Radiation-assisted metal ion interference tumor therapy by barium peroxide-based nanoparticles

2019 ◽  
Vol 6 (5) ◽  
pp. 1034-1040 ◽  
Author(s):  
Meng Zhang ◽  
Bo Shen ◽  
Ruixue Song ◽  
Han Wang ◽  
Bin Lv ◽  
...  
Keyword(s):  
Metal Ion ◽  
Biological Effects ◽  
Tumor Therapy ◽  
Therapy Strategy ◽  
Barium Peroxide

In this paper, we report the ion interference tumor therapy strategy by employing the specific biological effects of Ba2+ ions.

Photoactive conjugated polymer/graphdiyne nanocatalyst for CO2 reduce into CO in living cells for hypoxia tumor treatment

2021 ◽  
Author(s):  
Endong Zhang ◽  
Zicheng Zuo ◽  
Wen Yu ◽  
Hao Zhao ◽  
Shengpeng Xia ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Conjugated Polymer ◽  
Tumor Therapy ◽  
Living Cells ◽  
Tumor Treatment ◽  
Treatment Efficiency ◽  
Therapy Strategy ◽  
Co Gas

Carbon monoxide (CO) gas therapy has grown to be an emerging tumor therapy strategy to avoid low treatment efficiency of photodynamic therapy (PDT) caused by the hypoxia tumor microenvironment. However,...

Metal Ion Release after Hip and Knee Arthroplasty – Causes, Biological Effects and Diagnostics

2019 ◽  
Vol 158 (04) ◽  
pp. 369-382 ◽  
Author(s):  
Jörg Lützner ◽  
Klaus-Peter Günther ◽  
Anne Postler ◽  
Michael Morlock
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Biological Effects ◽  
Ion Concentration ◽  
Blood Levels ◽  
Ceramic Head ◽  
Ion Release ◽  
Imaging Results ◽  
Metal Ion Release ◽  
Metal Metal

AbstractAll metal implants in human bodies corrode which results in metal ions release. This is not necessarily a problem and represents for most patients no hazard. However, if a critical metal ion concentration is exceeded, local or rarely systemic problems can occur. This article summarizes the mechanisms of metal ion release and its clinical consequences. Several situations can result in increased metal ion release: metal-on-metal hip arthroplasties with increased wear, increased micromotion at taper interfaces, direct metal-metal contact (polyethylene wear, impingement), erroneously used metal heads after ceramic head fracture. Possible problems are in most cases located close to the concerned joint. Furthermore, there are reports about toxic damage to several organs. Most of these reports refer to erroneously used metal heads in revisions after a broken ceramic head. There is currently no evidence of carcinogenic or teratogenic effects of implants but data is not sufficient to exclude possible effects. Cobalt and chromium blood levels (favorably in whole blood) should be measured in patients with suspected elevated metal ions. According to current knowledge levels below 2 µg/l seem to be uncritical, levels between 2 and 7 µg/l are considered borderline with unknown biological consequences and levels above 7 µg/l indicate a local problem which should be further diagnosed. Metal ion levels always need to be interpreted together with clinical symptoms and imaging results.

scholarly journals Ultrasound microbubble contrast agent – carried chemotherapeutic drug microbubbles

2019 ◽  
Vol 131 ◽  
pp. 01015
Author(s):  
Junyang Song
Keyword(s):  
Contrast Agent ◽  
Biological Effects ◽  
Tumor Therapy ◽  
Development Prospect ◽  
Research Progress ◽  
Chemotherapeutic Drug ◽  
Invasive Treatment ◽  
Microbubble Contrast Agent ◽  
Chemotherapy Drugs ◽  
Non Invasive

With the continuous research and development of ultrasound microbubble contrast agent-carried chemotherapeutic drug microbubbles, ultrasound microbubble contrast agent not only facilitates the early detection and early diagnosis of tumors but also provides a new direction and development prospect for the drug delivery route. With a broad development prospect, it is expected to become a new safe, effective and non-invasive treatment. This paper reviews the biological effects and research progress of contrast-enhanced microbubble-loaded chemotherapy drugs in tumor therapy.

scholarly journals Cocktail Strategy Based on NK Cell-Derived Exosomes and Their Biomimetic Nanoparticles for Dual Tumor Therapy

Cancers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1560 ◽  
Author(s):  
Wang ◽  
Hu ◽  
Chen ◽  
Shou ◽  
Ye ◽  
...  
Keyword(s):  
Laser Scanning ◽  
Nk Cell ◽  
Imaging System ◽  
Tumor Therapy ◽  
Killer Cell ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Shell Nanoparticles ◽  
Therapy Strategy

