Circulating adhesion molecules are correlated with ultrasonic assessment of carotid plaques

The relationship between levels of circulating intercellular cell-adhesion molecule-1 (cICAM-1) or P-selectin (cP-selectin) and the severity of carotid atherosclerosis was examined in 301 outpatients undergoing duplex ultrasonographic examination. Carotid plaque was defined as an intima-media thickness greater than 1.0 mm, and a plaque score (PS) was calculated from the plaque thickness in both carotid arteries. Multivariate analysis demonstrated significant positive associations between cICAM-1 and the number of plaques [β = 0.11; confidence interval (CI), 0.007–0.213], maximum intima-media thickness (β = 0.11; CI, 0.01–0.219), and PS (β = 0.10; CI, 0.001–0.205). In contrast, no significant association was found for cP-selectin. cP-selectin did not increase until atherosclerosis was advanced (PS > 10), showing a marked increase in patients with ≥ 50% stenosis. The circulating levels of both proteins are related to real measurements of plaque formation in the carotid arteries independently of classical risk factors. Marked elevation of cP-selectin occurs in advanced carotid atherosclerosis after gradual elevation of cICAM-1.

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Carotid Atherosclerosis Evolution When Targeting a Low-Density Lipoprotein Cholesterol Concentration <70 mg/dL After an Ischemic Stroke of Atherosclerotic Origin

Circulation ◽

10.1161/circulationaha.120.046774 ◽

2020 ◽

Vol 142 (8) ◽

pp. 748-757 ◽

Cited By ~ 2

Author(s):

Pierre Amarenco ◽

Cristina Hobeanu ◽

Julien Labreuche ◽

Hugo Charles ◽

Maurice Giroud ◽

...

Keyword(s):

Ischemic Stroke ◽

Carotid Arteries ◽

Carotid Atherosclerosis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Intima Media Thickness ◽

Target Group ◽

Low Density Lipoprotein Cholesterol ◽

Media Thickness ◽

Common Carotid Arteries

Background: The TST trial (Treat Stroke to Target) showed the benefit of targeting a low-density lipoprotein cholesterol (LDL-C) concentration of <70 mg/dL in terms of reducing the risk of major cardiovascular events in 2860 patients with ischemic stroke with atherosclerotic stenosis of cerebral vasculature. The impact on carotid atherosclerosis evolution is not known. Methods: TST-PLUS (Treat Stroke to Target–Plaque Ultrasound Study) included 201 patients assigned to an LDL-C concentration of <70 mg/dL and 212 patients assigned to a target of 100±10 mg/dL. To achieve these goals, investigators used the statin and dosage of their choice and added ezetimibe as needed. Ultrasonographers were certified and carotid ultrasound examinations were performed using M′Ath software at baseline and at 2, 3, and 5 years. All images were uploaded to the Intelligence in Medical Technologies database directly from the carotid ultrasound device. The central core laboratory performed all offline measurements of the intima–media thickness of both common carotid arteries blinded from the randomization arm. The main outcomes were newly diagnosed atherosclerotic plaque on carotid bifurcation or internal carotid artery using the Mannheim consensus definition and between-group comparison of common carotid arteries intima–media thickness change. Results: After a median follow-up of 3.1 years, the achieved LDL-C concentrations were 64 mg/dL (1.64 mmol/L) in the lower-target group and 106 mg/dL (2.72 mmol/L) in the higher-target group. Compared with the higher-target group, patients in the lower-target group had a similar incidence of newly diagnosed carotid plaque: 46/201 (5-year rate, 26.1%) versus 45/212 (5-year rate, 29.7%). The change in common carotid arteries intima–media thickness was −2.69 µm (95% CI, −6.55 to 1.18) in the higher-target group and −10.53 µm (95% CI, −14.21 to −6.85) in the lower-target group, resulting in an absolute between-group difference of −7.84 µm (95% CI, −13.18 to −2.51; P =0.004). Conclusions: In patients with ischemic stroke and atherosclerosis, an LDL-C target of <70 mg/dL (1.8 mmol/L) did not reduce the incidence of new carotid plaques but produced significantly greater regression of carotid atherosclerosis than an LDL-C target of 90 to 110 mg/dL. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01252875.

