Calotropis gigantea- A Review

2021 ◽  
pp. 261-264
Author(s):  
Snehal Lad ◽  
Priya S. Rao ◽  
Dattaprasad N Vikhe
Keyword(s):  
Methanolic Extract ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
The Body ◽  
Perennial Herb ◽  
Root Bark ◽  
Nootropic Activity ◽  
Calotropis Gigantea ◽  
Traditional Medicines ◽  
History Of Use

Calotropis gigantea plant has a family Asclepiadaceae commonly and sub family Apocynaceae known as Madar in Hindi. It is a perennial herb with a very long history of use in traditional medicines. Calotropis gigantea is a hoary, laticiferous shrub, which is also known as “the milkweed”. Calotropis is used as a traditional medicinal plant in whole world. Calotropis gigantea plant contain chemical constituents in which cardenolides, flavonoids, terpenes, pregnanes and nonprotein amino acid and more in various concentration. The root bark contains α-amyrin, β-amyrin, taraxasterol and its ψ-isomer taraxasteryl isovalerate, taraxasteryl acetate, gigantin, giganteol, isogiganteol, β-sitosterol and wax. The rootalso shows Nootropic activity in methanolic extract. The latex, leaves, flowers and bark are used as caustic, acrid, expectorant, to removes body hairs, anthelmintics and alsoused in leprosy, ulceration, cough, scabies ring worm of the scalp, piles, explosion on the body, asthma, enlargement of spleen or liver, edema and in painful joint swellings. Also, evaluate possible anxiogenic effect, sedative action and anxiolytic potential of crude ethanolic extract of Calotropis gigantealeaf. Methanolic extract of Calotropis gigantea root used as memory increasing activity. This review gives an idea about its pharmacological activity and phytochemistry.

Isolation of Stigmasterol and β-Sitosterol from Methanolic Extract of Root Bark of Calotropis gigantea (Linn)

2007 ◽  
Vol 10 (22) ◽  
pp. 4174-4176 ◽  
Author(s):  
M. Rowshanul ◽  
Farjana Nikkon . ◽  
Matiar Rahman . ◽  
M. Ekramul Haque . ◽  
M. Rezaul Karim .
Keyword(s):  
Methanolic Extract ◽  
Root Bark ◽  
Calotropis Gigantea

Bioactivity guided isolation of oxypregnane-oligoglycosides (calotroposides) from the root bark of Calotropis gigantea as potent anticancer agents

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 104215-104226 ◽  
Author(s):  
Rohit Mahar ◽  
Shivani Dixit ◽  
Trapti Joshi ◽  
Sanjeev Kanojiya ◽  
Dipak K. Mishra ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
Ethanolic Extract ◽  
Root Bark ◽  
Calotropis Gigantea ◽  
Pure Compounds

Bioactivity guided isolation of oxypregnane-oligoglycosides (calotroposides) from the ethanolic extract of root bark of Calotropis gigantea (L.) Dryand. with purple flowers has been performed and isolated pure compounds has been evaluated for anticancer activity.

scholarly journals Evaluation of phytochemical compounds in Corbichonia decumbens (Frossk). Excell by using Gas Chromatography – Mass Spectrometry

2019 ◽  
Vol 4 (3) ◽  
pp. 89
Author(s):  
M.S. Sri Saranya ◽  
A. Arunprasath
Keyword(s):  
Organic Solvent ◽  
Methanolic Extract ◽  
Ethanolic Extract ◽  
Gas Chromatography Mass Spectrometry ◽  
Phytochemical Analysis ◽  
Traditional Medicines ◽  
Organic Solvent Extraction ◽  
Soxhlet Apparatus ◽  
Phytochemical Compounds ◽  
Extraction Solvents

The aim of the present study was to investigate the presence of phytochemical compounds and GCMS analysis of Corbichonia decumbens. The Soxhlet apparatus was used for the organic solvent extraction. Solvents used were hexane and ethanol. The results showed in preliminary phytochemical analysis alkaloids, Flavonoids, Saponins, Glycosides, Steroids were observed in hexane and ethanolic extracts. The Phenols and Tanins were present only in ethanolic extract. The GC-MS analysis has shown the presence of different phytochemical compounds in the ethanolic extract Corbichonia decumbens. A total of 30 compounds were identified representing 84.49% of total methanolic extract composition. Our findings provided evidence that organic solvent extracts of tested plant contain medicinally important bioactive compounds and it justifies their use in the traditional medicines for the treatment of different diseases. 

