Calcium and magnesium in essential hypertension

1988 ◽  
Vol 75 (4) ◽  
pp. 395-402 ◽  
Author(s):  
D. M. Tillman ◽  
P. F. Semple
Keyword(s):  
Essential Hypertension ◽  
Urinary Excretion ◽  
Systolic Pressure ◽  
Ionized Calcium ◽  
Serum Concentrations ◽  
Total Calcium ◽  
Control Subjects ◽  
Calcium Magnesium ◽  
The Difference ◽  
And Control

1. Because disturbances of calcium metabolism have been described in hypertension, measurements of plasma and serum concentrations of ionized calcium, total calcium, magnesium and renin were made in 38 patients with essential hypertension and age- and sex-matched control subjects. Urinary excretion of calcium, magnesium and sodium was also determined. 2. The mean serum concentration of ionized calcium was 1.23 ± 0.04 (sd) mmol/l in the hypertensive group and 1.21 ±0.03 mmol/l in controls, and results were similar after correction for pH. There was a weak positive correlation between serum ionized calcium (pH 7.4) and systolic pressure (r = 0.26, P < 0.02), but no correlation with plasma renin concentration. 3. Although the difference between serum total calcium concentration in the hypertensive (2.29 ±0.09 mmol/l) and control (2.26 ±0.07 mmol/l) subjects was not significant, there was a significant correlation between total calcium and systolic pressure (r = 0.23, P < 0.05) which was maintained after correction for other variables. 4. There were no differences in plasma concentrations of parathyroid hormone or 1,25-dihydroxycholecalciferol between hypertensive and control subjects. 5. The hypertensive group showed higher urinary excretion of calcium (5.9 ±3.0 mmol/24h) than controls (4.6 ± 1.7 mmol/24 h), but the difference was not maintained after correction for sodium excretion. 6. Serum concentrations of magnesium were similar in the two groups, but urinary excretion of magnesium was significantly lower in hypertensive (3.7 ± 1.3 mmol/24 h) than control (4.5 ±1.6 mmol/24 h) subjects and there was an inverse correlation between magnesium excretion and blood pressure (r = 0.3–0.35, P < 0.01).

Platelet Cytosolic Free Calcium in Essential Hypertension: Responses to Vasopressin

1989 ◽  
Vol 77 (2) ◽  
pp. 183-188 ◽  
Author(s):  
A. F. Dominiczak ◽  
J. J. Morton ◽  
G. Murray ◽  
P. F. Semple
Keyword(s):  
Essential Hypertension ◽  
Arginine Vasopressin ◽  
Calcium Concentration ◽  
Systolic Pressure ◽  
Extracellular Calcium ◽  
Free Calcium ◽  
Cytosolic Free Calcium ◽  
Hypertensive Patients ◽  
Free Calcium Concentration ◽  
The Difference

1. Resting and stimulated free calcium concentrations have been measured in platelets loaded with the fluorescent probe quin2 from 30 patients with essential hypertension and from 30 age-matched controls. 2. Cytosolic free calcium concentrations were 94.6 ± 2.7 (mean ± sem) in the hypertensive group and 91.7 ± 2.8 nmol/l in the normotensive group, the difference was not significant. 3. Arginine vasopressin caused a transient increase in platelet free calcium concentration in all subjects. In the presence of extracellular calcium the increase was significantly higher in the control subjects than in the hypertensive patients (P = 0.005). In the absence of extracellular calcium, arginine vasopressin caused much smaller increases, and there was then no difference between the responses of the two groups. 4. Platelet free calcium concentrations were measured again in 13 patients after 8 weeks treatment with either verapamil (n = 6) or atenolol (n = 7). The reductions in systolic pressure after drug treatment were correlated with the changes in cytosolic free calcium concentrations (r = 0.75, P < 0.01).