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CAROTID ATHEROSCLEROSIS

The Professional Medical Journal ◽

10.29309/tpmj/2016.23.01.789 ◽

2016 ◽

Vol 23 (01) ◽

pp. 039-044

Author(s):

Hassan Bukhari ◽

Asim Shaukat ◽

Nosheen Ahmed Ahmed

Keyword(s):

Hepatic Steatosis ◽

Carotid Arteries ◽

Carotid Atherosclerosis ◽

Linear Array ◽

Intima Media Thickness ◽

Obese Patients ◽

Media Thickness ◽

Array Transducer ◽

Carotid Bulb ◽

Atherosclerotic Changes

Objectives: To determine the frequency of carotid atherosclerosis in obesepatients having hepatic steatosis and its effect on the development of MI. Design: Crosssectionalstudy. Setting: Department of Radiology Allied Hospital, Faisalabad. Period: FromJanuary 2012 to June 2013, Patients and method: A total of 96 patients were included in thisstudy. LOGIC 5 Doppler ultrasound machine was used. B-mode ultrasonography of commoncarotid arteries was performed on both sides with a 7.5 MHz linear array transducer. Ultrasoundwas done in supine position & elevation of chest by pillow. Patient head will be turned to theopposite side. Intima media thickness was accessed in the distal wall of common carotidartery of both sides 1.0 cm proximal to carotid bulb. Results: Mean age of the patients was46.69±11.86 years. Out of 96 patients, 51 (53.1%) were males while remaining 45 patients(46.9%) were females. Presence of carotid atherosclerosis was noted in 96 patients (100.0%).Out of these patients, myocardial infarction was present in 81 patients (84.4%). Mean BMI was30.67±0.47, mean weight was 91.86±7.57 Kg and intima media thickness was 0.84±0.12 mm.Conclusion Prevalence of atherosclerotic changes in carotid arteries detected by Dopplerultrasound among obese patients having hepatic steatosis and its effect on the developmentof MI is remarkable

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Relationship Between Dietary Patterns and Carotid Atherosclerosis Among People Aged 50 Years or Older: A Population-Based Study in China

Frontiers in Nutrition ◽

10.3389/fnut.2021.723726 ◽

2021 ◽

Vol 8 ◽

Author(s):

Yunyun Liu ◽

Xuena Wang ◽

Qing Zhang ◽

Ge Meng ◽

Li Liu ◽

...

Keyword(s):

Dietary Patterns ◽

Dietary Pattern ◽

Carotid Atherosclerosis ◽

Adult Population ◽

Intima Media Thickness ◽

Dietary Intakes ◽

Cross Sectional ◽

Media Thickness ◽

Significant Difference ◽

The Relationship

Background: The relationship between dietary patterns and atherosclerosis is inconclusive. Usually, diets vary greatly among different regions due to cultural differences and lifestyles. Few studies to date based on a Chinese population have investigated the relationship between dietary patterns and the formation of atherosclerosis in carotid arteries. We aimed to investigate whether dietary patterns were related to carotid atherosclerosis among an adult population in Tianjin, China.Methods: This cross-sectional study included a total of 2,346 participants aged 50 years or older (mean: 59.7 ± 6.29 years). Dietary intakes were assessed using a validated 81-item semiquantitative food frequency questionnaire, and factor analysis was used to identify dietary patterns. Carotid atherosclerosis was defined as a common carotid artery intima-media thickness ≥1.0 mm or plaques, or a carotid bifurcation intima-media thickness ≥1.2 mm. Multiple logistic regression models were used to explore the relationship between dietary patterns and carotid atherosclerosis.Results: Three factors were determined: “health” dietary pattern (factor 1), “traditional Tianjin” dietary pattern (factor 2), and “sweets” dietary pattern (factor 3). The multivariable-adjusted odds ratios (95% CI) of carotid atherosclerosis for the increasing quartiles of the sweets dietary pattern scores in women were as follows: 1.00 (reference), 1.33 (0.91, 1.97), 1.21 (0.82, 1.79), 1.64 (1.08, 2.51) (p for trend <0.05). No significant difference was found between any dietary pattern and carotid atherosclerosis in men.Conclusion: Greater adherence to “sweets” dietary patterns was positively related to a higher prevalence of carotid atherosclerosis in women aged 50 or older. No relationship was found between any dietary pattern and carotid atherosclerosis in men. Further prospective studies are warranted to test this finding in other populations.

