scholarly journals CLVII.—The root bark of Calotropis gigantea

1915 ◽  
Vol 107 (0) ◽  
pp. 1437-1442 ◽  
Author(s):  
Ernest George Hill ◽  
Annoda Prasad Sirkar
Keyword(s):  
Root Bark ◽  
Calotropis Gigantea

Hepatoprotective Activity of Calotropis gigantea Root Bark Experimental Liver Damage Induced by D-Galactosamine in Rats

1970 ◽  
Vol 1 (3) ◽  
pp. 281-286
Author(s):  
Pradeep Deshmukh ◽  
Tanaji Nandgude ◽  
Mahendra Singh Rathode ◽  
Anil Midha ◽  
Nitin Jaiswal
Keyword(s):  
Methyl Cellulose ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Root Bark ◽  
Significant Activity ◽  
Alcoholic Extract ◽  
Calotropis Gigantea ◽  
Wistar Albino Rats ◽  
Experimental Liver ◽  
Hepatoprotective Drug

The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carboxy methyl cellulose (CMC) were evaluated for hepatoprotective activity in Wistar albino rats by inducing hepatic injury with D-galactosamine (400 mg/kg). Alcoholic extract of root bark of the plant Calotropis gigantea at an oral dose of 200 mg/kg and 400 mg/kg exhibited a significant (P<0.001, P<0.01 and P<0.05) protection effect by normalizing the levels of aspartate amino transferase (ASAT/ GOT), alanine amino transferase (ALAT/GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), which were significantly (P<0.001) increased in rats by treatment with 400 mg/kg i.p. of D-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001).

Isolation of Stigmasterol and β-Sitosterol from Methanolic Extract of Root Bark of Calotropis gigantea (Linn)

2007 ◽  
Vol 10 (22) ◽  
pp. 4174-4176 ◽  
Author(s):  
M. Rowshanul ◽  
Farjana Nikkon . ◽  
Matiar Rahman . ◽  
M. Ekramul Haque . ◽  
M. Rezaul Karim .
Keyword(s):  
Methanolic Extract ◽  
Root Bark ◽  
Calotropis Gigantea

scholarly journals Antimicrobial Activity of Akanda (Calotropis gigantea L.) on Some Pathogenic Bacteria.

1970 ◽  
Vol 43 (3) ◽  
pp. 397-404 ◽  
Author(s):  
M Ashraful Alam ◽  
M Rowshanul Habib ◽  
Rarjana Nikkon ◽  
Matiar Rahman ◽  
M Rezaul Karim
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Ethyl Acetate ◽  
Petroleum Ether ◽  
Methanol Extract ◽  
Ethyl Acetate Fraction ◽  
Chloroform Fraction ◽  
Root Bark ◽  
Calotropis Gigantea ◽  
Petroleum Ether Fraction ◽  
Ether Fraction

The antibacterial activity of methanol extract from the root bark of Akanda (Calotropis gigantea L.) and its petroleum ether, chloroform and ethyl acetate fractions were investigated. Both of methanol extract and its chloroform fraction showed activity against Sarcina lutea, Bacillus megaterium and Pseudomonas aeruginosa. Petroleum ether fraction showed activity against Bacillus subtilis and Shigella sonnei whereas ethyl acetate fraction showed activity against Pseudomonas aeruginosa and Escherichia coli at 20ìg/disc, 30ìg/disc and 40ìg/disc doses. Among the tested materials, methanol extract and its chloroform fraction showed comparatively better results. Minimum inhibitory concentration (MIC) for methanol extract and each fraction were also determined by serial dilution technique. Keywords: Methanol extract, Akonda (Calotropis gigantea), Petroleum ether fraction, Chloroform fraction and Ethyl acetate fraction.   DOI = 10.3329/bjsir.v43i3.1156Bangladesh J. Sci. Ind. Res. 43(3), 397-404, 2008

scholarly journals Activity of Extracts and Procesterol from Calotropis gigantea against Entamoeba histolytica

