scholarly journals The association of serum selenium with serum lipids in US adults

2021 ◽  
Vol 271 ◽  
pp. 03066
Author(s):  
Nuan Wen
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Selenium Concentration ◽  
Serum Selenium ◽  
Health And Nutrition ◽  
Serum Selenium Concentration ◽  
High Selenium

High selenium concentrations were associated with cardiovascular diseases, type 2 diabetes, and central nervous disorders. The author examined the relation of serum selenium concentration with serum lipids levels with the use of the National Health and Nutrition Examination Survey (NHANES) 2017-2018. 759 adults aged more than 20 years old from NHANES 2017-2018 were examined in the analysis. Serum selenium was measured by mass spectrometry. Triglyceride, HDL cholesterol, and total cholesterol were measured through enzymatical methods. LDL cholesterol was calculated then. Comparing Q4 to Q1 of serum selenium, the multivariable adjusted average differences (95% CI) in triglyceride, HDL cholesterol, LDL cholesterol, and total cholesterol were 21.3 mg/dL (9.1, 33.4 mg/dL), 2.3 mg/dL (-0.6, 5.2 mg/dL), 6.3 mg/dL (-1.3, 13.9 mg/dL), 12.8 (95% CI: 4.2, 21.5 mg/dL), respectively. Hence, The increasing serum selenium concentration is associated with increasing triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol among US adults.

Effects of diacerein intake on cardiometabolic profiles in type 2 diabetics: a systematic review and meta-analysis of clinical trials.

2020 ◽  
Vol 27 ◽  
Author(s):  
Peyman Nowrouzi-Sohrabi ◽  
Reza Tabrizi ◽  
Mohammad Jalali ◽  
Navid Jamali ◽  
Shahla Rezaei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Body Weight ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Hdl Cholesterol ◽  
Cochrane Central Register ◽  
Statistical Heterogeneity

Introduction: A systematic review and meta-analysis of clinical trials was undertaken to evaluate the effect of diacerein intake on cardiometabolic profiles in patients with type 2 diabetes mellitus (T2DM). Methods: Electronic databases such as PubMed, EMBASE, Scopus, Web of Science, Google Scholar, and Cochrane Central Register of Controlled Trials were searched from inception to 31 July 2019. Statistical heterogeneity was evaluated using Cochran’s Q test and I-square (I2 ) statistic. Data were pooled using random-effect models and weighted mean difference (WMD). Results: From 1,733 citations, seven clinical trials were eligible for inclusion and meta-analysis. A significant reduction in hemoglobin A1c (HbA1c) (WMD -0.73; 95%CI -1.25 to -0.21; P= 0.006; I2 = 72.2%) and body mass index (BMI) (WMD -0.55; 95%CI -1.03 to -0.07; P= 0.026; I2 = 9.5%) were identified. However, no significant effect of diacerein intake was identified on fasting blood sugar (FBS) (WMD - 9.00; 95%CI -22.57 to 4.57; P= 0.194; I2 = 60.5%), homeostatic model assessment for insulin resistance (HOMA-IR) (WMD 0.39; 95%CI 0.95 to 1.73; P= 0.569; I2 = 2.2%), body weight (WMD -0.54; 95%CI -1.10 to 0.02; P= 0.059), triglycerides (WMD -0.56; 95%CI -24.16 to 23.03; P= 0.963; I2 = 0.0%), total-cholesterol (WMD -0.21; 95%CI -12.19 to 11.78; P= 0.973; I2 = 0.0%), HDL-cholesterol (WMD -0.96; 95%CI -2.85 to 0.93; P= 0.321; I2 = 0.0%), and LDL-cholesterol levels (WMD -0.09; 95%CI -8.43 to 8.25; P= 0.983; I2 = 37.8%). Conclusion: Diacerein intake may reduce HbA1c and BMI; however, no evidence of effect was observed for FBS, HOMA-IR, body weight, triglycerides, total-cholesterol, HDL-cholesterol or LDL-cholesterol.

scholarly journals Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia

2001 ◽  
Vol 86 (2) ◽  
pp. 233-239 ◽  
Author(s):  
Robert Volpe ◽  
Leena Niittynen ◽  
Riitta Korpela ◽  
Cesare Sirtori ◽  
Antonello Bucci ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Plant Sterols ◽  
Dependent Manner ◽  
Low Fat ◽  
Treatment Groups ◽  
Cholesterol Levels ◽  
Dose Dependent

