scholarly journals Advance on synthesis, pharmacokinetics, and pharmacodynamics of the anti-epileptic drug: Levetiracetam

2020 ◽  
Vol 185 ◽  
pp. 03006
Author(s):  
Wei Wang

Over the past few decades, many patients around the world have suffered from epilepsy, and epilepsy treatment is a long-term process. Thus, the safety and efficacy of medication for epilepsy are of equal importance. Levetiracetam is a second-generation anti-epileptic drug with a unique mechanism of action, good anti-epileptic efficacy, and safety. The therapeutic field has broad application prospects because levetiracetam offers several advantages over other anti-epileptic drugs. In this review, the synthesis, pharmacokinetics, pharmacodynamics, and reverse reaction of levetiracetam were summarized and discussed. This paper will be helpful for the development and application of levetiracetam.

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 569
Author(s):  
Jean-Nicolas Tournier ◽  
Joseph Kononchik

The eradication of infectious diseases has been achieved only once in history, in 1980, with smallpox. Since 1988, significant effort has been made to eliminate poliomyelitis viruses, but eradication is still just out of reach. As the goal of viral disease eradication approaches, the ability to recreate historically eradicated viruses using synthetic biology has the potential to jeopardize the long-term sustainability of eradication. However, the emergence of the severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 pandemic has highlighted our ability to swiftly and resolutely respond to a potential outbreak. This virus has been synthetized faster than any other in the past and is resulting in vaccines before most attenuated candidates reach clinical trials. Here, synthetic biology has the opportunity to demonstrate its truest potential to the public and solidify a footing in the world of vaccines.


2021 ◽  
Vol 13 (16) ◽  
pp. 3264 ◽  
Author(s):  
Shuang Li ◽  
Zhongqiu Sun ◽  
Yafei Wang ◽  
Yuxia Wang

Studying urban expansion from a longer-term perspective is of great significance to obtain an in-depth understanding of the process of urbanization. Remote sensing data are mostly selected to investigate the long-term expansion of cities. In this study, we selected the world-class urban agglomeration of Beijing-Tianjin-Hebei (BTH) as the study area, and then discussed how to make full use of multi-source, multi-category, and multi-temporal spatial data (old maps and remote sensing images) to study long-term urbanization. Through this study, we addressed three questions: (1) How much has the urban area in BTH expanded in the past 100 years? (2) How did the urban area expand in the past century? (3) What factors or important historical events have changed the development of cities with different functions? By comprehensively using urban spatial data, such as old maps and remote sensing images, geo-referencing them, and extracting built-up area information, a long-term series of urban built-up areas in the BTH region can be obtained. Results show the following: (1) There was clear evidence of dramatic urban expansion in this area, and the total built-up area had increased by 55.585 times, from 126.181 km2 to 7013.832 km2. (2) Continuous outward expansion has always been the main trend, while the compactness of the built-up land within the city is constantly decreasing and the complexity of the city boundary is increasing. (3) Cities in BTH were mostly formed through the construction of city walls during the Ming and Qing dynasties, and the expansion process was mostly highly related to important political events, traffic development, and other factors. In summary, the BTH area, similarly to China and most regions of the world, has experienced rapid urbanization and the history of such ancient cities should be further preserved with the combined use of old maps.


2012 ◽  
Vol 62 (4) ◽  
pp. 423-434
Author(s):  
Jan Winiecki

A look at the Western debate about West’s problems reveals what the present writer regards in a large measure as an irritating superficiality. Nowhere is it better visible than in the mainstream discussions about the euro zone and its problems, where most debaters glide over the fundamentals of Europe’s long-term problems and concentrate on the superficial and short-term issues. The discussions on how to “save” the euro zone strangely forget the defects in its creation, glide over the lessons to be drawn from policies pursued during the past decade, and defend the virtue of maintaining its present membership. But the problems of Europe run much deeper than the survival or collapse of the monetary union. Even if we assume that the problems of confidence the member states have in each other’s behaviour are restored and the rest of the world regains confidence in the institutions of the monetary union, the fundamental problems will remain unsolved. A clue to the real long-term problems may be found in the answer to a rather simple question. It runs as follows: “Why is the large majority of European countries indebted to such an extent that any further increase in debt to GDP ratio generates panic reactions among potential lenders?”


2013 ◽  
Vol 385-386 ◽  
pp. 995-998
Author(s):  
Hong Peng He ◽  
Jun Liu

Smart grid puts forward higher requirements for measurement equipments, so optical current transducer (OCT) used in power system possess broad application prospects. In this paper, magnetism gathering technology is applied in the design of OCTs optical structure and the magnetism gathering optical structure based on solenoid coil is proposed. Compared with traditional bulk optical structure, this structure simplifies the optical structure significantly. Results of simulation and field operation indicate that this structure can not only enhance the magnetic field created by the measured current significantly, but also improve the long-term operation stability of OCT.


