A near-infrared biothiol-specific fluorescent probe for cancer cell recognition

The Analyst ◽  
2019 ◽  
Vol 144 (16) ◽  
pp. 4750-4756 ◽  
Author(s):  
Li Liu ◽  
Rui-Jie Lv ◽  
Jong-Kai Leung ◽  
Qian Zou ◽  
Yue Wang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Cancer Cell ◽  
Cancer Diagnosis ◽  
Near Infrared ◽  
Great Promise ◽  
Cell Recognition ◽  
Normal Cells

A novel near-infrared biothiol-specific fluorescent probe can discriminate cancer cells from normal cells showing great promise for cancer diagnosis.

Amphiphilic fluorescent probe self-encored in plasma to detect pH fluctuations in cancer cell membranes

2021 ◽  
Author(s):  
Arup Podder ◽  
Manu M. Joseph ◽  
Shayeri Biswas ◽  
Sanjib Samanta ◽  
Kaustabh K. Maiti ◽  
...  
Keyword(s):  
Cell Surface ◽  
Cancer Cells ◽  
Fluorescent Probe ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Normal Cells ◽  
Turn On ◽  
Ph Fluctuations

Newly developed an amphiphilic “turn-on” fluorescent probe (P1CS) enables to distinguish of cancer cells from normal cells through mapping of pH fluctuations in cell-surface.

A copper-mediated on–off–on gold nanocluster for endogenous GSH sensing to drive cancer cell recognition

2019 ◽  
Vol 7 (13) ◽  
pp. 2169-2176 ◽  
Author(s):  
Hemiao Zhao ◽  
Xiangping Wen ◽  
Wenyan Li ◽  
Yingqi Li ◽  
Caixia Yin
Keyword(s):  
Tumor Cells ◽  
Cancer Cell ◽  
Cancer Diagnosis ◽  
Potential Application ◽  
Selective Detection ◽  
Cell Recognition ◽  
Gold Nanocluster ◽  
Normal Cells ◽  
Great Potential Application

The AuNCs@Tf-Cu2+system for the sensitive and selective detection of endogenous glutathione (GSH) can illuminate tumor cells rather than normal cells, which implied its great potential application in cancer diagnosis.

A near-infrared fluorescent probe for accurately diagnosing cancer by sequential detection of cysteine and H+

2021 ◽  
Author(s):  
Zun-Pan She ◽  
Wen-Xin Wang ◽  
Guo-Jiang Mao ◽  
Wen-Li Jiang ◽  
Zhi-Qing Wang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Sequential Detection ◽  
Normal Cells

A near-infrared fluorescent probe, CyAc, is synthesized for accurately diagnosing cancer in vivo by sequential detection of Cys and H+. CyAc can not only discriminate normal cells and cancer cells, but also distinguish normal mice from tumor mice.

A fluorescent probe for simultaneously sensing NTR and hNQO1 and distinguishing cancer cells

2019 ◽  
Vol 7 (43) ◽  
pp. 6822-6827 ◽  
Author(s):  
Fanpeng Kong ◽  
Ying Li ◽  
Chao Yang ◽  
Xiao Li ◽  
Junlin Wu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Normal Cells

A dual-enzyme-responsive probe, CNN, was rationally designed and synthesized for differentiating cancer cells from normal cells owing to the existence of relatively high endogenous levels of both biomarkers in cancer cells.

A novel water-soluble fluorescent probe with ultra-sensitivity over a wider pH range and its application for differentiating cancer cells from normal cells

The Analyst ◽  
2019 ◽  
Vol 144 (23) ◽  
pp. 6975-6980 ◽  
Author(s):  
Zilu Li ◽  
Chen Yu ◽  
Yanan Chen ◽  
Zihan Zhuang ◽  
Bin Tian ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Water Soluble ◽  
Normal Cells ◽  
Ph Range

A water-soluble fluorescent probe with ultra-sensitivity over a wider pH range was developed to differentiate cancer cells from normal cells.

scholarly journals Selective imaging and cancer cell death via pH switchable near-infrared fluorescence and photothermal effects

2016 ◽  
Vol 7 (9) ◽  
pp. 5995-6005 ◽  
Author(s):  
Jingye Zhang ◽  
Zining Liu ◽  
Peng Lian ◽  
Jun Qian ◽  
Xinwei Li ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Ph Changes ◽  
Cancer Cell Death ◽  
Photothermal Effects

