Isolation of Stigmasterol and β-Sitosterol from Methanolic Extract of Root Bark of Calotropis gigantea (Linn)

2007 ◽  
Vol 10 (22) ◽  
pp. 4174-4176 ◽  
Author(s):  
M. Rowshanul ◽  
Farjana Nikkon . ◽  
Matiar Rahman . ◽  
M. Ekramul Haque . ◽  
M. Rezaul Karim .
Keyword(s):  
Methanolic Extract ◽  
Root Bark ◽  
Calotropis Gigantea

Calotropis gigantea- A Review

2021 ◽  
pp. 261-264
Author(s):  
Snehal Lad ◽  
Priya S. Rao ◽  
Dattaprasad N Vikhe
Keyword(s):  
Methanolic Extract ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
The Body ◽  
Perennial Herb ◽  
Root Bark ◽  
Nootropic Activity ◽  
Calotropis Gigantea ◽  
Traditional Medicines ◽  
History Of Use

Calotropis gigantea plant has a family Asclepiadaceae commonly and sub family Apocynaceae known as Madar in Hindi. It is a perennial herb with a very long history of use in traditional medicines. Calotropis gigantea is a hoary, laticiferous shrub, which is also known as “the milkweed”. Calotropis is used as a traditional medicinal plant in whole world. Calotropis gigantea plant contain chemical constituents in which cardenolides, flavonoids, terpenes, pregnanes and nonprotein amino acid and more in various concentration. The root bark contains α-amyrin, β-amyrin, taraxasterol and its ψ-isomer taraxasteryl isovalerate, taraxasteryl acetate, gigantin, giganteol, isogiganteol, β-sitosterol and wax. The rootalso shows Nootropic activity in methanolic extract. The latex, leaves, flowers and bark are used as caustic, acrid, expectorant, to removes body hairs, anthelmintics and alsoused in leprosy, ulceration, cough, scabies ring worm of the scalp, piles, explosion on the body, asthma, enlargement of spleen or liver, edema and in painful joint swellings. Also, evaluate possible anxiogenic effect, sedative action and anxiolytic potential of crude ethanolic extract of Calotropis gigantealeaf. Methanolic extract of Calotropis gigantea root used as memory increasing activity. This review gives an idea about its pharmacological activity and phytochemistry.

Hepatoprotective Activity of Calotropis gigantea Root Bark Experimental Liver Damage Induced by D-Galactosamine in Rats

1970 ◽  
Vol 1 (3) ◽  
pp. 281-286
Author(s):  
Pradeep Deshmukh ◽  
Tanaji Nandgude ◽  
Mahendra Singh Rathode ◽  
Anil Midha ◽  
Nitin Jaiswal
Keyword(s):  
Methyl Cellulose ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Root Bark ◽  
Significant Activity ◽  
Alcoholic Extract ◽  
Calotropis Gigantea ◽  
Wistar Albino Rats ◽  
Experimental Liver ◽  
Hepatoprotective Drug

The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carboxy methyl cellulose (CMC) were evaluated for hepatoprotective activity in Wistar albino rats by inducing hepatic injury with D-galactosamine (400 mg/kg). Alcoholic extract of root bark of the plant Calotropis gigantea at an oral dose of 200 mg/kg and 400 mg/kg exhibited a significant (P<0.001, P<0.01 and P<0.05) protection effect by normalizing the levels of aspartate amino transferase (ASAT/ GOT), alanine amino transferase (ALAT/GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), which were significantly (P<0.001) increased in rats by treatment with 400 mg/kg i.p. of D-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001).

scholarly journals CLVII.—The root bark of Calotropis gigantea

1915 ◽  
Vol 107 (0) ◽  
pp. 1437-1442 ◽  
Author(s):  
Ernest George Hill ◽  
Annoda Prasad Sirkar
Keyword(s):  
Root Bark ◽  
Calotropis Gigantea

scholarly journals The Triterpene Constituents of the Root Bark of a Hybrid between Morus alba L. and M. rotundiloba Koidz. and its Antityrosinase Activities