1998 ◽  
Vol 37 (4II) ◽  
pp. 1053-1070 ◽  
Author(s):  
Sohail Jehangir Malik ◽  
Hina Nazli

By highlighting the lack of rigorous evidence and calling for a greater understanding of the interaction of the two processes, a recent study [Nelson et al. (1997)] has called into question the strong perception that poverty is both a consequence as well as a cause of resource degradation.1 This perception which is widely held is strongly evident in the writings of the multilateral development agencies such as the World Bank (1990) and IFAD (1992) and exists despite extensive reviews which indicate that the short- and long-term implications of land degradation are not very clear [see Scherr and Yadav (1995)]. Similarly, while knowledge about poverty is expanding rapidly, thanks in large parts to the massive international focus and resources brought to bear on its understanding in the past ten.........................


Author(s):  
Robert Pool

The past couple of decades have been a confusing, frustrating period for engineers. With their creations making the world an ever richer, healthier, more comfortable place, it should have been a time of triumph and congratulation for them. Instead, it has been an era of discontent. Even as people have come to rely on technology more and more, they have liked it less. They distrust the machines that are supposedly their servants. Sometimes they fear them. And they worry about the sort of world they are leaving to their children. Engineers, too, have begun to wonder if something is wrong. It is not simply that the public doesn’t love them. They can live with that. But some of the long-term costs of technology have been higher than anyone expected: air and water pollution, hazardous wastes, the threat to the Earth’s ozone layer, the possibility of global warming. And the drumbeat of sudden technological disaster over the past twenty years is enough to give anyone pause: Three Mile Island, Bhopal, the Challenger, Chernobyl, the Exxon Valdez, the downing of a commercial airliner by a missile from the U.S.S. Vincennes. Is it time to rethink our approach to technology? Some engineers believe that it is. In one specialty after another, a few prophets have emerged who argue for doing things in a fundamentally new way. And surprisingly, although these visionaries have focused on problems and concerns unique to their own particular areas of engineering, a single underlying theme appears in their messages again and again: Engineers should pay more attention to the larger world in which their devices will function, and they should consciously take that world into account in their designs. Although this may sound like a simple, even a self-evident, bit of advice, it is actually quite a revolutionary one for engineering. Traditionally, engineers have aimed at perfecting their machines as machines. This can be seen in the traditional measures of machines: how fast they are, how much they can produce, the quality of their output, how easy they are to use, how much they cost, how long they last.


2019 ◽  
pp. 120-129
Author(s):  
D. L. Lopatnikov

Anthropogenic CO2 emissions are currently considered by the UN and other authoritative international organizations engaged in monitoring changes in the Earth’s biogeosphere as one of the main indicators of the global environmental situation. According to the official Doctrine of Sustainable Development, anthropogenic CO2 emissions are one of the main causes of global warming. The article examines the dynamics of CO2 emissions by countries and regions of the world from the 1970s to the 2010s. The correlation between the volume of CO2 emissions and changes in the overall territorial distribution of the world economy has been demonstrated. Over the past fifty years, the geography of anthropogenic CO2 emissions by countries and macro-regions of the world has changed dramatically. The share of the most economically developed countries in the volume of CO2 emissions has decreased. The main epicenter of anthropogenic CO2 emissions has shifted to the countries belonging to the semi-periphery of the world. The movement of the main foci of anthropogenic CO2 emissions on the world map reflects qualitative shifts in the global geoecological panorama over the past fifty years. The dynamics and spatial transformation of anthropogenic CO2 emissions is an illustration of the long-term trend of the change from negative to positive through the cycle of multidirectional shifts of one of the many ecologically significant processes on Earth.


2005 ◽  
Vol 16 (3-4) ◽  
pp. 441-456 ◽  
Author(s):  
Wolfgang E. Kasper

Against the human experience of long-term stagnation and misery, the record of growing prosperity over the past two centuries, and in particular the last fifty years, is astounding. Economic growth owes much to the mobilisation of resources and structural flexibility, but this depends on the ‘software of economic development’ – institutions, which change slowly. Now, old fears and growth-impeding policies are being justified on environmental grounds. One example is Jared Diamond's recent book ‘Collapse’, which discusses the possibility of a swift descent of the world into social disintegration. To anyone familiar with long-term economic history and the theory of growth, the book is pure millennial pessimism. It could become self-fulfilling if environmentalist doomsayers win the political argument with the doers — the engineers, entrepreneurs and economists.


2013 ◽  
Vol 05 (04) ◽  
pp. 43-52
Author(s):  
John WONG

Recently, China published its Gini coefficients for the past 10 years, which all exceeded the warning level of 0.4. China's inequality level is among the highest 10% of countries in the world. In fact, the sources of China's income inequality stemmed from the sources of China's economic growth. Long-term remedy requires fundamental structural changes like removing institutional biases against equality and providing a more equal access to educational and income-earning opportunities.


2009 ◽  
Vol 2009 ◽  
pp. 1-2
Author(s):  
Yusuf Ata ◽  
Tamer Turk ◽  
Cüneyt Eris ◽  
Mihriban Yalcin ◽  
Filiz Ata ◽  
...  

The Starr-Edwards caged ball valve is one of the oldest cardiac valve prosthesis and was widely used all around the world in the past decades. Despite the long-term results that have been reported there are only a few cases reported that exceed 30 years of durability. Here in, we report a 53-year-old patient with a well-functioning 35-year-old aortic Starr-Edwards caged ball prosthesis.


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