PEGylated AIEgen Molecular Probe for Hypoxia-Mediated Tumor Imaging and Photodynamic Therapy

2021 ◽  
Author(s):  
Jun Li ◽  
Wei Liu ◽  
Zhuhao Li ◽  
Yingcai Hu ◽  
Jinfeng Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Tumor Imaging ◽  
Fluorescence Emission ◽  
Molecular Probe ◽  
Enhanced Fluorescence ◽  
High Concentrations

Unlike the aggregation caused quenching (ACQ) and reduced singlet oxygen (1O2) production of traditional photosensitizers at high concentrations, AIEgen photosensitizers show enhanced fluorescence emission and photosensitization ability in the aggregated...

An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy

2016 ◽  
Vol 45 (33) ◽  
pp. 13021-13024 ◽  
Author(s):  
Sun Y. S. Chow ◽  
Pui-Chi Lo ◽  
Dennis K. P. Ng
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Fluorescence Emission ◽  
Oxygen Production ◽  
Enhanced Fluorescence ◽  
Acidic Environments

A novel self-quenched phthalocyanine tetramer has been prepared which can be activated in acidic environments, resulting in enhanced fluorescence emission and singlet oxygen production.

scholarly journals Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Mohammad Tavakkoli Yaraki ◽  
Min Wu ◽  
Eshu Middha ◽  
Wenbo Wu ◽  
Soroosh Daqiqeh Rezaei ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Enhancement Factor ◽  
Fluorescence Emission ◽  
Localized Surface Plasmon ◽  
Enhanced Fluorescence ◽  
Oxygen Generation ◽  
Image Guided ◽  
Singlet Oxygen Generation

AbstractDual-functional aggregation-induced photosensitizers (AIE-PSs) with singlet oxygen generation (SOG) ability and bright fluorescence in aggregated state have received much attention in image-guided photodynamic therapy (PDT). However, designing an AIE-PS with both high SOG and intense fluorescence via molecular design is still challenging. In this work, we report a new nanohybrid consisting of gold nanostar (AuNS) and AIE-PS dots with enhanced fluorescence and photosensitization for theranostic applications. The spectral overlap between the extinction of AuNS and fluorescence emission of AIE-PS dots (665 nm) is carefully selected using five different AuNSs with distinct localized surface plasmon (LSPR) peaks. Results show that all the AuNSs can enhance the 1O2 production of AIE-PS dots, among which the AuNS with LSPR peak at 585 nm exhibited the highest 1O2 enhancement factor of 15-fold with increased fluorescence brightness. To the best of our knowledge, this is the highest enhancement factor reported for the metal-enhanced singlet oxygen generation systems. The Au585@AIE-PS nanodots were applied for simultaneous fluorescence imaging and photodynamic ablation of HeLa cancer cells with strongly enhanced PDT efficiency in vitro. This study provides a better understanding of the metal-enhanced AIE-PS nanohybrid systems, opening up new avenue towards advanced image-guided PDT with greatly improved efficacy.

Cubic POSS engineering of photosensitizer-doped semiconducting polymer nanoparticles for enhanced fluorescence imaging and amplified photodynamic therapy

2020 ◽  
Vol 11 (44) ◽  
pp. 7035-7041
Author(s):  
Biqing Bao ◽  
Xue Zhai ◽  
Tianqi Liu ◽  
Peng Su ◽  
Luyao Zhou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Fluorescence Imaging ◽  
Polymer Nanoparticles ◽  
Enhanced Fluorescence ◽  
Semiconducting Polymer ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Semiconducting Polymer Nanoparticles

PorPOSSC12 -doped semiconducting polymer nanoparticles with simultaneously enhanced fluorescence brightness and amplified singlet oxygen generation ability were designed for imaging-guided photodynamic therapy.

scholarly journals Photosensitizer synergistic effects: D–A–D structured organic molecule with enhanced fluorescence and singlet oxygen quantum yield for photodynamic therapy