2007 ◽  
Vol 2 (4) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Nisakarn Pianwijanpong ◽  
Narongchai Pongpan ◽  
Leena Suntornsuk ◽  
Omboon Luanratana
Keyword(s):  
Betulinic Acid ◽  
Methanolic Extract ◽  
Limit Of Detection ◽  
Linear Regression Analysis ◽  
Morus Alba ◽  
Bark Extract ◽  
Root Bark ◽  
Limit Of Quantification ◽  
Linear Coefficient ◽  
Spectroscopic Analyses

Mulberry plants have various traditional uses in Thailand, China, Korea and Vietnam. Recently, the root bark of Morus alba L. is used as whitening ingredient in various skin preparations. This paper describes the isolation of two triterpenes from the root bark of a 5 years old hybrid between M. alba L. and M. rotundiloba Koidz., a mulberry sericulture NM60 which is widely grown in Thailand for tea and silk industries. Pentacyclic triterpenes, α-amyrin acetate and betulinic acid, were isolated and identified, their structures were elucidated on the basis of spectroscopic analyses. The antityrosinase activities were tested having the IC50 values of 1.57 mM and 0.50 mM respectively. A validated HPLC technique for betulinic acid was also reported. Linear regression analysis of betulinic acid fell within the range of 61.25-409.15 μg/mL with a linear coefficient of 0.9992. The percentage of recovery is in accordance with that specified by the USP. The limit of detection and limit of quantification were 14.7 and 61.25 μg/mL, respectively. The analysis of the crude methanolic extract revealed 0.14% w/w betulinic acid in the root bark. These findings promote the use of the root bark extract of Thai mulberry hybrid in whitening cosmetics using betulinic acid as a marker and promote further study for the development of antimelanoma agent.

scholarly journals Antidiarrheal activity of methanolic extract of the root bark of Cordia africana

2016 ◽  
Vol Volume 8 ◽  
pp. 53-59 ◽  
Author(s):  
Assefa Belay Asrie ◽  
Mohammedbrhan Abdelwuhab ◽  
Zewdneh Shewamene ◽  
Desalegn Asmelashe Gelayee ◽  
Getnet Mequanint Adinew ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Root Bark ◽  
Antidiarrheal Activity ◽  
Cordia Africana

Isoflavonoids from the Root Bark of Piscidia erythrina and a Note on the Structure of Piscidone

1989 ◽  
Vol 44 (11-12) ◽  
pp. 905-913 ◽  
Author(s):  
John L. Ingham ◽  
Satoshi Tahara ◽  
Seiji Shibaki ◽  
Junya Mizutani
Keyword(s):  
Methanolic Extract ◽  
Partial Characterization ◽  
Bark Extract ◽  
Root Bark ◽  
Chemical Methods ◽  
H Nmr

Abstract A methanolic extract of Piscidia erythrina root bark has been found to contain various isofla-vonoids including rotenone (rotenoid), lisetin (coum aronochrom one) and six known isoflavones (ichthynone, piscidone, piscerythrone, 2′-deoxypiscerythrone, 6′-prenylpiscerythrone and 3′,5′-diprenylgenistein). The extract additionally yielded three new 5-hydroxyisoflavones (piscery-thrinetin, 2′-hydroxypiscerythrinetin and isow ighteone) and a previously unreported coum arono­ chrom one (8-prenyl-lisetin). All four com pounds were identified using a com bination of spectro­ scopic (UV , MS, 1H NMR) and chemical methods. Although several other 5-hydroxyisoflavones were also isolated from the root bark extract, the quantities of each were sufficient only to permit their partial characterization. Structure 2 for piscidone has been confirmed by 1H NMR spectros­ copy.

scholarly journals Antimicrobial Activity of Akanda (Calotropis gigantea L.) on Some Pathogenic Bacteria.

