Magnesiuric and calciuric effects of terbutaline in man

1988 ◽  
Vol 74 (6) ◽  
pp. 595-597 ◽  
Author(s):  
W. J. W. Bos ◽  
D. S. Postma ◽  
J. J. van Doormaal

1. The effect of terbutaline infusion over 4 h on serum levels of potassium, ionized calcium, phosphate and magnesium and urinary excretion of potassium, calcium, magnesium and adenosine 3′:5′-cyclic monophosphate was studied in six healthy volunteers. 2. Serum levels of potassium, calcium, phosphate and magnesium decreased. Urinary excretion of potassium decreased, whereas those of calcium, magnesium and adenosine 3′:5′-cyclic monophosphate increased. 3. These results indicate that the hypocalcaemic and hypomagnesaemic effects of terbutaline can, at least partly, be explained by enhanced urinary excretion of calcium and magnesium. This may have important implications for the short-term terbutaline treatment of patients with, for example, cardiac disease.

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Claudia Luevano-Contreras ◽  
Rosalia Lopez-Gutierrez ◽  
Armando Gomez-Ojeda ◽  
Ma Eugenia Garay-Sevilla ◽  
Jorge Ramirez-Telles

Abstract Objectives Dietary advanced glycation end products (AGEs) are a group of compounds formed by the Maillard reaction. Carboxymethyl-lysine (CML), a marker of AGEs in foods, may contribute to cardiometabolic diseases. However, CML health effects and its absorption and excretion in healthy individuals remained controversial. For this reason, the aim of this study was to evaluate serum and urinary excretion CML levels in healthy adults after a short-term diet high in CML. Methods A randomized clinical trial was conducted in 30 healthy adults (18–35 years old). After signing the informed consent, subjects were randomly assigned to a low or a high CML diet. All participant followed a diet with low CML content for seven days (washing period) before the 5-days intervention. During the 5 days participants received all the foods according to their group. Blood and 24-hour urine samples were collected before and after the intervention to evaluate serum and urinary CML levels. CML measurement in foods, serum, and urine was carried out by HPLC-ESI-ITMS/MS. Comparison between groups was carried out by a t-test. The research was approved by the Institutional Review Board and the clinical trial registration number NCT03208946. Results Biochemical and anthropometric variables were similar between groups (P > 0.05). The average consumption of CML was 1.93 ± 1.47 mg/day for the low CML diet and 5.03 ± 2.22 mg/day for the high CML diet, whereas caloric, protein and fat intake were similar. Serum levels decreased significantly in both groups (low diet: basal 488.1 ± 135.4 μg/L, final 383.2 ± 78.6 μg/L (P = 0.007)) (high diet: basal 463.5 ± 90.3 μg/L, final 390.3 ± 99.1 μg/L (P = 0.02)). No significant difference was found when comparing the final CML levels between groups (P = 0.47). The excretion of CML in urine was adjusted by creatinine (mg) and the high CML group had a greater excretion (4.5 ± 8.0 ug CML/mg) when compared to the low CML group (−1.5 ± 7.2 ug CML/mg) (P = 0.04). Conclusions A high CML diet increases urinary CML excretion levels in healthy adults when compared to a low CML diet. There were no significant differences in serum CML levels between both groups. However, a greater decrease was observed in the subjects who followed a diet with a low content of AGEs. Funding Sources University of Guanajuato. CONACYT.


Author(s):  
D. M. Kvitka ◽  
V. O. Palamarchuk ◽  
S. V. Zemskov ◽  
V. A. Smoliar