The objective of the present study was to assess the effect of consumption of a yoghurt-based drink enriched with 1–2 g plant sterols/d on serum lipids, transaminases, vitamins and hormone status in patients with primary moderate hypercholesterolaemia. Thirty patients were randomly assigned to one of two treatment groups: a low-fat low-lactose yoghurt-based drink enriched with 1 g plant sterol extracted from soyabean/dv.a low-fat low-lactose yoghurt, for a period of 4 weeks. After a 2-week wash-out period, patients were crossed over for an additional 4-week period. Second, after a 4-week wash-out period, eleven patients were treated with 2 g plant sterols/d in a second open part of the study for a period of 8 weeks. The yoghurt enriched with plant sterols significantly reduced, in a dose-dependent manner, serum total cholesterol and LDL-cholesterol levels and LDL-cholesterol:HDL-cholesterol (P<0·001), whereas no changes were observed in HDL-cholesterol and triacylglycerol levels, either in the first or the second part of the study. There were only slight, not statistically significant, differences in serum transaminase, vitamin and hormone levels. To conclude, a low-fat yoghurt-based drink moderately enriched with plant sterols may lower total cholesterol and LDL-cholesterol effectively in patients with primary moderate hypercholesterolaemia.

scholarly journals Oxidized LDL and lipids as risk factors for ischemic heart disease in type 2 diabetes

2005 ◽  
Vol 62 (7-8) ◽  
pp. 529-536 ◽  
Author(s):  
Miroslava Zamaklar ◽  
Katarina Lalic ◽  
Natasa Rajkovic ◽  
Danijela Trifunovic ◽  
Mirjana Dragasevic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Oxidized Ldl ◽  
Hdl Cholesterol ◽  
Apo B ◽  
Significant Difference

Background. Abnormal lipid profile is an important risk factor in the development of macrovascular atherosclerotic complications in patients with type 2 diabetes mellitus (T2D). Factors that contribute to endothelial cell dysfunction associated with the initiation of atherosclerosis include oxidative stress. The aim of this study was to investigate the relationship between lipid profile and oxidative stress in type 2 diabetics with and without ischemic heart disease (IHD). Methods. We studied 80 patients with T2D, 40 with IHD (group A1) and 40 without IHD (group A2). We also studied 51 non-diabetics, 31 with IHD (group B1), and 20 without IHD (group B2 - control group). Lipid profile was estimated by the total cholesterol, HDL cholesterol, LDL cholesterol, the level of triglyceride (Tg), lipoproteina a (Lp a), Apo A I, A II, B 100 and E. To evaluate the oxidative status we measured circulating oxidized LDL (ox LDL), erythrocyte antioxidative enzyme activity: superoxide dismutase (E-SOD), glutathione peroxidase (E-GPX), as well as the total antioxidative serum activity (TAS). Inflammatory reaction was estimated by C-reactive protein (CRP) and fibrinogen. Results. No significant difference was found in the lipid profile in groups A1, A2 and B1, but the group B2 had the lowest one. Lp a level was significantly higher in group B1 comparing to other groups (p < 0.05). There was no significant difference in the level of ox LDL between the groups. In diabetics, ox LDL positively correlated with the total cholesterol, LDL cholesterol, non HDL cholesterol, Apo B 100 and the relations between LDL/HDL and Tg/HDL (p < 0.001), as well as with Tg and fibrinogen (p < 0.05). In group B1, ox LDL positively correlated with total cholesterol, Tg (p < 0.01), LDL, and non HDL cholesterol (p < 0.05) and significantly with Apo B 100 (p < 0.001). There was no significant difference in the antioxidant enzyme activities between the groups of diabetics (A1 and A2), but fibrinogen was higher in the group with IHD (group A1, p < 0.05). Group B1 had lower ESOD activity than the groups A1 and A2 (p < 0.05), but CRP was higher (p < 0.05). There were no significant correlations between oxLDL and CRP in groups A1 and A2, but it was statistically significant in the group B1 (p < 0.05). Conclusion. In this study we demonstrated the increased oxidative stress in diabetics compared to non-diabetics regardless of the presence of IHD. Fibrinogen, but not CRP, was higher in diabetics with IHD, compared to diabetics without IHD. The increased oxidative stress, the reduced antioxidative activity E-SOD, and the higher level of CRP were found in non-diabetics with IHD compared to non-diabetics without IHD.

scholarly journals Estrogen Replacement Therapy, Serum Lipids, and Polymorphism of the Apolipoprotein E Gene

