One-pot peptide cyclisation and surface modification of photosensitiser-loaded red blood cells for targeted photodynamic therapy

2021 ◽  
Author(s):  
Jacky Chu ◽  
Chihao Shao ◽  
Summer Y. Y. Ha ◽  
Wing-Ping Fong ◽  
Clarence Tsun Ting Wong ◽  
...  
Keyword(s):  
Surface Modification ◽  
Photodynamic Therapy ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Tumour Targeting ◽  
One Pot ◽  
Boron Dipyrromethene ◽  
Targeting Peptide ◽  
Targeted Photodynamic Therapy

We report herein a one-pot approach to cyclise a tumour-targeting peptide and conjugate it on the surface of red blood cells loaded with a boron dipyrromethene-based photosensitiser using a bifunctional...

Ruthenium(II) Conjugates of Boron-Dipyrromethene and Biotin for Targeted Photodynamic Therapy in Red Light

2019 ◽  
Vol 59 (1) ◽  
pp. 913-924
Author(s):  
Subhadeep Paul ◽  
Paramita Kundu ◽  
Utso Bhattacharyya ◽  
Aditya Garai ◽  
Ram Chandra Maji ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Red Light ◽  
Boron Dipyrromethene ◽  
Targeted Photodynamic Therapy

scholarly journals Diplatinum(II) Catecholate of Photoactive Boron-Dipyrromethene for Lysosome-Targeted Photodynamic Therapy in Red Light

2019 ◽  
Vol 58 (14) ◽  
pp. 9067-9075 ◽  
Author(s):  
Vanitha Ramu ◽  
Srishti Gautam ◽  
Paturu Kondaiah ◽  
Akhil R. Chakravarty
Keyword(s):  
Photodynamic Therapy ◽  
Red Light ◽  
Boron Dipyrromethene ◽  
Targeted Photodynamic Therapy

Facile one-pot synthesis of cyclic peptide-conjugated photosensitisers for targeted photodynamic therapy

2020 ◽  
Vol 56 (80) ◽  
pp. 11941-11944
Author(s):  
Jacky C. H. Chu ◽  
Caixia Yang ◽  
Wing-Ping Fong ◽  
Clarence T. T. Wong ◽  
Dennis K. P. Ng
Keyword(s):  
Photodynamic Therapy ◽  
Cyclic Peptide ◽  
One Pot ◽  
One Pot Synthesis ◽  
Synthetic Strategy ◽  
Targeted Photodynamic Therapy

A facile synthetic strategy for in situ cyclisation of peptides and conjugation with functional boron dipyrromethenes (BODIPYs) using a bifunctional linker is reported.

Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells

2021 ◽  
Author(s):  
Thibault J. Harmand ◽  
Novalia Pishesha ◽  
Fabian B. H. Rehm ◽  
Weiyi Ma ◽  
William B. Pinney ◽  
...  
Keyword(s):  
Surface Modification ◽  
Cell Surface ◽  
Red Blood Cells ◽  
Blood Cells ◽  
One Step

Loading and Unloading Properties of Encapsulated Methylene Blue in Silica Nanoparticles for Photodynamic Applications

2014 ◽  
Vol 1024 ◽  
pp. 292-295 ◽  
Author(s):  
Ghaseb N. Makhadmeh ◽  
Azlan Abdul Aziz ◽  
Khairunisak Abdul Razak
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Diffusion Process ◽  
Physical Properties ◽  
Red Blood Cells ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Target Area ◽  
Loading And Unloading

In this report, we discussed the physical properties of encapsulated Methylene Blue (MB) by Silica Nanoparticles (SiNPs) intended for photodynamic therapy application. The aim of this discussion is to determine the suitable concentration of MB which can be delivered to the target area. Results shows that the size of SiNP is not affected by the change in MB concentration from out-diffusion process even when the concentration of loaded MB were reduce by more than 50 percent. The applicability of the encapsulated MB in SiNP was demonstrated on Red Blood Cells (RBCs) and the results were compared to those obtained from naked MB.

scholarly journals Pyriplatin-Boron-Dipyrromethene Conjugates for Imaging and Mitochondria-Targeted Photodynamic Therapy

2018 ◽  
Vol 57 (22) ◽  
pp. 14374-14385 ◽  
Author(s):  
Md Kausar Raza ◽  
Srishti Gautam ◽  
Prodip Howlader ◽  
Arnab Bhattacharyya ◽  
Paturu Kondaiah ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Boron Dipyrromethene ◽  
Targeted Photodynamic Therapy

scholarly journals Photodynamic Inactivation of Candida albicans in Blood Plasma and Whole Blood

Antibiotics ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 221 ◽  
Author(s):  
Vera Sousa ◽  
Ana T. P. C. Gomes ◽  
Américo Freitas ◽  
Maria A. F. Faustino ◽  
Maria G. P. M. S. Neves ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Candida Albicans ◽  
Photodynamic Therapy ◽  
Blood Plasma ◽  
Red Blood Cells ◽  
Whole Blood ◽  
Blood Cells ◽  
Antimicrobial Photodynamic Therapy ◽  
Photodynamic Inactivation ◽  
Blood Components

The few approved disinfection techniques for blood derivatives promote damage in the blood components, representing risks for the transfusion receptor. Antimicrobial photodynamic therapy (aPDT) seems to be a promising approach for the photoinactivation of pathogens in blood, but only three photosensitizers (PSs) have been approved, methylene blue (MB) for plasma and riboflavin and amotosalen for plasma and platelets. In this study, the efficiency of the porphyrinic photosensitizer Tri-Py(+)-Me and of the porphyrinic formulation FORM was studied in the photoinactivation of Candida albicans in plasma and in whole blood and the results were compared to the ones obtained with the already approved PS MB. The results show that FORM and Tri-Py(+)-Me are promising PSs to inactivate C. albicans in plasma. Although in whole blood the inactivation rates obtained were higher than the ones obtained with MB, further improvements are required. None of these PSs had promoted hemolysis at the isotonic conditions when hemolysis was evaluated in whole blood and after the addition of treated plasma with these PSs to concentrates of red blood cells.

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