A theranostic probe is designed that specifically illuminates and photoablates cancer cells by sensing pH changes in the lysosomes and mitochondria.

scholarly journals Pulsed Magnetic Fields Cause hes1 and hsa-Circ-0068530 Expression Changes in Gastric Cancer Cell Line and Human Normal Fibroblast Cell Line

2021 ◽  
Vol 12 (3) ◽  
Author(s):  
Fereshteh Mansoury ◽  
Soheila Abdi ◽  
Nahid Babaei ◽  
Maliheh Entezari ◽  
Abbas Doosti ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Magnetic Flux ◽  
Cancer Cells ◽  
Cell Line ◽  
Electromagnetic Fields ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Normal Cells

Background: In recent years, the relationship between cancer cells and electromagnetic radiation has received much attention. Objectives: The present study aimed to evaluate the effects of different intensities of electromagnetic fields on gastric cancer cell lines (AGS). Methods: After preparing AGS and Hu02 (normal) cell lines, they were exposed to magnetic flux densities of 0.25, 0.5, 1, and 2 millitesla (mT) for 18 h. The cell viability was studied by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The expression levels of hes1 and hsa-circ-0068530 RNAs were studied by the quantitative Real-time-PCR technique. Results: The inhibition of gastric cancer cell line growth was observed under the influence of electromagnetic fields at different intensities. However, they did not affect the viability of normal cells. A sharp increase in the expression of hes1 and hsa-circ-0068530 genes was observed in normal cells exposed to 2 mT electromagnetic fields. Conclusions: In general, it can be concluded that the effect of electromagnetic fields on gastric cancer cells depends on their intensity. Magnetic flux densities of 0.25 and 0.5 mT had anti-cancer effects and magnetic flux density of 2 mT showed carcinogenic effects.

scholarly journals Overview on the Side Effects of Doxorubicin

2020 ◽  
Author(s):  
Chittipolu Ajaykumar
Keyword(s):  
Side Effects ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cytotoxic Effect ◽  
Molecular Mechanisms ◽  
Current Understanding ◽  
Preventive Strategies ◽  
Normal Cells ◽  
Dna Strand

Doxorubicin is an anthracycline antibiotic extracted from the bacterium Streptomyces peucetius. Its cytotoxic effect produced by intercalating with DNA causing breakdown of DNA strand which causes cancer cell apoptosis. Despite being an effective anticancer agent it causes several crucial side effects like carditoxicity, neuropathy, hepatotoxicity, nephrotoxicity, alopecia, typhlitis, myelosuppression, neutropenia, anaemia, thrombocytopenia, nausea, and diarrhoea were caused mainly due to the inability to distinguish between cancer cells and normal cells. This chapter mainly focuses on doxorubicin’s side effects, current understanding of the molecular mechanisms, and management and preventive strategies of doxorubicin’s cardiotoxicity during the treatment of various type of cancer.

scholarly journals A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Bei-Bei Zhang ◽  
Jun-gang Liu ◽  
Xian-Yu Bai ◽  
Yuan-Jiao Huang ◽  
Ning Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cancer Diagnosis ◽  
Drug Exposure ◽  
Fluorescent Dye ◽  
Cancer Cell Proliferation ◽  
Ros Production

Development of multiple agents has a significant impact on the cancer diagnosis and therapy. Several fluorescent dyes including near-infrared (NIR) fluorescent agents have been already well studied in the field of photodynamic therapy (PDT). In the present study, we reported a novel fluorescent dye could obviously inhibit cancer cell proliferation with slight toxic effects on the biological organism. Furthermore, it displayed selective staining on cancer cells, particularly on cancer stem cells (CSCs), rather than normal cells. Mechanically, this dye preferred to invading mitochondria of cancer cells and inducing overwhelming reactive oxygen species (ROS) production. The in vivo experiments further demonstrated that this dye could image cancer cells and even CSCs in a short-time intratumor injection manner using a zebrafish model and subsequently inhibit cancer cell proliferation after a relatively long-time drug exposure. Taken together, the future development of this agent will promise to make an essential contribution to the cancer diagnosis and therapeutics.

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