1970 ◽  
Vol 43 (3) ◽  
pp. 397-404 ◽  
Author(s):  
M Ashraful Alam ◽  
M Rowshanul Habib ◽  
Rarjana Nikkon ◽  
Matiar Rahman ◽  
M Rezaul Karim
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Ethyl Acetate ◽  
Petroleum Ether ◽  
Methanol Extract ◽  
Ethyl Acetate Fraction ◽  
Chloroform Fraction ◽  
Root Bark ◽  
Calotropis Gigantea ◽  
Petroleum Ether Fraction ◽  
Ether Fraction

The antibacterial activity of methanol extract from the root bark of Akanda (Calotropis gigantea L.) and its petroleum ether, chloroform and ethyl acetate fractions were investigated. Both of methanol extract and its chloroform fraction showed activity against Sarcina lutea, Bacillus megaterium and Pseudomonas aeruginosa. Petroleum ether fraction showed activity against Bacillus subtilis and Shigella sonnei whereas ethyl acetate fraction showed activity against Pseudomonas aeruginosa and Escherichia coli at 20ìg/disc, 30ìg/disc and 40ìg/disc doses. Among the tested materials, methanol extract and its chloroform fraction showed comparatively better results. Minimum inhibitory concentration (MIC) for methanol extract and each fraction were also determined by serial dilution technique. Keywords: Methanol extract, Akonda (Calotropis gigantea), Petroleum ether fraction, Chloroform fraction and Ethyl acetate fraction.   DOI = 10.3329/bjsir.v43i3.1156Bangladesh J. Sci. Ind. Res. 43(3), 397-404, 2008

scholarly journals Activity of Extracts and Procesterol from Calotropis gigantea against Entamoeba histolytica

2010 ◽  
Vol 5 (6) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Shailendra Singh ◽  
Neelam Bharti ◽  
Manoj Chugh ◽  
Fehmida Naqvi ◽  
Amir Azam
Keyword(s):  
Entamoeba Histolytica ◽  
Chromatographic Separation ◽  
Chloroform Extract ◽  
Root Bark ◽  
Inhibitory Effects ◽  
Calotropis Gigantea ◽  
Growth Inhibitory ◽  
Antiamoebic Activity

Extracts from the root bark of Calotropis gigantea were subjected to bioactivity-guided fractionation using growth inhibitory effects against Entamoeba histolytica. The n-hexane soluble portion of the chloroform extract showed in vitro antiamoebic activity against the HK-9 strain of Entamoeba histolytica. Chromatographic separation of the chloroform extract afforded the known compound, procesterol, which showed activity against E. histolytica.

Cytotoxic cardenolides from the root bark of Calotropis gigantea

Steroids ◽  
2013 ◽  
Vol 78 (10) ◽  
pp. 1029-1034 ◽  
Author(s):  
Hanyun You ◽  
Min Lei ◽  
Weibin Song ◽  
Hu Chen ◽  
Yuhui Meng ◽  
...  
Keyword(s):  
Root Bark ◽  
Calotropis Gigantea

Bioactivity guided isolation of oxypregnane-oligoglycosides (calotroposides) from the root bark of Calotropis gigantea as potent anticancer agents

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 104215-104226 ◽  
Author(s):  
Rohit Mahar ◽  
Shivani Dixit ◽  
Trapti Joshi ◽  
Sanjeev Kanojiya ◽  
Dipak K. Mishra ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
Ethanolic Extract ◽  
Root Bark ◽  
Calotropis Gigantea ◽  
Pure Compounds

Bioactivity guided isolation of oxypregnane-oligoglycosides (calotroposides) from the ethanolic extract of root bark of Calotropis gigantea (L.) Dryand. with purple flowers has been performed and isolated pure compounds has been evaluated for anticancer activity.

Sign in / Sign up

Export Citation Format

Share Document