Feasibility Study of Photoacoustic Imaging for Monitoring Temperature in Photothermal Therapy

Photothermal therapy relies on the principle of converting light energy into heat causing localized lesion destruction. For safe and effective treatment, it is necessary to monitor temperature diffusion in the boundaries of the irradiated region, to minimize damage to surrounding normal tissues. This paper gives a pilot study of the feasibility of photoacoustic imaging for monitoring temperature changes during photothermal therapy. The results showed that our system of photoacoustic imaging (PAI) can play the role of biosensor, for the photoacoustics signal amplitude depend on temperature of tissue-mimicking phantoms. Whats more, photoacoustic signal can determinate the boundary of photoabsorder-enhance tissue during therapeutic procedure.

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CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES

Journal of Innovative Optical Health Sciences ◽

10.1142/s1793545813500296 ◽

2014 ◽

Vol 07 (01) ◽

pp. 1350029 ◽

Cited By ~ 13

Author(s):

JUNPING ZHONG ◽

SIHUA YANG

Keyword(s):

Indocyanine Green ◽

Contrast Agents ◽

Near Infrared ◽

Photoacoustic Imaging ◽

Signal Amplitude ◽

Photoacoustic Signal ◽

Infrared Wavelength ◽

Contrast Enhanced ◽

Human Use ◽

Good Contrast

Contrast agents are attracting a great deal of attention in photoacoustic imaging. Here we introduce an exogenous contrast agent that provides high photoacoustic signal amplitude at the near-infrared wavelength. Our agents consist of Indocyanine green (ICG) and phospholipid–polyethylene glycol (PL–PEG), entitled ICG–PL–PEG nanoparticles. These nanoparticles have overcome numerous limitations of ICG, such as poor aqueous stability, concentration-dependent aggregation and lack of target specificity. ICG–PL–PEG nanoparticles are biocompatible and relatively nontoxic. All the components of ICG–PL–PEG nanoparticles have been approved for human use. Upon pulsed laser irradiation, the nanoparticles are more efficient in producing photoacoustic waves than ICG alone. The results showed that ICG–PL–PEG nanoparticles act as good contrast agents for photoacoustic imaging. These unique ICG–PL–PEG nanoparticles have great potential in clinical applications.

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In situ formation of pH-responsive Prussian blue for photoacoustic imaging and photothermal therapy of cancer

RSC Advances ◽

10.1039/c7ra01879g ◽

2017 ◽

Vol 7 (30) ◽

pp. 18270-18276 ◽

Cited By ~ 6

Author(s):

Ming Cheng ◽

Wei Peng ◽

Peng Hua ◽

Zhengrong Chen ◽

Jia Sheng ◽

...

Keyword(s):

Prussian Blue ◽

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Ph Responsive ◽

Background Signal ◽

Normal Tissues ◽

Theranostic Agent ◽

In Situ Formation

Dual pH-responsive theranostic agent reduces the background signal in photoacoustic imaging and non-specific heating of normal tissues in photothermal therapy.

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A dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapy

Journal of Materials Chemistry B ◽

10.1039/c5tb02367j ◽

2016 ◽

Vol 4 (9) ◽

pp. 1696-1703 ◽

Cited By ~ 52

Author(s):

Shuo Huang ◽

Paul Kumar Upputuri ◽

Hui Liu ◽

Manojit Pramanik ◽

Mingfeng Wang

Keyword(s):

Small Molecules ◽

Photothermal Therapy ◽

Near Infrared ◽

Photoacoustic Imaging ◽

Photoacoustic Signal ◽

Colloidal Nanoparticles ◽

Theranostic Agent ◽

Dual Functional ◽

Narrow Bandgap ◽

Theranostic Agents

Colloidal nanoparticles of BBT-based narrow-bandgap small molecules as theranostic agents show a strong near-infrared photoacoustic signal and high photothermal conversion efficiency.

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Precision Photothermal Therapy and Photoacoustic Imaging by In Situ Activatable Thermoplasmonics

Chemical Science ◽

10.1039/d1sc02203b ◽

2021 ◽

Author(s):

Yahua Liu ◽

Fengye Mo ◽

Jialing Hu ◽

Qunying Jiang ◽

Xiuyuan Wang ◽

...

Keyword(s):

Side Effects ◽

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Clinical Translation ◽

Great Promise ◽

Disease Treatment ◽

Normal Tissues

Phototherapy holds great promise for disease treatment; however, traditional “always-on” photoagents have been restricted for clinical translation due to nonspecific response and side effects on normal tissues. Here, we show...

