Precision Photothermal Therapy and Photoacoustic Imaging by In Situ Activatable Thermoplasmonics

Phototherapy holds great promise for disease treatment; however, traditional “always-on” photoagents have been restricted for clinical translation due to nonspecific response and side effects on normal tissues. Here, we show...

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In situ formation of pH-responsive Prussian blue for photoacoustic imaging and photothermal therapy of cancer

RSC Advances ◽

10.1039/c7ra01879g ◽

2017 ◽

Vol 7 (30) ◽

pp. 18270-18276 ◽

Cited By ~ 6

Author(s):

Ming Cheng ◽

Wei Peng ◽

Peng Hua ◽

Zhengrong Chen ◽

Jia Sheng ◽

...

Keyword(s):

Prussian Blue ◽

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Ph Responsive ◽

Background Signal ◽

Normal Tissues ◽

Theranostic Agent ◽

In Situ Formation

Dual pH-responsive theranostic agent reduces the background signal in photoacoustic imaging and non-specific heating of normal tissues in photothermal therapy.

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Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair

Science Advances ◽

10.1126/sciadv.abb1311 ◽

2020 ◽

Vol 6 (32) ◽

pp. eabb1311

Author(s):

Lingling Ma ◽

Yanling Zhou ◽

Zhaowenbin Zhang ◽

Yaqin Liu ◽

Dong Zhai ◽

...

Keyword(s):

Photothermal Therapy ◽

Treatment Temperature ◽

Temperature Monitoring ◽

Tumor Treatment ◽

Treatment Technology ◽

Excessive Heat ◽

Normal Tissues ◽

Normal Tissue Damage ◽

Photothermal Property

Photothermal therapy (PTT), an emerging tumor treatment technology, has attracted tremendous interest, but excessive heat will cause damage to surrounding healthy tissues. Therefore, in situ temperature monitoring during PTT is of great importance to determine optimal treatment temperature and repair heat-damaged normal tissues. Here, we report the preparation of multifunctional Nd-Ca-Si silicate glasses and glass/alginate composite hydrogels that not only have photothermal property but also emit fluorescence under 808-nm laser irradiation, and its fluorescence intensity is linearly correlated with in situ temperature. With this feature, optimal PTT temperature for effective tumor treatment with minimal normal tissue damage can be obtained. In addition, because of the bioactive silicate components, the composite hydrogel has bioactivity to repair heat damage caused by PTT. This implantable multifunctional material with unique temperature monitoring, photothermal function, and wound healing bioactivity can be used for localized thermal therapy.

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In situ aqueous synthesis of genetically engineered polypeptide-capped Ag2S quantum dots for second near-infrared fluorescence/photoacoustic imaging and photothermal therapy

Journal of Materials Chemistry B ◽

10.1039/c8tb03043j ◽

2019 ◽

Vol 7 (15) ◽

pp. 2484-2492 ◽

Cited By ~ 8

Author(s):

Dong-Hui Zhao ◽

Xiao-Quan Yang ◽

Xiao-Lin Hou ◽

Yang Xuan ◽

Xian-Lin Song ◽

...

Keyword(s):

Quantum Dots ◽

Photothermal Therapy ◽

Near Infrared ◽

Photoacoustic Imaging ◽

Silver Sulfide ◽

Genetically Engineered ◽

Aqueous Synthesis ◽

Near Infrared Fluorescence ◽

Ag2s Quantum Dots

Polypeptide-engineering capped silver sulfide quantum dots were prepared and used for second near-infrared fluorescence and photoacoustic imaging, and the photothermal therapy of tumors.

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Feasibility Study of Photoacoustic Imaging for Monitoring Temperature in Photothermal Therapy

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.760-762.872 ◽

2013 ◽

Vol 760-762 ◽

pp. 872-875

Author(s):

Yu Bin Liu ◽

Zhi Fang Li ◽

Wen Ming Xie ◽

Hui Li ◽

Wei R. Chen ◽

...

Keyword(s):

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Signal Amplitude ◽

Photoacoustic Signal ◽

Therapeutic Procedure ◽

Temperature Changes ◽

Normal Tissues ◽

Temperature Diffusion ◽

Monitoring Temperature

Photothermal therapy relies on the principle of converting light energy into heat causing localized lesion destruction. For safe and effective treatment, it is necessary to monitor temperature diffusion in the boundaries of the irradiated region, to minimize damage to surrounding normal tissues. This paper gives a pilot study of the feasibility of photoacoustic imaging for monitoring temperature changes during photothermal therapy. The results showed that our system of photoacoustic imaging (PAI) can play the role of biosensor, for the photoacoustics signal amplitude depend on temperature of tissue-mimicking phantoms. Whats more, photoacoustic signal can determinate the boundary of photoabsorder-enhance tissue during therapeutic procedure.

