Ruthenium(II) complex containing cinnamic acid derivative inhibits cell cycle progression at G0/G1 and induces apoptosis in melanoma cells

2022 ◽  
Author(s):  
Amanda Negreti ◽  
Guilherme Álvaro Ferreira da Silva ◽  
Carolina G Pressete ◽  
Rafael Fonseca ◽  
Caio Cesar Candido ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Targeted Therapy ◽  
Skin Cancer ◽  
Tumor Cell ◽  
Cell Cycle Progression ◽  
Tumor Cell Lines ◽  
Cinnamic Acid Derivative ◽  
Cycle Progression ◽  
Apoptotic Effect ◽  
Malignant Tumor Cell

Melanoma is a highly aggressive skin cancer with limited targeted therapy arsenal. The Ruthenium-based complexes have shown interesting pro-apoptotic effect on malignant tumor cell lines. In this study three Ruthenium(II)...

Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines

1995 ◽  
Vol 36 (5) ◽  
pp. 411-417 ◽  
Author(s):  
Christophe J. Bergeron ◽  
Hirak S. Basu ◽  
Laurence J. Marton ◽  
Dennis F. Deen ◽  
Malgorzata Pellarin ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Brain Tumor ◽  
Tumor Cell ◽  
Human Brain ◽  
Cell Cycle Progression ◽  
Tumor Cell Lines ◽  
Human Brain Tumor ◽  
Cycle Progression ◽  
Brain Tumor Cell ◽  
Polyamine Analogs

Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly af fect growth, survival, and cell cycle progression in two human brain tumor cell lines

1995 ◽  
Vol 36 (5) ◽  
pp. 411-417 ◽  
Author(s):  
Christophe J. Bergeron ◽  
Hirak S. Basu ◽  
Laurence J. Marton ◽  
Dennis F. Deen ◽  
Malgorzata Pellarin ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Brain Tumor ◽  
Tumor Cell ◽  
Human Brain ◽  
Cell Cycle Progression ◽  
Tumor Cell Lines ◽  
Human Brain Tumor ◽  
Cycle Progression ◽  
Brain Tumor Cell ◽  
Polyamine Analogs

scholarly journals Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines

2010 ◽  
Vol 5 (1) ◽  
Author(s):  
Benjamin P Soule ◽  
Nicole L Simone ◽  
William G DeGraff ◽  
Rajani Choudhuri ◽  
John A Cook ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Cell ◽  
Cell Lines ◽  
Cell Cycle Progression ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Cycle Progression ◽  
Human Tumor Cell Lines

scholarly journals A Proteome-Wide CDK/CRK-Specific Kinase Inhibitor Promotes Tumor Cell Death in the Absence of Cell Cycle Progression

2005 ◽  
Vol 12 (10) ◽  
pp. 1103-1115 ◽  
Author(s):  
Maureen Caligiuri ◽  
Frank Becker ◽  
Krishna Murthi ◽  
Faith Kaplan ◽  
Severine Dedier ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Tumor Cell ◽  
Cell Cycle Progression ◽  
Kinase Inhibitor ◽  
Tumor Cell Death ◽  
Cycle Progression ◽  
Specific Kinase Inhibitor

Glucocorticoid Inhibition of 235-1 Rat Pituitary Tumor Cell Cycle Progression

Endocrine ◽  
2002 ◽  
Vol 17 (2) ◽  
pp. 119-128 ◽  
Author(s):  
Beverly C Delidow ◽  
Miranda Wang ◽  
Sonita V Bhamidipaty ◽  
Lynn D Black
Keyword(s):  
Cell Cycle ◽  
Tumor Cell ◽  
Pituitary Tumor ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Rat Pituitary ◽  
Pituitary Tumor Cell

scholarly journals Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas

Blood ◽  
2007 ◽  
Vol 110 (5) ◽  
pp. 1631-1638 ◽  
Author(s):  
Tint Lwin ◽  
Lori A. Hazlehurst ◽  
Sophie Dessureault ◽  
Raymond Lai ◽  
Wenlong Bai ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Adhesion ◽  
Tumor Cell ◽  
Ubiquitin Ligase ◽  
Cell Cycle Progression ◽  
Response To Therapy ◽  
G1 Arrest ◽  
Down Regulation ◽  
Cycle Progression ◽  
Mantle Cell

Abstract Mounting evidence suggests that dynamic interactions between a tumor and its microenvironment play a critical role in tumor development, cell-cycle progression, and response to therapy. In this study, we used mantle cell lymphoma (MCL) as a model to characterize the mechanisms by which stroma regulate cell-cycle progression. We demonstrated that adhesion of MCL and other non-Hodgkin lymphoma (NHL) cells to bone marrow stromal cells resulted in a reversible G1 arrest associated with elevated p27Kip1 and p21 (WAF1) proteins. The adhesion-mediated p27Kip1 and p21 increases were posttranslationally regulated via the down-regulation of Skp2, a subunit of SCFSkp2 ubiquitin ligase. Overexpression of Skp2 in MCL decreased p27Kip1, whereas inhibition of Skp2 by siRNA increased p27Kip1 and p21 levels. Furthermore, we found cell adhesion up-regulated Cdh1 (an activating subunit of anaphase-promoting complex [APC] ubiquitin ligase), and reduction of Cdh1 by siRNA induced Skp2 accumulation and hence p27Kip1 degradation, thus implicating Cdh1 as an upstream effector of the Skp2/p27Kip1 signaling pathway. Overall, this report, for the first time, demonstrates that cell-cell contact controls the tumor cell cycle via ubiquitin-proteasome proteolytic pathways in MCL and other NHLs. The understanding of this novel molecular pathway may prove valuable in designing new therapeutic approaches for modifying tumor cell growth and response to therapy.

scholarly journals Cell cycle progression data on human skin cancer cells with anticancer synthetic peptide LTX-315 treatment

Data in Brief ◽  
2020 ◽  
Vol 30 ◽  
pp. 105443 ◽  
Author(s):  
Gloria A. Santa-González ◽  
Edwin Patiño-González ◽  
Marcela Manrique-Moreno
Keyword(s):  
Cell Cycle ◽  
Skin Cancer ◽  
Cancer Cells ◽  
Human Skin ◽  
Synthetic Peptide ◽  
Cell Cycle Progression ◽  
Cycle Progression
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