scholarly journals Association between vitamin D receptor BsmI, FokI, and Cdx2 polymorphisms and osteoporosis risk: an updated meta-analysis

2020 ◽  
Vol 40 (7) ◽  
Author(s):  
Bin Chen ◽  
Wang-fa Zhu ◽  
Yi-yang Mu ◽  
Biao Liu ◽  
Hong-zhuo Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Biological Factors ◽  
Vdr Polymorphism ◽  
Bsmi Polymorphism ◽  
Positive Report ◽  
Meta Analyses ◽  
Osteoporosis Risk ◽  
Positive Results

Abstract Background: Many studies have reported the association between vitamin D receptor (VDR) polymorphism and osteoporosis risk. However, their results were conflicting. Six previous meta-analyses have been published to analyze VDR BsmI, FokI, and Cdx2 polymorphisms on osteoporosis risk. However, they did not evaluate the reliability of statistically significant associations. Furthermore, a lot of new articles have been published on these themes, and therefore an updated meta-analysis was performed to further explore these issues. Objectives: To explore the association between VDR BsmI, FokI, and Cdx2 polymorphisms polymorphisms and osteoporosis risk. Methods: The odds ratios (ORs) and 95% confidence intervals (95% CIs) were pooled to evaluate the association between VDR BsmI, FokI, and Cdx2 polymorphisms and osteoporosis risk. To evaluate the credibility of statistically significant associations, we applied the false-positive report probabilities (FPRPs) test and the Venice criteria. Results: Overall, statistically significantly increased osteoporosis risk was found in Indians and women for VDR FokI polymorphism. Statistically significantly decreased osteoporosis risk was found in West Asians for VDR BsmI polymorphism. However, when we performed a sensitivity analysis after excluding low quality and Hardy–Weinberg Disequilibrium (HWD) studies, significantly decreased osteoporosis risk was only found in overall population for VDR BsmI polymorphism. Further, less-credible positive results were identified when we evaluated the credibility of positive results. Conclusion: These positive findings should be interpreted with caution and indicate that significant association may most likely result from less-credible, rather than from true associations or biological factors on the VDR BsmI and FokI polymorphisms with osteoporosis risk.

Vitamin D Receptor BsmI Polymorphism and Osteoporosis Risk: A Meta-Analysis from 26 Studies

2013 ◽  
Vol 17 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Fu Jia ◽  
Rui-Fen Sun ◽  
Qun-Hui Li ◽  
Da-Xing Wang ◽  
Feng Zhao ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Bsmi Polymorphism ◽  
Osteoporosis Risk

scholarly journals Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Juan Li ◽  
Li Sun ◽  
Jinghui Sun ◽  
Min Yan
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Genetic Effect ◽  
Analysis Data ◽  
Case Control ◽  
Case Control Studies ◽  
Significant Difference ◽  
Meta Analyses ◽  
The Impact

Abstract Background The study aims at scientifically investigating the genetic effect of four polymorphisms (rs7975232, rs1544410, rs2228570, and rs731236) within the human Vitamin D Receptor (VDR) gene on the odds of psoriasis through an updated meta-analysis. Methods We searched eight databases and screened the studies for pooling. Finally, a total of eighteen eligible case-control studies were included. BH (Benjamini & Hochberg) adjusted P-values of association (Passociation) and odd ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated under the allele, homozygote, heterozygote, dominant, recessive, and carrier models. Results Compared with the negative controls, no statistically significant difference in the odds of psoriasis was detected for the cases under any genetic models (BH adjusted Passociation > 0.05). We also performed subgroup meta-analyses by the source of controls, ethnicity, country, Hardy-Weinberg equilibrium, and genotyping method. Similar results were observed in most subgroup meta-analyses (BH adjusted Passociation > 0.05). Besides, data of Begg’s and Egger’s tests excluded the significant publication bias; while the sensitivity analysis data further indicated the statistical reliability of our pooling results. Conclusion The currently available data fails to support a robust association between VDR rs7975232, rs1544410, rs2228570 and rs731236 polymorphisms and psoriasis susceptibility, which still required the support of more case-control studies.

Vitamin D Receptor BsmІ Polymorphism and Ovarian Cancer Risk: A Meta-Analysis

2013 ◽  
Vol 23 (7) ◽  
pp. 1178-1183 ◽  
Author(s):  
Xue Qin ◽  
Yu Lu ◽  
Aiping Qin ◽  
Zhiping Chen ◽  
Qiliu Peng ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Asian Population ◽  
European Population ◽  
Ovarian Cancer Risk ◽  
Bsmi Polymorphism ◽  
Inheritance Model ◽  
The Relationship