1999 ◽  
Vol 45 (8) ◽  
pp. 1214-1223 ◽  
Author(s):  
Philip J Garry ◽  
Richard N Baumgartner ◽  
Steven G Brodie ◽  
George D Montoya ◽  
Hwa Chi Liang ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Estrogen Replacement Therapy ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Estrogen Replacement ◽  
Apolipoprotein E Gene ◽  
Apoe Genotypes

Abstract Background: Pharmacogenomics, the study of genetic loci that modulate drug responsiveness, may help to explain why estrogen replacement therapy (ERT) has differential effects on serum lipid and lipoprotein concentrations in postmenopausal women who inherit distinct alleles of the apolipoprotein E gene (APOE). Methods: We compared total-cholesterol, triglyceride, and lipoprotein (LDL and HDL) concentrations in 66 postmenopausal women receiving ERT ([+]ERT) with 174 postmenopausal women not receiving ERT ([−]ERT), controlling for three APOE genotypes divided into three groups: E2 (ε2/ε3, n = 31), E3 (ε3/ε3, n = 160), and E4 (ε3/ε4 + ε4/ε4, n = 49). Results: Mean total-cholesterol concentrations were lower in all three [+]ERT groups compared with their [−]ERT counterparts but were statistically significant only for women in group E4 (P = 0.014). The mean LDL-cholesterol concentrations were significantly lower in all three [+]ERT groups compared with their [−]ERT counterparts (P ≤0.005). Although all three groups of [+]ERT women tended to have higher mean HDL-cholesterol concentrations compared with their [−]ERT counterparts, the differences were not statistically significant. [+]ERT women in groups E2 and E3 had significantly higher (P &lt;0.05) triglyceride concentrations than their [−]ERT counterparts. In [+]ERT women, the ratios of total and LDL-cholesterol to HDL-cholesterol were significantly higher in group E3 and E4 women compared with E2 women (P &lt;0.006). Group E4 [+]ERT women had ratios of total and LDL-cholesterol to HDL-cholesterol that were comparable to group E2 [−]ERT women. Conclusions: Triglyceride concentrations in group E2 [+]ERT women may need to be monitored more closely than those in E3 or E4 [+]ERT women. Group E4 women should probably be targeted for ERT. Results suggest that APOE genotypes have a differential effect on serum lipids and lipoproteins in [+]ERT postmenopausal women.

scholarly journals Effect of increased calcium consumption from fat-free milk in an energy-restricted diet on the metabolic syndrome and cardiometabolic outcomes in adults with type 2 diabetes mellitus: a randomised cross-over clinical trial

2018 ◽  
Vol 119 (4) ◽  
pp. 422-430 ◽  
Author(s):  
Junia M. G. Gomes ◽  
Jorge d. A. Costa ◽  
Rita C. G. Alfenas
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Restricted Diet ◽  
The Metabolic Syndrome

AbstractWe investigated the effects of high-Ca fat-free milk phase (MD) (prescription of approximately 1500 mg of Ca/d) v. low-Ca phase (CD) (prescription of approximately 800 mg of Ca/d) in an energy-restricted diet on the metabolic syndrome (MetS) and cardiometabolic measures in individuals with type 2 diabetes mellitus (T2DM) and low habitual Ca consumption (<600 mg/d). In this randomised cross-over design, fourteen adults with T2DM (49·5 (sd 8·6) years, BMI 29·4 (sd 4·5) kg/m2) consumed either MD or CD for 12 weeks, with a washout of 18 weeks between phases. A breakfast shake containing 700 mg (MD) or 6·4 mg (CD) of Ca was consumed in the laboratory. In addition, energy-restricted diets were prescribed (800 mg of dietary Ca/d). Waist circumference (WC), fasting glucose, fasting TAG, systolic (SBP) and diastolic blood pressure (DBP), fasting total cholesterol, fasting LDL-cholesterol, fasting HDL-cholesterol, HDL:LDL ratio, HDL:TAG ratio and lipid accumulation product (LAP) index were assessed at baseline and after each phase. Ca consumption during the study was equivalent to 1200 mg/d during MD and 525 mg/d during CD. There was a greater reduction in WC, SBP, DBP and LAP index after MD compared with CD. HDL:LDL ratio increased and total cholesterol, LDL-cholesterol, SBP, DBP and LAP index decreased only in MD. The consumption of approximately 1200 mg of Ca/d (700 mg from fat-free milk+500mg from other dietary sources) associated with an energy-restricted diet decreased some of the MetS components and cardiometabolic measures in adults with T2DM.

