scholarly journals The role of endogenous intoxication in pathogenetic mechanisms of heat stress in cattle

2021 ◽  
Vol 273 ◽  
pp. 02017
Author(s):  
Ekaterina Rud ◽  
Elena Kuzminova ◽  
Marina Semenenko ◽  
Ksenia Semenenko ◽  
Andrey Abramov

The article presents the results of studies to identify the role of endogenous intoxication in the pathogenetic mechanisms of heat stress in cows in a comparative aspect between healthy animals and animals with hepatopathology. The obtained data indicate that in summer period in a farm located on the flat territory of the Krasnodar region the cattle are influenced by the heat stress. The relationship between the state of moderate heat stress in dairy cattle and the dynamics of a number of indicators characterizing the syndrome of endogenous intoxication of their body was revealed. The increase in the concentration of medium mass molecules (MMM) in healthy livestock was almost two times lower than in animals with fatty hepatosis. The obtained results can serve as a rationale for the development of an effective strategy for pharmacological correction of heat stress in cattle.

1994 ◽  
Vol 24 (2) ◽  
pp. 415-418 ◽  
Author(s):  
A.M. Shirazi ◽  
J.H. Siller-Cepeda ◽  
L.H. Fuchigami

This study reports on the relationship of glutathione to the recovery and death of red-osier dogwood, Cornussericea L., plants from "near-lethal" (NL) heat stress. Shoots of dormant red-osier dogwood plants were exposed to 51 °C for 1 h during early February, and then incubated in the dark at either 0 or 23 °C post-stress environment (PSE). In a previous study, NL heat stress treated plants incubated at 23 and 0 °C PSE recovered and died, respectively. Reduced and oxidized forms of glutathione (GSH and GSSG, respectively) were measured with HPLC at 365 nm absorbance after 0 h, 24 h, 2 weeks, and 4 weeks PSE, respectively. Incubation of the NL heat stress treatments for 24 h at 23 ± 3 °C prior to post-treatments resulted in a significant decrease of GSSG and slight decrease of GSH. In contrast, the sudden exposure of NL stressed plants to 0 °C for 24 h resulted in a significant reduction of both GSH and GSSG levels after 2 and 4 weeks incubation. At 23 °C PSE, GSH and GSSG levels of NL heat stressed plants increased, while at 0 °C PSE the levels of both decreased.


Author(s):  
V. H. Dzhyvak ◽  
O. I. Khlibovska ◽  
I. M. Klishch

Background. Endogenous intoxication is a multicomponent complex process due to the endogenous biological products or dysfunction of systemic natural detoxification. Objective. The aim of the research was to study the dynamics of indices of endogenous intoxication in rats with traumatic muscle damage in the experiment. Methods. The experiment was performed on 45 non-linear white rats, which were modeled with traumatic muscle damage. The level of endogenous intoxication was assessed by the content of medium plasma molecules (MMM), leukocyte and erythrocytic index of intoxication (LII and EII). The research was conducted on the 1st, 3rd, 7th, 14th days after the injury. Results. It was found that traumatic muscle damage causes endotoxemia. Manifestations of endogenous intoxication are: the increase of MMM1 in 2.3 times, MMM2 in 2.8 times compare to the intact animals. The level of this indicator slightly decreased in 7 days. Simultaneously with an increase in the MCT level in the post-traumatic period, the total toxic effect on the erythrocyte membrane also increased, which was manifested by a significant increase in EII in all terms of observation. Conclusions. Traumatic damage of the muscles is accompanied by the growth of molecules of average mass in upto 7 days of observation, which significantly differ from the indicators of the intact group. The results of our research prove that traumatic muscle damage causes endotoxicosis development evidenced by accumulation of endotoxins in the animals’ body that is proved by significant changes in endogenous intoxication indices: i.e. erythrocytic and leukocytic indexes of intoxication and content of medium mass molecules.


2020 ◽  
Vol 9 (5) ◽  
pp. 1921
Author(s):  
Made wahyu Krisna Upadana ◽  
Komang Agus Satria Pramudana

In order to stay in competition, Starbucks Coffee must be able to develop and innovate to determine an effective strategy. One of them is by using attractive social media marketing to builds brand awareness and leading to consumer purchasing decisions. The research objective is to determine the role of brand awareness mediating the effect of social media marketing on purchasing decisions. This research was conducted in Denpasar with 110 respondents through a purposive sampling method. Data collected through questionnaires and analyzed by path analysis. Based on the results, social media marketing has apositive and significant effect on purchasing decisions. This shows that the better the use of social media marketing, the more purchasing decisions from consumers. Brand awareness positively and significantly mediates the relationship between social media marketing and purchasing decisions. Brand awareness is able to mediate the relationship of social media marketing to purchasing decisions Keywords: social media marketing, brand awareness, purchasing decisions


2020 ◽  
Vol 43 ◽  
Author(s):  
Thomas Parr

Abstract This commentary focuses upon the relationship between two themes in the target article: the ways in which a Markov blanket may be defined and the role of precision and salience in mediating the interactions between what is internal and external to a system. These each rest upon the different perspectives we might take while “choosing” a Markov blanket.