2010 ◽  
Vol 5 (6) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Shailendra Singh ◽  
Neelam Bharti ◽  
Manoj Chugh ◽  
Fehmida Naqvi ◽  
Amir Azam
Keyword(s):  
Entamoeba Histolytica ◽  
Chromatographic Separation ◽  
Chloroform Extract ◽  
Root Bark ◽  
Inhibitory Effects ◽  
Calotropis Gigantea ◽  
Growth Inhibitory ◽  
Antiamoebic Activity

Extracts from the root bark of Calotropis gigantea were subjected to bioactivity-guided fractionation using growth inhibitory effects against Entamoeba histolytica. The n-hexane soluble portion of the chloroform extract showed in vitro antiamoebic activity against the HK-9 strain of Entamoeba histolytica. Chromatographic separation of the chloroform extract afforded the known compound, procesterol, which showed activity against E. histolytica.

Cytotoxic cardenolides from the root bark of Calotropis gigantea

Steroids ◽  
2013 ◽  
Vol 78 (10) ◽  
pp. 1029-1034 ◽  
Author(s):  
Hanyun You ◽  
Min Lei ◽  
Weibin Song ◽  
Hu Chen ◽  
Yuhui Meng ◽  
...  
Keyword(s):  
Root Bark ◽  
Calotropis Gigantea

Bioactivity guided isolation of oxypregnane-oligoglycosides (calotroposides) from the root bark of Calotropis gigantea as potent anticancer agents

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 104215-104226 ◽  
Author(s):  
Rohit Mahar ◽  
Shivani Dixit ◽  
Trapti Joshi ◽  
Sanjeev Kanojiya ◽  
Dipak K. Mishra ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
Ethanolic Extract ◽  
Root Bark ◽  
Calotropis Gigantea ◽  
Pure Compounds

Bioactivity guided isolation of oxypregnane-oligoglycosides (calotroposides) from the ethanolic extract of root bark of Calotropis gigantea (L.) Dryand. with purple flowers has been performed and isolated pure compounds has been evaluated for anticancer activity.

Wound healing activity of Calotropis gigantea root bark in rats

2009 ◽  
Vol 125 (1) ◽  
pp. 178-181 ◽  
Author(s):  
Pradeep T. Deshmukh ◽  
Jennifer Fernandes ◽  
Akarte Atul ◽  
Emmanuel Toppo
Keyword(s):  
Wound Healing ◽  
Root Bark ◽  
Calotropis Gigantea ◽  
Wound Healing Activity

scholarly journals Cytotoxicity and Antifungal Activities of Root Bark of Calotropis gigantea

2010 ◽  
Vol 2 (2) ◽  
pp. 38-41 ◽  
Author(s):  
M Rowshanul Habib ◽  
M Ashraful Alam ◽  
MA Haque ◽  
Farjana Nikkon ◽  
M Rezaul Karim
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Ethyl Acetate ◽  
Petroleum Ether ◽  
Trichoderma Harzianum ◽  
Brine Shrimp ◽  
Methanol Extract ◽  
Root Bark ◽  
Calotropis Gigantea ◽  
Penicillium Sp

In this study, methanol extract from the root bark of Calotropis gigantea L. and its petroleum ether (40°C-60°C), chloroform and ethyl acetate soluble fractions were tested for their cytotoxic activity against brine shrimp nauplii (Artemia salina, Leach) and for antifungal activity against Aspergillus flavus, Aspergillus niger, Penicillium sp and Trichoderma harzianum. Thin layer chromatography (TLC) screening showed that methanol extract and its different fractions contained different type compounds such as steroid, terpene, glycoside, heterocyclic and flavonoid. In brine shrimp lethality bioassay, it was found that chloroform fraction was highly cytotoxic (LD50 14.72 μg/ml) among the tested samples. Though methanol extract and ethyl acetate fraction have no activity against all the tested fungi but petroleum ether and chloroform fractions showed potent activity against Aspergillus niger, Penicillium sp, Trichoderma harzianum and Aspergillus niger, Trichoderma harzianum, respectively, in antifungal activity test.  Key words: Calotropis gigantea; Methanol extract; Antifungal activity; Cytotoxicty.DOI: 10.3329/sjps.v2i2.2187Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 38-41

scholarly journals Evaluation of effect of Calotropis gigantea root bark in some animal models of Wister albino rats