Background. The postoperative hypoparathyroidism remains a specific complication in the thyroid surgery. The incidence of iatrogenic hypoparathyroidism ranges from 3.0 % to 31.5 %. The decrease in the level of parathyroid hormone leads to the launch of a cascade of the electrolyte changes. The standard methods for controlling and correcting hypoparathyroidism do not guarantee the prevention of hypocalcemiacases. The role of calcium and magnesium in the conduction of the nerve impulses along muscle fibers is well known. The study of the role of magnesium will enable further correction of the manifestations of postoperative hypoparathyroidism.Aim — to study a relationship between postoperative hypoparathyroidism, changes in calcium-magnesium metabolism and their clinical manifestations; to analyze the effects of hypomagnesemia on the clinical manifestations of hypocalcemia; to study the possibility of correcting calcium-magnesium metabolism in the postoperative period.Materials and methods. The study involved 145 patients operated for the thyroid diseases. The patients were divided into two groups. The main group (n = 73) included the patients who took magnesium medications in the preoperative period for 10—14 days at a dose of 1500—2000 mg/day. In the observation group (n = 72), the patients did not take the magnesium medications. Parameters of the parathyroid hormone, ionized calcium, and magnesium were measured in all patients in the preoperative period and on the first day of the postoperative period. The parathyroid hormones’levels on the first day of postoperative period were ranged into the “ranges”: 1) parathyroid hormone — ≤ 1 pg/ml, 2) parathyroid hormone — 1—5 pg/ml, 3) parathyroid hormone — 5—10 pg/ml, 4) parathyroid hormone — > 10 pg/ml. The clinical manifestations of hypoparathyroidism were assessed on a scale: not pronounced, poorly pronounced, pronounced, sharply pronounced.Results. The correlations were found between the levels of the postoperative magnesium, ionized calcium and parathyroid hormone. In the main group, the number of the pronounced and sharply pronounced manifestations of hypocalcemia was observed in the parathyroid hormone range — ≤ 1 pg/ml. In the observation group, the largest number of the prono­unced and sharply pronounced clinical manifestations was recorded in the parathyroid hormone range — ≤ 1 pg/ml, parathyroid hormone — 1—5 pg/ml. In the main group, in comparison with the observation group, the total number of the clinical manifestations of hypocalcemia was lower.Conclusions. There were revealed the positive cor­rela­tions in the changes in the levels of the parathyroid hormone, ionized calcium and magnesium. It has been proven that uncorrected hypomagnesemia in the early postoperative period can be a predictor of the clinical manifestations of hypoparathyroidism. The correction of the serum magnesium levels in most patients reduces the clinical manifestations of hypocalcemia.


1988 ◽  
Vol 75 (4) ◽  
pp. 395-402 ◽  
Author(s):  
D. M. Tillman ◽  
P. F. Semple

1. Because disturbances of calcium metabolism have been described in hypertension, measurements of plasma and serum concentrations of ionized calcium, total calcium, magnesium and renin were made in 38 patients with essential hypertension and age- and sex-matched control subjects. Urinary excretion of calcium, magnesium and sodium was also determined. 2. The mean serum concentration of ionized calcium was 1.23 ± 0.04 (sd) mmol/l in the hypertensive group and 1.21 ±0.03 mmol/l in controls, and results were similar after correction for pH. There was a weak positive correlation between serum ionized calcium (pH 7.4) and systolic pressure (r = 0.26, P < 0.02), but no correlation with plasma renin concentration. 3. Although the difference between serum total calcium concentration in the hypertensive (2.29 ±0.09 mmol/l) and control (2.26 ±0.07 mmol/l) subjects was not significant, there was a significant correlation between total calcium and systolic pressure (r = 0.23, P < 0.05) which was maintained after correction for other variables. 4. There were no differences in plasma concentrations of parathyroid hormone or 1,25-dihydroxycholecalciferol between hypertensive and control subjects. 5. The hypertensive group showed higher urinary excretion of calcium (5.9 ±3.0 mmol/24h) than controls (4.6 ± 1.7 mmol/24 h), but the difference was not maintained after correction for sodium excretion. 6. Serum concentrations of magnesium were similar in the two groups, but urinary excretion of magnesium was significantly lower in hypertensive (3.7 ± 1.3 mmol/24 h) than control (4.5 ±1.6 mmol/24 h) subjects and there was an inverse correlation between magnesium excretion and blood pressure (r = 0.3–0.35, P < 0.01).