Serum oncoproteins in asbestosis patients

1995 ◽  
Vol 41 (12) ◽  
pp. 1844-1847 ◽  
Author(s):  
R Partanen ◽  
H Koskinen ◽  
P Oksa ◽  
K Hemminki ◽  
W Carney ◽  
...  
Keyword(s):  
Transforming Growth Factor ◽  
P53 Protein ◽  
Statistical Significance ◽  
Mutant P53 ◽  
Serum Concentrations ◽  
Serum Samples ◽  
Patients With Cancer ◽  
Control Subjects ◽  
Factor Alpha ◽  
And Control

Abstract Using ELISAs, we determined the concentrations of transforming growth factor alpha (TGF-alpha), the extracellular domain of the erbB-2 receptor (erbB-2 ECD), and mutant p53 protein in stored serum samples of asbestosis patients with and without cancer and control subjects (without asbestosis or cancer). The percentage of individuals in these three groups with increased serum concentrations of TGF-alpha, erbB-2 ECD, and mutant p53, respectively, were: asbestosis patients with cancer, 36%, 16%, 19%; asbestosis patients without cancer, 38%, 19%, 6%; control subjects, 0%, 5%, 10%. Although differences in serum positivity for these oncoproteins were apparent among these groups, the differences did not achieve statistical significance (P &gt; 0.05). In several of the cancer cases, increased concentrations of TGF-alpha, erbB-2 ECD, and mutant p53 were also detected in the stored serum samples collected years before the clinical diagnosis of disease.

Seroprevalence of Helicobacter pylori infection in patients with chronic nonspecific pharyngitis: preliminary study

2007 ◽  
Vol 122 (1) ◽  
pp. 61-64 ◽  
Author(s):  
İ Aladag ◽  
Y Bulut ◽  
M Guven ◽  
A Eyibilen ◽  
K Yelken
Keyword(s):  
Helicobacter Pylori ◽  
Treatment Strategies ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Control Groups ◽  
Chi Square ◽  
Control Subjects ◽  
The Difference ◽  
H Pylori ◽  
And Control

AbstractBackground and objectives:Chronic nonspecific pharyngitis is a chronic inflammation of the pharynx. It is found worldwide, and treatment is difficult. The underlying aetiopathogenesis is still controversial. The aim of this study was to investigate Helicobacter pylori seroprevalence in chronic nonspecific pharyngitis patients without other possible causative factors for chronic pharyngeal irritation and without H pylori gastric mucosal infection.Materials and methods:Forty-one patients with symptoms of chronic nonspecific pharyngitis and 30 healthy control subjects were enrolled in this prospective, controlled, clinical study. In both study and control groups, selected patients were shown to have gastric mucosa uninfected by H pylori, as demonstrated by the 14C-urea breath test. Comprehensive otorhinolaryngological examination did not elicit any factor contributing to the chronic pharyngeal complaint. Serum H pylori immunoglobulin G antibody titres were assayed using serum enzyme-linked immunosorbent assay. The difference between the study and control groups was analysed by the chi-square test (the likelihood ratio was used).Results:Thirty-two of the 41 patients (78 per cent) and 14 of the 30 control subjects (46.7 per cent) were found to be H pylori positive. Patients with chronic nonspecific pharyngitis were found to have a significantly higher rate of H pylori seropositivity than the control group (p = 0.016).Conclusion:These data may be important in developing future treatment strategies for chronic nonspecific pharyngitis.

Increased urinary excretion of prostaglandin E2 in patients with idiopathic hypercalciuria is a primary phenomenon

1992 ◽  
Vol 83 (1) ◽  
pp. 75-80 ◽  
Author(s):  
C. Henríquez-la Roche ◽  
B. Rodríguez-Iturbe ◽  
G. Parra
Keyword(s):  
Urinary Excretion ◽  
Prostaglandin E2 ◽  
Idiopathic Hypercalciuria ◽  
Water Restriction ◽  
Water Diuresis ◽  
Control Subjects ◽  
Calcium Diet ◽  
High Calcium ◽  
And Control ◽  
Primary Phenomenon