2021 ◽  
Vol 10 (7) ◽  
pp. 795
Author(s):  
Sujata Dudhgaonkar ◽  
Kavita M. Jaiswal ◽  
Pravin S. Uike ◽  
Latesh B. Raghute
Keyword(s):  
Animal Models ◽  
Antiinflammatory Activity ◽  
Diclofenac Sodium ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
Root Extract ◽  
Root Bark ◽  
Alcoholic Extract ◽  
Calotropis Gigantea ◽  
Anti Inflammatory

Background: Calotropis gigantea is a well-documented traditional medicinal plant useful for many disease conditions. The present study deals with the effect of alcoholic extract of roots bark of Calotropis gigantean in some animal models.Methods: Acute anti-inflammatory activity of root extract was assessed on carrageenin induced paw edema and chronic antiinflammatory activity on cotton pellet granuloma formation in rats and compared with standard diclofenac sodium. Antiasthmatic activity was assessed in histamine and actylcholine induced bronchoconstriction in guinea pigs.Results: 100 and 200 mg/kg p.o. root extract of CG showed significant anti-inflammatory and bronchodilator activity. Antiinflammatory activity was higher than Diclofenac Sodium 50mg/kg. The combination of low dose diclofenac sodium 25mg/kg potentiated the effect. Inhibitory effect on synthesis and release of various inflammatory mediators might contribute to both of these actions. Steroid like phytoconstituents might be responsible for these effects. Further research is needed to understand the exact mechanism behind these effects.Conclusions: In the present study Calotropis gigantea root bark exhibited anti-inflammatory activity in animal models. 

Calotropis gigantea- A Review

2021 ◽  
pp. 261-264
Author(s):  
Snehal Lad ◽  
Priya S. Rao ◽  
Dattaprasad N Vikhe
Keyword(s):  
Methanolic Extract ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
The Body ◽  
Perennial Herb ◽  
Root Bark ◽  
Nootropic Activity ◽  
Calotropis Gigantea ◽  
Traditional Medicines ◽  
History Of Use

Calotropis gigantea plant has a family Asclepiadaceae commonly and sub family Apocynaceae known as Madar in Hindi. It is a perennial herb with a very long history of use in traditional medicines. Calotropis gigantea is a hoary, laticiferous shrub, which is also known as “the milkweed”. Calotropis is used as a traditional medicinal plant in whole world. Calotropis gigantea plant contain chemical constituents in which cardenolides, flavonoids, terpenes, pregnanes and nonprotein amino acid and more in various concentration. The root bark contains α-amyrin, β-amyrin, taraxasterol and its ψ-isomer taraxasteryl isovalerate, taraxasteryl acetate, gigantin, giganteol, isogiganteol, β-sitosterol and wax. The rootalso shows Nootropic activity in methanolic extract. The latex, leaves, flowers and bark are used as caustic, acrid, expectorant, to removes body hairs, anthelmintics and alsoused in leprosy, ulceration, cough, scabies ring worm of the scalp, piles, explosion on the body, asthma, enlargement of spleen or liver, edema and in painful joint swellings. Also, evaluate possible anxiogenic effect, sedative action and anxiolytic potential of crude ethanolic extract of Calotropis gigantealeaf. Methanolic extract of Calotropis gigantea root used as memory increasing activity. This review gives an idea about its pharmacological activity and phytochemistry.

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