1973 ◽  
Vol 45 (6) ◽  
pp. 751-764 ◽  
Author(s):  
S. P. Gray ◽  
J. E. W. Morris ◽  
C. J. Brooks

1. Fifteen healthy young men were exposed to an atmosphere of 0–7% CO2 in air for 7 weeks. 2. For 1 week before and during the exposure to CO2, serum calcium, magnesium and inorganic phosphate (Pi) levels were measured at intervals, together with 24 h urinary excretion of these three components, and net urinary acid excretion. 3. The urinary excretion of Ca2+, Mg2+ and Pi fell during exposure to CO2, whereas the serum levels of these components increased. 4. Serum levels of calcium were inversely correlated with urinary Ca2+ excretion both in control conditions and during exposure to CO2 5. An increase in urinary acid excretion in the third to fourth week of exposure to CO2 was associated with an increase in the urinary excretion of Ca2+, but not of Mg2+. 6. It is suggested that there is a difference from the normal in the renal handling of H+ and Ca2+ ions during exposure to CO2 which may lead to a retention of Ca2+ in the tissues.


1993 ◽  
Vol 13 (3) ◽  
pp. 219-223 ◽  
Author(s):  
Alastair J. Hutchison ◽  
Mahendra Merchant ◽  
Helen F. Boulton ◽  
Rod Hinchcliffe ◽  
Ram Gokal

Objective To examine the effect of a reduced calcium/magnesium dialysis fluid (1.25/0.25 mmol/L, respectively) on calcium and magnesium mass transfer in both 1.36% and 3.86% glucose solutions. Design Each patient underwent four test exchanges, two with a standard dialysis fluid containing 1.36% and 3.86% glucose, and two with a reduced calcium/magnesium fluid containing 1.36% and 3.86% glucose. Calcium and magnesium were measured in dialysate and serum at ° and 240 minutes. Setting Single renal unit of a university teaching hospital. Patients Sixteen patients established on CAPD, and peritonitis-free, for at least 3 months. Results A lower dialysate calcium results in negative mass transfer when serum-ionized calcium exceeds dialysate calcium (mean -.0.21±0.15 mmol/exchange), and positive mass transfer when serum-ionized calcium is less than dialysate calcium in 1.36% glucose solutions (mean 0.57±0.18 mmol/exchange). A negative correlation was found between serum-ionized calcium level and calcium mass transfer. With a 3.86% reduced calcium/magnesium solution, calcium mass transfer is always negative (-.0.88±0.18 mmol/exchange) due to ultrafiltration and solute drag. Fifteen patients were found to be hypermagnesemic at the time of the study. Magnesium mass transfer was neutral with the standard 1.36% glucose fluid (mean -.0.01 mmol/exchange), but negative with the reduced calcium/magnesium 1.36% glucose fluid (mean -.0.58±0.13 mmol/exchange). With the 3.86% glucose solution, both fluids produced negative magnesium mass transfer (mean -.0.32±0.11 and -1.07±0.11 mmol/exchange for standard and reduced calcium/magnesium fluids, respectively). Conclusions We conclude that this fluid formulation should reduce hypercalcemia and hypermagnesemia in CAPD patients.


2019 ◽  
Vol 8 (1) ◽  
pp. 79-86
Author(s):  
Huda J. Waheed ◽  
Saad B. Nashtar ◽  
Ali I. Al-Gareeb ◽  
Hayder M. Al-Kuraishy

Background: Aescin or β-escin is the main and active constituent of horse chestnut seed (Aesculus hippocastanum) used for the treatment of inflammatory edema, venous insufficiency and ischemic ulcerations. Aescin has many actions due to induction of endothelial nitric oxide and prostaglandin F2-α production moreover; aescin antagonizes the effect of histamine and 5HT at receptor levels. </P><P> Objective: The aim of the present study was to evaluate the neurobehavioral effects of aescin on normal healthy volunteers. </P><P> Method: A total number of 65 healthy participants with mean age of 21+1.1 years were recruited to study the effects of aescin on the neurobehavioral effects of normal healthy volunteers compared to placebo. The neurobehavioral effects were assessed by psychomotor performances and sensorimotor reaction, cortical arousal and central integrity processes and assessment of memory capacity. Results: Placebo produced insignificant amelioration of TRT and RRT p>0.05, with mild significant effect on MRT p=0.03. Aescin produced a significant effect in the amelioration of psychomotor performances and sensorimotor reaction p=0.0001. Regarding the differential effect of placebo and aescin on the cortical arousal and central integrity processes, placebo illustrated insignificant effect at p>0.05 whereas; aescin showed mild significant effect on Critical Fusion Frequency (CFFA) p<0.05 and highly significant effect on the other parameters p<0.01 except for critical-fusion frequency threshold when aescin illustrated insignificant effect at p>0.05. Aescin illustrated significant acceleration of ІІ-back WMA, ІІІ-back WMA and Second trial Short-Term Memory (STM) at p<0.01 compared to the placebo effect. Conclusion: Short-term therapy with aescin improves the neurobehavioral effects on healthy volunteers.