scholarly journals Anti-Inflammatory and Anti-Microbial Potential of Plumbago zeylanica L.: A Review

2020 ◽  
Vol 10 (5-s) ◽  
pp. 229-235
Author(s):  
Mohd Aleem
Keyword(s):  
Chemical Constituents ◽  
Antimicrobial Properties ◽  
Root Bark ◽  
Plumbago Zeylanica ◽  
Traditional Medicines ◽  
Whole Plant ◽  
Perennial Shrub ◽  
Anti Inflammatory ◽  
Microbial Potential ◽  
Memory Enhancer

Plumbago zeylanica L. (Pz) is one of the most important medicinal plant belonging to the family Plumbaginaceae. It is a perennial shrub, growing throughout India and most places of Sri Lanka. It contains various bioactive compounds like alkaloids, flavonoids, naphthoquinones, glycoside, saponins, steroids, tri-terpenoids, coumarins, phenolic compounds etc. Of all the chemical constituents, plumbagin is the principal active compound. Plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone-C11H8O3) is primarily present in roots in higher amounts with only about 1% in the whole plant. The literature reveals that the root and root bark have a wider claim in traditional medicines against various diseases as a memory enhancer, anti-inflammatory, anti-microbial, wound healing, anti-malarial, anti-infertility, anticancer, blood coagulation, and anti-oxidant activities. The present study aims to evaluate the anti-inflammatory and antimicrobial properties of this plant. Keyword: Plumbago zeylanica; Sheetraj; Chitrak; Anti-inflammatory; Antimicrobial; Traditional uses

scholarly journals Acute Toxicity and Hepatotoxicity Evaluation of Methanol Extract of Root Bark of Calotropis gigantea in Rats

2018 ◽  
Vol 17 (2) ◽  
pp. 243-250
Author(s):  
Kartini Hasballah ◽  
Murniana Sarong ◽  
Renzavaldy Rusly ◽  
Karina Tantri ◽  
Vera Dewi Mulia
Keyword(s):  
Acute Toxicity ◽  
Rattus Norvegicus ◽  
Methanol Extract ◽  
Chemical Constituents ◽  
Hepatic Cell ◽  
Behavioral Changes ◽  
Root Extract ◽  
Root Bark ◽  
Safety Level ◽  
Calotropis Gigantea

Many studies of root extract of Calotropis gigantea have been done to prove its potential as anticancer, antimicrobial, etc. agent C. gigantea plant itself is very easy to grow in tropical countries. However, studies of acute toxicity of C. gigantea root extract has not been performed.The purpose of this research was to know the safety level, the chemical constituents, and the acute toxicity of methanol extract of C. gigantea root bark given orally on Rattus norvegicus in rats. C. gigantea root bark was extracted by using methanol. The methanol extract was suspended in 1% sodium carboxymethyl cellulose (CMC) and administered orally by gavage (1250, 2500 and 5000 mg/kg) in separate groups. On the day of fifteen, all animals were anesthetized and some selected vital organs were excised, weighed and macroscopically examined. The liver was assessed histopathologically. There were no lethal effects, behavioral changes and no significant change in body and organ weights compared to control after the administration of the extracts. Thus, the value of LD50 for oral administration of methanol extracts from root bark of C. gigantea was larger than 5000 mg/kg. Methanol extract of C. gigantea root bark must be considered safe enough as none of the rats were died along the study. But, it can damage the hepatic cell, if given in higher dose. Dhaka Univ. J. Pharm. Sci. 17(2): 243-250, 2018 (December)

In-vivo evaluation of lipid lowering ability of Chloris paraguaiensis extracts

2020 ◽  
Vol 7 (2) ◽  
pp. 21-24
Author(s):  
Pavani C H
Keyword(s):  
Medicinal Plants ◽  
Chemical Constituents ◽  
The Body ◽  
Lipid Lowering ◽  
Medical Systems ◽  
In Vivo Evaluation ◽  
Standard Drug ◽  
Anti Oxidant ◽  
And Control