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The Relationship between Circulating Levels of Osteopontin with Carotid Intima-Media Thickness in Children on Regular Hemodialysis

Open Journal of Nephrology ◽

10.4236/ojneph.2021.114039 ◽

2021 ◽

Vol 11 (04) ◽

pp. 467-476

Author(s):

Raghda Mohamed ◽

Enas Tawfeek ◽

Manal Abdel-Salam ◽

Niveen Mohamed Ghoraba ◽

Hala Maghraby

Keyword(s):

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Media Thickness ◽

The Relationship ◽

Circulating Levels ◽

Regular Hemodialysis

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Ultrasonic assessment of carotid intima-media thickness in migraine: a meta-analysis

Journal of International Medical Research ◽

10.1177/0300060519851354 ◽

2019 ◽

Vol 47 (7) ◽

pp. 2848-2855 ◽

Cited By ~ 2

Author(s):

Qiao Wang ◽

Zhen-Yu Liu ◽

Jia Zhou

Keyword(s):

Meta Analysis ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Cerebrovascular Diseases ◽

Cochrane Library ◽

Carotid Imt ◽

Media Thickness ◽

The Cochrane Library ◽

Ultrasonic Assessment ◽

The Relationship

Objective Migraine is believed to be a risk factor for cerebrovascular diseases, and previous studies have indicated an association between migraine and cerebral atherosclerosis. Carotid artery intima-media thickness (IMT) is considered to be a biomarker of atherosclerosis pathology. This study aimed to investigate the relationship between carotid IMT and migraine by conducting a meta-analysis. Methods We searched Web of Science, PubMed, and the Cochrane Library for eligible studies assessing carotid IMT in patients with migraine and controls. Data were extracted independently by two reviewers and analyzed using Review Manager 5.3 software. Results The meta-analysis included seven articles with 555 subjects (279 migraine patients, 276 controls). Carotid IMT was significantly greater in patients with migraine compared with controls. However, there were no significant differences in IMT between patients with migraine with aura (MA) and controls, migraine without aura (MO) and controls, and patients with MA and MO. Conclusion Patients with migraine have greater carotid IMT than individuals without migraine, suggesting an association between atherosclerosis and migraine. However, further studies with more samples are needed to confirm this finding.

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Abstract 13452: Serum Apolipoprotein B-48 levels Are Significantly Correlated with Plaque Score of Carotid Arteries

Circulation ◽

10.1161/circ.130.suppl_2.13452 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Daisaku Masuda ◽

Manabu Okubo ◽

Hiroyuki Hanada ◽

Masahiro Matsui ◽

Yoh Hidaka ◽

...

Keyword(s):

Carotid Arteries ◽

Carotid Atherosclerosis ◽

Intima Media Thickness ◽

High Serum ◽

Apo B ◽

Plaque Score ◽

Increased Risk ◽

Basic Studies ◽

Atherosclerotic Cardiovascular Diseases ◽

Chylomicron Remnants

Introduction: Fasting hypertriglyceridemia is a “residual risk” factor for atherosclerotic cardiovascular diseases and related to postprandial hypertriglyceridemia (PHTG). Intestine-derived lipoproteins such as chylomicrons and chylomicron remnants (CM-Rs), which contain one apolipoprotein(apo) B-48 molecule per one particle, are accumulated in patients with PHTG. Basic studies showed that CM-R had an atherogenic nature and apoB-48 molecule was observed in atherosclerotic plaque twice as many as apoB-100 molecule histologically. We established a CLEIA for measuring serum apoB-48 concentrations and reported that high apoB-48 concentrations correlated with the prevalence of dyslipidemia, diabetes mellitus, metabolic syndrome, chronic kidney disease and coronary heart disease. Hypothesis: We investigated whether serum apoB-48 concentration correlated with subclinical carotid atherosclerosis. Methods: A total of 163 subjects who received ultrasonography of carotid arteries in Osaka University were enrolled. Blood pressure (BP) at the supine position and serum concentrations of apoB-48, plasma glucose, HbA1c, TC, TG HDL-C and LDL-C were measured. Intima-media thickness (IMT) of carotid arteries was measured and plaque score (PS) were calculated in all subjects. Results: All subjects were classified into 4 groups by apoB-48 concentration quartiles: 1st (0-2.2 μg/mL, n=41), 2nd (2.3-3.5 μg/mL, n=39), 3rd (3.6-6.7 μg/mL, n=42) and 4th quartile (≧6.8 μg/mL, n=41), respectively. TG concentrations, prevalence of high BMI (≧25), max-IMT and PS were increased as apoB-48 concentrations were increased. Max-IMT and PS had significant correlations with age, eGFR, systolic BP, log-TG and log-apoB-48 levels and a multiple regression analysis indicated that the age, eGFR, and log-apoB-48 concentrations (p<0.05) were a significant determinant of an increased max-IMT and PS. In subjects whose TG concentrations were <150 mg/dL, max-IMT and PS were significantly higher in subjects of the 4th quartile than those of other quartiles. Conclusions: High serum apoB-48 concentrations strongly correlated with increased max-IMT and PS, indicating that the accumulated CM-Rs might be one of the increased risk for subclinical carotid atherosclerosis.

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