Iron Metabolism after Renal Transplantation

1973 ◽  
Vol 44 (1) ◽  
pp. 27-32 ◽  
Author(s):  
K. Boddy ◽  
G. Will ◽  
D. H. Lawson ◽  
Priscilla C. King ◽  
A. L. Linton
Keyword(s):  
Renal Failure ◽  
Renal Transplantation ◽  
Chronic Renal Failure ◽  
Iron Metabolism ◽  
Oral Absorption ◽  
Normal Subjects ◽  
The Body ◽  
Whole Body ◽  
The Mean

1. The oral absorption and the rate of loss from the body of radioactive iron were measured by whole-body monitoring in patients with functioning renal homografts. The incorporation of radioactive iron into erythrocytes was also measured. 2. The results were compared with corresponding values in normal subjects and in non-dialysed and dialysed patients with chronic renal failure. 3. The mean oral absorption and incorporation into erythrocytes of radioactive iron was intermediate between that of normal subjects and of both non-dialysed and dialysed patients with chronic renal failure. 4. The mean rate of loss from the body was not significantly different from that in normal subjects and non-dialysed patients with chronic renal failure but it was significantly less than that in dialysed patients.

Iron Metabolism in Patients with Chronic Renal Failure

1970 ◽  
Vol 39 (1) ◽  
pp. 115-121 ◽  
Author(s):  
K. Boddy ◽  
D. H. Lawson ◽  
A. L. Linton ◽  
G. Will
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Iron Deficiency ◽  
Iron Metabolism ◽  
Normal Subjects ◽  
The Body ◽  
Whole Body ◽  
Red Cell ◽  
Monitoring Technique

1. Iron metabolism has been investigated in patients suffering from chronic renal failure, using a whole body monitoring technique. 2. Absorption of labelled inorganic iron was decreased. 3. Radio-iron was lost from the body at a rate comparable to that found in normal subjects. 4. The red cell incorporation of radioactive iron was diminished. 5. The results suggest that anaemia in these patients was due to decreased erythropoiesis and not due to iron deficiency despite the evidence of markedly abnormal iron handling presented.

Iron Metabolism in Patients with Chronic Renal Failure on Regular Dialysis Treatment

1971 ◽  
Vol 41 (4) ◽  
pp. 345-351 ◽  
Author(s):  
D. H. Lawson ◽  
K. Boddy ◽  
P. C. King ◽  
A. L. Linton ◽  
G. Will
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Iron Metabolism ◽  
Oral Absorption ◽  
The Body ◽  
Whole Body ◽  
Dialysis Treatment ◽  
Regular Dialysis Treatment ◽  
Considerable Controversy

1. By using a whole-body monitoring technique iron metabolism has been investigated in patients suffering from chronic renal failure who required regular dialysis treatment. 2. Oral absorption of inorganic iron was low. 3. The incorporation of radioactive iron into erythrocytes was diminished. 4. The rate of loss of radioactive iron from the body was significantly greater than in normal control and non-dialysed patients with chronic renal failure. 5. Iron exchange between dialysate and patient was studied. Patients with chronic renal failure are known to have a decreased rate of erythropoiesis and to develop abnormalities in iron metabolism (Kaye, 1958; Logue, Lange & Moore, 1958; Boddy, Lawson, Linton & Will, 1970). However, considerable controversy exists about the effect of haemodialysis on iron metabolism in such patients (Shaldon, 1966; Eschbach, Funk, Adamson, Kuhn, Scribner & Finch, 1967; Eschbach, Cook & Finch, 1970). The use of a whole-body monitor permitted measurement in a single study of the oral absorption of a tracer dose of 59Fe, its incorporation into erythrocytes and the subsequent long-term rate of loss of 59Fe from the body. We have previously reported the results of an investigation of iron metabolism by using this method in patients with chronic renal failure (Boddy et al., 1970). We now report the results of a similar investigation of iron metabolism in patients with chronic renal failure undergoing regular haemodialysis therapy.