Hyperlipidemia is the immediate results of the excessive fat intake in food. This results in the elevated levels of cholesterol and triglycerides in the blood. This leads to heart conditions like CAD, hypertension, congestive heart failure as risk factors which can be lethal. There are many drugs to treat and control the lipids levels in the body. These drugs are either designed to prevent LDL accumulation and VLDL synthesis. Some drugs also lower the elevated levels of saturated lipids in the body. But many drugs are known to cause side effects and adverse effects; therefore, alternatives to the drugs are the subjects for current investigations. Herbs and medicinal plants are used as treatment sources for many years. They have been used in the Indian medical systems like Ayurveda, Siddha etc. As the application of herbs in the treatment is growing, there is an urgent need for the establishment of Pharmacological reasoning and standardization of the activity of the medicinal plants. Chloris paraguaiensis Steud. is Poyaceae member that is called locally as Uppugaddi. Traditionally it is used to treat Rheumatism, Diabetes, fever and diarrhoea. The chemical constituents are known to have anti-oxidant properties and most of the anti-oxidants have anti-hyperlipidemic activity too. Since the plant has abundant flavonoid and phenol content, the current research focusses on the investigation of the anti-hyperlipidemic activity of the plant Chloris extracts. Extracts of Chloris at 200mg/kg showed a comparably similar anti hyperlipidemia activity to that of the standard drug. The extracts showed a dose based increase in the activity at 100 and 200mg/kg body weight.

Determination of Antioxidant Activities and Bioactive Components of Foeniculum vulgare Mill. (Samonsabar)

2019 ◽  
Vol 30 (3) ◽  
pp. 16-22
Keyword(s):  
Antioxidant Activities ◽  
Biological Activities ◽  
Scientific Information ◽  
Ethanolic Extract ◽  
The Body ◽  
World Health ◽  
Gas Chromatography Mass Spectrometry ◽  
Molecular Formula ◽  
Bioactive Components ◽  
Foeniculum Vulgare

World Health Organization (WHO) estimated that 80% of the population of developing countries use traditional medicines, mostly natural plant products, for their primary health care needs. In the past few decades, the medicinal value of plants has been assumed more important dimension owing largely to the discovery that extracts from plants contain not only primary metabolites but also a diverse array of secondary metabolites with antioxidant potential. Medicinal plants are potential sources of natural compounds with biological activities and therefore attract the attention of researchers worldwide. Antioxidants are vital substances which possess ability to protect the body from damage due to free radical-induced oxidative stress. The purpose of current study was to determine the antioxidant activities and bioactive components of Foeniculum vulgare (fennel) (Samonsabar) seeds by using UV Visible Spectrophotometer (UV-Vis) and Gas Chromatography-Mass Spectrometry (GC-MS). Aqueous extract of fennel seeds showed more antioxidant activity (IC50: 0.28 ug/ml) than ethanolic extract (IC50: 0.83 ug/ml) and comparable to standard antioxidant, ascorbic acid (IC50: 0.59 ug/ml). GC-MS analysis was fruitful in identification of compounds based on peak area, retention time, molecular formula, molecular weight, MS Fragmentions and pharmacological actions. Ten bioactive phytochemical compounds from aqueous extracts and 11 from ethanolic extract of fennel seeds were identified. These findings indicated that fennel seeds are potential to provide preventive properties against oxidative damage. These results will give scientific information for quality control of indigenous drug to herbal medicine users and local practitioners using fennel for different types of ailments

Hepatoprotective Activity of Calotropis gigantea Root Bark Experimental Liver Damage Induced by D-Galactosamine in Rats

1970 ◽  
Vol 1 (3) ◽  
pp. 281-286
Author(s):  
Pradeep Deshmukh ◽  
Tanaji Nandgude ◽  
Mahendra Singh Rathode ◽  
Anil Midha ◽  
Nitin Jaiswal
Keyword(s):  
Methyl Cellulose ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Root Bark ◽  
Significant Activity ◽  
Alcoholic Extract ◽  
Calotropis Gigantea ◽  
Wistar Albino Rats ◽  
Experimental Liver ◽  
Hepatoprotective Drug

The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carboxy methyl cellulose (CMC) were evaluated for hepatoprotective activity in Wistar albino rats by inducing hepatic injury with D-galactosamine (400 mg/kg). Alcoholic extract of root bark of the plant Calotropis gigantea at an oral dose of 200 mg/kg and 400 mg/kg exhibited a significant (P<0.001, P<0.01 and P<0.05) protection effect by normalizing the levels of aspartate amino transferase (ASAT/ GOT), alanine amino transferase (ALAT/GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), which were significantly (P<0.001) increased in rats by treatment with 400 mg/kg i.p. of D-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001).

