scholarly journals Tumor targeting inorganic nanomaterials synthesized by living cells

2021 ◽  
Author(s):  
Yuzhu Yao ◽  
Dongdong Wang ◽  
Jun Hu ◽  
Xiangliang Yang
Keyword(s):  
Physicochemical Properties ◽  
Potential Application ◽  
Tumor Targeting ◽  
Living Cells ◽  
Inorganic Nanomaterials

Inorganic nanomaterials (NMs) have shown potential application in tumor targeting theranostics, owing to their unique physicochemical properties. Some living cells in nature can absorb surrounding ions in environment and then...

scholarly journals Characterization and influence of hydroxyapatite nanopowders on living cells

2018 ◽  
Vol 9 ◽  
pp. 3079-3094 ◽  
Author(s):  
Przemyslaw Oberbek ◽  
Tomasz Bolek ◽  
Adrian Chlanda ◽  
Seishiro Hirano ◽  
Sylwia Kusnieruk ◽  
...  
Keyword(s):  
Particle Size ◽  
Biological Activity ◽  
Physicochemical Properties ◽  
Living Cells ◽  
Great Promise ◽  
Medical Applications ◽  
Synthesis Methods ◽  
Hydroxyapatite Nanoparticles ◽  
Manufacturing Methods ◽  
The Impact

Nanomaterials, such as hydroxyapatite nanoparticles show a great promise for medical applications due to their unique properties at the nanoscale. However, there are concerns about the safety of using these materials in biological environments. Despite a great number of published studies of nanoobjects and their aggregates or agglomerates, the impact of their physicochemical properties (such as particle size, surface area, purity, details of structure and degree of agglomeration) on living cells is not yet fully understood. Significant differences in these properties, resulting from different manufacturing methods, are yet another problem to be taken into consideration. The aim of this work was to investigate the correlation between the properties of nanoscale hydroxyapatite from different synthesis methods and biological activity represented by the viability of four cell lines: A549, CHO, BEAS-2B and J774.1 to assess the influence of the nanoparticles on immune, reproductive and respiratory systems.

A tumor-targeting and lysosome-specific two-photon fluorescent probe for imaging pH changes in living cells

2017 ◽  
Vol 5 (5) ◽  
pp. 988-995 ◽  
Author(s):  
Baoli Dong ◽  
Xuezhen Song ◽  
Xiuqi Kong ◽  
Chao Wang ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Tumor Targeting ◽  
Living Cells ◽  
Lysosomal Ph ◽  
Ph Changes ◽  
Two Photon

Lysosomal pH is closely related to the metastasis and apoptosis of cancer cells.

scholarly journals Understanding Nanoparticle Toxicity to Direct a Safe-by-Design Approach in Cancer Nanomedicine

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2186 ◽  
Author(s):  
Jossana A. Damasco ◽  
Saisree Ravi ◽  
Joy D. Perez ◽  
Daniel E. Hagaman ◽  
Marites P. Melancon
Keyword(s):  
Heavy Metals ◽  
Physicochemical Properties ◽  
Tumor Targeting ◽  
Rational Design ◽  
Inorganic Materials ◽  
Cancer Therapies ◽  
Inorganic Nanoparticle ◽  
Treatment And Prevention ◽  
Cancer Nanomedicine ◽  
Safe By Design

Nanomedicine is a rapidly growing field that uses nanomaterials for the diagnosis, treatment and prevention of various diseases, including cancer. Various biocompatible nanoplatforms with diversified capabilities for tumor targeting, imaging, and therapy have materialized to yield individualized therapy. However, due to their unique properties brought about by their small size, safety concerns have emerged as their physicochemical properties can lead to altered pharmacokinetics, with the potential to cross biological barriers. In addition, the intrinsic toxicity of some of the inorganic materials (i.e., heavy metals) and their ability to accumulate and persist in the human body has been a challenge to their translation. Successful clinical translation of these nanoparticles is heavily dependent on their stability, circulation time, access and bioavailability to disease sites, and their safety profile. This review covers preclinical and clinical inorganic-nanoparticle based nanomaterial utilized for cancer imaging and therapeutics. A special emphasis is put on the rational design to develop non-toxic/safe inorganic nanoparticle constructs to increase their viability as translatable nanomedicine for cancer therapies.