A radioimmunoassay for bone Gla protein (BGP) in human plasma

1987 ◽  
Vol 114 (3) ◽  
pp. 410-416 ◽  
Author(s):  
Julia S. Johansen ◽  
J. E. Mølholm Hansen ◽  
Claus Christiansen
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Human Plasma ◽  
Biochemical Marker ◽  
Normal Subjects ◽  
Bone Gla Protein ◽  
Low Concentrations ◽  
Metabolic Bone ◽  
The Mean ◽  
Bone Physiology

Abstract. To study the value of bone Gla protein (BGP) as a biochemical marker of normal bone physiology and metabolic bone disorders, we have developed a radioimmunoassay (RIA) for the detection of BGP in human plasma. Antibodies were generated in rabbits immunized with purified calf BGP conjugated to thyroglobulin. Human plasma BGP reacted identically with the calf BGP standard, thus demonstrating the suitability of the assay to measure plasma BGP levels in man. The RIA is sensitive, accurate, and technically simple. Plasma BGP levels were determined in normal subjects (N = 35) and in patients with hypothyroidism (N = 10), hyperthyroidism (N = 22) and chronic renal failure (N = 35). The mean (± 1 sem) concentration of plasma BGP in normal subjects was 1.27 ± 0.07 nmol/l. Plasma BGP was significantly increased in patients with hyperthyroidism, 4.04 ± 0.78 nmol/l (P < 0.001) and chronic renal failure, 10.17 ± 2.47 nmol/l (P < 0.001). Low concentrations were found in patients with hypothyroidism, 0.74 ± 0.11 nmol/l (P <0.01). Our studies indicate that plasma BGP provides a useful technique in the diagnosis of patients with bone disease.

scholarly journals P0953NITRIC OXIDE AND LEFT VENTRICULAR HYPERTROPHY IN PATIENTS WITH CHRONIC RENAL FAILURE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Leila Azouaou ◽  
Khelfi Abderrezak ◽  
Bellouti Wafa ◽  
Medina Arab
Keyword(s):  
Nitric Oxide ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Mean Value ◽  
Left Ventricular ◽  
The Body ◽  
Cardiac Complications ◽  
The Mean

Abstract Background and Aims Nitric oxide, nitric oxide, nitric oxide or NO is an endogenous molecule released by endothelial cells, macrophages, liver cells and neurons. There are three forms of nitric oxide synthase in the body. : the inducible form (iNO), the neuronal form and the endothelial form (eNO). In this work we are interested in (iNO) in patients with CKD and their impact on cardiac complications. Method A study of 202 patients with chronic renal failure at different stages (2.3.4.5 and 5D) was performed in our department. We investigated the correlation between mean (iNO) values in patients with CKD and its relationship with left ventricular hypertrophy. Results The mean age of the patients is 56.5 ± 17 years with a sex ratio of 1.43. The mean value of (iNO) is 65.82 ± 1.06 μmol / l. Its value increases significantly with the degradation of renal function (p &lt;0.05) (stage 2 (61.75 ± 2.34), stage 3 (63.91 ± 2.21). ), stage 4 (64.08 ± 2.18), stage 5 (67 ± 2.7) and stage 5D (72.47 ± 2.18μmol / l). It is found that the mean value of nitric oxide NO is slightly higher in patients with HVG + ( 67.58 ± 1.48) versus HVG-patients (63.1 ± 1.39) (p &lt;0.05).Discussion: iNOS secreted nitric oxide (NO) initiates cardiac remodeling to lead to left ventricular hypertrophy and cardiac fibrosis Conclusion Cardiac complications are the leading cause of death in patients with chronic renal failure. oxidative stress is a risk factor for these cardiac complications, iNOS accelerates cardiac aging.

Abnormal erythrocyte choline transport in patients with chronic renal failure

1991 ◽  
Vol 80 (2) ◽  
pp. 137-141 ◽  
Author(s):  
F. C. Fervenza ◽  
D. Meredith ◽  
J. C. Ellory ◽  
B. M. Hendry
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Normal Subjects ◽  
Choline Transport ◽  
Maintenance Haemodialysis ◽  
Control Subjects ◽  
Transplant Patients ◽  
The Mean