Phytochemical, Pharmacological Activities and Ayurvedic Significances of Magical Plant Mimosa pudica Linn

2020 ◽  
Vol 17 ◽  
Author(s):  
Vijay Kumar
Keyword(s):  
Therapeutic Potential ◽  
Wide Spectrum ◽  
Chemical Constituents ◽  
Future Research ◽  
Mimosa Pudica ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Traditional Medicines ◽  
Crude Extracts ◽  
Anti Cancer

: Mimosa pudica Linn is an integrated part of Traditional Medicines Systems of India, China, Africa, Korea and America. It has been used from centuries in traditional medicines to cure different diseases like fever, diabetes, constipation, jaundice, ulcers, biliousness, and dyspepsia. It is an important ingredient of wide class of herbal formulations. To assess the scientific evidence for therapeutic potential of Mimosa pudica Linn and to identify the gaps for future research. The available information on the ethno-medicinal uses, phytochemistry, pharmacology and toxicology of Mimosa pudica Linn was collected via a library and electronic searches in Sci-Finder, Pub-Med, Science Direct, Google Scholar for the period, 1990 to 2020. In traditional medicinal systems, variety of ethno-medicinal applications of Mimosa pudica Linn has been noticed. Phytochemical investigation has resulted in identification of 40 well known chemical constituents, among which alkaloids, phenols and flavionoids are the predominant groups. The crude extracts and isolates have exhibited a wide spectrum of in vitro and in vivo pharmacological activities including anti-cancer, anti-inflammation, osteoporosis, neurological disorders, hypertension etc.. To quantify the Mimosa pudica Linn and its formulations, analytical techniques like HPLC and HPTLC has shown dominancy with good range of recovery and detection limit. Mimosa pudica Linn is the well-known herb since an ancient time. The pharmacological results supported some of the applications of Mimosa pudica Linn in traditional medicine systems. Perhaps, the predominance of alkaloids, phenols and flavionoids are responsible for the pharmacological activities the crude extracts and isolates of Mimosa pudica Linn. Further, there is need to isolate and evaluate the active chemical constituents of Mimosa pudica Linn having significant medicinal values. In future, it is important to study the exact mechanism associated with the phytochemicals of Mimosa pudica Linn especially on anti-cancer activities. Notably, toxicity studies on Mimosa pudica Linn are limited which are to be explored in future for the safe application of Mimosa pudica Linn and its formulations.

scholarly journals Ethnomedical uses, chemical constituents, and evidence-based pharmacological properties of Chenopodium ambrosioides L.: extensive overview

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Félicien Mushagalusa Kasali ◽  
Jonans Tusiimire ◽  
Justin Ntokamunda Kadima ◽  
Amon Ganafa Agaba
Keyword(s):  
Large Scale ◽  
Chemical Constituents ◽  
Main Body ◽  
Pharmacological Properties ◽  
Chenopodium Ambrosioides ◽  
Traditional Medicines ◽  
Plant Parts ◽  
Chemical Studies ◽  
Ethnomedicinal Uses ◽  
Significant Health

Abstract Background The Chenopodium genus is a plant family widely spread worldwide that includes various plant species reputed to possess several medicinal virtues in folk medicines. Chenopodium ambrosioides L. is among the most used plants in traditional medicines worldwide. This review aimed to highlight ethnomedicinal uses, phytochemical status, and pharmacological properties of C. ambrosioides L. Main body of the abstract The analysis of relevant data highlights various ethnomedicinal uses against human and veterinary diseases in forty countries. Most indications consisted of gastrointestinal tract dysfunctioning troubles and worms parasitemia. Around 330 chemical compounds have been identified in different plant parts, especially in its essential oil fractions (59.84%). However, only a few compounds—mainly monoterpenes and glycosides—have been isolated and characterized. Experimental pharmacological studies validated a large scale of significant health benefits. It appeared that many monoterpenes are antioxidant, insecticidal, trypanocidal, analgesic, antifungal, anti-inflammatory, anti-arthritic, acaricidal, amoebicidal, anthelmintic, anticancer, antibacterial, antidiabetic, antidiarrheal, antifertility, antifungal, anti-leishmanial, antimalarial, antipyretic, antisickling, antischistosomal, antiulcer, anxiolytic, immunomodulatory, molluscicidal, and vasorelaxant agents. Short conclusion Thus, the Chenopodium ambrosioides species necessitates further chemical studies to isolate and characterize new bioactive secondary metabolites and pharmacological investigations to precise the mechanisms of action before clinical trials.

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