Successful cancer therapy requires drugs being precisely delivered to tumors. Nanosized drugs have attracted considerable recent attention, but their toxicity and high immunogenicity are important obstacles hampering their clinical translation. Here we report a novel “cocktail therapy” strategy based on excess natural killer cell-derived exosomes (NKEXOs) in combination with their biomimetic core–shell nanoparticles (NNs) for tumor-targeted therapy. The NNs were self- assembled with a dendrimer core loading therapeutic miRNA and a hydrophilic NKEXOs shell. Their successful fabrication was confirmed by transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). The resulting NN/NKEXO cocktail showed highly efficient targeting and therapeutic miRNA delivery to neuroblastoma cells in vivo, as demonstrated by two-photon excited scanning fluorescence imaging (TPEFI) and with an IVIS Spectrum in vivo imaging system (IVIS), leading to dual inhibition of tumor growth. With unique biocompatibility, we propose this NN/NKEXO cocktail as a new avenue for tumor therapy, with potential prospects for clinical applications.

The Influence of Different Metal-Chelators on the Biological Profile of Nanoparticles for Gallium-68 Based Molecular Imaging

2012 ◽  
Vol 20 ◽  
pp. 21-31 ◽  
Author(s):  
Quinn K.T. Ng ◽  
Tatiana Segura ◽  
Anat Ben-Shlomo ◽  
Thomas Krause ◽  
Thomas L. Mindt ◽  
...  
Keyword(s):  
Surface Modification ◽  
Molecular Imaging ◽  
Metal Ion ◽  
Biological Effects ◽  
Metal Chelators ◽  
Biological Profile ◽  
Positron Emission ◽  
Pharmacokinetic Properties ◽  
Gallium 68 ◽  
Metal Ion Chelators

The use of metal chelators is becoming increasingly important in the development of new tracers for molecular imaging. With the rise of the field of nanotechnology, the fusion of both technologies has shown great potential for clinical applications. The pharmacokinetcs of nanoparticles can be monitored via positron emission tomography (PET) after surface modification and radiolabeling with positron emitting radionuclides. Different metal ion chelators can be used to facilitate labeling of the radionuclides and as a prerequisite, optimized radiolabeling procedure is necessary to prevent nanoparticle aggregation and degradation. However, the effects of chelator modification on nanoparticle pharmacokinetic properties have not been well studied and currently no studies to date have compared the biological effects of the use of different chelators in the surface modification of nanoparticles.

A Drug-Free Tumor Therapy Strategy: Cancer-Cell-Targeting Calcification

2016 ◽  
Vol 55 (17) ◽  
pp. 5225-5229 ◽  
Author(s):  
Ruibo Zhao ◽  
Ben Wang ◽  
Xinyan Yang ◽  
Yun Xiao ◽  
Xiaoyu Wang ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Tumor Therapy ◽  
Cell Targeting ◽  
Therapy Strategy ◽  
Cancer Cell Targeting ◽  
Drug Free

scholarly journals Significance of Elevated Blood Metal Ion Levels in Patients with Metal-on-Metal Prostheses: An Evaluation of Oxidative Stress Markers

2010 ◽  
Vol 4 (1) ◽  
pp. 221-227 ◽  
Author(s):  
Cathy Tkaczyk ◽  
Alain Petit ◽  
John Antoniou ◽  
David J Zukor ◽  
Maryam Tabrizian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metal Ion ◽  
Biological Effects ◽  
Redox Status ◽  
Heme Oxygenase 1 ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Metal On Metal ◽  
Significant Difference

It is widely known that cobalt and chromium ions can enhance the production of reactive oxygen species, known to be damaging to cells by disturbing their redox status and then generating oxidative stress. The aim of the present study was to determine if increased metal ion levels induce a state of oxidative stress in patients with metal-on-metal (MM) hip arthroplasty. Results indicated that there was no significant difference in the concentration of oxidative stress markers (total antioxidants, peroxides, and nitrated proteins) in the patients with MM bearings compared to patients without prostheses. The activity antioxidant enzymes was stable (catalase and glutathione peroxidase) or slightly decreased (superoxide dismutase and heme oxygenase-1) over time. This work is the first to determine the biological effects of metal ions released from MM hip implants with regards to mid-term systemic oxidative stress and showed that the increased levels of Co and Cr ions are not associated with significant oxidative stress damage in the plasma of patients with these implants.

scholarly journals Immune Checkpoint LAG3 and Its Ligand FGL1 in Cancer

2022 ◽  
Vol 12 ◽  
Author(s):  
An-Ping Shi ◽  
Xi-Yang Tang ◽  
Yan-Lu Xiong ◽  
Kai-Fu Zheng ◽  
Yu-Jian Liu ◽  
...  
Keyword(s):  
Immune Checkpoint ◽  
Immune Cell ◽  
Biological Effects ◽  
Tumor Therapy ◽  
Interaction Mechanism ◽  
Therapy Resistance ◽  
Comprehensive Overview ◽  
Intracellular Signals ◽  
Interaction Domains ◽  
Therapy Strategies