1. Erythrocyte choline transport has been studied in nine patients on maintenance haemodialysis for chronic renal failure, six patients on continuous ambulatory peritoneal dialysis, 31 patients with renal transplants and in nine normal control subjects. 2. The mean maximum rate of choline influx (Vmax., measured at an extracellular choline concentration of 250 μmol/l) was 66.7 (sd 14.1) μmol h−1 l−1 cells in patients on haemodialysis, 87.8 (sd 18.5) μmol h−1 l−1 cells in patients on continuous ambulatory peritoneal dialysis and 30.5 (sd 4.9) μmol h−1 l−1 cells in control subjects. The increase in choline flux in patients on haemodialysis and patients on continuous ambulatory peritoneal dialysis compared with control subjects was highly significant (P < 0.001). 3. Renal transplant patients showed variable values for the Vmax. of choline influx (range 17.7-71.7 μmol h−1 l−1 cells). The values showed a signifcant negative correlation with creatinine clearance and this correlation correctly extrapolated to the maximum choline flux in normal subjects and in patients on dialysis. 4. The kinetics of choline transport have been studied in erythrocytes of patients on haemodialysis and control subjects in ‘zero-trans’ conditions after depletion of intracellular choline. The mean Vmax. in these conditions was 38.4 (sd 4.6) μmol h−1 l−1 cells in patients on haemodialysis compared with 14.2 (sd 3.7) μmol h−1 l−1 cells in control subjects. The mean Km under ‘zero-trans’ conditions was 19.4 (sd 2.4) μmol/l in patients on haemodialysis and 7.4 (sd 1.4) μmol/l in control subjects. These differences were significant (P < 0.001).

Evidence for an Increased Generation of Prostacyclin in the Microvasculature and an Impairment of the Platelet α-Granule Release in Chronic Renal Failure

1988 ◽  
Vol 60 (02) ◽  
pp. 205-208 ◽  
Author(s):  
Paul A Kyrle ◽  
Felix Stockenhuber ◽  
Brigitte Brenner ◽  
Heinz Gössinger ◽  
Christian Korninger ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Blood Clotting ◽  
Normal Subjects ◽  
Chronic Uraemia ◽  
Wall Interaction ◽  
End Stage ◽  
Granule Release

SummaryThe formation of prostacyclin (PGI2) and thromboxane A2 and the release of beta-thromboglobulin (beta-TG) at the site of platelet-vessel wall interaction, i.e. in blood emerging from a standardized injury of the micro vasculature made to determine bleeding time, was studied in patients with end-stage chronic renal failure undergoing regular haemodialysis and in normal subjects. In the uraemic patients, levels of 6-keto-prostaglandin F1α (6-keto-PGF1α) were 1.3-fold to 6.3-fold higher than the corresponding values in the control subjects indicating an increased PGI2 formation in chronic uraemia. Formation of thromboxane B2 (TxB2) at the site of plug formation in vivo and during whole blood clotting in vitro was similar in the uraemic subjects and in the normals excluding a major defect in platelet prostaglandin metabolism in chronic renal failure. Significantly smaller amounts of beta-TG were found in blood obtained from the site of vascular injury as well as after in vitro blood clotting in patients with chronic renal failure indicating an impairment of the a-granule release in chronic uraemia. We therefore conclude that the haemorrhagic diathesis commonly seen in patients with chronic renal failure is - at least partially - due to an acquired defect of the platelet a-granule release and an increased generation of PGI2 in the micro vasculature.

RELATIONSHIP BETWEEN CARDIOVASCULAR DISEASES AND ANATOMOSIS OF ARTERIOVENOUS FISTULAR IN PATIENTS WITH REGULARLY HEMODIALYSIS

2017 ◽  
pp. 88-92
Author(s):  
Van Hien Pham ◽  
Huu Vu Quang Nguyen ◽  
Tam Vo
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Cardiovascular Diseases ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Negative Correlation ◽  
Mean Value ◽  
The Mean