1. Urinary excretion of prostaglandin E2 is increased in patients with idiopathic hypercalciuria, but in order to conclude that hyperprostaglandinuria is a primary phenomenon, it must be demonstrated that high levels of urinary prostaglandin E2 can be dissociated from other factors, such as urine volume and natriuresis, and from the hypercalciuria itself. 2. We studied 10 patients with idiopathic hypercalciuria and 10 control subjects on high and low calcium diets providing daily calcium intakes of 30-35 mmol and 7.5-10 mmol, respectively, and similar sodium intakes. In addition, patients with idiopathic hypercalciuria and control subjects were studied during water restriction and water diuresis. 3. Urinary prostaglandin E2 excretion was more than twice as high in patients with idiopathic hypercalciuria than in control subjects on the low and high calcium diets as well as during water restriction and water diuresis (P<0.01). 4. Urinary prostaglandin E2 excretion was not affected by changes in urinary calcium excretion in patients with idiopathic hypercalciuria and in control subjects. Patients with idiopathic hypercalciuria on the low calcium diet and control subjects on the high calcium diet had similar levels of calciuria and natriuresis, yet urinary prostaglandin E2 excretion (mean ± SEM) was 11.62 ± 1.71 nmol/day in the patients with idiopathic hypercalciuria and 3.26 ± 0.48 nmol/day in the control subjects (P= 0.0006). 5. These results indicate that increased urinary prostaglandin E2 excretion is a cardinal characteristic of patients with idiopathic hypercalciuria.

Magnesiuric and calciuric effects of terbutaline in man

1988 ◽  
Vol 74 (6) ◽  
pp. 595-597 ◽  
Author(s):  
W. J. W. Bos ◽  
D. S. Postma ◽  
J. J. van Doormaal
Keyword(s):  
Calcium Phosphate ◽  
Urinary Excretion ◽  
Healthy Volunteers ◽  
Cardiac Disease ◽  
Serum Levels ◽  
Ionized Calcium ◽  
Short Term ◽  
Cyclic Monophosphate ◽  
Calcium Magnesium ◽  
Calcium And Magnesium

1. The effect of terbutaline infusion over 4 h on serum levels of potassium, ionized calcium, phosphate and magnesium and urinary excretion of potassium, calcium, magnesium and adenosine 3′:5′-cyclic monophosphate was studied in six healthy volunteers. 2. Serum levels of potassium, calcium, phosphate and magnesium decreased. Urinary excretion of potassium decreased, whereas those of calcium, magnesium and adenosine 3′:5′-cyclic monophosphate increased. 3. These results indicate that the hypocalcaemic and hypomagnesaemic effects of terbutaline can, at least partly, be explained by enhanced urinary excretion of calcium and magnesium. This may have important implications for the short-term terbutaline treatment of patients with, for example, cardiac disease.

scholarly journals Asupan gizi dan status gizi sebagai faktor risiko hipertensi esensial pada lansia di Puskesmas Curup dan Perumnas Kabupaten Rejang Lebong Propinsi Bengkulu

2007 ◽  
Vol 4 (1) ◽  
pp. 43
Author(s):  
Agung Riyadi ◽  
P Wiyono ◽  
R Dwi Budiningsari
Keyword(s):  
Risk Factors ◽  
Essential Hypertension ◽  
Health Center ◽  
Protective Factor ◽  
Smoking Status ◽  
The Elderly ◽  
Nutrition Status ◽  
High Intake ◽  
Calcium Magnesium ◽  
And Control