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Recent advances in MoS2-based photothermal therapy for cancer and infectious disease treatment

Journal of Materials Chemistry B ◽

10.1039/d0tb01018a ◽

2020 ◽

Vol 8 (27) ◽

pp. 5793-5807

Author(s):

Jinping Shi ◽

Juan Li ◽

Yan Wang ◽

Jingjing Cheng ◽

Can Yang Zhang

Keyword(s):

Infectious Disease ◽

Side Effects ◽

Therapeutic Efficacy ◽

Photothermal Therapy ◽

Disease Treatment ◽

Recent Advances

MoS2-based PTT with high therapeutic efficacy and minimal side-effects could show potential for improving cancer and infectious disease treatments.

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Silicon nanowires decorated with gold nanoparticles via in situ reduction for photoacoustic imaging-guided photothermal cancer therapy

Journal of Materials Chemistry B ◽

10.1039/c9tb00147f ◽

2019 ◽

Vol 7 (28) ◽

pp. 4393-4401 ◽

Cited By ~ 3

Author(s):

Lina Sun ◽

Ying Chen ◽

Fei Gong ◽

Qian Dang ◽

Guangzhen Xiang ◽

...

Keyword(s):

Gold Nanoparticles ◽

Cancer Therapy ◽

Solid Tumors ◽

Silicon Nanowires ◽

Photothermal Therapy ◽

Near Infrared ◽

Photoacoustic Imaging ◽

In Situ Reduction ◽

Great Progress

Photothermal therapy (PTT) in the first near-infrared (NIR-I) window has made great progress in the treatment of solid tumors, while only a few PTT agents in the second NIR (NIR-II) region have been studied.

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RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near-Infrared Photoacoustic Imaging and Photothermal Therapy

Nano-Micro Letters ◽

10.1007/s40820-020-00429-x ◽

2020 ◽

Vol 12 (1) ◽

Cited By ~ 6

Author(s):

Dongye Zheng ◽

Peiwen Yu ◽

Zuwu Wei ◽

Cheng Zhong ◽

Ming Wu ◽

...

Keyword(s):

Photothermal Therapy ◽

Near Infrared ◽

Photoacoustic Imaging ◽

Reticuloendothelial System ◽

The Body ◽

Polymer Nanoparticles ◽

Infrared Light ◽

Great Promise ◽

Therapeutic Effects ◽

Immune Recognition

Abstract Semiconducting conjugated polymer nanoparticles (SPNs) represent an emerging class of phototheranostic materials with great promise for cancer treatment. In this report, low-bandgap electron donor–acceptor (D–A)-conjugated SPNs with surface cloaked by red blood cell membrane (RBCM) are developed for highly effective photoacoustic imaging and photothermal therapy. The resulting RBCM-coated SPN (SPN@RBCM) displays remarkable near-infrared light absorption and good photostability, as well as high photothermal conversion efficiency for photoacoustic imaging and photothermal therapy. Particularly, due to the small size (< 5 nm), SPN@RBCM has the advantages of deep tumor penetration and rapid clearance from the body with no appreciable toxicity. The RBCM endows the SPNs with prolonged systematic circulation time, less reticuloendothelial system uptake and reduced immune-recognition, hence improving tumor accumulation after intravenous injection, which provides strong photoacoustic signals and exerts excellent photothermal therapeutic effects. Thus, this work provides a valuable paradigm for safe and highly efficient tumor photoacoustic imaging and photothermal therapy for further clinical translation.

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Cancer Nanotheranostics: A Nanomedicinal Approach for Cancer Therapy and Diagnosis

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520619666190820145930 ◽

2020 ◽

Vol 20 (11) ◽

pp. 1288-1299

Author(s):

Paromita Kundu ◽

Deepika Singh ◽

Abhalaxmi Singh ◽

Sanjeeb K. Sahoo

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Cancer Diagnosis ◽

Specific Drug ◽

Novel Therapies ◽

Future Directions ◽

Normal Tissues ◽

Cancer Management ◽

Single Probe ◽

Therapy And Diagnosis

The panorama of cancer treatment has taken a considerable leap over the last decade with the advancement in the upcoming novel therapies combined with modern diagnostics. Nanotheranostics is an emerging science that holds tremendous potential as a contrivance by integrating therapy and imaging in a single probe for cancer diagnosis and treatment thus offering the advantage like tumor-specific drug delivery and at the same time reduced side effects to normal tissues. The recent surge in nanomedicine research has also paved the way for multimodal theranostic nanoprobe towards personalized therapy through interaction with a specific biological system. This review presents an overview of the nano theranostics approach in cancer management and a series of different nanomaterials used in theranostics and the possible challenges with future directions.

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