Background: Cardiovascular diseases are the leading cause of death in patients with chronic renal failure. When a patient undergoes dialysis, making AVF or AVG causes cardiovascular events. Understanding the relationship between complications: hypertension, heart failure, AVF or AVG (formation time, position, diameter) helps us monitor, detect, prevent and treatment of complications to limit the risk of death in patients with dialysis. Objective: Relationship between cardiovascular diseases and anatomosis of arteriovenous fistular in patients with regularly hemodialysis at Cho Ray Hospital. Methods: A cross-sectional study was conducted at Cho Ray Hospital from 2015 to 2016. The survey some cardiovascular diseases are done by clinical examination, tests for diagnostic imaging such as X-ray, electrocardiogram and echocardiogram: heart and diameter of anastomosis AVF, AVG. Results: The study population included 303 patients with chronic renal failure who were dialysis. Of which, patients aged 25-45 accounted for the highest proportion (43.9%). The proportion of male and female patients was similar (48.5% and 51.5% respectively). The mean value of systolic blood pressure on patients made AVF, AVG less than 12 months is higher than patients made AVF, AVG over 12 months, and there is negative correlation (r = -0.43) between AVF, AVG and systolic blood pressure (p <0.05). The mean value of diastolic blood pressure on patients made AVF, AVG less than 12 months is lower than patients made AVF, AVG over 12 months, and and there is positive correlation (r = -0.43) between AVF, AVG and diastolic blood pressure (p <0.05) (p <0.05). The prevalence of patients with heart failure made AVF, AVG over 12 months is higher than that of the under 12 months group, there is a negative correlation (r = - 0.43) between AVF, AVG diameter and EF index (p <0.05). Conclusion: It is important to note the diameter of anastomosis AVF, AVG in patients with chronic renal failure dialysis to limit cardiovascular complications, especially heart failure. Key words: Chronic kidney disease, hemodialysis.

Oral and Maxillofacial Manifestations of Mineral and Bone Disorders Associated with Chronic Renal Failure

2017 ◽  
Vol 68 (6) ◽  
pp. 1325-1328
Author(s):  
Andrada Raluca Doscas ◽  
Mihail Balan ◽  
Mihai Liviu Ciofu ◽  
Doriana Agop Forna ◽  
Marius Cristian Martu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Health Concern ◽  
Oral Manifestations ◽  
End Stage Renal Failure ◽  
Brown Tumors ◽  
The Mean ◽  
End Stage

Chronic kidney disease (CKD) is a multifactorial syndrome and a global health concern. As renal function declines, there is a progressive deterioration of mineral homeostasis. Starting from stage 3 of CKD oral manifestations of mineral disorders can occasionally appear and become more frequent and evident in stage 5. We retrospectively analysed 43 patients diagnosed with end stage renal failure undergoing dialysis, hospitalized in our clinic for different oral and maxillofacial pathologies. The mean dialysis period was 5.43 years. Radiographic alterations afecting the jaws were found in all patients. The most common feature was partial or total loss of lamina dura, followed by alterations of the bony trabeculae. 9 patients presented brown tumors which are considered the final stage of secondary hyperparathyroidism associated with renal failure.

scholarly journals A Multi-Channel Uncertainty-Aware Multi-Resolution Network for MR to CT Synthesis

2021 ◽  
Vol 11 (4) ◽  
pp. 1667
Author(s):  
Kerstin Klaser ◽  
Pedro Borges ◽  
Richard Shaw ◽  
Marta Ranzini ◽  
Marc Modat ◽  
...  
Keyword(s):  
Medical Image Analysis ◽  
Absolute Error ◽  
Magnetic Resonance Images ◽  
The Body ◽  
Whole Body ◽  
Image Size ◽  
Body Images ◽  
Image Translation ◽  
The Mean ◽  
Synthetic Ct

Synthesising computed tomography (CT) images from magnetic resonance images (MRI) plays an important role in the field of medical image analysis, both for quantification and diagnostic purposes. Convolutional neural networks (CNNs) have achieved state-of-the-art results in image-to-image translation for brain applications. However, synthesising whole-body images remains largely uncharted territory, involving many challenges, including large image size and limited field of view, complex spatial context, and anatomical differences between images acquired at different times. We propose the use of an uncertainty-aware multi-channel multi-resolution 3D cascade network specifically aiming for whole-body MR to CT synthesis. The Mean Absolute Error on the synthetic CT generated with the MultiResunc network (73.90 HU) is compared to multiple baseline CNNs like 3D U-Net (92.89 HU), HighRes3DNet (89.05 HU) and deep boosted regression (77.58 HU) and shows superior synthesis performance. We ultimately exploit the extrapolation properties of the MultiRes networks on sub-regions of the body.

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