Crisis ◽  
2016 ◽  
Vol 37 (3) ◽  
pp. 212-217 ◽  
Author(s):  
Thomas E. Joiner ◽  
Melanie A. Hom ◽  
Megan L. Rogers ◽  
Carol Chu ◽  
Ian H. Stanley ◽  
...  

Abstract. Background: Lowered eye blink rate may be a clinically useful indicator of acute, imminent, and severe suicide risk. Diminished eye blink rates are often seen among individuals engaged in heightened concentration on a specific task that requires careful planning and attention. Indeed, overcoming one’s biological instinct for survival through suicide necessitates premeditation and concentration; thus, a diminished eye blink rate may signal imminent suicidality. Aims: This article aims to spur research and clinical inquiry into the role of eye blinks as an indicator of acute suicide risk. Method: Literature relevant to the potential connection between eye blink rate and suicidality was reviewed and synthesized. Results: Anecdotal, cognitive, neurological, and conceptual support for the relationship between decreased blink rate and suicide risk is outlined. Conclusion: Given that eye blinks are a highly observable behavior, the potential clinical utility of using eye blink rate as a marker of suicide risk is immense. Research is warranted to explore the association between eye blink rate and acute suicide risk.


2015 ◽  
Vol 36 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Erin N. Stevens ◽  
Joseph R. Bardeen ◽  
Kyle W. Murdock

Parenting behaviors – specifically behaviors characterized by high control, intrusiveness, rejection, and overprotection – and effortful control have each been implicated in the development of anxiety pathology. However, little research has examined the protective role of effortful control in the relation between parenting and anxiety symptoms, specifically among adults. Thus, we sought to explore the unique and interactive effects of parenting and effortful control on anxiety among adults (N = 162). Results suggest that effortful control uniquely contributes to anxiety symptoms above and beyond that of any parenting behavior. Furthermore, effortful control acted as a moderator of the relationship between parental overprotection and anxiety, such that overprotection is associated with anxiety only in individuals with lower levels of effortful control. Implications for potential prevention and intervention efforts which specifically target effortful control are discussed. These findings underscore the importance of considering individual differences in self-regulatory abilities when examining associations between putative early-life risk factors, such as parenting, and anxiety symptoms.


2016 ◽  
Vol 37 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Nicole L. Hofman ◽  
Austin M. Hahn ◽  
Christine K. Tirabassi ◽  
Raluca M. Gaher

Abstract. Exposure to traumatic events and the associated risk of developing Posttraumatic stress disorder (PTSD) symptoms is a significant and overlooked concern in the college population. It is important for current research to identify potential protective factors associated with the development and maintenance of PTSD symptoms unique to this population. Emotional intelligence and perceived social support are two identified protective factors that influence the association between exposure to traumatic events and PTSD symptomology. The current study examined the mediating role of social support in the relationship between emotional intelligence and PTSD symptoms. Participants included 443 trauma-exposed university students who completed online questionnaires. The results of this study indicated that social support mediates the relationship between emotional intelligence and reported PTSD symptoms. Thus, emotional intelligence is significantly associated with PTSD symptoms and social support may play an integral role in the relationship between emotional intelligence and PTSD. The current study is the first to investigate the role of social support in the relationship between emotional intelligence and PTSD symptoms. These findings have important treatment and prevention implications with regard to PTSD.


2017 ◽  
Vol 16 (3) ◽  
pp. 155-159 ◽  
Author(s):  
Peizhen Sun ◽  
Jennifer J. Chen ◽  
Hongyan Jiang

Abstract. This study investigated the mediating role of coping humor in the relationship between emotional intelligence (EI) and job satisfaction. Participants were 398 primary school teachers in China, who completed the Wong Law Emotional Intelligence Scale, Coping Humor Scale, and Overall Job Satisfaction Scale. Results showed that coping humor was a significant mediator between EI and job satisfaction. A further examination revealed, however, that coping humor only mediated two sub-dimensions of EI (use of emotion and regulation of emotion) and job satisfaction. Implications for future research and limitations of the study are discussed.


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