scholarly journals Association of High Density Lipoprotein Cholesterol with Renal Function in Type 2 Diabetic Subjects in a Bangladeshi Population

2012 ◽  
Vol 2 (1) ◽  
pp. 15-19
Author(s):  
Muhammad Saiedullah ◽  
Muhammad Rezwanur Rahman ◽  
Shahnaj Begum ◽  
Shoma Hayat ◽  
Md Aminul Haque Khan
Keyword(s):  
Renal Function ◽  
Total Cholesterol ◽  
Filtration Rate ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Bangladeshi Population ◽  
Lipid Parameters ◽  
Type 2 Diabetic

Background: Abnormalities in lipid metabolism are associated with renal diseases. Association of serum lipid parameters with renal function is less studied in subjects with type 2 diabetes in Bangladeshi population. Objective: To assess the correlation of high density  lipoprotein cholesterol with glomerular filtration rate (GFR) in type 2 diabetic subjects.Materials and Methods: One thousand three hundred thirty confirmed diabetic subjects advised for HbA1c, serum creatinine, serum total cholesterol, serum triglycerides, serum HDL cholesterol and LDL cholesterol were included in the study. Serum total cholesterol, HDL cholesterol, triglyceride, serum creatinine, HbA1c were measured by standard methods and serum LDL cholesterol was calculated by Friedewald’s formula. GFR was calculated by MDRD4 variables prediction equation. Total subjects were grouped according to sex; both males and females were subdivided into three subgroups depending on GFR values. Results of lipid parameters were compared by one-way ANOVA among different groups and correlation of lipid parameters with GFR were expressed by Pearson r.Results: HDL cholesterol was significantly different among different GFR groups (p<0.05) and positively correlated with GFR (r = 0.1386, p<0.001) in males. Total cholesterol and LDL cholesterol showed feeble positive correlation with GFR (r = 0.0789, p<0.05 for total cholesterol and r = 0.0768, p<0.05 for LDL cholesterol), but are not significantly different among GFR groups (p>0.05) in males. Total cholesterol, HDL cholesterol, LDL cholesterol, non-HDL cholesterol and LDLC/HDL-C were significantly different among three different GFR groups (p<0.01) and only HDL cholesterol and LDL-C/HDL-C showed weak correlation with GFR (r = 0.0770, p<0.05 for HDL cholesterol and r = -0.0803, p<0.05 for LDL-C/HDL-C) in females.Conclusion: The study revealed that HDL cholesterol was significantly and positively correlated with glomerular filtration rate in both male and female diabetic subjects and assessment of lipid parameters might be a helpful tool to prevent or delay the progression of renal insufficiency. DOI: http://dx.doi.org/10.3329/jemc.v2i1.11916 J Enam Med Col 2012; 2(1): 15-19    

scholarly journals Serum lipid profile in dengue patients: a simple laboratory tool to predict disease severity

Biomedicine ◽  
2021 ◽  
Vol 41 (2) ◽  
pp. 227-232
Author(s):  
M. Thejaswini ◽  
Chandrashekar Udyavara Kudru ◽  
Shivashankara Kaniyoor Nagiri ◽  
Arpita Chakraborty ◽  
Vasudeva Guddattu
Keyword(s):  
Total Cholesterol ◽  
Disease Severity ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Severe Dengue ◽  
Cholesterol Levels ◽  
Laboratory Tool ◽  
Lipid Parameters

Introduction and Aim: Serum lipids play a pivotal role in the immune response of the host during dengue. The aim of this study was to evaluate the serum lipid abnormalities in dengue patients and to study the relationship between serum lipids with disease severity and platelet count.   Materials and Methods: This case control study was carried out in 75 cases of dengue of age group > 18 years divided into three groups namely dengue without warning symptoms (DNWS), dengue with warning symptoms (DWWS) and severe dengue (SD) and 75 age and gender matched healthy controls. Lipid parameters such as total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides were thereafter measured in all the subjects.   Results: Among 75 patients with dengue fever, 52 (69.4%) were classified as DNWS, 15 (20%) as DWWS and the remaining 8 (10.6%) as SD. Lower levels of serum total cholesterol (TC) levels (118.8 + 30.71) (p <0.0001) were observed among patients with DNWS when compared to controls. A strong significant positive correlation was seen between the platelets and serum HDL cholesterol levels among the subjects with SD (r = 0.712, p=.047*) and weak negative correlation was observed between the platelets and triglycerides in patients with dengue with warning signs (r = -0.275, p=.048*).   Conclusion: We observed a strong association of diminished TC, HDL and LDL cholesterol levels with the severity of dengue. Based on our findings, these three lipid parameters could be utilized as a simple laboratory tool to identify dengue severity in resource limited settings.

