Passive cancer targeting with a viral nanoparticle depends on the stage of tumorigenesis

Nanoscale ◽  
2021 ◽  
Author(s):  
Juan Zhang ◽  
Wenjing Zhang ◽  
Mengsi Yang ◽  
Weiwei Zhu ◽  
Ming Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Solid Tumors ◽  
Cancer Diagnosis ◽  
Tumor Targeting ◽  
Diagnosis And Treatment ◽  
Cancer Targeting ◽  
Promising Strategy ◽  
Nanoparticle Design ◽  
Viral Nanoparticle

Tumor targeting with nanoparticles is a promising strategy for cancer diagnosis and treatment, especially drug delivery to solid tumors. Previous studies mainly focused on nanoparticle design to improve their targeting...

Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

2019 ◽  
Vol 25 (37) ◽  
pp. 3917-3926
Author(s):  
Sajjad Molavipordanjani ◽  
Seyed Jalal Hosseinimehr
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Medical Imaging ◽  
Cancer Diagnosis ◽  
Carbon Nanoparticles ◽  
Tumor Targeting ◽  
Polymeric Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Active Targeting ◽  
Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

scholarly journals Recent Advances in pH- or/and Photo-Responsive Nanovehicles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 725
Author(s):  
Yuseon Shin ◽  
Patihul Husni ◽  
Kioh Kang ◽  
Dayoon Lee ◽  
Sehwa Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Design ◽  
Solid Tumors ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Efficacy And Safety ◽  
Stimulus Responsive ◽  
External Signals

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

A multifunctional PEG–PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery

2015 ◽  
Vol 3 (38) ◽  
pp. 7594-7603 ◽  
Author(s):  
Zhuxian Zhou ◽  
Jianbin Tang ◽  
Qihang Sun ◽  
William J. Murdoch ◽  
Youqing Shen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
High Stability ◽  
Cancer Targeting ◽  
Drug Conjugate ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Triggered Drug Release

Tumor-targeting camptothecin (CPT)-conjugated nanoparticles with high stability and GSH-triggered drug release were developed for cancer targeting drug delivery.

scholarly journals Advances in the use of nanocarriers for cancer diagnosis and treatment

2016 ◽  
Vol 14 (1) ◽  
pp. 99-103 ◽  
Author(s):  
Débora Braga Vieira ◽  
Lionel Fernel Gamarra
Keyword(s):  
Drug Delivery ◽  
Cancer Diagnosis ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Surface Engineering ◽  
Diagnosis And Treatment ◽  
Pharmacological Properties ◽  
Clinical Use ◽  
Targeted Drug ◽  
Future Work

ABSTRACT The use of nanocarriers as drug delivery systems for therapeutic or imaging agents can improve the pharmacological properties of commonly used compounds in cancer diagnosis and treatment. Advances in the surface engineering of nanoparticles to accommodate targeting ligands turned nanocarriers attractive candidates for future work involving targeted drug delivery. Although not targeted, several nanocarriers have been approved for clinical use and they are currently used to treat and/or diagnosis various types of cancers. Furthermore, there are several formulations, which are now in various stages of clinical trials. This review examined some approved formulations and discussed the advantages of using nanocarriers in cancer therapy.

Cancer nanomedicine: focus on recent developments and self-assembled peptide nanocarriers

2019 ◽  
Vol 7 (48) ◽  
pp. 7639-7655 ◽  
Author(s):  
Faisal Raza ◽  
Hajra Zafar ◽  
Xinru You ◽  
Asifullah Khan ◽  
Jun Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Diagnosis ◽  
Diagnosis And Treatment ◽  
Cancer Nanomedicine ◽  
Recent Developments ◽  
Self Assembled

The applications of nanoparticulate drug delivery have received abundant interest in the field of cancer diagnosis and treatment.

scholarly journals Tumor Targeting Strategies of Smart Fluorescent Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

2019 ◽  
Vol 31 (40) ◽  
pp. 1902409 ◽  
Author(s):  
Jiuyang He ◽  
Chenchen Li ◽  
Lin Ding ◽  
Yanan Huang ◽  
Xuelian Yin ◽  
...  
Keyword(s):  
Cancer Diagnosis ◽  
Tumor Targeting ◽  
Diagnosis And Treatment ◽  
Fluorescent Nanoparticles

scholarly journals Ex Vivo Identification of the Circulating Tumor Cells in Peripheral Blood by Fluorometric “Turn on” Aptamer-Nanoparticles

2021 ◽  
Author(s):  
Wenxi Xia ◽  
Xiaoyan Shangguan ◽  
Miao Li ◽  
Yang Wang ◽  
Dongmei Xi ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Diagnosis ◽  
Peripheral Blood ◽  
Ex Vivo ◽  
Diagnosis And Treatment ◽  
Turn On

The detection of the circulating tumor cells (CTCs) detached from solid tumors has emerged as a burgeoning topic for cancer diagnosis and treatment. The conventional CTCs enrichment and identification mainly...

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