LAG3 is the most promising immune checkpoint next to PD-1 and CTLA-4. High LAG3 and FGL1 expression boosts tumor growth by inhibiting the immune microenvironment. This review comprises four sections presenting the structure/expression, interaction, biological effects, and clinical application of LAG3/FGL1. D1 and D2 of LAG3 and FD of FGL1 are the LAG3-FGL1 interaction domains. LAG3 accumulates on the surface of lymphocytes in various tumors, but is also found in the cytoplasm in non-small cell lung cancer (NSCLC) cells. FGL1 is found in the cytoplasm in NSCLC cells and on the surface of breast cancer cells. The LAG3-FGL1 interaction mechanism remains unclear, and the intracellular signals require elucidation. LAG3/FGL1 activity is associated with immune cell infiltration, proliferation, and secretion. Cytokine production is enhanced when LAG3/FGL1 are co-expressed with PD-1. IMP321 and relatlimab are promising monoclonal antibodies targeting LAG3 in melanoma. The clinical use of anti-FGL1 antibodies has not been reported. Finally, high FGL1 and LAG3 expression induces EGFR-TKI and gefitinib resistance, and anti-PD-1 therapy resistance, respectively. We present a comprehensive overview of the role of LAG3/FGL1 in cancer, suggesting novel anti-tumor therapy strategies.

scholarly journals Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma

2021 ◽  
Vol 9 ◽  
Author(s):  
Chaopei Zhou ◽  
Xiuxiu Dong ◽  
Chunxiang Song ◽  
Shuang Cui ◽  
Tiantian Chen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Tumor Cells ◽  
Immune Checkpoint ◽  
Targeted Delivery ◽  
Rational Design ◽  
Mixed Micelle ◽  
Tumor Therapy ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Therapy Strategy

The application of combinational therapy breaks the limitation of monotherapy and achieves better clinical benefit for tumor therapy. Herein, a hyaluronic acid/Pluronic F68-based copolymer-mixed micelle was constructed for targeted delivery of chemotherapeutical agent docetaxel (PHDM) in combination with programmed cell death ligand-1(PD-L1) antibody. When PHDM+anti-PDL1 was injected into the blood system, PHDM could accumulate into tumor sites and target tumor cells via CD44-mediated endocytosis and possess tumor chemotherapy. While anti-PDL1 could target PD-L1 protein expressed on surface of tumor cells to the immune checkpoint blockade characteristic for tumor immunotherapy. This strategy could not only directly kill tumor cells but also improve CD8+ T cell level and facilitate effector cytokines release. In conclusion, the rational-designed PHDM+anti-PDL1 therapy strategy creates a new way for tumor immune-chemotherapy.

Biocorrosion Studies of Gold and Rhodium Ion Implanted Titanium and Ti-6Al-4V Alloy

1987 ◽  
Vol 110 ◽  
Author(s):  
In-Seop Lee ◽  
R. A. Buchanan ◽  
J. M. Williams
Keyword(s):  
Corrosion Resistance ◽  
Noble Metal ◽  
Metal Ion ◽  
Noble Metals ◽  
Driving Forces ◽  
Biological Effects ◽  
Surface Modifications ◽  
Degradation Rates ◽  
Ion Implanted

AbstractConcern continues over the possible long-term biological effects of corrosion products released by degradation of metallic surgical implant materials in the human body. One approach to improve long-term biological performance involves surface modifications to significantly reduce degradation rates. Fundamentally, the elements with lowest driving forces (lowest ΔG functions) for corrosion in aqueous solutions over a wide pH range are the noble metals. With regard to surface-modifications, one of the most effective methods is through ion implantation.In the present on-going study, static in vitro corrosion properties of noble-metal ion-implanted surgical Ti-6Al-4V and commercially-pure(CP) Ti are being investigated in nonpassivating acid and passivating saline solutions. It was postulated that during the early stages of corrosion (or during a corrosion pretreatment) the implanted noble metal would enrich at the surface and significantly reduce subsequent corrosion rates. Thus far, the effects of ion-implanted Au and Rh have been studied, with mixed results. The Au implanted material yielded early benefits, but the enhanced corrosion resistance deteriorated with time, probably because the Au, during the enrichment stage, was not adequately adherent to the substrate. On the other hand, the observed behavior for the Rh implanted material appeared to follow the postulated mechanism, with both initial and time-dependent improvements in corrosion resistance.

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