scholarly journals Toremifene Improves Lipid Profiles in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer: Interim Analysis of a Multicenter Phase III Study

2008 ◽  
Vol 26 (11) ◽  
pp. 1824-1829 ◽  
Author(s):  
Matthew R. Smith ◽  
S. Bruce Malkowicz ◽  
Franklin Chu ◽  
John Forrest ◽  
Paul Sieber ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Placebo Group ◽  
Total Cholesterol ◽  
Interim Analysis ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Phase Iii ◽  
Fasting Serum

Purpose Androgen-deprivation therapy (ADT) is associated with greater risk of incident coronary heart disease and hospital admission for myocardial infarction; treatment-related increases in serum lipids may contribute to greater cardiovascular disease risk. We evaluated the effects of toremifene, a selective estrogen-receptor modulator, on fasting serum lipid levels in men receiving ADT for prostate cancer. Patients and Methods In an ongoing, multicenter, double-blind, placebo-controlled phase III fracture-prevention study, 1,389 men receiving ADT for prostate cancer were randomly assigned to receive toremifene (80 mg/d) or placebo. In this interim analysis of 188 patients, changes in fasting serum lipids from baseline to month 12 were compared between the placebo and toremifene groups. Results Changes in serum lipids differed significantly between the groups. Mean (± SE) total cholesterol decreased by 1.0% ± 1.7% from baseline to month 12 in the placebo group and decreased by 8.1% ± 1.4% in the toremifene group (P = .001 for between group comparison). Low-density lipoprotein (LDL) cholesterol increased by 0.8% ± 2.5% in the placebo group and decreased by 8.2% ± 2.5% in the toremifene group (P = .003). In contrast, high-density lipoprotein (HDL) cholesterol decreased by 4.9% ± 1.2% in the placebo group and increased by 0.5% ± 2.2% in the toremifene group (P = .018). Triglycerides increased by 6.9% ± 4.2% in the placebo group and decreased by 13.2% ± 3.6% in the toremifene group (P = .003). Conclusion Toremifene significantly decreased total cholesterol, LDL cholesterol, and triglycerides, and increased HDL cholesterol in men receiving ADT for prostate cancer.

scholarly journals Evaluation of Tumour Necrosis Factor Alpha, Interleukin-2 Soluble Receptor, Nitric Oxide Metabolites, and Lipids as Inflammatory Markers in Type 2 Diabetes Mellitus

2006 ◽  
Vol 2006 ◽  
pp. 1-7 ◽  
Author(s):  
Flávia Ozorio Pereira ◽  
Tânia Silvia Frode ◽  
Yara Santos Medeiros
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Interleukin 2 ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Type 2 Dm ◽  
Nitric Oxide Metabolites

This study compared the results of tumour necrosis factor alpha (TNF-α), interleukin-2 soluble receptor (sIL-2R), nitric oxide metabolites (NOx), C-reactive protein (CRP), and lipids (total cholesterol, high-density lipoprotein (HDL-cholesterol), low-density lipoprotein (LDL-cholesterol), and triglycerides) between control group (nondiabetic subjects) and overweight type 2 DM subjects. To restrict the influence of variables that could interfere in the interpretation of data, subjects with obesity and/or acute or chronic inflammatory disease, haemoglobinopathies, recent use of antibiotics, antiinflammatory drugs, and trauma were excluded. Type 2 DM patients (n=39; age53.3±9.0years; median glycated haemoglobinA1c<8%) presented higher levels of TNF-α, triglycerides (P<.01), NOxand sIL-2R (P<.05) than control group (n=28; age39.7±14.1years). CRP, LDL-cholesterol, total cholesterol, and HDL-cholesterol did not differ among groups. Diabetic women (n=21) had higher levels of TNF-α, total cholesterol, LDL-cholesterol, and HDL-cholesterol than diabetic men (n=18) (P<.05), but there were no differences among sexes in the control group. This study indicates that increased level of proinflammatory markers occurs in type 2 DM even in the absence of obesity and marked hyperglycaemia, confirming that the inflammation course of the atherosclerotic process is more severe in diabetic patients than in nondiabetic subjects.

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