ObjectiveVitamin D receptor (VDR) FokI polymorphism has been reported to influence ovarian cancer (OC) susceptibility, but the association between VDR BsmI polymorphism and OC risk remains controversial. To clarify the relationship between them, we performed a meta-analysis.MethodsA comprehensive literature search was conducted to examine all the eligible studies of VDR BsmI polymorphism and OC risk. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to assess the strength of this association.ResultsSeven separate comparisons consisting of 1977 OC cases and 2832 healthy controls were included in our meta-analysis. The pooled analyses showed no significant association between VDR BsmI G/A polymorphism and OC in all of the comparisons (AA vs GG: OR, 1.01; P = 0.919; AG vs GG: OR, 1.12; P = 0.087; AG + AA vs GG: OR, 1.10; P = 0.146; AA vs AG + GG: OR, 0.96; P = 0.629). However, subgroup analysis showed a significant contribution of the dominant inheritance model to OC development in the European group: AG + AA vs GG (OR, 1.43; P = 0.029); AG vs GG (OR, 1.46; P = 0.031).ConclusionsVitamin D receptor BsmI G/A gene variant might be a moderate risk factor of OC development in the European population instead of North America or Asian population.

scholarly journals Association between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms with lung cancer risk: an updated meta-analysis

2020 ◽  
Vol 40 (9) ◽  
Author(s):  
Wen-Ping Zhang ◽  
Xiao-Feng He ◽  
Xiang-Hua Ye
Keyword(s):  
Lung Cancer ◽  
Meta Analysis ◽  
Combined Effects ◽  
Glutathione S Transferase ◽  
Increased Risk ◽  
Cyp1a1 Mspi ◽  
Discovery Probability ◽  
Positive Report ◽  
Meta Analyses ◽  
Positive Results

Abstract Background: Many studies have been performed to explore the combined effects of glutathione-S-transferase M1 (GSTM1) present/null and cytochrome P4501A1 (CYP1A1) MspI polymorphisms with lung cancer (LC) risk, but the results are contradictory. Two previous meta-analyses have been reported on the issue in 2011 and 2014. However, several new articles since then have been published. In addition, their meta-analyses did not valuate the credibility of significantly positive results. Objectives: We performed an updated meta-analysis to solve the controversy following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Methods: False-positive report probability (FPRP), Bayesian false discovery probability (BFDP), and the Venice criteria were used to verify the credibility of meta-analyses. Results: Twenty-three publications including 5734 LC cases and 7066 controls met the inclusion criteria in the present study. A significantly increased risk of LC was found in overall analysis, Asians and Indians. However, all positive results were considered as ‘less-credible’ when we used the Venice criteria, FPRP, and BFDP test to assess the credibility of the positive results. Conclusion: These positive findings should be interpreted with caution and results indicate that significant associations may be less-credible, there are no significantly increased LC risk between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms.

Unveiling the association between Vitamin D Receptor and Poly Cystic Ovary Syndrome – a systematic review and meta-analysis

2017 ◽  
Vol 87 (3-4) ◽  
pp. 207-218 ◽  
Author(s):  
Ritu Deswal ◽  
Smiti Nanda ◽  
Amita Suneja Dang
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Case Control Studies ◽  
Ovary Syndrome ◽  
Vdr Polymorphism ◽  
Cystic Ovary

Abstract. Background: Low Vitamin D status observed in the populations globally and its associations with diverse systems have kindled the interest for Vitamin D in medical literature in last two decades. Accumulating evidence manifest that deficiency of Vitamin D might be a causal factor in the pathogenesis of various features of Poly Cystic Ovary Syndrome (PCOS). This notion is supported by the fact that > 3 % of the human genome is regulated by vitamin D receptor (VDR). Therefore, this meta-analysis was carried out to quantify the magnitude of risk associated with VDR polymorphisms (BsmI, TaqI, FokI and ApaI) and PCOS susceptibility. Methods: Pub-med, EMBASE, Cochrane database, Science direct, Scirus, ISI web of knowledge and Google scholar were searched for all years until July 2016. The case control studies related to VDR polymorphism and PCOS risk were selected according to inclusion and exclusion criteria. Nine studies of the initial 553 hits reporting VDR polymorphism in PCOS were included. All statistical analysis was performed using the STATA 11.0 software and odd ratio with 95 % confidence intervals was used as effect size to assess the strength of associations. Results: Nine studies comprising 1558 cases and 1033 controls were included in this meta-analysis. Significant association between VDR Fok1 polymorphisms and PCOS risk was observed. In further stratified analysis, an increased risks were observed among Asian and African populations for Taq1 polymorphism. Apa1 and Bsm1 polymorphism was found not to be a risk factor for PCOS susceptibility. Conclusion: The FokI polymorphism is found to be a significant risk factor for PCOS.

BsmI polymorphism of vitamin D receptor gene and cancer risk: A comprehensive meta-analysis

2014 ◽  
Vol 769 ◽  
pp. 17-34 ◽  
Author(s):  
Sara Raimondi ◽  
Elena Pasquali ◽  
Patrizia Gnagnarella ◽  
Davide Serrano ◽  
Davide Disalvatore ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Bsmi Polymorphism
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