Ionic liquids as modulators of physicochemical properties and nanostructures of sodium dodecyl sulfate in aqueous solutions and potential application in pesticide microemulsions

2016 ◽  
Vol 18 (43) ◽  
pp. 29797-29807 ◽  
Author(s):  
Jing Li ◽  
Tengfei Fan ◽  
Yong Xu ◽  
Xuemin Wu
Keyword(s):  
Ionic Liquids ◽  
Sodium Dodecyl Sulfate ◽  
Physicochemical Properties ◽  
Aqueous Solutions ◽  
Potential Application ◽  
Sodium Dodecyl ◽  
Dodecyl Sulfate

The change of morphology of ILs/SDS aggregates with increased concentration of ILs.

Tomás Torres’ research in a nutshell

2016 ◽  
Vol 20 (08n11) ◽  
pp. 966-986 ◽  
Author(s):  
Giovanni Bottari ◽  
Andrés de la Escosura ◽  
David González-Rodríguez ◽  
Gema de la Torre
Keyword(s):  
Organic Chemistry ◽  
Physicochemical Properties ◽  
Self Assembly ◽  
Potential Application ◽  
Synthetic Methods ◽  
65Th Birthday ◽  
Research Career

This review, dedicated to Professor Tomás Torres on the occasion of his 65th birthday, offers an overview of the main achievements in his research career. Having a strong background in organic chemistry, he and his group have constantly devoted much effort to the development of synthetic methods towards novel systems based on phthalocyanines and other porphyrinoid analogues. Not less important, the founding of solid collaborations with other prominent scientists has led to study the physicochemical properties of these [Formula: see text]-conjugated dyes, and to evaluate their potential application in multidisciplinary areas such as self-assembly, nanochemistry, optoelectronics and biomedicine.

scholarly journals The Rate of Proflavin Passage into Single Living Cells with Application to Permeability Studies

1960 ◽  
Vol 43 (4) ◽  
pp. 853-866 ◽  
Author(s):  
Elliott Robbins
Keyword(s):  
Tissue Culture ◽  
Physicochemical Properties ◽  
Single Cell ◽  
Uptake Rate ◽  
Living Cells ◽  
Dye Transport ◽  
Permeability Studies ◽  
Single Living Cells ◽  
Kinetics Of ◽  
Single Living

A technique for the measurement of the uptake rate of proflavin by the single cell in tissue culture has been developed, and the kinetics of the dye transport are discussed in terms of its physicochemical properties. Some applications of the technique to the study of permeability are given.

scholarly journals Biochemistry of fluoroprolines: the prospect of making fluorine a bioelement

2021 ◽  
Vol 17 ◽  
pp. 439-460
Author(s):  
Vladimir Kubyshkin ◽  
Rebecca Davis ◽  
Nediljko Budisa
Keyword(s):  
Amino Acids ◽  
Protein Expression ◽  
Physicochemical Properties ◽  
Protein Production ◽  
Living Cells ◽  
Evolutionary Methods ◽  
Hypothetical Scenario ◽  
Synthetic Cells ◽  
A Cell ◽  
Heterocyclic Structure

Due to the heterocyclic structure and distinct conformational profile, proline is unique in the repertoire of the 20 amino acids coded into proteins. Here, we summarize the biochemical work on the replacement of proline with (4R)- and (4S)-fluoroproline as well as 4,4-difluoroproline in proteins done mainly in the last two decades. We first recapitulate the complex position and biochemical fate of proline in the biochemistry of a cell, discuss the physicochemical properties of fluoroprolines, and overview the attempts to use these amino acids as proline replacements in studies of protein production and folding. Fluorinated proline replacements are able to elevate the protein expression speed and yields and improve the thermodynamic and kinetic folding profiles of individual proteins. In this context, fluoroprolines can be viewed as useful tools in the biotechnological toolbox. As a prospect, we envision that proteome-wide proline-to-fluoroproline substitutions could be possible. We suggest a hypothetical scenario for the use of laboratory evolutionary methods with fluoroprolines as a suitable vehicle to introduce fluorine into living cells. This approach may enable creation of synthetic cells endowed with artificial biodiversity, containing fluorine as a bioelement.

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