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NOB1: A Potential Biomarker or Target in Cancer

Current Drug Targets ◽

10.2174/1389450120666190308145346 ◽

2019 ◽

Vol 20 (10) ◽

pp. 1081-1089

Author(s):

Weiwei Ke ◽

Zaiming Lu ◽

Xiangxuan Zhao

Keyword(s):

Cancer Treatment ◽

Molecular Mechanisms ◽

Rna Binding ◽

Binding Protein ◽

Tumor Development ◽

Anticancer Therapy ◽

Research Progress ◽

Normal Tissues ◽

Potential Biomarker

Human NIN1/RPN12 binding protein 1 homolog (NOB1), an RNA binding protein, is expressed ubiquitously in normal tissues such as the lung, liver, and spleen. Its core physiological function is to regulate protease activities and participate in maintaining RNA metabolism and stability. NOB1 is overexpressed in a variety of cancers, including pancreatic cancer, non-small cell lung cancer, ovarian cancer, prostate carcinoma, osteosarcoma, papillary thyroid carcinoma, colorectal cancer, and glioma. Although existing data indicate that NOB1 overexpression is associated with cancer growth, invasion, and poor prognosis, the molecular mechanisms behind these effects and its exact roles remain unclear. Several studies have confirmed that NOB1 is clinically relevant in different cancers, and further research at the molecular level will help evaluate the role of NOB1 in tumors. NOB1 has become an attractive target in anticancer therapy because it is overexpressed in many cancers and mediates different stages of tumor development. Elucidating the role of NOB1 in different signaling pathways as a potential cancer treatment will provide new ideas for existing cancer treatment methods. This review summarizes the research progress made into NOB1 in cancer in the past decade; this information provides valuable clues and theoretical guidance for future anticancer therapy by targeting NOB1.

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PPM1G promotes the progression of hepatocellular carcinoma via phosphorylation regulation of alternative splicing protein SRSF3

Cell Death and Disease ◽

10.1038/s41419-021-04013-y ◽

2021 ◽

Vol 12 (8) ◽

Author(s):

Dawei Chen ◽

Zhenguo Zhao ◽

Lu Chen ◽

Qinghua Li ◽

Jixue Zou ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Alternative Splicing ◽

Protein Function ◽

Vital Role ◽

Normal Tissues ◽

Mechanistic Analysis ◽

Highly Correlated ◽

Splicing Patterns

AbstractEmerging evidence has demonstrated that alternative splicing has a vital role in regulating protein function, but how alternative splicing factors can be regulated remains unclear. We showed that the PPM1G, a protein phosphatase, regulated the phosphorylation of SRSF3 in hepatocellular carcinoma (HCC) and contributed to the proliferation, invasion, and metastasis of HCC. PPM1G was highly expressed in HCC tissues compared to adjacent normal tissues, and higher levels of PPM1G were observed in adverse staged HCCs. The higher levels of PPM1G were highly correlated with poor prognosis, which was further validated in the TCGA cohort. The knockdown of PPM1G inhibited the cell growth and invasion of HCC cell lines. Further studies showed that the knockdown of PPM1G inhibited tumor growth in vivo. The mechanistic analysis showed that the PPM1G interacted with proteins related to alternative splicing, including SRSF3. Overexpression of PPM1G promoted the dephosphorylation of SRSF3 and changed the alternative splicing patterns of genes related to the cell cycle, the transcriptional regulation in HCC cells. In addition, we also demonstrated that the promoter of PPM1G was activated by multiple transcription factors and co-activators, including MYC/MAX and EP300, MED1, and ELF1. Our study highlighted the essential role of PPM1G in HCC and shed new light on unveiling the regulation of alternative splicing in malignant transformation.

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Biodegradable Charge Transfer Complexes for Glutathione Depletion Induced Ferroptosis and NIR‐II Photoacoustic Imaging Guided Cancer Photothermal Therapy

Angewandte Chemie ◽

10.1002/ange.202014852 ◽

2021 ◽

Author(s):

Changjin Ou ◽

Weidan Na ◽

Wei Ge ◽

Han Huang ◽

Fan Gao ◽

...

Keyword(s):

Charge Transfer ◽

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Glutathione Depletion ◽

Charge Transfer Complexes

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Activation of MAT2A-RIP1 signaling axis reprograms monocytes in gastric cancer

Journal for ImmunoTherapy of Cancer ◽

10.1136/jitc-2020-001364 ◽

2021 ◽

Vol 9 (2) ◽

pp. e001364

Author(s):

Yan Zhang ◽

Hui Yang ◽

Jun Zhao ◽

Ping Wan ◽

Ye Hu ◽

...

Keyword(s):

Gastric Cancer ◽

Cell Metabolism ◽

Vital Role ◽

Methionine Metabolism ◽

Promoter Regions ◽

Normal Tissues ◽

Methionine Cycle

BackgroundThe activation of tumor-associated macrophages (TAMs) facilitates the progression of gastric cancer (GC). Cell metabolism reprogramming has been shown to play a vital role in the polarization of TAMs. However, the role of methionine metabolism in function of TAMs remains to be explored.MethodsMonocytes/macrophages were isolated from peripheral blood, tumor tissues or normal tissues from healthy donors or patients with GC. The role of methionine metabolism in the activation of TAMs was evaluated with both in vivo analyses and in vitro experiments. Pharmacological inhibition of the methionine cycle and modulation of key metabolic genes was employed, where molecular and biological analyses were performed.ResultsTAMs have increased methionine cycle activity that are mainly attributed to elevated methionine adenosyltransferase II alpha (MAT2A) levels. MAT2A modulates the activation and maintenance of the phenotype of TAMs and mediates the upregulation of RIP1 by increasing the histone H3K4 methylation (H3K4me3) at its promoter regions.ConclusionsOur data cast light on a novel mechanism by which methionine metabolism regulates the anti-inflammatory functions of monocytes in GC. MAT2A might be a potential therapeutic target for cancer cells as well as TAMs in GC.

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