scholarly journals Levels of IL-6 and soluble IL-6 receptor are increased in HIV patients with a history of immune restoration disease after HAART

HIV Medicine ◽  
2002 ◽  
Vol 3 (1) ◽  
pp. 21-27 ◽  
Author(s):  
SF Stone ◽  
P Price ◽  
NM Keane ◽  
RJ Murray ◽  
MA French
Keyword(s):  
Immune Restoration ◽  
Hiv Patients ◽  
Immune Restoration Disease ◽  
History Of

Mycobacterial antibody levels and immune restoration disease in HIV patients treated in South East Asia

2011 ◽  
Vol 5 (6) ◽  
pp. 847-853 ◽  
Author(s):  
Hermi R Sumatoh ◽  
Benjamin G Oliver ◽  
Manoj Kumar ◽  
Julian H Elliott ◽  
Saphonn Vonthanak ◽  
...  
Keyword(s):  
East Asia ◽  
South East Asia ◽  
Immune Restoration ◽  
Hiv Patients ◽  
Immune Restoration Disease ◽  
Antibody Levels

scholarly journals The Search for a Genetic Factor Associating with Immune Restoration Disease in HIV Patients Co-Infected withMycobacterium tuberculosis

2013 ◽  
Vol 34 (6) ◽  
pp. 445-449 ◽  
Author(s):  
Jacquita S. Affandi ◽  
Manoj Kumar ◽  
Upasna Agarwal ◽  
Sarman Singh ◽  
Patricia Price
Keyword(s):  
Genetic Factor ◽  
Nucleotide Polymorphisms ◽  
Mycobacterial Disease ◽  
Immune Restoration ◽  
Hiv Patients ◽  
Single Nucleotide ◽  
Immune Restoration Disease ◽  
Genes Encoding ◽  
Per Se ◽  
Immune Related Genes

BACKGROUND: Up to 43% of HIV-infected patients co-infected withMycobacterium tuberculosisexperience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies.OBJECTIVE: We investigate if single nucleotide polymorphisms (SNP) in genes encoding cytokines, chemokines and their receptors associate with development of an IRD event in patients of two different ethnicities.METHODS: DNA samples were available from small well-characterised groups of HIV patients treated in Cambodia (TB-IRD,n= 17; HIV+TB+controls, n = 55) and India (TB-IRD,n= 19; HIV+TB+controls,n= 43). HIV patients with a TB diagnosis but no evidence of IRD were included to control for susceptibility to TB per se. Sixteen SNP implicated in inflammation or mycobacterial disease were genotyped.RESULTS: Susceptibility to TB-IRD associated with carriage of TNFA-1031*T (rs1799964;P=0.05) and SLC11A1 D543N*G (rs17235409;P=0.04) in Cambodian patients and carriage of IL18-607*G (rs1946518;P=0.02) and VDR FokI (F/f)*T (rs10735810;P=0.05) in Indian patients.CONCLUSIONS: Associations between polymorphisms in immune-related genes and TB-IRD were found, but none were common across two ethnicities.

Interferon-γ and IL-5 Production Correlate Directly in HIV Patients Co-Infected with Mycobacterium tuberculosis with or without Immune Restoration Disease

2010 ◽  
Vol 26 (12) ◽  
pp. 1287-1289 ◽  
Author(s):  
Benjamin G. Oliver ◽  
Julian H. Elliott ◽  
Vonthanak Saphonn ◽  
Mean Chhi Vun ◽  
Martyn A. French ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Interferon Γ ◽  
Immune Restoration ◽  
Hiv Patients ◽  
Immune Restoration Disease

TLR2-induced cytokine responses may characterize HIV-infected patients experiencing mycobacterial immune restoration disease

AIDS ◽  
2011 ◽  
Vol 25 (12) ◽  
pp. 1455-1460 ◽  
Author(s):  
Dino B.A. Tan ◽  
Andrew Lim ◽  
Yean K. Yong ◽  
Sasheela Ponnampalavanar ◽  
Sharifah Omar ◽  
...  
Keyword(s):  
Immune Restoration ◽  
Immune Restoration Disease ◽  
Cytokine Responses

scholarly journals Treatment with Tumor Necrosis Factor-α Inhibitors, History of Allergy, and Hypercalcemia Are Risk Factors of Immune Reconstitution Inflammatory Syndrome in HIV-Negative Pulmonary Tuberculosis Patients

2019 ◽  
Vol 9 (1) ◽  
pp. 96
Author(s):  
Yoshimasa Hachisu ◽  
Yasuhiko Koga ◽  
Shu Kasama ◽  
Kyoichi Kaira ◽  
Masakiyo Yatomi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Immune Reconstitution ◽  
Tumor Necrosis ◽  
Hiv Patients ◽  
Tnf Α ◽  
History Of ◽  
Inflammatory Syndrome ◽  
Necrosis Factor ◽  
Inhibitor Treatment

Immune reconstitution inflammatory syndrome (IRIS) is an immune reaction that occurs along with the recovery of the patient’s immunity. Tuberculosis-related IRIS (TB-IRIS) upon tumor necrosis factor (TNF)-α inhibitor treatment has been reported in non-human immunodeficiency virus (HIV) patients. However, the importance of biological treatment, as a risk factor of IRIS, has not yet been established. In this study, we examined TB-IRIS in non-HIV patients to explore the role of TNF-α inhibitor treatment. Out of 188 patients with pulmonary TB, seven patients had IRIS. We examined univariate logistic and multivariate analysis to elucidate risk factors of TB-IRIS. Univariate analysis indicated that usage of immunosuppressive drugs, TNF-α inhibitors, and history of food or drug allergy were significantly related with TB-IRIS. On initial treatment, the values of serological markers such as serum albumin and serum calcium were significantly related with TB-IRIS. There was a higher mortality rate in patients with TB-IRIS. Furthermore, multivariate analysis revealed that usage of TNF-α inhibitors, history of allergy, and serum hypercalcemia were related to TB-IRIS. Usage of TNF-α inhibitors, history of allergy, and serum hypercalcemia may be independent predictors of TB-IRIS in non-HIV patients. Since higher mortality has been reported for TB-IRIS, we should pay attention to TB patients with these risk factors.

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