2018 ◽  
Vol 9 (8) ◽  
pp. 2188-2194 ◽  
Author(s):  
Jianhua Zou ◽  
Zhihui Yin ◽  
Peng Wang ◽  
Dapeng Chen ◽  
Jinjun Shao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Cancer Diagnosis ◽  
Organic Molecule ◽  
Synergistic Effects ◽  
Quantum Yields ◽  
Enhanced Fluorescence ◽  
Strong Fluorescence

Novel photosensitizers have been developed with high 1O2 quantum yields and strong fluorescence for cancer diagnosis and PDT.

scholarly journals Spermine and Spermidine Detection through Restricted Intramolecular Rotations in a Tetraphenylethylene Derivative

Chemosensors ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 8
Author(s):  
Mariana Barros ◽  
Samuel Ceballos ◽  
Pau Arroyo ◽  
José Antonio Sáez ◽  
Margarita Parra ◽  
...  
Keyword(s):  
Growth And Development ◽  
Fluorescence Enhancement ◽  
Fluorescence Emission ◽  
Molecular Probe ◽  
Theoretical Studies ◽  
Age Related ◽  
Phenyl Rings ◽  
Biogenic Polyamines ◽  
High Concentrations ◽  
Shed Light

Biogenic polyamines, especially spermine and spermidine, are associated with cell growth and development. These amines can be found at high concentrations in the tumor cells, tissues, and urine of cancer patients. In contrast, spermidine levels drop with age, and a possible connection between low endogenous spermidine concentrations and age-related deterioration has been suggested. Thus, the quantification of these amines in body fluids like urine could be used in the diagnosis of different pathological situations. Here a new fluorescent molecular probe based on a tetraphenylethylene derivative is reported. This probe is able to selectively detect these amines through the enhancement of the fluorescence emission of the resulting complex. This fluorescence enhancement may be related to restricted intramolecular rotations of TPE phenyl rings induced by the analyte. Theoretical studies were carried out to shed light on the observed selectivity. Finally, the detection of these amines in urine was performed with limits of detection of 0.70 µM and 1.17 µM for spermine and spermidine, respectively.

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Enhanced-Fluorescence of a Dye on DNA- assembled Gold Nano-Dimers Discriminated by Lifetime Correlation Spectroscopy

2017 ◽  
Author(s):  
Pedro M. R. Paulo ◽  
David Botequim ◽  
Agnieszka Jóskowiak ◽  
Sofia Martins ◽  
Duarte M. F. Prazeres ◽  
...  
Keyword(s):  
Single Molecule ◽  
Fluorescence Emission ◽  
Directed Assembly ◽  
Plasmon Mode ◽  
Correlation Spectroscopy ◽  
Enhanced Fluorescence ◽  
Detection Volume ◽  
Relaxation Component ◽  
Good Agreement ◽  
Confocal Detection

<div> <div> <div> <p>We have employed DNA-directed assembly to prepare dimers of gold nanoparticles and used their longitudinally coupled plasmon mode to enhance the fluorescence emission of an organic red-emitting dye, Atto-655. The plasmon- enhanced fluorescence of this dye using dimers of 80 nm particles was measured at single molecule detection level. The top enhancement factors were above 1000-fold in 71% of the dimers within a total of 32 dimers measured, and, in some cases, they reached almost 4000-fold, in good agreement with model simulations. Additionally, fluorescence lifetime correlation analysis enabled the separation of enhanced from non-enhanced emission simultaneously collected in our confocal detection volume. This approach allowed us to recover a short relaxation component exclusive to enhanced emission that is attributed to the interaction of the dye with DNA in the interparticle gaps. </p> </div> </div> </div>

Design of Novel Photosensitizers and Controlled Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Esra Tanrıverdi Eçik ◽  
Onur BULUT ◽  
Hasan Hüseyin Kazan ◽  
Elif Şenkuytu ◽  
Bunyemin Cosut
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Side Effect ◽  
Side Effect Profile ◽  
High Ability ◽  
Lower Side ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Promising Strategy

Photodynamic therapy (PDT) is a promising strategy in cancer treatment with its relatively lower side effect profile. Undoubtedly, the key component of PDT is the photosensitizers with a high ability...

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