Background: Hypertension is happened generally at someone who has age more than 40 year. The prevalence of hypertension was tend to increase along with the increasing of amount of the elderly. Changing of nutrition status and unfavorable nutrition intakes like is high fat, sodium and low micronutrients (potassium, calcium, magnesium) have an effect to incidence of essential hypertension. Retreating of biologic accompanying aging process sometimes make the elderly become resistance to get quality of intakes nutrition.Objective: The study was conducted to know relations between nutrition intakes and nutrition status with occurrence on essential hypertension of the elderly in the health center Curup and Perumnas, Rejang Lebong District.Method: The study was observational analytic with case control matched study. Subject of the study was divided into two group i.e. case and control with comparison case and control 1:1 which matched to age and sex. Total subject were 150, taken by simple random method. The cases were essential hypertension patients who had recently diagnosed by doctors. Blood pressure measurements were three times in supine position. Hypertension was defined as average of three times supine systolic/diastolic blood pressures at p >140/ 90 mmHg. Nutrition status was determined by Body Mass Index (BMI). Intake nutrients were collected using Food Frequency Questionnaire (FFQ) in the last 3 months by using food model. χ 2 McNemar were used to bivariate analytic and condition logistic regression to identify risk factors associated with essential hypertension.Result: This study showed that there were 4 variables significantly related with essential hypertension, i.e. intakes of sodium (OR: 3.43; CI 95%:1.09-10.77), potassium (OR: 0.24; CI 95%:0.07-0.84), stress (OR: 3.79; CI 95%:1.18-12.12), and obesity (OR: 4.57; CI 95%:1.49-13.95). The no significant correlation (p>0.05) identified for intakes of fat, calcium, magnesium, coffee consumption, smoking status and family history of essential hypertension.Conclusion: High intake of sodium, stress and obesity were the risk factors on occurrence of essential hypertension. In the other hand, high intake of potassium were reduce the risk on occurrence of essential hypertension (protective factor) in the health center Curup and Perumnas, Rejang Lebong District.

Reduced Plasma Renin Activity in Essential Hypertension: Effects of Blood Pressure, Age and Sodium

1976 ◽  
Vol 51 (s3) ◽  
pp. 185s-188s ◽  
Author(s):  
G. W. Thomas ◽  
J. G. G. Ledingham ◽  
L. J. Beilin ◽  
A. N. Stott
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Inverse Relationship ◽  
Plasma Renin ◽  
Renin Activity ◽  
Hypertensive Patients ◽  
Significant Inverse Relationship ◽  
Control Subjects ◽  
And Control

1. Supine plasma renin activity and its responsiveness to erect posture and frusemide were reduced in fifty-one patients with essential hypertension, compared with fifty-one age- and sex-matched control subjects. 2. Twenty-four hour urinary sodium excretion was similar in hypertensive patients and control subjects, but after intravenous frusemide hypertensive patients excreted significantly less sodium. 3. A significant inverse relationship between plasma renin activity and diastolic blood pressure was demonstrated in hypertensive patients and in normotensive control subjects. 4. A significant inverse relationship between plasma renin activity and age, independent of blood pressure, was shown in hypertensive patients and control subjects. 5. It is concluded that the reduced renin values found in essential hypertension are, in part, the result of the elevated blood pressure acting on the kidney.

Dopa, Catecholamines and Their Metabolites in Essential Hypertension

1974 ◽  
Vol 48 (s2) ◽  
pp. 295s-298s
Author(s):  
W. Januszewicz ◽  
B. Wocial
Keyword(s):  
Essential Hypertension ◽  
Urinary Excretion ◽  
Homovanillic Acid ◽  
Catecholamine Metabolism ◽  
Vanillylmandelic Acid ◽  
Control Subjects ◽  
Healthy Control ◽  
Catecholamine Metabolites ◽  
The Relationship

1. Urinary excretion of dopa, catecholamines and their metabolites (vanillylmandelic acid, methoxycatecholamines, 3-methoxy-4-hydroxyphenylglycol and homovanillic acid) were studied in eighty patients with essential hypertension and in twenty-five healthy control subjects. 2. Increased urinary excretion of catecholamines, dopa and catecholamine metabolites was found in a proportion of cases. 3. The relationship between urinary excretion of catecholamine metabolites and the excretion of dopa and noradrenaline was studied. 4. In view of the suggested significance of 3-methoxy-4-hydroxyphenylglycol as an index of brain catecholamine metabolism, particular attention was paid to urinary excretion of this metabolite in the subjects under study.

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