Author(s):  
Usha Choudhary ◽  
Meenaxi Sareen ◽  
Anil Moolchandani

The present study was carried out to evaluate the variations in serum minerals ( viz. calcium, magnesium and phosphorus) and transaminases in ketotic buffaloes. Results of blood analysis revealed a significant (P<0.05) reduction in serum phosphorus in ketotic buffaloes whereas nonsignificant (P>0.05) difference occur in serum calcium and magnesium in ketotic buffaloes as compared to control. At the same time significant increase in transaminases GPT, GOT and GGT have been observed .


2019 ◽  
Vol 130 ◽  
pp. 32-43 ◽  
Author(s):  
Elias Begas ◽  
Maria Bounitsi ◽  
Thomas Kilindris ◽  
Evangelos Kouvaras ◽  
Konstantinos Makaritsis ◽  
...  

1988 ◽  
Vol 62 (5) ◽  
pp. 298-301 ◽  
Author(s):  
Jan Bonde ◽  
Niels Melchior Jensen ◽  
Lars E. Pedersen ◽  
Niels A. Graudal ◽  
Helle R. Angelo ◽  
...  

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R Zanoni ◽  
V Ferrara ◽  
G Lanati ◽  
G Vitale ◽  
F Di Nicola ◽  
...  

Abstract Background Anderson Fabry (AF) disease is a X-linked lysosomal storage disorder with multiorgan involvement. Cardiac disease, mainly represented by left ventricular hypertrophy (LVH) and arrhythmias, is the most frequent cause of premature death. It is well know that specific therapy is less effective after the development of LVH and myocardial fibrosis, therefore early cardiac detection (before LVH) is important. New cardiac magnetic resonance (CMR) parametric imaging techniques (T1 and T2 maps) enable myocardial tissue changes associated with AF disease. Purpose To evaluate the relationship between CMR tissue characterization and clinical and instrumental manifestations of AF disease to find early markers of cardiac involvement. Methods 31 AF patients (9 males, mean age 49±16 years) underwent ECG, echocardiogram and contrast CMR. TnI, BNP, pro-BNP and serum lyso-Gb3 were dosed. T1 mapping was performed in a pre-contrast acquisition with the modified Look-Locker inversion recovery (MOLLI) sequences. CMR results were compared with those of 43 healthy age and gender-matched controls. Results In AF patients native septal T1 values were significantly lower compared to healthy controls (median 949 vs 991 msec, p=0.0137) and were inversely related to Lyso-Gb3 serum levels (p=0.003). Patients with LVH had lower T1 septal values in comparison with patients without LVH (892 vs 981 msec; p=0.0012). Patients with classic form had abnormal low T1 values more frequently than pts with late onset variant (78 vs 23%; p=0.038). In AF patients native septal T2 values were significantly higher compared to the control group (53 vs 49 msec; p=0.0004) and correlated with troponin I (p=0.008) and NT-pro BNP (p=0.006) serum levels. No difference was found between pts with and without LVH (53.5 vs 52.5 ms; p=0.797) and the prevalence of abnormal high T2 values was similar between patients with late onset AF and pts with classical form (53% vs 50%; p=1.000). All patients with late onset AF and high T2 values were females. Conclusions CMR T1 (low values) and T2 (high values) mapping are useful tools to detect early cardiac involvement before LVH and to better understand the pathophysiology of cardiac disease in AF patients. Subclinical tissue inflammation, detectable through T2 maps, seems to be an additional pathogenetic mechanism related to the Gb3 storage that contributes to organ damage and precedes LVH, particularly in females patients with late onset phenotype. Funding Acknowledgement Type of funding source: Public hospital(s). Main funding source(s): Sant'Orsola-Malpighi Hospital


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