluorescence intensity of the NMM is the output signal. Lacking of CA15-3 or NMM, there is no significant fluorescence enhancing, and the output of the signal is “0”. The fluorescence signal was dramatically increasing and the output of the signal is “1” only when CA15-3 protein and NMM were added at the same time. Results: This biosensor strategy possessed selectivity, high sensitivity for detecting CA15-3 protein from 10 to 500 U mL-1 and the detection limit was 10 U mL-1, and also showed good reproducibility in spiked human serum. Conclusion: In summary, the proposed AND logic gate fluorescent aptasensor could specifically detect CA15-3.

Triazole-appended pyrano[2,3-c]pyrazolone based colorimetric chemosensors for recognition of Fe3+ ions and their molecular logic gate behavior

2019 ◽  
Vol 11 (25) ◽  
pp. 3230-3243 ◽  
Author(s):  
Harshita Jain ◽  
Nidhi Deswal ◽  
Ankita Joshi ◽  
C. N. Ramachandran ◽  
Rakesh Kumar
Keyword(s):  
Logic Gate ◽  
Practical Applications ◽  
Molecular Logic Gate ◽  
Molecular Logic

Two novel triazole-appended pyrano[2,3-c]pyrazolone based colorimetric and reversible chemosensors have been synthesized for recognition of Fe3+ ions for practical applications.

Sign in / Sign up

Export Citation Format

Share Document